Validation of x-ray fluorescence measurements of metals in toenail clippings against inductively coupled plasma mass spectrometry in a Nigerian population.

Abstract:

OBJECTIVE:Metal exposures have been linked with many adverse health outcomes affecting nearly every system in the body. Exposure to metals has been tracked primarily using blood. Blood metal concentrations have drawbacks as biomarkers stemming from the metals' short biologic half-lives, shipping and storage requirements, and invasive collection procedures. Toenails, which capture a longer exposure period, can be collected non-invasively and stored at room temperature, and can be more feasible and cost-effective for large-scale population studies. APPROACH:Inductively coupled plasma mass spectrometry (ICP-MS) has been used for analysis of toenail metal concentrations, but x-ray fluorescence (XRF) has many advantages in versatility and cost effectiveness over these analyses. This study compared toenail concentrations of manganese (Mn) and lead (Pb) measured with XRF against ICP-MS, in samples collected from 20 adults in Nigeria. To do this we developed a novel calibration method that corrects XRF measurements for toenail weight and thickness to reduce the variability in XRF measurements of toenail clippings. MAIN RESULTS:We found a high correlation (R  =  0.91) between toenail manganese metal measurements made with XRF and ICP-MS and a correlation of (R  =  0.32) between toenail lead XRF and ICP-MS with over half of the lead results below the detection limit of the instrumentation. SIGNIFICANCE:XRF can be used effectively to quantify metals at the part per million level or lower depending on the XRF equipment used in the measurements.

journal_name

Physiol Meas

authors

Specht AJ,Kponee K,Nkpaa KW,Balcom PH,Weuve J,Nie LH,Weisskopf MG

doi

10.1088/1361-6579/aad947

subject

Has Abstract

pub_date

2018-08-31 00:00:00

pages

085007

issue

8

eissn

0967-3334

issn

1361-6579

journal_volume

39

pub_type

杂志文章
  • Chronodiagnostic acquisition of recovery speed of heart rate under bathing stress.

    abstract::Cycling on an ergometer is one effective means of measuring cardiovascular function while applying stress on the heart. Bathing in a hot water bath applies a low stress to the heart. The electrocardiograms of a healthy adult male (aged 35 at the start of study) were recorded while taking a hot water bath with no elect...

    journal_title:Physiological measurement

    pub_type: 临床试验,杂志文章

    doi:10.1088/0967-3334/20/4/304

    authors: Ishijima M,Togawa T

    更新日期:1999-11-01 00:00:00

  • Is dynamic cerebral autoregulation measurement using transcranial Doppler ultrasound reproducible in the presence of high concentration oxygen and carbon dioxide?

    abstract::Reliability of cerebral blood flow velocity (CBFV) and dynamic cerebral autoregulation estimates (expressed as autoregulation index: ARI) using spontaneous fluctuations in blood pressure (BP) has been demonstrated. However, reliability during co-administration of O2 and CO2 is unknown. Bilateral CBFV (using transcrani...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/37/5/673

    authors: Minhas JS,Syed NF,Haunton VJ,Panerai RB,Robinson TG,Mistri AK

    更新日期:2016-05-01 00:00:00

  • A wireless platform for in vivo measurement of resistance properties of the gastrointestinal tract.

    abstract::Active locomotion of wireless capsule endoscopes has the potential to improve the diagnostic yield of this painless technique for the diagnosis of gastrointestinal tract disease. In order to design effective locomotion mechanisms, a quantitative measure of the propelling force required to effectively move a capsule in...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/35/7/1197

    authors: Natali CD,Beccani M,Obstein KL,Valdastri P

    更新日期:2014-07-01 00:00:00

  • Ballistocardiography and seismocardiography detection of hemodynamic changes during simulated obstructive apnea.

    abstract:OBJECTIVE:To investigate if modern seismocardiography (SCG) and ballistocardiography (BCG) are useful in the detection of hemodynamic changes occurring during simulated obstructive apneic events. METHODS:Forty-seven healthy volunteers performed a voluntary maximum Mueller maneuver (MM) for 10 s, and SCG and BCG signal...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/1361-6579/ab924b

    authors: Morra S,Hossein A,Gorlier D,Rabineau J,Chaumont M,Migeotte PF,Van De Borne P

    更新日期:2020-07-09 00:00:00

  • A phantom for evaluating bone mineral density of the hand by dual-energy x-ray absorptiometry.

    abstract::Dual-energy x-ray absorptiometry (DXA) is a precise, widely used method for measuring bone mineral density (BMD), usually of the lumbar spine and femoral neck. Recent developments, such as a lower x-ray tube current and pixel by pixel analysis, enable smaller bones and thinner tissues volumes, as in the hand, to be me...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/18/3/008

    authors: Steel SA,Swann P,Langley G,Langton CM

    更新日期:1997-08-01 00:00:00

  • Decomposition method of an electrical bio-impedance signal into cardiac and respiratory components.

    abstract::The paper presents a method for adaptive decomposition of an electrical bio-impedance (BI) signal into two components: cardiac and respiratory. The decomposition of a BI signal is not a trivial process because of the non-stationarity of the signal components and overlapping of their harmonic spectra. An application sp...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/29/6/S02

    authors: Krivoshei A,Kukk V,Min M

    更新日期:2008-06-01 00:00:00

  • Aging in autonomic control by multifractal studies of cardiac interbeat intervals in the VLF band.

    abstract::The heart rate responds dynamically to various intrinsic and environmental stimuli. The autonomic nervous system is said to play a major role in this response. Multifractal analysis offers a novel method to assess the response of cardiac interbeat intervals. Twenty-four hour ECG recordings of RR interbeat intervals (o...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/32/10/014

    authors: Makowiec D,Rynkiewicz A,Wdowczyk-Szulc J,Zarczyńska-Buchowiecka M,Gałaska R,Kryszewski S

    更新日期:2011-10-01 00:00:00

  • Length and activation dependent variations in muscle shear wave speed.

    abstract::Muscle stiffness is known to vary as a result of a variety of disease states, yet current clinical methods for quantifying muscle stiffness have limitations including cost and availability. We investigated the capability of shear wave elastography (SWE) to measure variations in gastrocnemius shear wave speed induced v...

    journal_title:Physiological measurement

    pub_type: 临床试验,杂志文章

    doi:10.1088/0967-3334/34/6/713

    authors: Chernak LA,DeWall RJ,Lee KS,Thelen DG

    更新日期:2013-06-01 00:00:00

  • A comb filter based signal processing method to effectively reduce motion artifacts from photoplethysmographic signals.

    abstract::A photoplethysmographic (PPG) signal can provide very useful information about a subject's cardiovascular status. Motion artifacts (MAs), which usually deteriorate the waveform of a PPG signal, severely obstruct its applications in the clinical diagnosis and healthcare area. To reduce the MAs from a PPG signal, in the...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/36/10/2159

    authors: Peng F,Liu H,Wang W

    更新日期:2015-10-01 00:00:00

  • Adaptive filtering of ECG interference on surface EEnGs based on signal averaging.

    abstract::An external electroenterogram (EEnG) is the recording of the small bowel myoelectrical signal using contact electrodes placed on the abdominal surface. It is a weak signal affected by possible movements and by the interferences of respiration and, principally, of the cardiac signal. In this paper an adaptive filtering...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/27/6/005

    authors: Garcia-Casado J,Martinez-de-Juan JL,Ponce JL

    更新日期:2006-06-01 00:00:00

  • Network proteomics of human dermal wound healing.

    abstract:OBJECTIVE:The healing of wounds is critical in protecting the human body against environmental factors. The mechanisms involving protein expression during this complex physiological process have not been fully elucidated. APPROACH:Here, we use reverse-phase protein microarrays (RPPA) involving 94 phosphoproteins to st...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/1361-6579/aaee19

    authors: Gao X,Petricoin EF 3rd,Ward KR,Goldberg SR,Duane TM,Bonchev D,Arodz T,Diegelmann RF

    更新日期:2018-12-07 00:00:00

  • A multi-frequency EIT system design based on telecommunication signal processors.

    abstract::A multi-frequency electrical impedance tomography system for cardiopulmonary monitoring has been designed with specialized digital signal processors developed primarily for the telecommunications sector. The system consists of two modules: a scan-head and a base-station. The scan-head, located close to the patient's t...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/30/6/S04

    authors: Robitaille N,Guardo R,Maurice I,Hartinger AE,Gagnon H

    更新日期:2009-06-01 00:00:00

  • Permutation Lempel-Ziv complexity measure of electroencephalogram in GABAergic anaesthetics.

    abstract::Monitoring the brain state in anaesthesia is crucial for clinical doctors. In this study, we propose a novel nonlinear method, the permutation Lempel-Ziv complexity (PLZC) index, which describes the complexity in the electroencephalographic (EEG) signal to quantify the effect of GABAergic anaesthetics on brain activit...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/36/12/2483

    authors: Bai Y,Liang Z,Li X,Voss LJ,Sleigh JW

    更新日期:2015-12-01 00:00:00

  • Real-time arrhythmia detection with supplementary ECG quality and pulse wave monitoring for the reduction of false alarms in ICUs.

    abstract::False intensive care unit (ICU) alarms induce stress in both patients and clinical staff and decrease the quality of care, thus significantly increasing both the hospital recovery time and rehospitalization rates. In the PhysioNet/CinC Challenge 2015 for reducing false arrhythmia alarms in ICU bedside monitor data, th...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/37/8/1273

    authors: Krasteva V,Jekova I,Leber R,Schmid R,Abächerli R

    更新日期:2016-08-01 00:00:00

  • An efficient unsupervised fetal QRS complex detection from abdominal maternal ECG.

    abstract::Non-invasive fetal heart rate is of great relevance in clinical practice to monitor fetal health state during pregnancy. To date, however, despite significant advances in the field of electrocardiography, the analysis of abdominal fetal ECG is considered a challenging problem for biomedical and signal processing commu...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/35/8/1607

    authors: Varanini M,Tartarisco G,Billeci L,Macerata A,Pioggia G,Balocchi R

    更新日期:2014-08-01 00:00:00

  • Effect of organic and inorganic nitrates on cerebrovascular pulsatile power transmission in patients with heart failure and preserved ejection fraction.

    abstract:OBJECTIVE:Increased penetration of pulsatile power to the brain has been implicated in the pathogenesis of age-related cognitive dysfunction and dementia, a common comorbidity in patients with heart failure and preserved ejection fraction (HFpEF). However, there is a lack of knowledge on the effects of organic and inor...

    journal_title:Physiological measurement

    pub_type: 杂志文章,随机对照试验

    doi:10.1088/1361-6579/aab2ef

    authors: Londono-Hoyos F,Zamani P,Beraun M,Vasim I,Segers P,Chirinos JA

    更新日期:2018-04-20 00:00:00

  • Assessment of cerebrospinal fluid outflow conductance using constant-pressure infusion--a method with real time estimation of reliability.

    abstract::The outflow conductance (C(out)) of the cerebrospinal fluid (CSF) system is a parameter considered to be predictive in selection for hydrocephalus surgery. C(out) can be determined through an infusion test. A new apparatus for performing infusion tests in a standardized and automated way was developed. The objective w...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/26/6/022

    authors: Andersson N,Malm J,Bäcklund T,Eklund A

    更新日期:2005-12-01 00:00:00

  • Invasive and noninvasive means of measuring intracranial pressure: a review.

    abstract::Measurement of intracranial pressure (ICP) can be invaluable in the management of critically ill patients. Cerebrospinal fluid is produced by the choroid plexus in the brain ventricles (a set of communicating chambers), after which it circulates through the different ventricles and exits into the subarachnoid space ar...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/1361-6579/aa7256

    authors: Zhang X,Medow JE,Iskandar BJ,Wang F,Shokoueinejad M,Koueik J,Webster JG

    更新日期:2017-07-24 00:00:00

  • Video rate electrical impedance tomography of vascular changes: preclinical development.

    abstract::Peripheral vasculature disease is strongly correlated with cardiovascular-associated mortality. Monitoring circulation health, especially in the peripheral limbs, is vital to detecting clinically significant disease at a stage when it can still be addressed through medical intervention. Electrical impedance tomography...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/29/3/006

    authors: Halter R,Hartov A,Paulsen K

    更新日期:2008-03-01 00:00:00

  • Measurement of pupil reactivity using fast pupillometry.

    abstract::Analysis of human eye pupil reactivity is a very valuable diagnostic method used mainly for evaluation of the condition of the autonomic nervous system and the visual system. The paper presents an experimental pupillometer built in the Institute of Physics of the Wroclaw University of Technology. The apparatus makes i...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/28/1/006

    authors: Hachol A,Szczepanowska-Nowak W,Kasprzak H,Zawojska I,Dudzinski A,Kinasz R,Wygledowska-Promienska D

    更新日期:2007-01-01 00:00:00

  • Relationship between detrended fluctuation analysis and spectral analysis of heart-rate variability.

    abstract::The recently-introduced technique of detrended fluctuation analysis (DFA) for heart-rate variability appears to yield improved prognostic power in cardiovascular disease through calculation of the fractal scaling exponent alpha. However, the physiological meaning of alpha remains unclear. In DFA, the signal is segment...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/23/2/314

    authors: Willson K,Francis DP,Wensel R,Coats AJ,Parker KH

    更新日期:2002-05-01 00:00:00

  • Auditory magnetic fields in cochlear-implant patients.

    abstract::Neuromagnetic recordings were used to check if electrical stimulation of the auditory nerve in cochlear-implant patients activates cortical auditory areas in a similar manner as acoustic stimulation in normal hearing subjects or whether the excitation processes are different. The waveform of the evoked magnetic field ...

    journal_title:Physiological measurement

    pub_type: 杂志文章,评审

    doi:10.1088/0967-3334/14/4a/014

    authors: Pelizzone M

    更新日期:1993-11-01 00:00:00

  • Direct EIT Jacobian calculations for conductivity change and electrode movement.

    abstract::Electrical impedance tomography (EIT) is very sensitive to deformations of the medium boundary shape. For lung imaging, breathing and changes in posture move the electrodes and change the chest shape, resulting in image artefacts. Several approaches have been proposed to improve the reconstructed images; most methods ...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/29/6/S08

    authors: Gómez-Laberge C,Adler A

    更新日期:2008-06-01 00:00:00

  • An intelligent ventilation and oxygenation management system in neonatal intensive care using fuzzy trend template fitting.

    abstract::This paper describes an open loop feedback intelligent system for neonatal intensive care management. The system provides a tool enabling the user to make the final decision to accept or reject the advice given. The system collects 18 parameters from the bedside monitor and ventilator using a Medical Information Bus (...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/26/4/019

    authors: Belal SY,Taktak AF,Nevill A,Spencer A

    更新日期:2005-08-01 00:00:00

  • Test-retest reliability and minimal detectable change of repeated sit-to-stand analysis using one body fixed sensor in geriatric patients.

    abstract::A majority of geriatric patients experience difficulty in performing sit-to-stand (SiSt) transitions. A detailed assessment of SiSt ability is a prerequisite for successful rehabilitation. Body fixed sensors (BFSs) are increasingly used to assess functional performances. As to date there is no system which analyzes cl...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/33/11/1931

    authors: Schwenk M,Gogulla S,Englert S,Czempik A,Hauer K

    更新日期:2012-11-01 00:00:00

  • Imaging pathologic pulmonary air and fluid accumulation by functional and absolute EIT.

    abstract::The increasing use of EIT in clinical research on severely ill lung patients requires a clarification of the influence of pathologic impedance distributions on the validity of the resulting tomograms. Significant accumulation of low-conducting air (e.g. pneumothorax or emphysema) or well-conducting liquid (e.g. haemat...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/27/5/S16

    authors: Hahn G,Just A,Dudykevych T,Frerichs I,Hinz J,Quintel M,Hellige G

    更新日期:2006-05-01 00:00:00

  • A method of reducing the error caused by boundary shape and electrode positions in electrical impedance tomography.

    abstract::This paper describes a method of reducing the influence of the data error caused by non-ideal boundary shape and electrode placement on reconstructed images. A data calibration and a modified Newton-Raphson reconstruction are combined in the method to ensure rapid convergence and small reconstruction error. The method...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/15/2a/022

    authors: Li J

    更新日期:1994-05-01 00:00:00

  • Fetal motion estimation from noninvasive cardiac signal recordings.

    abstract::Fetal motility is a widely accepted indicator of the well-being of a fetus. In previous research, it has be shown that fetal motion (FM) is coherent with fetal heart rate accelerations and an indicator for active/rest cycles of the fetus. The most common approach for FM and fetal heart rate (FHR) assessment is by Dopp...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/37/11/2003

    authors: Biglari H,Sameni R

    更新日期:2016-11-01 00:00:00

  • Are ejection fractions from gated SPECT perfusion studies clinically useful? A comparison with radionuclide ventriculography.

    abstract::Gated SPECT (GSPECT) was evaluated for the measurement of left ventricular ejection fraction (LVEF) by comparing with equilibrium gated radionuclide ventriculography (RNVG). A total of 99 subjects underwent GSPECT and RNVG imaging. All studies were acquired in list mode with GSPECT studies processed to give 16- and 8-...

    journal_title:Physiological measurement

    pub_type: 临床试验,杂志文章

    doi:10.1088/0967-3334/22/2/312

    authors: Wright GA,McDade M,Keeble W,Martin W,Hutton I

    更新日期:2001-05-01 00:00:00

  • Hidden Markov model-based activity recognition for toddlers.

    abstract:OBJECTIVE:Physical activity has been shown to impact future health outcomes in adults, but little is known about the long-term impact of physical activity in toddlers. Accurately measuring the specific types and amounts of physical activity in toddlers will help us to understand, predict, and better affect their future...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/1361-6579/ab6ebb

    authors: Albert MV,Sugianto A,Nickele K,Zavos P,Sindu P,Ali M,Kwon S

    更新日期:2020-03-06 00:00:00