Abstract：
:In embryonic mesencephalic transplant in patients with Parkinson s disease dopaminergic survival is low (5 10%), and for this reason the use of multiple donors has been considered. The difficulty of obtaining more tissue determines the need for a procedure that enables human nigral tissue to be stored for a time without affecting its physiological state in any significant way. This study was designed to determine whether hibernation of tissue fragments has any influence on viability, how the viability of the mesencephalic cells behaves after 7 days hibernation and the glutathione levels in the hibernated tissue (HT). The viability of the HT in pieces (82.37 2.12) was found to be higher than the value for the whole mesencephalon (70.29 3.43). Viability of the HT, seven days at 4 C, at different post dissociation times, did not differ significantly. Despite the significant differences found between hibernated and fresh tissue at t= 0, this procedure does not seem to affect the mesencephalic tissue in any significant way, as it conserved a 94% viability after hibernation. No evidence was found of increased glutathione content as an antioxidizing response to the damage that might be caused by hibernation. These results suggest that since hibernation does not have any significant effect on the state of the cells it could be considered a useful procedure for conserving tissue to be used in clinical transplants. Moreover, further research is needed on survival and functionality of hibernated cells after being transplanted into animal models in order to evaluate their potential for use in cell therapy.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
De La Cuétara-Bernal K,Castillo-Díaz L,Cruz-Aguado R,González-Mena Y,García-Varona AYsubject
Has Abstractpub_date
2002-06-01 00:00:00pages
1030-4issue
11eissn
0210-0010issn
1576-6578pii
rn2002029journal_volume
34pub_type
杂志文章abstract：INTRODUCTION:Cochrane Collaboration (CC) contains detailed, critical and up-to-date systematic reviews (SR) of the best scientific evidence available. AIM:To analyse the bibliometric characteristics of the SR related to paediatric neurology published in the 50 Collaborative Review Groups (CRG) of the CC. MATERIALS AN...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2006-11-16 00:00:00
abstract：INTRODUCTION:Based on medullary traction as responsible for idiopathic syringomyelia (SMI), idiopathic scoliosis (ESCID), Arnold Chiari malformation (ARCH), platybasia (PTB), basilar impression (IMB), odontoid recess (RTO) kinking of the brain stem (KTC) and considering the medullary traction to be transmitted by the f...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1997-04-01 00:00:00
abstract：INTRODUCTION:Neuronal ceroid lipofuscinosis (NCL), represents a group of inherited neurodegenerative disorders. Based on the age of the patient at onset, clinical course and ultrastructural morphology it has been identified three clinical types for the pediatric group: 1) Infantile NCL (INCL); 2) Late infantile NCL (LI...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：INTRODUCTION:The Iowa Rating Scale for Personality Change (IRSPC) presents some features (puts an emphasis on the motivational and emotional functions; evaluates the 'cognitive' executive functions in the daily life; estimates the premorbid personality; values the informant reliability) that make it use really interest...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2015-01-01 00:00:00
abstract：INTRODUCTION:The hyperperfusion syndrome (HS) is described as an infrequent complication of carotid endarterectomy. It may also occur in percutaneous transluminal carotid angioplasty with a similar causal mechanism and clinical features to those seen in HS related to carotid endarterectomy. CLINICAL CASE:We describe t...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-11-16 00:00:00
abstract：INTRODUCTION:The cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is caused by mutations of the Notch3 gene in the chromosome 19p13.1. and is characterized by small-vessel disease of the cerebral. The clinical feature consists of migraine, recurrent strokes, mood chan...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2000-11-16 00:00:00
abstract：INTRODUCTION:At the present time it is well established that cranial magnetic resonance (MR) is the imaging technique of choice for diagnosis of thrombosis of the dural sinuses. However, few studies have been done to evaluate its role in follow-up in this cerebrovascular disorder. OBJECTIVE:To assess the alterations i...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1998-06-01 00:00:00
abstract：INTRODUCTION:5% of patients with sarcoidosis are affected by neurological complications, of which myopathy is one of the least frequent. We report the clinical course and therapeutic response of two patients with sarcoid myopathy. CASE REPORTS:We observed two females aged 63 and 55 who were previously diagnosed with s...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2005-08-01 00:00:00
abstract：INTRODUCTION:Electrophysiological studies are of recognized use in the confirmation of alterations of neuromuscular transmission in further determining their physiopathological characteristics, helping to differentiate them from other conditions with secondary effects on their function. DEVELOPMENT AND CONCLUSIONS:In ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2000-01-01 00:00:00
abstract：AIMS:In the search for new, potentially treatable, vascular risk factors, one of the most recent to be put forward is the presence of increased total homocysteine (tHc) levels in blood plasma and this has also given rise to a large amount of literature and controversy. The origin of this hypothesis lies in the observat...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2004-02-16 00:00:00
abstract：INTRODUCTION:Over the last twenty years much work has been done to study the P300 in alcoholism. A systematically reduced amplitude, both in patients and in populations at risk (children of alcoholics) was found. Besides, studies on twins indicate that the waves of the evoked potentials are under genetic control. Furth...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2000-04-16 00:00:00
abstract：INTRODUCTION:Vestibular evoked myogenic potential (VEMP) elicited by acoustic stimulation, has been proposed in the assessment of vestibulospinal pathways. AIM:To research the clinical utility of VEMP on multiple sclerosis (MS). SUBJECTS AND METHODS:Forty-four individuals were evaluated (30 normal state and 14 had MS...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2009-03-16 00:00:00
abstract：INTRODUCTION:Treatment of acute strokes in a Stroke Unit reduces intrahospital mortality and dependence by 29%. One year later this effect is still present. It is not known whether the use of intermediate care in the so-called Acute Stroke Units, with continuous cardiovascular and neurological monitoring, provides furt...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1999-10-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2009-01-23 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,meta分析
doi：
更新日期：2010-02-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2009-10-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2008-08-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1998-11-01 00:00:00
abstract：INTRODUCTION:In the last decades psychological studies have demonstrated the effectiveness of the cognitive-behavioural therapy for most anxiety and depressive disorders. Recently, a different and complementary approach in terms of validation of cognitive-behavioural therapy has emerged: testing the efficacy of these t...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2010-02-01 00:00:00
abstract：INTRODUCTION AND OBJECTIVE:Some medical factors related with cardiopulmonary resuscitation (CPR) outcome are known. Moreover, there are other factors, not strictly medical ones, as age, gender, race and socioeconomic status, that influence on decisions of CPR. The aim of this study was to analyse the influence of all t...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1997-10-01 00:00:00
abstract：INTRODUCTION:Advances in neuroimaging in the last decade have allowed a number of new findings about attention deficit hyperactivity disorder (ADHD) to be obtained. Quickly developing technology, together with the progress being made in genetics and neurochemical research, suggests a dysfunction of the fronto striatal ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2010-03-03 00:00:00
abstract：INTRODUCTION:Since description of the expansion of the number of CTG trinucleotides on the long arm of chromosome 19 in the 19 q 13.2-13.3 interval as being responsible for myotonic dystrophy (DM), many studies have established a direct relationship between the size of the expansion and the severity of the manifestatio...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-09-16 00:00:00
abstract：INTRODUCTION:It is known as segmental neurofibromatosis type 1 (NF1) a type of NF1 characterized by the features circumscribed to one or more body cutaneous and/or subcutaneous segments. This entity is recognized from recently and it is related with somatic mosaicism. PATIENTS AND METHODS:43 patients (29 females and 1...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2008-10-16 00:00:00
abstract：:Autism spectrum disorder (autism) is a highly prevalent and heterogeneous family of neurodevelopmental disorders of genetic origins with potentially devastating implications for child, family, health and educational systems. Despite advances in paper-and-pencil screening and in standardization of diagnostic procedures...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2015-02-25 00:00:00
abstract：INTRODUCTION:Ocrelizumab is a humanised monoclonal antibody that targets the CD20 antigen on B cells. It has recently been approved by the US (Food and Drug Administration) and European health agencies (European Medicines Agency) for the treatment of multiple sclerosis (MS) and is the first drug marketed for both relap...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2018-06-16 00:00:00
abstract：UNLABELLED:Introduction. Epileptic crises presenting exclusively during sleep are rare and pose more problems of diagnosis than do crises of diurnal presentation. PATIENTS:We present the clinical and electroencephalographic data of 20 patients with exclusively sleep-induced epileptic crises, evaluating not only the ty...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
abstract：INTRODUCTION:Throughout the history of thought, science and philosophy have addressed the problem of mind-brain from different epistemic perspectives. The first covers specific areas of reality and constructs hypotheses with limited scope and multiple inter-scientific connectivity with the aim of validating theoretical...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2016-08-01 00:00:00
abstract：INTRODUCTION:Throughout history a number of speculations have been put forward concerning the functional role of the pineal gland, perhaps some of the most important being the neurophysiological proposals by Descartes. DEVELOPMENT:The psychophysiological role conferred on the pineal gland by Descartes in the 17th cent...
journal_title：Revista de neurologia
pub_type： 历史文章,杂志文章,评审
doi：
更新日期：2010-01-16 00:00:00
abstract：INTRODUCTION:Diverse evidences have shown that the process of natural aging causes a decline in different cognitive functions, including among them the attentional process. AIM:To determine how the healthy aging affects to the different attentional networks. SUBJECTS AND METHODS:Two groups: young subjects (32.5 ± 9.7...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：AIMS:Following the diagnosis of intellectual disability, a prognosis can be offered concerning the degree of autonomy the child will be able to achieve based on prior experience, but which depends on the aetiology of the disability. It is still difficult to give a prospective answer regarding the capacity to reach an o...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2005-01-15 00:00:00
