Abstract：
BACKGROUND:Pemphigus vegetans is a rare variant of pemphigus vulgaris, comprising 1 to 2% of all pemphigus cases. Exposures to oral agents such as captopril and penicillamine and, less commonly, physical or chemical factors have been implicated in the development of pemphigus. METHODS:We report a 42-year-old white male with a 12-month history of hypertrophic, vegetative plaques affecting primarily his external nares and upper lips. The patient had a history of alcoholism and intermittent drug abuse, primarily intranasal cocaine, since his youth. He had been using cocaine heavily three to four times/week for 1 month prior to and 1 month following the onset of the eruption but has since ceased use. His clinical features and histopathologic findings were consistent with a diagnosis of pemphigus vegetans. Treatment with high-dose prednisone (80 mg/d) and mycophenolate mofetil (1.5 g/d) resulted in resolution of the lesions after 18 months. RESULTS AND CONCLUSIONS:To our knowledge, this is the second report proposing an association between intranasal cocaine use and the pemphigus family of disorders. Although the relationship between illicit drug use and the development of pemphigus is unclear, we postulate that intranasal cocaine abuse is operative in our patient's disease. Herein we discuss drug and other external precipitants of pemphigus and review previous case reports of pemphigus associated with illicit drugs.
journal_name
J Cutan Med Surgjournal_title
Journal of cutaneous medicine and surgeryauthors
Ngo JT,Trotter MJ,Robertson LHdoi
10.1177/120347541201600512subject
Has Abstractpub_date
2012-09-01 00:00:00pages
344-9issue
5eissn
1203-4754issn
1615-7109journal_volume
16pub_type
杂志文章abstract：BACKGROUND:In 1997, it was reported that a PTEN gene deletion, a common genetic mutation in Cowden's disease (CD), was identified in a patient with Bannayan-Riley-Ruvacalba (BRR), suggesting that the two diseases were allelic. However, the clinical overlap between the two diseases has largely remained unclear. OBJECTI...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/120347540100500307
更新日期：2001-05-01 00:00:00
abstract：BACKGROUND:Darier's disease is an autosomal dominant genodermatosis typified by hyperkeratotic papules and plaques in a predominately seborrheic distribution. The vesiculo-bullous variant of Darier's disease is rare. Several previously reported cases have demonstrated clinical and microscopic features resembling famili...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/1203475416660295
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:Lymphangiosarcoma is a rare, aggressive malignancy that originates from the endothelial cells lining lymphatic vessels and carries an extremely poor prognosis. Its clinical and histologic features are often indistinguishable from angiosarcoma. OBJECTIVE:We sought to better characterize the clinical and hist...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.2310/7750.2013.13025
更新日期：2014-03-01 00:00:00
abstract：:As clinical dermatologists, we are all striving to achieve the highest possible accuracy in our clinical acumen and diagnostic skills. Over the past decade, one relatively simple advance, epiluminescence microscopy with the use of the dermatoscope, has significantly contributed to our diagnostic skills in the detectio...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/120347549800200401
更新日期：1998-04-01 00:00:00
abstract：BACKGROUND:Epidermolysis bullosa acquisita (EBA) is a chronic subepidermal blistering disease that is frequently resistant to therapy. OBJECTIVE:A 58-year-old man who had a one-year history of a bullous eruption involving the hands, forearms, trunk, scalp, and oral mucosa. Histopathology revealed a subepidermal bulla,...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1007/s10227-001-0008-y
更新日期：2001-09-01 00:00:00
abstract：BACKGROUND:Pustular psoriasis is an uncommon form of psoriasis that often affects areas of the hands and feet. It typically manifests as small pustules that develop within erythematous areas of the palms and soles. Infliximab, a tumor necrosis factor inhibitor, can be used to treat pustular psoriasis. Infliximab can al...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.2310/7750.2008.07080
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Calciphylaxis is a rare syndrome of vascular calcification with subsequent cutaneous and tissue necrosis. It usually manifests as a complication of end-stage renal failure, affecting 1 to 4% of long-term dialysis patients. Very exceptionally, it can occur without chronic renal failure. OBJECTIVE:The goal of...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.2310/7750.2011.10046
更新日期：2011-09-01 00:00:00
abstract：:Psoriasis has been associated with a number of behavioral and systemic comorbidities, including psoriatic arthritis, anxiety, depression, obesity, hypertension, diabetes mellitus, hyperlipidemia, metabolic syndrome, smoking, cardiovascular disease, alcoholism, Crohn's disease, lymphoma, and multiple sclerosis. Many of...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.2310/7750.2009.00024
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:Diphenylcyclopropenone (DPCP) immunotherapy for viral warts has been used for many years, but no studies have analyzed the treatment effects of DPCP alone, without the use of conventional therapy before immunotherapy. OBJECTIVES:We evaluated clinical efficacy of DPCP monotherapy compared to cryotherapy and ...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/1203475418764106
更新日期：2018-05-01 00:00:00
abstract：:Actinic keratosis (AK), located on sun-exposed areas of the skin, is an increasing global health burden. Multiple ablative and topical treatment options are available to manage this disease; however, topical treatment options are receiving significant interest because AK is commonly associated with areas of substantia...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1007/s10227-004-0804-2
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND:Pyodermatitis-pyostomatitis vegetans (PDPSV) is a rare inflammatory disorder of the skin and oral mucosa that is commonly associated with inflammatory bowel disease (IBD). Ocular involvement is uncommon. OBJECTIVE:Given the association with IBD, it is important for dermatologists to be aware of the varying ...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/1203475415615324
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Alefacept (Amevive) is a fully human LFA-3/IgG1 fusion protein with a dual mechanism of action inhibiting T-cell activation and selectively reducing memory T cells. Alefacept is currently approved as a 12-week course of weekly 15 mg intramuscular (IM) injections for the treatment of adults with moderate to s...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.2310/7750.2007.00025
更新日期：2007-07-01 00:00:00
abstract：BACKGROUND:Direct-acting antivirals (DAAs) are known to present with additional dermatological events over pegylated-interferon/ribavirin (Peg-IFN/RBV). OBJECTIVE:A systematic review and meta-analysis was conducted to assess the incidence/risk of cutaneous adverse events (AEs) for simeprevir, sofosbuvir, ABT450/r-ombi...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章,meta分析,评审
doi：10.1177/1203475415595775
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVE:To better understand cutaneous photosensitivity reactions, a review of its etiologic factors, clinical characteristics, pathogenesis, and treatment modalities was undertaken. METHODS:Articles discussing the above aspects of phototoxic and photoallergic reactions were used to demonstrate what is currently kno...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1007/s10227-005-0017-3
更新日期：2004-11-01 00:00:00
abstract：BACKGROUND:Skin cancer is extremely common. Epidemiological studies indicated that ultraviolet radiation (UV) is the primary cause for skin cancers, and that retinoic acid (RA) is able to inhibit this UV-induced skin carcinogenesis; however, the molecular mechanism of the anti-UV action of RA is unclear. OBJECTIVE:The...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/120347540000400102
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Patient nonattendance is a frequent occurrence in dermatology clinics, and our responsibility regarding the follow-up of these patients remains nebulous. OBJECTIVE:This study sought to evaluate the beliefs and practices of physicians at a university-affiliated medical dermatology clinic regarding patient no...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.2310/7750.2011.11004
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND:The development of knowledge concerning the role of sun exposure in causing skin cancer has been a gradual one. OBJECTIVE:This article reviews the article by Urbach who used manikin coated with an ultraviolet dosimeter to see exactly where on the head and neck the exposure was greatest. CONCLUSION:Urbach s...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 传,历史文章,杂志文章
doi：10.1177/120347549900300302
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:Paget's disease is an extremely rare condition of the male breast that presents as an eczematous change of the nipple and areola. It is almost always associated with an underlying intraductal carcinoma. OBJECTIVE:A case of Paget's disease of the male breast with extension into adnexal structures is reported...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/120347540000400408
更新日期：2000-10-01 00:00:00
abstract：BACKGROUND:Molluscum contagiosum is a viral infection of the skin that is widely considered to be a self-resolving disease that can be treated with benign neglect. However, the clinical reality is that the disease can vary widely by anatomic site and by recalcitrance to treatment and remains a significant cause of morb...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.2310/7750.2013.13133
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:Multiple symmetric lipomatosis (MSL) is a relatively uncommon entity of unknown etiology characterized by symmetrically subcutaneous accumulation of nonencapsulated adipose tissue. Approximately 200 to 300 cases have been published. OBJECTIVES:The aims of this article are to report the case of a 58-year-old...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.2310/7750.2011.10026
更新日期：2011-07-01 00:00:00
abstract：:Coronavirus disease (COVID-19), a respiratory disease caused by a novel coronavirus designated severe acute respiratory syndrome coronavirus 2, has rapidly spread worldwide and has been recognized as a pandemic by the World Health Organization. Patients with altered immunologic function are at higher risk of acquiring...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1177/1203475420945234
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:A patient with concurrent Raynaud disease presented for hyperhidrosis of the axillae and palms. After a positive response to botulinum toxin type A (BoNTA) for axillary hyperhidrosis, she returned requesting palmar treatment. OBJECTIVES:Our goal was to investigate the effect of BoNTA on Raynaud disease in c...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.2310/7750.2008.07044
更新日期：2008-07-01 00:00:00
abstract：BACKGROUND:Sun-induced malignancies (basal cell and squamous cell carcinomas) are common in oculocutaneous albinism, however, the incidence of malignant melanoma is a topic of controversy. OBJECTIVE:We have reviewed the literature and report a case of a woman with oculocutaneous albinism with an amelanotic melanoma of...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/120347540000400307
更新日期：2000-07-01 00:00:00
abstract：BACKGROUND:Indoor tanning (IT) in fitness facilities encourages a misleading positive relationship between tanning and health. While IT in Canadian fitness facilities has been studied, American literature regarding this topic is lacking. OBJECTIVES:The objective of this study is to evaluate availability, cost, reporte...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/1203475420923645
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:Emotional stress has been associated with the development of alopecia areata (AA) and androgenetic alopecia (AGA). Emotional intelligence (EI), a component of general intelligence, is thought to govern the recognition, expression, and control of stress and other emotions. People with low EI are unable to ade...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.2310/7750.2012.12003
更新日期：2013-01-01 00:00:00
abstract：:Acne vulgaris, a condition that can affect people at any age, is the most common cause of referral to a dermatologist. Isotretinoin (ITT) is the most effective treatment available, but serious adverse effects, including a possible association with depression and suicide, limit its use. We review the current literature...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1177/1203475417719052
更新日期：2018-01-01 00:00:00
abstract：:The Maintenance of Certification (MOC) Program administered by the Royal College of Physicians and Surgeons applies to all Fellows of the Royal College including dermatologists. It is mandatory for those who wish to maintain their fellowship in the Royal College and can be critical for maintaining licensure requiremen...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/1203475417709194
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:The use of photodynamic therapy (PDT) with topical aminolevulinic acid (ALA) on large skin surfaces has recently been reported for patients with multiple actinic keratoses. OBJECTIVE:The current study compared the ability of topical and systemic ALA-PDT as well as topical ALA-PDT with blue light to delay th...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1007/s10227-004-0117-5
更新日期：2004-03-01 00:00:00
abstract：BACKGROUND:Bullous pemphigoid (BP) is an autoimmune polymorphic skin disease characterized by erythematous papules and plaques and tense bullae. A skin biopsy for direct immunofluorescence (DIF) is used to detect autoantibodies and complement proteins. OBJECTIVE:We sought to determine which location would provide the ...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.2310/7750.2014.14004
更新日期：2014-11-01 00:00:00
abstract：BACKGROUND:Crohn disease of the vulva is a rare disease that is difficult to diagnose. There are limited reports describing treatment of this condition. OBJECTIVE:To describe the diagnosis and treatment of a 16-year-old girl with Crohn disease of the vulva, without onset of intestinal symptoms. METHODS:Crohn disease ...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.2310/7750.2014.14005
更新日期：2015-01-01 00:00:00
