Abstract：
INTRODUCTION:Recent studies indicate that decreased energy generation by mitochondria is a feature that is common across neurodegenerative diseases. PATIENTS AND METHODS:In order to obtain direct evidence that mitochondrial functioning is altered, we measured the hydrolytic activity of F0F1-ATPase and its capacity to generate a stable proton gradient in submitochondrial particles in 29 patients diagnosed with probable Alzheimer's disease (AD). Submitochondrial particles were obtained from platelets of patients with a diagnosis of probable AD and from clinically healthy controls. RESULTS:Data revealed that the hydrolytic activity of F0F1-ATPase increases significantly in patients with probable AD (41.7+/-4.3 nmol PO4 min-1[mg protein]-1, n=29) as compared to the control subjects (29.1+/-1.9 nmol PO4 min-1 [mg protein]-1, n=29). It is important to note that, in the male population with probable AD, we found that hydrolytic activity of F0F1-ATPase increased as cerebral deterioration progressed. We also detected a lower pH gradient in the submitochondrial particles of patients with probable AD (0.28+/-0.08 pH units, n=25) as compared to the controls (0.5+/-0.1 pH units, n=20). CONCLUSIONS:Overall, these data point to an alteration in the functioning of the enzyme.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Martínez-Cano E,Ortiz-Genaro G,Pacheco-Moisés F,Macías-Islas MA,Sánchez-Nieto S,Rosales-Corral SAsubject
Has Abstractpub_date
2005-01-16 00:00:00pages
81-5issue
2eissn
0210-0010issn
1576-6578pii
rn2004150journal_volume
40pub_type
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更新日期：1997-09-01 00:00:00
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pub_type： 历史文章,杂志文章
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更新日期：2004-05-01 00:00:00
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更新日期：2006-05-01 00:00:00
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doi：
更新日期：2003-06-16 00:00:00
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更新日期：1996-04-01 00:00:00
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