Abstract:
:Restoration of blood flow is necessary when treating brain ischemia. However, except in very early cases, this is insufficient to prevent the cascade of mediators of cell damage unleashed by ischemia which, on the other hand, is boosted by the deleterious effects of reperfusion. We therefore consider adequate treatment for brain ischemia ought to associate, early on, reperfusion with pharmacological inhibition of those intermediaries in damage caused by ischemia/reperfusion (cytoprotection), basically an excess of cytosolic calcium and of free radicals. In this way, spreading of the infarct may be avoided more effectively than just with reperfusion alone. Our aim was to demonstrate this hypothesis using an experimental model. In order to do so, we shall embolize the right carotid artery territory of 50 Long Evans rats with autologous blood thrombi and check the location of the embolus using arteriography. Forty rats will receive thrombolytic treatment intravenously (rTPA at a dose of 20 mg/kg) two hours after embolization, while 10 control rats will receive similar treatment with saline serum. The thrombolysis treated animal group will be divided into four subgroups (A, B, C, D, ni = 10). Group A will be considered as the thrombolysis control group; group B will additionally receive calcium antagonists (dihydropyridines); group C will undergo antioxidant treatment (21-aminosteroids) and group D both calcium antagonists and antioxidants in association with thrombolysis. The size of infarct produced in each group, estimated following Cavalieri's principle, will be compared using nonparametric statistical tests (Mann-Whitney test and Willcoxon test). We present the preliminary results so obtained in a group of 14 control rats studied with the aim of assessing the usefulness of the proposed model.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Alonso de Leciñana M,Díez-Tejedor E,Carceller F,Vega A,Roda JMsubject
Has Abstractpub_date
1996-02-01 00:00:00pages
207-13issue
126eissn
0210-0010issn
1576-6578journal_volume
24pub_type
杂志文章abstract:OBJECTIVE:To evaluate the therapeutic response of West's syndrome (WS) associated with cerebral paralysis (CP) secondary to periventricular leucomalacia (PVL). MATERIAL AND METHODS:We made a retrospective analysis of the clinical histories of 10 patients with SW and CP secondary to periventricular leucomalacia. We stu...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1997-09-01 00:00:00
abstract:TITLE:Hematoma subdural cronico calcificado: cerebro blindado. : ...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2014-05-01 00:00:00
abstract:TITLE:Meningoencefalitis tuberculosa con quistes aracnoideos medulares y siringomielia aguda. ...
journal_title:Revista de neurologia
pub_type: 信件
doi:
更新日期:2017-10-16 00:00:00
abstract:INTRODUCTION AND DEVELOPMENT:Reported observations of acquired aphasia in children contain all the symptoms and syndromes that have been described in adult aphasiology. Recovery of colloquial language is good even if anomia and verbal memory deficits persist as the most frequent defects. At long term outcome there are ...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2008-01-01 00:00:00
abstract:TITLE:Signo del cerebelo blanco (reversal sign). : ...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2014-01-01 00:00:00
abstract:AIMS:To analyze the validity of the single deck 64-card Wisconsin Card Sorting Test (WCST-64) compared to the standard version (WCST-128), and to study the sensibility of both versions to identify changes over time in patients with traumatic brain injury (TBI). PATIENTS AND METHODS:The WCST was administered twice acro...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2008-02-01 00:00:00
abstract:INTRODUCTION AND DEVELOPMENT:Medulloblastoma is a cerebellar small cell tumor, whose ancestor cell has not been yet identified in the human normal embriology: its exact origin is, in fact, still unknown. Nevertheless, one of the most acceptable possibilities facing the origin of the tumor is the remaining rests of cere...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2006-08-16 00:00:00
abstract:INTRODUCTION AND OBJECTIVE:Cognitive deficits following lesions in parieto occipital areas tend to cause, among others, visuospatial and visuoperceptive alterations. The aim of this article is to examine the influence of others possible deficit over its rehabilitation. DEVELOPMENT:We discuss several patients who prese...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2004-03-01 00:00:00
abstract:AIM:To describe the main physiopathological mechanisms of obstructive sleep apnea syndrome (OSAS) associated with the development of stroke. DEVELOPMENT:Sleep breathing disorders have a high prevalence in the healthy population, among them, the OSAS is the most recognized. This syndrome has been associated with vascul...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:10.33588/rn.6906.2019061
更新日期:2019-09-16 00:00:00
abstract:INTRODUCTION AND CLINICAL CASE:A 58-year-old hypertensive man presented with the sudden onset of quadriplegia and inability to protrude the tongue. Magnetic resonance imaging showed a bilateral medial medullary infarction associated with an abnormally dilated and partially occluded vertebral artery. CONCLUSION:This is...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:To show the disorders of the brain cortical development and the possible origin in base to a large series studied in a Pediatric Neurology service. PATIENTS AND METHODS:A series of 144 children with ages ranging between newborn and 12 years was studied from the clinic, image (MR, 3DMR) and evolutive point of...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2003-08-16 00:00:00
abstract:INTRODUCTION:Diagnosing Alzheimer's disease (AD) as soon as possible is critical to achieve an effective treatment of patients. AIM:To make up a test capable of differentiating those patients suffering from the early stages of AD compared to healthy people or patients with mild cognitive impairment (MCI). SUBJECTS AN...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2007-04-16 00:00:00
abstract:INTRODUCTION:Behavior disorders are frequently seen in children attending a neuropaediatric clinic. The classical neuroleptic drugs are usually used for treatment. However response tends to be irregular with adverse effects at a cognitive level and extrapyramidal symptoms. PATIENTS AND METHODS:We started to use risper...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2001-08-01 00:00:00
abstract:OBJECTIVE:To standardize and to determine the structural validity of a conduct disorder self report questionnaire in adolescents. PATIENTS AND METHODS:One hundred ninety, 12 to 16 year old male participants from the different socioeconomic status were randomized selected from educational institutions of Medellin City,...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2000-06-16 00:00:00
abstract:INTRODUCTION:In recent years, significant advances have been made in the physiology and the pharmacology of vestibular disorders. It is now possible to elaborate an approximation of the mechanisms of action of the drugs used in the symptomatic treatment of vertigo. DEVELOPMENT:These drugs usually have a number of diff...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2004-08-16 00:00:00
abstract:OBJECTIVE:To review the current treatment and usefulness of lamotrigine in absence seizures. DEVELOPMENT:Absence seizures are classified amongst the generalized epilepsies. They are defined as a transient loss of consciousness of sudden onset and recovery characteristically associated with generalized spike-and-wave d...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2001-02-01 00:00:00
abstract:INTRODUCTION:Cognitive dysfunction in mesial temporal lobe epilepsy (MTLE) is still a controversial subject. Since refractory MTLE is considered a surgically remediable syndrome, the neuropsychological assessment to establish the presence of cognitive impairment in the surgical candidate became an important issue, give...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1999-12-16 00:00:00
abstract::We present the association of a distrophinopathy with a case of facioscupulohumeral dystrophy in two individuals belonging to the same family. The discrepancy in the seric creatinphosphokinase (CPK) of the two patients together with certain clinical data suggests the possibility that it is a question of two different ...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
abstract:INTRODUCTION:Stroke is a recognized cause of disability among adults. However the impact that the deficits that occur after a moderate/severe stroke have on long-term disability, as well as the response of the resultant deficits to rehabilitation, are not completely understood. PATIENTS AND METHODS:A total of 396 pati...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVES:Apolipoprotein E (ApoE) gen has been found to confer risk for Alzheimer disease in every population studied. We are interested in analyzed the exonic variants and the promoter polymorphisms in our Canary population. SUBJECTS AND METHODS:By means of PCR RFLP analysis of DNA from patients (NINCS ADRDA criteri...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2004-04-01 00:00:00
abstract:INTRODUCTION:Acute disseminated encephalomyelitis (ADEM) is a demyelinating disease that essentially affects the white matter of the central nervous system. The diagnosis is based on clinical-imaging and developmental findings. Magnetic resonance imaging of the brain is the most useful diagnostic tool. The disease cour...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:The atherosclerosis is the most common cause of death and disability in developed countries by causing ischemic cardiopathic and stroke. The ischemic atherotrombotic stroke is the most frequent form of the last one. In this sense we review herein the mechanisms underlying the artherosclerotic process. DEVELO...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2002-09-01 00:00:00
abstract:INTRODUCTION:Several studies have found that individuals with multiple sclerosis (MS) experience relatively high rates of anxiety and depression; however, there are few reports about social anxiety in individuals with MS. AIM:To analyze the prevalence of social anxiety disorder and other psychiatric comorbidities in M...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:10.33588/rn.7002.2019213
更新日期:2020-01-16 00:00:00
abstract:INTRODUCTION:In neuropathic pain, as occurs in epilepsy, researchers are striving to find a drug capable of inhibiting the pain-generating ectopic discharges that are produced as a result of neuronal hyperexcitability. This is mediated by ionic exchanges across the channels of the synaptic membrane. This is why the dru...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2007-10-01 00:00:00
abstract:TITLE:Facilitar el acceso a toda la informacion debe ser una obligacion para las revistas medicas. : ...
journal_title:Revista de neurologia
pub_type: 信件
doi:
更新日期:2018-02-16 00:00:00
abstract:INTRODUCTION:Vasculitis or angiitis is the term used to define the inflammation of the vessels, either blood or lymphatic, which causes may be primary related to immunological disorders, or secondary, with great variety of causal factors. CASE REPORT:We present a very uncommon case of a 36 year old man with brain vasc...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2005-06-16 00:00:00
abstract:INTRODUCTION:The development of scientific advances, constantly opening new frontiers of knowledge, leads to increasing complexity and specialization. DEVELOPMENT:The conflict between the never ending medical specialization and the opposite tendency, which is based mostly on economic grounds, prevents the acquisition ...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVES:To establish the role of the age on quality of life of a group of normotensive patients, older than 65 years with vertebrobasilar ischemia, treated with nicardipine. To evaluate the influence of the Nicardipine side effects on the quality of life of these patients within general practice prescription limits....
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1995-07-01 00:00:00
abstract:: TITLE:Sindrome de Guillain-Barre en tiempos de arbovirosis. ...
journal_title:Revista de neurologia
pub_type: 评论,信件
doi:
更新日期:2018-12-01 00:00:00
abstract:INTRODUCTION AND DEVELOPMENT:Psychostimulant drugs encompass amphetamines, natural alkaloids like cocaine, and methyl-xanthynes. These drugs induce a strong dependence, manifested as sensitization and tolerance at a neurobiological level. Sensitization is currently being studied experimentally, and it is made up of two...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2006-08-01 00:00:00