Abstract:
OBJECTIVE:Observational studies suggest that obesity might have a Mendelian origin, but it is not clear if gene expression patterns observed in obese subjects are secondary to genetic traits or not. APPROACH:Here we test a transcriptomic signature of obesity previously identified by our group on a large cohort of twin subjects (TwinsUK). MAIN RESULTS:The results show that the signature correlates strongly both with body mass index (BMI) and fat mass. Moreover, in paired transcriptomes of monozygotic twins, changes in signature correlate with changes in BMI and fat mass. We also identify a set of deregulated pathways involved in obesity, from inflammation to metabolism, and show that their pathway deregulation score is strongly correlated with BMI variations in pairs of identical twins. SIGNIFICANCE:Taken together, our results strongly indicate that alterations in gene expression observed in obese subjects are not due to their genetic background, and should therefore primarily be associated with environment and lifestyle.
journal_name
Physiol Measjournal_title
Physiological measurementauthors
Font-Clos F,Zapperi S,La Porta CAMdoi
10.1088/1361-6579/aab85asubject
Has Abstractpub_date
2018-04-26 00:00:00pages
044008issue
4eissn
0967-3334issn
1361-6579journal_volume
39pub_type
杂志文章abstract::Monitoring the brain state in anaesthesia is crucial for clinical doctors. In this study, we propose a novel nonlinear method, the permutation Lempel-Ziv complexity (PLZC) index, which describes the complexity in the electroencephalographic (EEG) signal to quantify the effect of GABAergic anaesthetics on brain activit...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/36/12/2483
更新日期:2015-12-01 00:00:00
abstract::Near infrared spectroscopy (NIRS) is a widely employed method for assessment of regional cerebral oxygenation (RcStO2). RcStO2 values are expected to vary with changes in the relative amount of oxyhaemoglobin. The present experimental study aimed to assess the response of RcStO2 to controlled alterations of carotid bl...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/35/7/1439
更新日期:2014-07-01 00:00:00
abstract::In this study, we developed a novel technique for estimating non-constrained and cuffless blood pressure (BP) that was based on electrocardiogram (ECG) and ballistocardiogram (BCG). The BCG was non-invasively measured using a common electronic weighing scale when a subject was standing on it. The ECG was measured usin...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/30/7/011
更新日期:2009-07-01 00:00:00
abstract::Balance is the ability to maintain equilibrium while sitting or standing. There are a number of different methods which are used to assess balance: technical methods such as sway magnetometry, ataxia meter and force platforms, and clinical methods such as the functional reach test, Berg balance test and fall risk inde...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/21/4/309
更新日期:2000-11-01 00:00:00
abstract::Electrical impedance tomography (EIT) image reconstruction is an ill-posed problem requiring maximum measurement precision. Recent EIT systems claim 60 to 80 dB precision. Achieving higher values is hard in practice since measurements must be performed at relatively high frequency, on a living subject, while using com...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/27/5/S05
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVE:The ventilators involved in non-invasive mechanical ventilation commonly provide ventilator support via a facemask. The interface of the mask with a patient promotes air leaks that cause errors in the feedback information provided by a pneumatic sensor and hence patient-ventilator asynchrony with multiple neg...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/aab7ac
更新日期:2018-04-26 00:00:00
abstract:OBJECTIVE:Plots of blood volume measurements over time (profiles) may identify euvolemia during fluid removal for acute heart failure. We assessed agreement between two noninvasive measurements of blood volume profiles during mechanical fluid removal, which exemplifies the interstitial fluid shifts that occur during di...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/ab21af
更新日期:2019-07-01 00:00:00
abstract::Fetal heart rate monitoring is used for pregnancy surveillance in obstetric units all over the world but in spite of recent advances in analysis methods, there are still inherent technical limitations that bound its contribution to the improvement of perinatal indicators. In this work, a previously published wavelet t...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/35/8/1723
更新日期:2014-08-01 00:00:00
abstract::Thermal sweating manikins are used to analyse the heat and mass transfer phenomena in the skin-clothing-environment system. However, the limiting factor of present thermal manikins is their inability to simulate adequately the human thermal behaviour, which has a significant effect on the clothing microenvironment. A ...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/29/2/002
更新日期:2008-02-01 00:00:00
abstract::The paper presents a method for adaptive decomposition of an electrical bio-impedance (BI) signal into two components: cardiac and respiratory. The decomposition of a BI signal is not a trivial process because of the non-stationarity of the signal components and overlapping of their harmonic spectra. An application sp...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/29/6/S02
更新日期:2008-06-01 00:00:00
abstract::This study investigates the cerebral hemodynamic changes during a routine sleep-deprived video-electroencephalogram (SD-VEEG) in healthy children. Forty-two children with normal intelligence were examined. The children were 5-14 years of age, and their electroencephalograms (EEGs) were within the normal range. Each su...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/37/7/981
更新日期:2016-07-01 00:00:00
abstract::Extension of the frequency range of electrical impedance myography (EIM) to 2 MHz discloses a major rise in the reactance of muscle above 3-500 kHz, together with a slow decrease in the resistance consonant with the Kramers-Kronig relations. This 'upturn' phenomenon is found when the distant current electrode configur...
journal_title:Physiological measurement
pub_type: 临床试验,杂志文章
doi:10.1088/0967-3334/29/6/S29
更新日期:2008-06-01 00:00:00
abstract::In magnetic resonance electrical impedance tomography (MREIT) we inject currents through electrodes placed on the surface of a subject and try to reconstruct cross-sectional resistivity (or conductivity) images using internal magnetic flux density as well as boundary voltage measurements. In this paper we present a st...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/24/2/367
更新日期:2003-05-01 00:00:00
abstract::We used finite element analysis to study the relationship between the intraventricular blood conductance and the right ventricular volume. Previous studies reported a quasi-linear dependence between these two quantities. We quantified the effects of the resistivities of the surrounding tissues (e.g. heart wall, lungs)...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/15/1/004
更新日期:1994-02-01 00:00:00
abstract::Dual-energy x-ray absorptiometry (DXA) is a precise, widely used method for measuring bone mineral density (BMD), usually of the lumbar spine and femoral neck. Recent developments, such as a lower x-ray tube current and pixel by pixel analysis, enable smaller bones and thinner tissues volumes, as in the hand, to be me...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/18/3/008
更新日期:1997-08-01 00:00:00
abstract::Plethysmographic measurement of airway resistance (R(aw)) has been determined by single-point analysis, usually at 50% of maximum inspiratory flow (MIF). Computer-assisted (best fit) analysis, however, allows R(aw) to be calculated by applying a regression line to any portion of the plethysmograph pressure-flow loop. ...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/23/2/304
更新日期:2002-05-01 00:00:00
abstract::Electrical impedance scanning (EIS) is a kind of potential bio-impedance measurement technology, especially aiding the diagnosis of breast cancer in women. By changing the frequency of the driving signal in turn while keeping the other conditions stable, multi-frequency measurement results on the object can be obtaine...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/28/7/S07
更新日期:2007-07-01 00:00:00
abstract::The postural stability of 30 normal subjects in the age range 15 to 64 years was measured on five separate occasions, using the sway magnetometry technique, to determine the day-to-day repeatability of this measurement technique. On each occasion the pathlength and area enclosed by movement of the hips in a horizontal...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/19/2/003
更新日期:1998-05-01 00:00:00
abstract::Idiopathic normal pressure hydrocephalus (INPH) patients have a disturbance in the dynamics of the cerebrospinal fluid (CSF) system. The outflow conductance, C, of the CSF system has been suggested to be prognostic for positive outcome after treatment with a CSF shunt. All current methods for estimation of C have draw...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/28/11/003
更新日期:2007-11-01 00:00:00
abstract::Patients with claudication have an inadequate haemodynamic response to exercise. Blood flow response will not only have a magnitude, but also a rate of change. There is scope for investigating these parameters, as manipulation of the factors which control them may benefit work to improve the treatment for claudication...
journal_title:Physiological measurement
pub_type: 临床试验,杂志文章
doi:10.1088/0967-3334/26/6/002
更新日期:2005-12-01 00:00:00
abstract::Electrical impedance tomography (EIT) could be significantly advantageous to continuous monitoring of lung development in newborn and, in particular, preterm infants as it is non-invasive and safe to use within the intensive care unit. It has been demonstrated that accurate boundary form of the forward model is import...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/35/6/1149
更新日期:2014-06-01 00:00:00
abstract::Temporal variability of parameters which describe dynamic cerebral autoregulation (CA), usually quantified by the short-term relationship between arterial blood pressure (BP) and cerebral blood flow velocity (CBFV), could result from continuous adjustments in physiological regulatory mechanisms or could be the result ...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/29/4/006
更新日期:2008-04-01 00:00:00
abstract::Electrical impedance spectroscopy has been developed as a potential method for the diagnosis of carcinoma in epithelial tissues. An understanding of the influence of structural changes in the tissue on the properties measured using this technique is essential for interpreting measured data and optimization of probe de...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/26/3/010
更新日期:2005-06-01 00:00:00
abstract::Sleep-wake patterns are often significantly disturbed in critically ill patients. This disturbance is closely linked to secondary brain dysfunctions in these patients. Sedation not only impairs sleep quality in ICU patients but also has detrimental effects on short- and long-term outcome. In other contexts, light ther...
journal_title:Physiological measurement
pub_type: 杂志文章,评审
doi:10.1088/0967-3334/37/9/R73
更新日期:2016-09-01 00:00:00
abstract::Body temperature measurement is an important clinical parameter. The performance of a number of non-invasive thermometers was measured by comparing intra- and inter-operator variability (n = 100) and clinical accuracy (n = 61). Variability was elevated in febrile compared to normothermic subjects for axillary and oral...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/31/9/003
更新日期:2010-09-01 00:00:00
abstract::Muscle stiffness is known to vary as a result of a variety of disease states, yet current clinical methods for quantifying muscle stiffness have limitations including cost and availability. We investigated the capability of shear wave elastography (SWE) to measure variations in gastrocnemius shear wave speed induced v...
journal_title:Physiological measurement
pub_type: 临床试验,杂志文章
doi:10.1088/0967-3334/34/6/713
更新日期:2013-06-01 00:00:00
abstract::This review describes recent developments in microfabricated flow cytometers and related microfluidic devices that can detect, analyze, and sort cells or particles. The high-speed analytical capabilities of flow cytometry depend on the cooperative use of microfluidics, optics and electronics. Along with the improvemen...
journal_title:Physiological measurement
pub_type: 杂志文章,评审
doi:10.1088/0967-3334/26/3/R02
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:Currently, continuous blood pressure (BP) measurements are mostly based on multi-sensor combinations and datasets with limited BP ranges. Besides, most BP-related features derive from the photoplethysmogram (PPG) signal. The mechanism of PPG signal formation is not considered. We aimed to design a noninvasive...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/abc8dd
更新日期:2021-01-01 00:00:00
abstract::One unfortunate occurrence in experimental measurements with electrical impedance tomography is electrodes which become detached or poorly connected, such that the measured data cannot be used. This paper presents an automatic approach to detect such erroneous electrodes. It is based on the assumption that all valid m...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/26/2/017
更新日期:2005-04-01 00:00:00
abstract::The increasing use of EIT in clinical research on severely ill lung patients requires a clarification of the influence of pathologic impedance distributions on the validity of the resulting tomograms. Significant accumulation of low-conducting air (e.g. pneumothorax or emphysema) or well-conducting liquid (e.g. haemat...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/27/5/S16
更新日期:2006-05-01 00:00:00