Abstract:
:This review describes recent developments in microfabricated flow cytometers and related microfluidic devices that can detect, analyze, and sort cells or particles. The high-speed analytical capabilities of flow cytometry depend on the cooperative use of microfluidics, optics and electronics. Along with the improvement of other components, replacement of conventional glass capillary-based fluidics with microfluidic sample handling systems operating in microfabricated structures enables volume- and power-efficient, inexpensive and flexible analysis of particulate samples. In this review, we present various efforts that take advantage of novel microscale flow phenomena and microfabrication techniques to build microfluidic cell analysis systems.
journal_name
Physiol Measjournal_title
Physiological measurementauthors
Huh D,Gu W,Kamotani Y,Grotberg JB,Takayama Sdoi
10.1088/0967-3334/26/3/R02subject
Has Abstractpub_date
2005-06-01 00:00:00pages
R73-98issue
3eissn
0967-3334issn
1361-6579pii
S0967-3334(05)85153-6journal_volume
26pub_type
杂志文章,评审abstract::In recent AASM practice, parameter actimetry is cited to measure total sleep time in obstructive sleep apnoea patients, when polysomnography is not available. An actigraph was therefore compared to polysomnographic data in 28 subjects with known sleep disordered breathing. Total sleep time (TST), sleep period time (SP...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/31/12/005
更新日期:2010-12-01 00:00:00
abstract::Urinary catheters (drainage tubes) are in widespread use. The most common type of long-term catheter is the Foley, which is made from natural or synthetic rubber. Foley catheters are passed into the bladder via the urethra or the suprapubic puncture channel (through the abdominal wall). A simulator for the abdominal w...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/22/3/308
更新日期:2001-08-01 00:00:00
abstract::Patients with claudication have an inadequate haemodynamic response to exercise. Blood flow response will not only have a magnitude, but also a rate of change. There is scope for investigating these parameters, as manipulation of the factors which control them may benefit work to improve the treatment for claudication...
journal_title:Physiological measurement
pub_type: 临床试验,杂志文章
doi:10.1088/0967-3334/26/6/002
更新日期:2005-12-01 00:00:00
abstract::This paper describes the design, construction, and testing of a multi-channel fetal electrocardiogram (fECG) signal generator based on LabVIEW. Special attention is paid to the fetal heart development in relation to the fetus' anatomy, physiology, and pathology. The non-invasive signal generator enables many parameter...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/37/2/238
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:It is accepted that changes in the peripheral pulse waveform characteristics occur with ageing. Pulse risetime is one important feature which has clinical value. However, it is unclear how it varies across the full age spectrum from child to senior and for different peripheral measurement sites. The objective...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/ab9b67
更新日期:2020-08-11 00:00:00
abstract::In this study, a framework for the characterization of the dynamic interactions between RR variability (RRV) and systolic arterial pressure variability (SAPV) is proposed. The methodology accounts for the intrinsic non-stationarity of the cardiovascular system and includes the assessment of both the strength and the p...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/33/3/315
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:Atrial fibrillation (AF) causes marked risk for patients, while silent fibrillation may remain unnoticed if not suspected and screened. Development of comfortable yet accurate beat-to-beat heart rate (HR) monitoring with good AF detection sensitivity would facilitate screening and improve treatment. The purpo...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/aac9a9
更新日期:2018-06-27 00:00:00
abstract::Twenty-nine patients were monitored overnight for breathing distress patterns during postoperative analgesia. Nasal flow apnoea monitoring and pulse oximetry data were recorded at 50 Hz. Respiratory inductive plethysmography (RIP) tracked tidal volume (TV) thoracoabdominal motion, and supplemented the flow monitoring ...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/20/2/307
更新日期:1999-05-01 00:00:00
abstract::An accurate reproducible measurement of left ventricular volume is important in the evaluation of cardiac disease. Four methods of left ventricular volume measurement by radionuclide ventriculography have been compared and their reproducibility assessed in a patient group. The methods studied were a geometric method, ...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/14/1/004
更新日期:1993-02-01 00:00:00
abstract:OBJECTIVE:To provide a non-invasive approach to monitoring lung function in spontaneously breathing lambs, from birth to five months of life, by the forced oscillation technique (FOT). This report describes the experimental set-up, data processing, and identification of normal predicted values of resistance (Rrs) and r...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/ab3493
更新日期:2019-11-04 00:00:00
abstract::Electrical impedance scanning (EIS) is a kind of potential bio-impedance measurement technology, especially aiding the diagnosis of breast cancer in women. By changing the frequency of the driving signal in turn while keeping the other conditions stable, multi-frequency measurement results on the object can be obtaine...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/28/7/S07
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVE:Currently, continuous blood pressure (BP) measurements are mostly based on multi-sensor combinations and datasets with limited BP ranges. Besides, most BP-related features derive from the photoplethysmogram (PPG) signal. The mechanism of PPG signal formation is not considered. We aimed to design a noninvasive...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/abc8dd
更新日期:2021-01-01 00:00:00
abstract::Near infrared spectroscopy (NIRS) is a widely employed method for assessment of regional cerebral oxygenation (RcStO2). RcStO2 values are expected to vary with changes in the relative amount of oxyhaemoglobin. The present experimental study aimed to assess the response of RcStO2 to controlled alterations of carotid bl...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/35/7/1439
更新日期:2014-07-01 00:00:00
abstract::The changes in haemoglobin oxygenation (SO2) occurring in the tuberculin reaction in human skin were measured using macro- and micro-lightguide spectrophotometry and the results compared. A significant difference was found between the measurements from the respective instruments, demonstrating that the micro-lightguid...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/15/2/002
更新日期:1994-05-01 00:00:00
abstract::If electrical impedance tomography is to be used as a clinical tool, the image reconstruction algorithms must yield accurate images of impedance changes. One of the keys to producing an accurate reconstructed image is the inclusion of prior information regarding the physical geometry of the object. To achieve this, ma...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/22/1/308
更新日期:2001-02-01 00:00:00
abstract::In this paper we present the concept, the design and the test procedure for a DSP-based high-precision and high-performance wide-band (up to 10 MHz) bioimpedance analyser module for application in EIT or bioimpedance spectroscopy. The module implements a digital concept with appropriate signal conditioning hardware fo...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/22/1/303
更新日期:2001-02-01 00:00:00
abstract::Measurement of the velocity of propagation and attenuation of ultrasound (200 kHz) is believed to be a useful non-invasive technique for assessing the mechanical properties of bone. A new method for the determination of ultrasound velocity and attenuation of longitudinal waves in cortical bone was used in vivo and in ...
journal_title:Physiological measurement
pub_type: 临床试验,杂志文章
doi:10.1088/0967-3334/17/3/006
更新日期:1996-08-01 00:00:00
abstract::Stroke is a major cause of disability within the western world. About 20% of strokes are a consequence of atheromatous narrowing of the origin of the internal carotid artery. Carotid endarterectomy has been shown to be an effective treatment for those with symptomatic and severe stenosis, provided the risk of death an...
journal_title:Physiological measurement
pub_type: 临床试验,杂志文章
doi:10.1088/0967-3334/24/2/310
更新日期:2003-05-01 00:00:00
abstract::There is considerable interest in unobtrusive and portable methods of monitoring sleepiness outside the laboratory setting. This study evaluates the usefulness of combined electrocardiogram (ECG) and photoplethysmogram (PPG) measurements for estimating psychomotor vigilance. The psychomotor vigilance test (PVT) was pe...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/29/8/001
更新日期:2008-08-01 00:00:00
abstract::In this paper we present the T-SCAN technology and its use as a diagnostic tool for breast cancer detection. We show, using theoretical models with simplified geometries, that displaying planar two-dimensional maps of the currents detected at the breast's surface relate to the electric field distribution within the br...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/22/1/301
更新日期:2001-02-01 00:00:00
abstract:OBJECTIVE:Sleep-stage scoring is important for sleep-quality evaluation and the diagnosis of related diseases. In this study, an automatic sleep-stage scoring method using photoplethysmographic (PPG) signals was proposed. APPROACH:To construct the classification model, we extracted 14 time-domain features, 17 frequenc...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/ab921d
更新日期:2020-06-30 00:00:00
abstract::Thermal sweating manikins are used to analyse the heat and mass transfer phenomena in the skin-clothing-environment system. However, the limiting factor of present thermal manikins is their inability to simulate adequately the human thermal behaviour, which has a significant effect on the clothing microenvironment. A ...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/29/2/002
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:Transfer function analysis (TFA) of dynamic cerebral autoregulation (dCA) requires smoothing of spectral estimates using segmentation of the data (SD). Systematic studies are required to elucidate the potential influence of SD on dCA parameters. APPROACH:Healthy subjects (HS, n = 237) and acute ischaemic str...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/ab7ddf
更新日期:2020-04-17 00:00:00
abstract:OBJECTIVE:U-shaped patterns, characteristic periods of time observed in tachograms, are a specific subgroup among very low frequency components characterized by relatively short periods of smooth accelerations followed by decelerations of heart rhythm. In this study, we characterize this phenomenon and its effect on he...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/ab9376
更新日期:2020-07-02 00:00:00
abstract::The widening application of automatic external defibrillators (AEDs) presents very strong requirements for external electrocardiogram (ECG) signal analysis. Highly accurate detection of shockable rhythms is required, aimed to approach the maximum of 100% sensitivity and specificity. In a previous study the performance...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/22/2/302
更新日期:2001-05-01 00:00:00
abstract::Polysomnography (PSG) has been extensively studied for sleep staging, where sleep stages are usually classified as wake, rapid-eye-movement (REM) sleep, or non-REM (NREM) sleep (including light and deep sleep). Respiratory information has been proven to correlate with autonomic nervous activity that is related to slee...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/35/12/2529
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:Observational studies suggest that obesity might have a Mendelian origin, but it is not clear if gene expression patterns observed in obese subjects are secondary to genetic traits or not. APPROACH:Here we test a transcriptomic signature of obesity previously identified by our group on a large cohort of twin...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/aab85a
更新日期:2018-04-26 00:00:00
abstract::The purpose of this study was to examine the validity and reliability of estimated parameters of the work-time relationship during cross-country ski ergometry using the traditional multi-trial critical power (CP) test and a 3 min 'all-out' test (3MT). Fourteen recreationally active male participants (mean ± SD; age: 2...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/35/1/31
更新日期:2014-01-01 00:00:00
abstract::An analytic solution of the potential distribution on a 2D homogeneous disk for electrical impedance tomography under the complete electrode model is expressed via an infinite system of linear equations. For the shunt electrode model with two electrodes, our solution coincides with the previously derived solution expr...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/32/9/008
更新日期:2011-09-01 00:00:00
abstract::A magnetic pulse generator has been set up in order to study gastric activity. Two coils 1.05 m in diameter, arranged in a Helmholtz configuration, were used. The system generated magnetic field pulses higher than 15 mT, of duration 17.3+/-1.2 ms. Measurements were performed in 11 male volunteers, with average age 29....
journal_title:Physiological measurement
pub_type: 临床试验,杂志文章
doi:10.1088/0967-3334/25/5/015
更新日期:2004-10-01 00:00:00