Multiple large-surface photodynamic therapy sessions with topical or systemic aminolevulinic acid and blue light in UV-exposed hairless mice.

Abstract:

BACKGROUND:The use of photodynamic therapy (PDT) with topical aminolevulinic acid (ALA) on large skin surfaces has recently been reported for patients with multiple actinic keratoses. OBJECTIVE:The current study compared the ability of topical and systemic ALA-PDT as well as topical ALA-PDT with blue light to delay the appearance of UV-induced skin cancer using the hairless mouse as a model. METHODS:Groups of hairless mice were exposed daily to UV radiation and weekly to ALA-PDT. Tumor-free survival was compared for mice exposed to UV and treated weekly with ALA-PDT and mice exposed only to UV radiation. RESULTS:Weekly topical or systemic ALA-PDT was able to delay the induction of skin tumors. A significant difference in tumor-free survival was also observed for both actinic keratoses and invasive squamous cell carcinoma in mice treated weekly with topical ALA-PDT performed with blue light. This was observed even when weekly ALA-PDT was started after 8 weeks of UV exposure. CONCLUSION:Large-surface topical ALA-PDT with blue light can delay the appearance of UV-induced actinic keratoses and squamous cell carcinoma in hairless mice.

journal_name

J Cutan Med Surg

authors

Liu Y,Viau G,Bissonnette R

doi

10.1007/s10227-004-0117-5

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

131-9

issue

2

eissn

1203-4754

issn

1615-7109

journal_volume

8

pub_type

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