Abstract：
INTRODUCTION:Recent studies suggest that furosemide (FUR), a chloride cotransporting antagonist, acts directly on neurons of central nervous system modifying the ionic flow. OBJECTIVE:The aim of the present study was to determine the extrarenal antiedema effect of FUR. MATERIAL AND METHODS:Male Sprague-Dawley rats were anesthetized with tiobarbital (60 mg/kg-1 ip), bilaterally nephrectomized and perfunded iv with solution of Ringer (RIN) (n= 5) or FUR (40 mg/kg-1) (n= 6), in equivalent volumes. The diuretic effect of FUR was excluded by bilateral nephrectomy. Two tungsten microelectrodes implanted on the cerebral cortex, registered the tissue impedance by the voltage fall of a square wave electric pulse (100 mA, 10 ms) tested every 120 seconds, before and after infusion of FUR or RIN and during global cerebral ischemia by D-tubocurarine induced respiratory arrest. RESULTS:Preischemic FUR infusion induced a significant increase of voltage (t= 15.68; p< 0.0001). During global cerebral ischemia, the voltage fall was significantly lower in FUR than for RIN infusion (Wilcoxon Z= 3.9; p< 0.00001). CONCLUSION:These results suggest that FUR reduced significantly the cerebral impedance i.e. antiedema effect, by an extrarenal action, under both basal and ischemia conditions.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Oria De Suárez C,Eblen Zajjur Asubject
Has Abstractpub_date
2001-03-01 00:00:00pages
414-6issue
5eissn
0210-0010issn
1576-6578journal_volume
32pub_type
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更新日期：2013-08-16 00:00:00
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更新日期：2001-05-16 00:00:00
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更新日期：2001-05-16 00:00:00
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