Abstract:
:The changes in haemoglobin oxygenation (SO2) occurring in the tuberculin reaction in human skin were measured using macro- and micro-lightguide spectrophotometry and the results compared. A significant difference was found between the measurements from the respective instruments, demonstrating that the micro-lightguide technique measures only in the most superficial capillaries. Laser Doppler flux (LDF) and transcutaneous oxygen (tcpO2) measurements were also obtained concurrently. At the height of the reaction, heating did not significantly change SO2 or LDF, showing that the vessels in the skin were maximally vasodilated. Although SO2 was increased in the reaction, tcpO2 decreased. This suggests that the infiltrating cells may present a diffusion barrier to oxygen between the capillaries and the tissue cells. This study has shown that micro-lightguide spectrophotometry gives a local picture of intracapillary oxygen supply, which is useful in elucidating the pathophysiological changes occurring during chronic inflammation.
journal_name
Physiol Measjournal_title
Physiological measurementauthors
Newton DJ,Harrison DK,Delaney CJ,Beck JS,McCollum PTdoi
10.1088/0967-3334/15/2/002subject
Has Abstractpub_date
1994-05-01 00:00:00pages
115-28issue
2eissn
0967-3334issn
1361-6579journal_volume
15pub_type
杂志文章abstract::There is a lack of studies that examine the dynamics of heat-induced shrinkage of organ tissues. Clinical procedures such as radiofrequency ablation, microwave ablation or high-intensity focused ultrasound, use heat to treat diseases such as cancer and cardiac arrhythmia. When heat is applied to tissues, shrinkage occ...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/35/1/55
更新日期:2014-01-01 00:00:00
abstract::The effects of mechanical stimulation on hemodynamics, such as due to mechanotransduction in vascular endothelial cells, have been widely discussed recently. We previously proposed a resonance model in which the arterial system is treated as a pressure-transmitting system, and suggested that the application of externa...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/27/2/004
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:Metal exposures have been linked with many adverse health outcomes affecting nearly every system in the body. Exposure to metals has been tracked primarily using blood. Blood metal concentrations have drawbacks as biomarkers stemming from the metals' short biologic half-lives, shipping and storage requirement...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/aad947
更新日期:2018-08-31 00:00:00
abstract:OBJECTIVE:U-shaped patterns, characteristic periods of time observed in tachograms, are a specific subgroup among very low frequency components characterized by relatively short periods of smooth accelerations followed by decelerations of heart rhythm. In this study, we characterize this phenomenon and its effect on he...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/ab9376
更新日期:2020-07-02 00:00:00
abstract::Controversial data exist on acute and chronic effects of competitive sports on central hemodynamics and arterial stiffness. We investigated chronic as well as acute training effects in professional rowers. The trial was planned as a non-randomized, controlled pilot-study comparing athletes and controls. 13 German nati...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/37/4/544
更新日期:2016-04-01 00:00:00
abstract::The point spread function (PSF) is the most widely used tool for quantifying the spatial resolution of imaging systems. However, prerequisites for the proper use of this tool are linearity and space invariance. Because EIT is non-linear it is only possible to compare different reconstruction algorithms using a standar...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/16/3a/021
更新日期:1995-08-01 00:00:00
abstract::Analysis of human eye pupil reactivity is a very valuable diagnostic method used mainly for evaluation of the condition of the autonomic nervous system and the visual system. The paper presents an experimental pupillometer built in the Institute of Physics of the Wroclaw University of Technology. The apparatus makes i...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/28/1/006
更新日期:2007-01-01 00:00:00
abstract::The holy grail of neuroimaging would be to have an imaging system, which could image neuronal electrical activity over milliseconds. One way to do this would be by imaging the impedance changes associated with ion channels opening in neuronal membranes in the brain during activity. In principle, we could measure this ...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/25/1/040
更新日期:2004-02-01 00:00:00
abstract::Electrical impedance is one of the most often used parameters for characterizing material properties, especially in biomedical applications. Electrical impedance spectroscopy (EIS), used for revealing both resistive and capacitive characteristics, is good for use in tissue characterization. In this study, a portable a...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/32/9/010
更新日期:2011-09-01 00:00:00
abstract::In nine healthy subjects, magnetic resonance imaging was used to measure blood flow waveforms in the common (CCA), internal (ICA) and external (ECA) carotid arteries. Useful data were acquired from 14 carotid arteries in total. Flow rates were determined from regions of interest placed over the arteries in CINE-phase ...
journal_title:Physiological measurement
pub_type: 临床试验,杂志文章
doi:10.1088/0967-3334/25/3/009
更新日期:2004-06-01 00:00:00
abstract::Sleep-wake patterns are often significantly disturbed in critically ill patients. This disturbance is closely linked to secondary brain dysfunctions in these patients. Sedation not only impairs sleep quality in ICU patients but also has detrimental effects on short- and long-term outcome. In other contexts, light ther...
journal_title:Physiological measurement
pub_type: 杂志文章,评审
doi:10.1088/0967-3334/37/9/R73
更新日期:2016-09-01 00:00:00
abstract::This observational study investigated digital auscultation for the purpose of assessing the clinical feasibility of monitoring vascular sounds in pregnancy. The study was performed at the Regional Hospital Viborg, Denmark, and included 29 pregnant women, 10 non-pregnant women and 10 male participants. Digital ausculta...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/37/7/1163
更新日期:2016-07-01 00:00:00
abstract::The specific heat capacity of tissue is a critical parameter for thermal therapies that act over a long period of time. It is also critical for thermoacoustic signal generation. We present ex vivo measurements of specific heat capacity performed by a dual-pin probe with tight temperature control of the specimen. One 3...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/32/11/N02
更新日期:2011-11-01 00:00:00
abstract::A photoacoustic technique is used for studying topically applied substance absorption in human skin. The proposed method utilizes a double-chamber PA cell. The absorption determination was obtained through the measurement of the thermal effusivity of the binary system substance-skin. The theoretical model assumes that...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/23/3/304
更新日期:2002-08-01 00:00:00
abstract::The electrocardiogram is a representative signal containing information about the condition of the heart. The shape and size of the P-QRS-T wave, the time intervals between its various peaks, etc may contain useful information about the nature of disease affecting the heart. However, the human observer cannot directly...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/25/5/005
更新日期:2004-10-01 00:00:00
abstract::Idiopathic normal pressure hydrocephalus (INPH) patients have a disturbance in the dynamics of the cerebrospinal fluid (CSF) system. The outflow conductance, C, of the CSF system has been suggested to be prognostic for positive outcome after treatment with a CSF shunt. All current methods for estimation of C have draw...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/28/11/003
更新日期:2007-11-01 00:00:00
abstract::Vascular and clinical assessments of arterio-venous fistula (AVF) function and access are important in patients undergoing or preparing to undergo renal dialysis. Objective assessment techniques include colour duplex ultrasound and more recently medical infrared thermography. Ideally, these should help assess problems...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/27/1/005
更新日期:2006-01-01 00:00:00
abstract::A photoplethysmographic (PPG) signal can provide very useful information about a subject's cardiovascular status. Motion artifacts (MAs), which usually deteriorate the waveform of a PPG signal, severely obstruct its applications in the clinical diagnosis and healthcare area. To reduce the MAs from a PPG signal, in the...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/36/10/2159
更新日期:2015-10-01 00:00:00
abstract::Impedance cardiography (ICG) has been proposed to estimate the stroke volume (SV) and cardiac output (CO) in various medical indications. The aim of this study was to explore the reliability of ICG during pregnancy with respect to SV and CO measurements. Blood pressure, heart rate and thoracic impedance were monitored...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/33/6/1015
更新日期:2012-06-01 00:00:00
abstract::One unfortunate occurrence in experimental measurements with electrical impedance tomography is electrodes which become detached or poorly connected, such that the measured data cannot be used. This paper presents an automatic approach to detect such erroneous electrodes. It is based on the assumption that all valid m...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/26/2/017
更新日期:2005-04-01 00:00:00
abstract::The Timed Up and Go (TUG) test is a widely used measure of mobility and fall risk among older adults that is typically scored using a stopwatch. We tested the hypothesis that a body-fixed accelerometer can enhance the ability of the TUG to identify community-living older adults with a relatively high fall risk of unkn...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/32/12/009
更新日期:2011-12-01 00:00:00
abstract::Infant multiple breath washout (MBW) testing serves as a primary outcome in clinical studies. However, it is still unknown whether current software algorithms allow between-centre comparisons. In this study of healthy infants, we quantified MBW measurement errors and tried to improve data quality by simply changing so...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/37/3/L1
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:Currently, continuous blood pressure (BP) measurements are mostly based on multi-sensor combinations and datasets with limited BP ranges. Besides, most BP-related features derive from the photoplethysmogram (PPG) signal. The mechanism of PPG signal formation is not considered. We aimed to design a noninvasive...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/abc8dd
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:Non-contact physiological measurement is a growing research area that allows capturing vital signs such as heart rate (HR) and breathing rate (BR) comfortably and unobtrusively with remote devices. However, most of the approaches work only in bright environments in which subtle photoplethysmographic and balli...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/aae625
更新日期:2018-10-30 00:00:00
abstract::Electrical impedance tomography (EIT) could be significantly advantageous to continuous monitoring of lung development in newborn and, in particular, preterm infants as it is non-invasive and safe to use within the intensive care unit. It has been demonstrated that accurate boundary form of the forward model is import...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/35/6/1149
更新日期:2014-06-01 00:00:00
abstract::Fetal hiccups emerge as early as nine weeks post-conception, being the predominant diaphragmatic movement before 26 weeks of gestation. They are considered as a programmed isometric inspiratory muscle exercise of the fetus in preparation for the post-natal respiratory function, or a manifestation of a reflex circuitry...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/28/6/005
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:The healing of wounds is critical in protecting the human body against environmental factors. The mechanisms involving protein expression during this complex physiological process have not been fully elucidated. APPROACH:Here, we use reverse-phase protein microarrays (RPPA) involving 94 phosphoproteins to st...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/aaee19
更新日期:2018-12-07 00:00:00
abstract::Focused impedance measurements (FIM) are used in several fields, and address the problem of measuring the volume impedance of an object within a volume conductor. Several electrode configurations are possible, and these have different properties. Sensitivity fields of four configurations have been investigated. We pre...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/35/6/1067
更新日期:2014-06-01 00:00:00
abstract::The outflow conductance (C(out)) of the cerebrospinal fluid (CSF) system is a parameter considered to be predictive in selection for hydrocephalus surgery. C(out) can be determined through an infusion test. A new apparatus for performing infusion tests in a standardized and automated way was developed. The objective w...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/26/6/022
更新日期:2005-12-01 00:00:00
abstract::In order to detect minute amounts of glucose in diluted urine, we applied the Raman spectroscopy method. To simulate abnormal diluted urine in a toilet bowl, we diluted normal urine ten-fold with water and added glucose up to 8 mg dl(-1). Data were collected using a low-resolution Raman spectrometer that was preproces...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/28/5/011
更新日期:2007-05-01 00:00:00