Abstract：
:Sleep homeostasis occurs during prolonged wakefulness. Drowsiness and sleep pressure are its behavioral manifestations and, when sleep is allowed, there is a sleep rebound of sufficient duration and intensity to compensate for the previous deprivation. Adenosine is one of the molecules involved in sleep homeostasic regulation. Caffeine and theophylline, stimulants widely consumed by the humans, are antagonists. It is an endogenous factor, resulting from ATP metabolism in neurons and glia. Adenosine accumulates in the extracellular space, where it can exert regulatory actions on the sleep-wakefulness cycle circuits. Adenosine acts through the purinergic receptors A1 and A2. This paper reviews: 1) the metabolic pathways of cerebral adenosine, and the mechanisms of its release by neurons and glia to the extracellular space; 2) the actions of adenosine and its antagonists in regions of the central nervous system related to wakefulness, non-REM sleep, and REM sleep, and 3) the synaptic mechanisms involved in these actions.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Carús-Cadavieco M,de Andrés Isubject
Has Abstractpub_date
2012-10-01 00:00:00pages
413-20issue
7eissn
0210-0010issn
1576-6578pii
rn2012258journal_volume
55pub_type
杂志文章,评审abstract：INTRODUCTION:The search for variables that mediate in the shift from mild cognitive impairment (MCI) to dementia is currently a very active field of research. In this area, the term cognitive plasticity or modifiability can be of great interest. Proof of the existence of plasticity in the elderly with MCI and its possi...
journal_title：Revista de neurologia
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更新日期：2001-06-01 00:00:00
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更新日期：2005-10-16 00:00:00
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更新日期：2011-06-16 00:00:00
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更新日期：2010-05-01 00:00:00
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更新日期：2009-04-16 00:00:00
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journal_title：Revista de neurologia
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更新日期：2002-02-01 00:00:00
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更新日期：2015-04-01 00:00:00
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更新日期：2001-09-01 00:00:00
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