Multiple breath washout analysis in infants: quality assessment and recommendations for improvement.


:Infant multiple breath washout (MBW) testing serves as a primary outcome in clinical studies. However, it is still unknown whether current software algorithms allow between-centre comparisons. In this study of healthy infants, we quantified MBW measurement errors and tried to improve data quality by simply changing software settings. We analyzed best quality MBW measurements performed with an ultrasonic flowmeter in 24 infants from two centres in Switzerland with the current software settings. To challenge the robustness of these settings, we also used alternative analysis approaches. Using the current analysis software, the coefficient of variation (CV) for functional residual capacity (FRC) differed significantly between centres (mean  ±  SD (%): 9.8  ±  5.6 and 5.8  ±  2.9, respectively, p  =  0.039). In addition, FRC values calculated during the washout differed between  -25 and  +30% from those of the washin of the same tracing. Results were mainly influenced by analysis settings and temperature recordings. Changing few algorithms resulted in significantly more robust analysis. Non-systematic inter-centre differences can be reduced by using correctly recorded environmental data and simple changes in the software algorithms. We provide implications that greatly improve infant MBW outcomes' quality and can be applied when multicentre trials are conducted.


Physiol Meas


Anagnostopoulou P,Egger B,Lurà M,Usemann J,Schmidt A,Gorlanova O,Korten I,Roos M,Frey U,Latzin P




Has Abstract


2016-03-01 00:00:00












  • Chronodiagnostic acquisition of recovery speed of heart rate under bathing stress.

    abstract::Cycling on an ergometer is one effective means of measuring cardiovascular function while applying stress on the heart. Bathing in a hot water bath applies a low stress to the heart. The electrocardiograms of a healthy adult male (aged 35 at the start of study) were recorded while taking a hot water bath with no elect...

    journal_title:Physiological measurement

    pub_type: 临床试验,杂志文章


    authors: Ishijima M,Togawa T

    更新日期:1999-11-01 00:00:00

  • The feasibility of in vivo quantification of bone-fluorine in humans by delayed neutron activation analysis: a pilot study.

    abstract::Fluorine (F) plays an important role in dental health and bone formation. Many studies have shown that excess fluoride (F(-)) can result in dental or skeletal fluorosis, while other studies have indicated that a proper dosage of fluoride may have a protective effect on bone fracture incidence. Fluorine is stored almos...

    journal_title:Physiological measurement

    pub_type: 临床试验,杂志文章


    authors: Chamberlain M,Gräfe JL,Byun SH,Chettle DR,Egden LM,Orchard GM,Webber CE,McNeill FE

    更新日期:2012-02-01 00:00:00

  • Coupling between arterial pressure, cerebral blood velocity, and cerebral tissue oxygenation with spontaneous and forced oscillations.

    abstract::We tested the hypothesis that transmission of arterial pressure to brain tissue oxygenation is low under conditions of arterial pressure instability. Two experimental models of hemodynamic instability were used in healthy human volunteers; (1) oscillatory lower body negative pressure (OLBNP) (N = 8; 5 male, 3 female),...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Rickards CA,Sprick JD,Colby HB,Kay VL,Tzeng YC

    更新日期:2015-04-01 00:00:00

  • Use of the discriminant Fourier-derived cepstrum with feature-level post-processing for surface electromyographic signal classification.

    abstract::Myoelectrical pattern classification is a crucial part in multi-functional prosthesis control. This paper investigates a discriminant Fourier-derived cepstrum (DFC) and feature-level post-processing (FLPP) to discriminate hand and wrist motions using the surface electromyographic signal. The Fourier-derived cepstrum t...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Chen X,Zhu X,Zhang D

    更新日期:2009-12-01 00:00:00

  • Acute and chronic effects on central hemodynamics and arterial stiffness in professional rowers.

    abstract::Controversial data exist on acute and chronic effects of competitive sports on central hemodynamics and arterial stiffness. We investigated chronic as well as acute training effects in professional rowers. The trial was planned as a non-randomized, controlled pilot-study comparing athletes and controls. 13 German nati...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Franzen K,Reppel M,Köster J,Mortensen K

    更新日期:2016-04-01 00:00:00

  • Estimating carotid pulse and breathing rate from near-infrared video of the neck.

    abstract:OBJECTIVE:Non-contact physiological measurement is a growing research area that allows capturing vital signs such as heart rate (HR) and breathing rate (BR) comfortably and unobtrusively with remote devices. However, most of the approaches work only in bright environments in which subtle photoplethysmographic and balli...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Chen W,Hernandez J,Picard RW

    更新日期:2018-10-30 00:00:00

  • The variability of the photoplethysmographic signal--a potential method for the evaluation of the autonomic nervous system.

    abstract::The heart rate variability is composed of low- and high-frequency fluctuations, which are mediated by the sympathetic and the parasympathetic nervous systems. The baseline and the amplitude of the photoplethysmographic (PPG) signal also show fluctuations in the same frequencies. In the current study, PPG examinations ...

    journal_title:Physiological measurement

    pub_type: 临床试验,杂志文章


    authors: Nitzan M,Babchenko A,Khanokh B,Landau D

    更新日期:1998-02-01 00:00:00

  • A comb filter based signal processing method to effectively reduce motion artifacts from photoplethysmographic signals.

    abstract::A photoplethysmographic (PPG) signal can provide very useful information about a subject's cardiovascular status. Motion artifacts (MAs), which usually deteriorate the waveform of a PPG signal, severely obstruct its applications in the clinical diagnosis and healthcare area. To reduce the MAs from a PPG signal, in the...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Peng F,Liu H,Wang W

    更新日期:2015-10-01 00:00:00

  • Repeatability of body sway measurements; day-to-day variation measured by sway magnetometry.

    abstract::The postural stability of 30 normal subjects in the age range 15 to 64 years was measured on five separate occasions, using the sway magnetometry technique, to determine the day-to-day repeatability of this measurement technique. On each occasion the pathlength and area enclosed by movement of the hips in a horizontal...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Elliott C,Murray A

    更新日期:1998-05-01 00:00:00

  • An intelligent ventilation and oxygenation management system in neonatal intensive care using fuzzy trend template fitting.

    abstract::This paper describes an open loop feedback intelligent system for neonatal intensive care management. The system provides a tool enabling the user to make the final decision to accept or reject the advice given. The system collects 18 parameters from the bedside monitor and ventilator using a Medical Information Bus (...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Belal SY,Taktak AF,Nevill A,Spencer A

    更新日期:2005-08-01 00:00:00

  • Carotid flow rates and flow division at the bifurcation in healthy volunteers.

    abstract::In nine healthy subjects, magnetic resonance imaging was used to measure blood flow waveforms in the common (CCA), internal (ICA) and external (ECA) carotid arteries. Useful data were acquired from 14 carotid arteries in total. Flow rates were determined from regions of interest placed over the arteries in CINE-phase ...

    journal_title:Physiological measurement

    pub_type: 临床试验,杂志文章


    authors: Marshall I,Papathanasopoulou P,Wartolowska K

    更新日期:2004-06-01 00:00:00

  • The influence of dilution on the offline measurement of exhaled nitric oxide.

    abstract:OBJECTIVE:Measurement of fractional exhaled nitric oxide (FeNO) is used to determine the presence and severity of eosinophilic airway inflammation in asthma and other wheezing illnesses. The gold standard of online measurement during a single prolonged exhalation is not suitable for use in young children. The internati...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: MacBean V,Pooranampillai D,Howard C,Lunt A,Greenough A

    更新日期:2018-02-26 00:00:00

  • The physiological impact of the nonlinearity of arterial elasticity in the ambulatory arterial stiffness index.

    abstract::The ambulatory arterial stiffness index (AASI) is claimed to be a new estimator for arterial rigidity. It was recently defined as one minus the slope of the linear regression of systolic to diastolic ambulatory pressure during 24 h. Although several reports testify its clinical relevance, the explanation of how this n...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Craiem D,Graf S,Salvucci F,Chironi G,Megnien JL,Simon A,Armentano RL

    更新日期:2010-07-01 00:00:00

  • A medical thermal imaging device for the prevention of diabetic foot ulceration.

    abstract::In this paper a description is given of the development, characterisation and first results of a thermal imaging device aimed at significantly reducing the incidence of diabetic foot ulceration (DFU). These devices will be used in three clinical centres and in two preliminary clinical trials. The first will be on heal...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Machin G,Whittam A,Ainarkar S,Allen J,Bevans J,Edmonds M,Kluwe B,Macdonald A,Petrova N,Plassmann P,Ring F,Rogers L,Simpson R

    更新日期:2017-03-01 00:00:00

  • An analytic solution to the homogeneous EIT problem on the 2D disk and its application to estimation of electrode contact impedances.

    abstract::An analytic solution of the potential distribution on a 2D homogeneous disk for electrical impedance tomography under the complete electrode model is expressed via an infinite system of linear equations. For the shunt electrode model with two electrodes, our solution coincides with the previously derived solution expr...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Demidenko E

    更新日期:2011-09-01 00:00:00

  • Measuring the rate of change of haemodynamic response at the onset of exercise in normal limbs and those with intermittent claudication.

    abstract::Patients with claudication have an inadequate haemodynamic response to exercise. Blood flow response will not only have a magnitude, but also a rate of change. There is scope for investigating these parameters, as manipulation of the factors which control them may benefit work to improve the treatment for claudication...

    journal_title:Physiological measurement

    pub_type: 临床试验,杂志文章


    authors: Meeson S,Srodon PD

    更新日期:2005-12-01 00:00:00

  • EIT data noise evaluation in the clinical environment.

    abstract::In the clinical environment the reliable interpretation of EIT images depends on the quality of the data. In the electrically noisy hospital environment the system performance needs to be assessed for each clinical investigation. From the model of noise presented, a figure of merit for comparisons of system performanc...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Meeson S,Blott BH,Killingback AL

    更新日期:1996-11-01 00:00:00

  • Relationship between detrended fluctuation analysis and spectral analysis of heart-rate variability.

    abstract::The recently-introduced technique of detrended fluctuation analysis (DFA) for heart-rate variability appears to yield improved prognostic power in cardiovascular disease through calculation of the fractal scaling exponent alpha. However, the physiological meaning of alpha remains unclear. In DFA, the signal is segment...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Willson K,Francis DP,Wensel R,Coats AJ,Parker KH

    更新日期:2002-05-01 00:00:00

  • Fetal beat detection in abdominal ECG recordings: global and time adaptive approaches.

    abstract::We present a method for location of fetal QRS in maternal abdominal ECG recordings. This method's initial, global approach was proposed in the context of the 2013 PhysioNet/Computing in Cardiology Challenge where it was tested on the 447 four channel one-minute recordings.The first step is filtering to eliminate basel...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Rodrigues R

    更新日期:2014-08-01 00:00:00

  • Pulmonary perfusion measured by means of electrical impedance tomography.

    abstract::Electrical impedance tomography (EIT) is a recent imaging technique based on electrical impedance, offering the possibility of measuring pulmonary perfusion. In the present study the influence of several pulmonary haemodynamical parameters on the EIT signal were investigated. First, the influence on the systolic wave ...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Vonk Noordegraaf A,Kunst PW,Janse A,Marcus JT,Postmus PE,Faes TJ,de Vries PM

    更新日期:1998-05-01 00:00:00

  • Wearable oxygen uptake and energy expenditure monitors.

    abstract::Obesity is a major health issue in both developed and developing countries. The balance between energy intake and exercise is important, and measurements of both energy intake and energy expenditure are required. Many studies have attempted to monitor energy intake via wearable technology, but no standard methods have...

    journal_title:Physiological measurement

    pub_type: 杂志文章,评审


    authors: Tamura T

    更新日期:2019-09-03 00:00:00

  • Aging in autonomic control by multifractal studies of cardiac interbeat intervals in the VLF band.

    abstract::The heart rate responds dynamically to various intrinsic and environmental stimuli. The autonomic nervous system is said to play a major role in this response. Multifractal analysis offers a novel method to assess the response of cardiac interbeat intervals. Twenty-four hour ECG recordings of RR interbeat intervals (o...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Makowiec D,Rynkiewicz A,Wdowczyk-Szulc J,Zarczyńska-Buchowiecka M,Gałaska R,Kryszewski S

    更新日期:2011-10-01 00:00:00

  • Gastrointestinal arrhythmias are associated with statistically significant fluctuations in systemic information dimension.

    abstract::Although cardiac arrhythmias have been studied extensively, little is known about arrhythmic phenomena in the gastrointestinal (GI) system. In this study, we demonstrate for the first time that the onset of GI arrhythmias is associated with statistically significant fluctuations in the information dimension of the ass...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Irimia A,Wikswo JP Jr

    更新日期:2008-05-01 00:00:00

  • Time-related heart autonomic balance characteristics in healthy subjects.

    abstract::Changes of the heart autonomic balance between morning (8-9 h) and afternoon (14-15 h) measurements were studied in 22 healthy subjects. The selection of these two daytime periods was substantiated by the established higher risk of cardiovascular incidents in the morning and the relative balance of the vegetative nerv...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Matveev M,Prokopova R,Nachev Ch

    更新日期:2003-08-01 00:00:00

  • A multifrequency multichannel electrical impedance data acquisition system for body fluid shift monitoring.

    abstract::This paper discusses some important issues for the design of electrical impedance measurement systems intended for body fluid shift monitoring, in particular during dialysis treatments. We have studied two common signal generation systems: digital synthesis and carrier recovery. We have found that in prolonged measure...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Lozano A,Rosell J,Pallás-Areny R

    更新日期:1995-11-01 00:00:00

  • Thermography and colour duplex ultrasound assessments of arterio-venous fistula function in renal patients.

    abstract::Vascular and clinical assessments of arterio-venous fistula (AVF) function and access are important in patients undergoing or preparing to undergo renal dialysis. Objective assessment techniques include colour duplex ultrasound and more recently medical infrared thermography. Ideally, these should help assess problems...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Allen J,Oates CP,Chishti AD,Ahmed IA,Talbot D,Murray A

    更新日期:2006-01-01 00:00:00

  • Empirically derived cut-points for sedentary behaviour: are we sitting differently?

    abstract::Sedentary behaviour (SB) is associated with a number of adverse health outcomes. Studies that have used ActiGraph monitors to define sedentary time tend to use a threshold of  <100 counts per minute (cpm) for classifying SB; however, this cut-point was not empirically derived for adults. It is not known whether ActiGr...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Clarke-Cornwell AM,Farragher TM,Cook PA,Granat MH

    更新日期:2016-10-01 00:00:00

  • Decomposition method of an electrical bio-impedance signal into cardiac and respiratory components.

    abstract::The paper presents a method for adaptive decomposition of an electrical bio-impedance (BI) signal into two components: cardiac and respiratory. The decomposition of a BI signal is not a trivial process because of the non-stationarity of the signal components and overlapping of their harmonic spectra. An application sp...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Krivoshei A,Kukk V,Min M

    更新日期:2008-06-01 00:00:00

  • Real-time arrhythmia detection with supplementary ECG quality and pulse wave monitoring for the reduction of false alarms in ICUs.

    abstract::False intensive care unit (ICU) alarms induce stress in both patients and clinical staff and decrease the quality of care, thus significantly increasing both the hospital recovery time and rehospitalization rates. In the PhysioNet/CinC Challenge 2015 for reducing false arrhythmia alarms in ICU bedside monitor data, th...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Krasteva V,Jekova I,Leber R,Schmid R,Abächerli R

    更新日期:2016-08-01 00:00:00

  • Effects of awareness and nociception on heart rate variability during general anaesthesia.

    abstract::During anaesthesia awareness and nociception are serious complications that may further lead to haemodynamic instability. Specific monitoring of depth of hypnosis and depth of analgesia based on heart rate variability (HRV) analysis is eligible to improve patient safety and reduce efforts in post-operative care. Conse...

    journal_title:Physiological measurement

    pub_type: 临床试验,杂志文章


    authors: Huhle R,Burghardt M,Zaunseder S,Wessel N,Koch T,Malberg H,Heller AR

    更新日期:2012-02-01 00:00:00