Abstract:
BACKGROUND:The use of photodynamic therapy (PDT) with topical aminolevulinic acid (ALA) on large skin surfaces has recently been reported for patients with multiple actinic keratoses. OBJECTIVE:The current study compared the ability of topical and systemic ALA-PDT as well as topical ALA-PDT with blue light to delay the appearance of UV-induced skin cancer using the hairless mouse as a model. METHODS:Groups of hairless mice were exposed daily to UV radiation and weekly to ALA-PDT. Tumor-free survival was compared for mice exposed to UV and treated weekly with ALA-PDT and mice exposed only to UV radiation. RESULTS:Weekly topical or systemic ALA-PDT was able to delay the induction of skin tumors. A significant difference in tumor-free survival was also observed for both actinic keratoses and invasive squamous cell carcinoma in mice treated weekly with topical ALA-PDT performed with blue light. This was observed even when weekly ALA-PDT was started after 8 weeks of UV exposure. CONCLUSION:Large-surface topical ALA-PDT with blue light can delay the appearance of UV-induced actinic keratoses and squamous cell carcinoma in hairless mice.
journal_name
J Cutan Med Surgjournal_title
Journal of cutaneous medicine and surgeryauthors
Liu Y,Viau G,Bissonnette Rdoi
10.1007/s10227-004-0117-5subject
Has Abstractpub_date
2004-03-01 00:00:00pages
131-9issue
2eissn
1203-4754issn
1615-7109journal_volume
8pub_type
杂志文章abstract:BACKGROUND:Pyodermatitis-pyostomatitis vegetans (PDPSV) is a rare inflammatory disorder of the skin and oral mucosa that is commonly associated with inflammatory bowel disease (IBD). Ocular involvement is uncommon. OBJECTIVE:Given the association with IBD, it is important for dermatologists to be aware of the varying ...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1177/1203475415615324
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Pemphigus vegetans is a rare variant of pemphigus vulgaris, comprising 1 to 2% of all pemphigus cases. Exposures to oral agents such as captopril and penicillamine and, less commonly, physical or chemical factors have been implicated in the development of pemphigus. METHODS:We report a 42-year-old white mal...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1177/120347541201600512
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:We report on a 42-year-old man with Stage IIA non-Hodgkin's lymphoma who developed a severe mucocutaneous blistering eruption. His diagnosis, paraneoplastic pemphigus, was based on clinical, histological, and immunofluorescence findings and confirmed by immunoprecipitation. Despite maximal ther...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1007/s10227-001-0130-x
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND:Onychomycosis is a persistent fungal nail infection that is notoriously hard to treat. Approximately 20% to 25% of patients with onychomycosis do not respond to treatment, and 10% to 53% of patients relapse. As such, successful treatment is imperative for long-term disease management. OBJECTIVE:To identify ...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1177/1203475416653734
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:This is a somewhat rare case of a 19-year-old African American female with multiple cutaneous granular cell tumors. Granular cell tumors are of neural origin, except in rare cases, and are considered benign, with a low incidence of malignancy. The clinical presentation varies greatly, but these...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.2310/7750.2011.10088
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:Oral isotretinoin treatment can cause ocular side effects. OBJECTIVE:This study was performed to detect possible toxic effects of oral isotretinoin treatment on the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL). METHODS:The study population consisted of 54 eyes of 27 patients with nodulocy...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 临床试验,杂志文章
doi:10.2310/7750.2013.13168
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:The gtring presence of dermatology platforms on Facebook has been acknowledged; however, little is known about the extent to which different types of content influence the level of engagement with online users. OBJECTIVE:To assess the level of public engagement with different types of content posted on Face...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.2310/7750.2014.14119
更新日期:2015-05-01 00:00:00
abstract::A renaissance is taking place in the field of wound healing. Interest in wounds has probably never been so great, and a number of key therapeutic advances in the last 2 or 3 years are only an indication of more progress to come. In large part, we are benefitting from decades of basic research that has provided the kno...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND:Hand dermatitis (HD) is one of the most common skin conditions; however, it is not a homogeneous disease entity. The severity of HD may range from very mild cases to severe chronic forms, which may result in prolonged disability and, occasionally, refractory HD. Chronic hand dermatitis (CHD) is associated wi...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.2310/7750.2010.09094
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:To date, there is no standard treatment of folliculitis decalvans (FD), a rare type of cicatricial alopecia. OBJECTIVE AND METHODS:The records of 23 patients with FD (1998-2012) were retrospectively analyzed, with added data review on the course and treatment of long-standing cases. RESULTS:Initial managem...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Multiple symmetric lipomatosis (MSL) is a relatively uncommon entity of unknown etiology characterized by symmetrically subcutaneous accumulation of nonencapsulated adipose tissue. Approximately 200 to 300 cases have been published. OBJECTIVES:The aims of this article are to report the case of a 58-year-old...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.2310/7750.2011.10026
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Cutaneous reactions to drugs are among the most common clinical manifestations of adverse drug events (ADEs); however, data on outpatient cutaneous adverse drug events (CADEs) are limited. PURPOSE:To provide national estimates of outpatient CADEs and determine their most frequent causes. METHODS:Outpatient...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.2310/7750.2013.12096
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Informed shared decision making is a mutual process engaging both doctor and patient and informed by best medical evidence and patient values and preferences. OBJECTIVE:Our aim was to identify the needs of psoriasis patients in decisions on selecting treatment. METHODS:Psoriasis subjects participated in an...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.2310/7750.2010.09049
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Giant basal cell carcinomas (GBCC) can demonstrate very malignant behavior and pose a surgical challenge. OBJECTIVE:To present a surgical technique utilizing Mohs and the resection of narrow bands of tissue to excise a GBCC that created a large facial defect of 5 cm × 2 cm. METHODS:A unique combination of ...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1177/120347541201600623
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:The onychodystrophies associated with Sézary syndrome (SzS) have rarely been described in the literature. We performed a retrospective analysis of SzS patients at a single institution and compared our data with previous publications. OBJECTIVES:The objectives of this study were to identify and describe the ...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1177/1203475419839937
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by massive infection with human papillomaviruses (HPVs) and development of skin cancer. Myelodysplastic syndromes (MDSs) are a group of chronic conditions that involve dysplastic hematopoiesis, peripheral blood cytopenias, and a high...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.2310/7750.2009.08049
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:Crohn disease of the vulva is a rare disease that is difficult to diagnose. There are limited reports describing treatment of this condition. OBJECTIVE:To describe the diagnosis and treatment of a 16-year-old girl with Crohn disease of the vulva, without onset of intestinal symptoms. METHODS:Crohn disease ...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.2310/7750.2014.14005
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Major advances have been made in the understanding of the pathophysiology of psoriasis. OBJECTIVES:The authors review the role of interleukin (IL) 17 in the pathogenesis of psoriasis and provide updates on approved and investigational therapies targeting IL-17 and the IL-17 receptor. METHODS:A PubMed searc...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1177/1203475416651605
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:A patient with concurrent Raynaud disease presented for hyperhidrosis of the axillae and palms. After a positive response to botulinum toxin type A (BoNTA) for axillary hyperhidrosis, she returned requesting palmar treatment. OBJECTIVES:Our goal was to investigate the effect of BoNTA on Raynaud disease in c...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.2310/7750.2008.07044
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:Biologics have transformed the management of moderate to severe psoriasis. The persistency of biologics lacks real-world data. OBJECTIVES:To quantify drug survival of infliximab (IFX), adalimumab (ADA), etanercept (ETA), and ustekinumab (UST) and to identify potential factors affecting drug survival. METHO...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1177/1203475417733957
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Sjögren syndrome (SS) is a chronic autoimmune inflammatory disease that involves primarily the exocrine glands, resulting in their functional impairment. SS typically presents as dry eyes (xerophthalmia) and dry mouth (xerostomia). This process can manifest either as the independent phenomenon of primary SS ...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.2310/7750.2010.09033
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To better understand cutaneous photosensitivity reactions, a review of its etiologic factors, clinical characteristics, pathogenesis, and treatment modalities was undertaken. METHODS:Articles discussing the above aspects of phototoxic and photoallergic reactions were used to demonstrate what is currently kno...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1007/s10227-005-0017-3
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND:PASI is an inadequate outcome measure for the assessment of psoriasis treatments. No currently used endpoints provide a benefit: risk assessment of treatment taking into consideration all available efficacy and safety data. OBJECTIVE:To propose a new outcome measure called "safe psoriasis control" (SPC), wh...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1007/s10227-005-0121-4
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Bullous pemphigoid (BP) is an autoimmune bullous disease requiring immunosuppressive therapy. Kaposi sarcoma (KS) is an angioproliferative tumor associated with the opportunistic viral infection human herpes virus 8 (HHV-8). It is a well-known condition associated with longstanding human immunodeficiency vir...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1177/1203475417712247
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Systemic therapy for atopic dermatitis (AD) has been challenging with limited safe and efficacious long-term treatment options. In 2017, dupilumab was approved in the United States, Europe, and Canada as the first targeted therapy for patients with moderate-to-severe AD. Despite promising efficacy and safety...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1177/1203475420928907
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Moderate to severe chronic hand dermatitis (CHD) is not well controlled by current medical strategies; however, recent studies have shown significant improvement in patients treated with up to 6 months of oral alitretinoin (9-cis-retinoic acid). The results of longer-term continuous treatment are lacking. O...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1177/120347541201600409
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:Cellular angiofibroma is a benign and rare tumor. It usually arises in middle-aged women and involves the vulva. Complete local excision of the tumor is the best cure, and, usually, there is no recurrence after surgery. CASE REPORT:We describe a 20-year-old woman with a painless, growing vulvar mass who pre...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.2310/7750.2013.13130
更新日期:2014-05-01 00:00:00
abstract::We present the extraordinary case of a 72-year-old man with a history of primary cutaneous peripheral T-cell lymphoma not otherwise specified (pcPTCL-NOS) previously controlled with topical agents who developed tumours in a sporotrichoid pattern. Culture of the tumours was negative, and histopathology showed findings ...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1177/1203475417721425
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Skin cancer is extremely common. Epidemiological studies indicated that ultraviolet radiation (UV) is the primary cause for skin cancers, and that retinoic acid (RA) is able to inhibit this UV-induced skin carcinogenesis; however, the molecular mechanism of the anti-UV action of RA is unclear. OBJECTIVE:The...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1177/120347540000400102
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:It has been postulated that periodic acid-Schiff staining of basement membrane can predict direct immunofluorescence patterns seen in epidermolysis bullosa acquisita and bullous pemphigoid. It has also been suggested that the type of inflammatory infiltrate or presence of fraying of basal keratinocytes may d...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1177/1203475417722734
更新日期:2018-01-01 00:00:00