Abstract:
:Infant multiple breath washout (MBW) testing serves as a primary outcome in clinical studies. However, it is still unknown whether current software algorithms allow between-centre comparisons. In this study of healthy infants, we quantified MBW measurement errors and tried to improve data quality by simply changing software settings. We analyzed best quality MBW measurements performed with an ultrasonic flowmeter in 24 infants from two centres in Switzerland with the current software settings. To challenge the robustness of these settings, we also used alternative analysis approaches. Using the current analysis software, the coefficient of variation (CV) for functional residual capacity (FRC) differed significantly between centres (mean ± SD (%): 9.8 ± 5.6 and 5.8 ± 2.9, respectively, p = 0.039). In addition, FRC values calculated during the washout differed between -25 and +30% from those of the washin of the same tracing. Results were mainly influenced by analysis settings and temperature recordings. Changing few algorithms resulted in significantly more robust analysis. Non-systematic inter-centre differences can be reduced by using correctly recorded environmental data and simple changes in the software algorithms. We provide implications that greatly improve infant MBW outcomes' quality and can be applied when multicentre trials are conducted.
journal_name
Physiol Measjournal_title
Physiological measurementauthors
Anagnostopoulou P,Egger B,Lurà M,Usemann J,Schmidt A,Gorlanova O,Korten I,Roos M,Frey U,Latzin Pdoi
10.1088/0967-3334/37/3/L1subject
Has Abstractpub_date
2016-03-01 00:00:00pages
L1-L15issue
3eissn
0967-3334issn
1361-6579journal_volume
37pub_type
杂志文章abstract:OBJECTIVE:Advanced neuroimaging has proved to be pivotal in the management of acute ischemic stroke. The use of CT perfusion (CTP) core and penumbra parameters to predict the outcome in wake-up stroke (WUS) patients in everyday clinical scenarios has not yet been investigated. The aim of our study was to investigate th...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/ab9c70
更新日期:2020-08-11 00:00:00
abstract::In this study, the selection of coil configuration parameters (coil radius and coil centre shift) for induced current EIT using circular coils is investigated. An alternative coil configuration is suggested, which produces approximately linear (spatially) magnetic fields in order to strengthen the currents in the cent...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/15/2a/007
更新日期:1994-05-01 00:00:00
abstract:OBJECTIVE:This paper aims to report on the accuracy of estimating sleep stages using a wrist-worn device that measures movement using a 3D accelerometer and an optical pulse photoplethysmograph (PPG). APPROACH:Overnight recordings were obtained from 60 adult participants wearing these devices on their left and right w...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/aa9047
更新日期:2017-10-31 00:00:00
abstract:OBJECTIVE:Increased penetration of pulsatile power to the brain has been implicated in the pathogenesis of age-related cognitive dysfunction and dementia, a common comorbidity in patients with heart failure and preserved ejection fraction (HFpEF). However, there is a lack of knowledge on the effects of organic and inor...
journal_title:Physiological measurement
pub_type: 杂志文章,随机对照试验
doi:10.1088/1361-6579/aab2ef
更新日期:2018-04-20 00:00:00
abstract::Measurement of intracranial pressure (ICP) can be invaluable in the management of critically ill patients. Cerebrospinal fluid is produced by the choroid plexus in the brain ventricles (a set of communicating chambers), after which it circulates through the different ventricles and exits into the subarachnoid space ar...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/aa7256
更新日期:2017-07-24 00:00:00
abstract::Fetal heart rate monitoring is used for pregnancy surveillance in obstetric units all over the world but in spite of recent advances in analysis methods, there are still inherent technical limitations that bound its contribution to the improvement of perinatal indicators. In this work, a previously published wavelet t...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/35/8/1723
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVE:Eye-tracking devices have become widely used as clinical assessment tools in a variety of applied-scientific fields to measure saccadic eye movements. With the emergence of multiple static and dynamic devices, the concurrent need for algorithm development and validation is paramount. APPROACH:This review ass...
journal_title:Physiological measurement
pub_type: 杂志文章,评审
doi:10.1088/1361-6579/ab02ab
更新日期:2019-02-26 00:00:00
abstract::Using the cross-sectional images taken with the zoom-in micro-tomography technique, we measured trabecular thicknesses of femur bones in postmortem rats. Since the zoom-in micro-tomography technique is capable of high resolution imaging of a small local region inside a large subject, we were able to measure the trabec...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/26/5/008
更新日期:2005-10-01 00:00:00
abstract::External defibrillation requires the application of high voltage electrical impulses via large external electrodes, placed on selected locations on the thorax surface. The position of the electrodes is one of the major determinants of the transthoracic impedance (TTI) which influences the intracardiac current flow dur...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/27/10/007
更新日期:2006-10-01 00:00:00
abstract::Dual-energy x-ray absorptiometry (DXA) is a precise, widely used method for measuring bone mineral density (BMD), usually of the lumbar spine and femoral neck. Recent developments, such as a lower x-ray tube current and pixel by pixel analysis, enable smaller bones and thinner tissues volumes, as in the hand, to be me...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/18/3/008
更新日期:1997-08-01 00:00:00
abstract:OBJECTIVE:The Actiwatch 2 (AW2) is a wrist-worn accelerometer typically used to measure sleep. Although it can measure physical activity, there is limited evidence supporting its validity. We assessed the validity and reliability of the AW2 to measure sedentary behavior and physical activity (light, moderate, vigorous ...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/aba80f
更新日期:2020-09-04 00:00:00
abstract::Using a primary coil that induces eddy currents in a volume conductor, and a pair of secondary coils configured to form a differential transformer, it is possible to measure the conductivity of a volume conductor by the magnetic fields of the induced eddy currents. This method is especially favourable for measuring im...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/14/4/007
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:Uterine activity monitoring is an essential part of managing the progress of pregnancy and labor. Although intrauterine pressure (IUP) is the only reliable method of estimating uterine mechanical activity, it is highly invasive. Since there is a direct relationship between the electrical and mechanical activ...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/ab37db
更新日期:2019-09-03 00:00:00
abstract::The increasing use of EIT in clinical research on severely ill lung patients requires a clarification of the influence of pathologic impedance distributions on the validity of the resulting tomograms. Significant accumulation of low-conducting air (e.g. pneumothorax or emphysema) or well-conducting liquid (e.g. haemat...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/27/5/S16
更新日期:2006-05-01 00:00:00
abstract::The recently-introduced technique of detrended fluctuation analysis (DFA) for heart-rate variability appears to yield improved prognostic power in cardiovascular disease through calculation of the fractal scaling exponent alpha. However, the physiological meaning of alpha remains unclear. In DFA, the signal is segment...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/23/2/314
更新日期:2002-05-01 00:00:00
abstract::During anaesthesia awareness and nociception are serious complications that may further lead to haemodynamic instability. Specific monitoring of depth of hypnosis and depth of analgesia based on heart rate variability (HRV) analysis is eligible to improve patient safety and reduce efforts in post-operative care. Conse...
journal_title:Physiological measurement
pub_type: 临床试验,杂志文章
doi:10.1088/0967-3334/33/2/207
更新日期:2012-02-01 00:00:00
abstract::Previous studies have used isokinetic dynamometry to assess joint torques and angles during passive extension of the knee, often without reporting upon methodological errors and reliability outcomes. In addition, the reliability of the techniques used to measure passive knee extension torque-angle and the extent to wh...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/34/11/1483
更新日期:2013-11-01 00:00:00
abstract::We tested the hypothesis that transmission of arterial pressure to brain tissue oxygenation is low under conditions of arterial pressure instability. Two experimental models of hemodynamic instability were used in healthy human volunteers; (1) oscillatory lower body negative pressure (OLBNP) (N = 8; 5 male, 3 female),...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/36/4/785
更新日期:2015-04-01 00:00:00
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journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/aa9693
更新日期:2017-11-30 00:00:00
abstract::There are currently no objective means of quantifying chest wall vibrations during manual physiotherapy. The aims of the study were to (i) develop a method to quantify physiotherapy-applied forces and simultaneous changes in respiratory flow and pressure, (ii) assess the feasibility of using this method in ventilated ...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/28/9/004
更新日期:2007-09-01 00:00:00
abstract::Electrical impedance tomography (EIT) estimates an image of change in electrical properties within a body from stimulations and measurements at surface electrodes. There is significant interest in EIT as a tool to monitor and guide ventilation therapy in mechanically ventilated patients. In lung EIT, the EIT inverse p...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/35/6/1035
更新日期:2014-06-01 00:00:00
abstract::Epidemiological studies have associated the negative effects of sedentary time and sedentary patterns on health indices. However, these studies have used methodologies that do not directly measure the sedentary state. Recent technological developments in the area of motion sensors have incorporated inclinometers, whic...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/33/11/1887
更新日期:2012-11-01 00:00:00
abstract::The specific heat capacity of tissue is a critical parameter for thermal therapies that act over a long period of time. It is also critical for thermoacoustic signal generation. We present ex vivo measurements of specific heat capacity performed by a dual-pin probe with tight temperature control of the specimen. One 3...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/32/11/N02
更新日期:2011-11-01 00:00:00
abstract::Generalizability theory was used to investigate the score consistency of observed extracellular fluid/intracellular fluid (ECF/ICF) ratio measurements for both the global and leg-segmental bio-impedance spectroscopy methods. The test instrument used was a Xitron Hydra ECF/ICF Bio-Impedance Analyzer System, model 4200 ...
journal_title:Physiological measurement
pub_type: 杂志文章,随机对照试验
doi:10.1088/0967-3334/27/4/005
更新日期:2006-04-01 00:00:00
abstract::We present the results of using electrical impedance tomographic spectroscopy (EITS) to follow the changes in lung water induced by oleic acid. Measurements were made on three goats before and after the injection of oleic acid. In addition to the EITs measurements, lung water was also measured using a double-indicator...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/17/4a/016
更新日期:1996-11-01 00:00:00
abstract::The holy grail of neuroimaging would be to have an imaging system, which could image neuronal electrical activity over milliseconds. One way to do this would be by imaging the impedance changes associated with ion channels opening in neuronal membranes in the brain during activity. In principle, we could measure this ...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/25/1/040
更新日期:2004-02-01 00:00:00
abstract::Heart rate variability (HRV) is often analysed using short-term studies. Our objective was to compare two of them in a group of diabetic patients (reduced HRV) and in a control group. From the same 10 min surface electrocardiogram (ECG) two recordings were obtained. In one of them the whole signal was acquired through...
journal_title:Physiological measurement
pub_type: 临床试验,杂志文章
doi:10.1088/0967-3334/25/6/n01
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:Brain-computer interfaces (BCIs) are aimed at providing a new way of communication between the human brain and external devices. One of the major tasks associated with the BCI system is to improve classification performance of the motor imagery (MI) signal. Electroencephalogram (EEG) signals are widely used f...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/aba07b
更新日期:2020-08-11 00:00:00
abstract::Vital signs monitoring is ubiquitous in clinical environments and emerging in home-based healthcare applications. Still, since current monitoring methods require uncomfortable sensors, respiration rate remains the least measured vital sign. In this paper, we propose a video-based respiration monitoring method that aut...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/37/1/100
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:Electrical impedance tomography (EIT) is a functional imaging technique in which cross-sectional images of structures are reconstructed based on boundary trans-impedance measurements. Continuous functional thorax monitoring using EIT has been extensively researched. Increasing the number of electrodes, number...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/ab0daa
更新日期:2019-04-03 00:00:00