Magnetographic assessment of fetal hiccups and their effect on fetal heart rhythm.

Abstract:

:Fetal hiccups emerge as early as nine weeks post-conception, being the predominant diaphragmatic movement before 26 weeks of gestation. They are considered as a programmed isometric inspiratory muscle exercise of the fetus in preparation for the post-natal respiratory function, or a manifestation of a reflex circuitry underlying the development of suckling and gasping patterns. The present paper provides the first evidence of non-invasive biomagnetic measurements of the diaphragm spasmodic contractions associated with fetal hiccups. The magnetic field patterns generated by fetal hiccups exhibit well-defined morphological features, consisting of an initial high frequency transient waveform followed by a more prolonged low frequency component. This pattern is consistent across recordings obtained from two fetal subjects, and it is confirmed by signals recorded in a neonatal subject. These results demonstrate that fetal biomagnetometry can provide insights into the electrophysiological mechanisms of diaphragm motor function in the fetus. Additionally, we study the correlation between hiccup events and fetal cardiac rhythm and provide evidence that hiccups may modulate the fetal heart rate during the last trimester of pregnancy.

journal_name

Physiol Meas

authors

Popescu EA,Popescu M,Bennett TL,Lewine JD,Drake WB,Gustafson KM

doi

10.1088/0967-3334/28/6/005

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

665-76

issue

6

eissn

0967-3334

issn

1361-6579

pii

S0967-3334(07)45602-7

journal_volume

28

pub_type

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