Gene expression signature of obesity in monozygotic twins.

Abstract:

OBJECTIVE:Observational studies suggest that obesity might have a Mendelian origin, but it is not clear if gene expression patterns observed in obese subjects are secondary to genetic traits or not. APPROACH:Here we test a transcriptomic signature of obesity previously identified by our group on a large cohort of twin subjects (TwinsUK). MAIN RESULTS:The results show that the signature correlates strongly both with body mass index (BMI) and fat mass. Moreover, in paired transcriptomes of monozygotic twins, changes in signature correlate with changes in BMI and fat mass. We also identify a set of deregulated pathways involved in obesity, from inflammation to metabolism, and show that their pathway deregulation score is strongly correlated with BMI variations in pairs of identical twins. SIGNIFICANCE:Taken together, our results strongly indicate that alterations in gene expression observed in obese subjects are not due to their genetic background, and should therefore primarily be associated with environment and lifestyle.

journal_name

Physiol Meas

authors

Font-Clos F,Zapperi S,La Porta CAM

doi

10.1088/1361-6579/aab85a

subject

Has Abstract

pub_date

2018-04-26 00:00:00

pages

044008

issue

4

eissn

0967-3334

issn

1361-6579

journal_volume

39

pub_type

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