Effect of retinoic acid on apoptosis and DNA repair in human keratinocytes after UVB irradiation.

Abstract:

BACKGROUND:Skin cancer is extremely common. Epidemiological studies indicated that ultraviolet radiation (UV) is the primary cause for skin cancers, and that retinoic acid (RA) is able to inhibit this UV-induced skin carcinogenesis; however, the molecular mechanism of the anti-UV action of RA is unclear. OBJECTIVE:The purpose of this study is to investigate if RA enhances the removal of UV-induced DNA damage. METHODS:The effect of RA on UV-induced apoptosis and DNA repair was investigated by ELISA apoptosis assay and CAT assay. RESULTS:Both all-trans-RA and 9-cis-RA did not promote UV-induced apoptosis nor the repair of UV-damaged DNA in human keratinocytes. Furthermore, RA did not induce the expression of p53. CONCLUSION:The inhibition of RA on skin carcinogenesis is not due to enhanced removal of UV-damaged DNA. Therefore, RA does not inhibit skin cancer development at the initiation stage, but possibly at the promotion and progression stages.

journal_name

J Cutan Med Surg

authors

Li G,Bush JA,Ho VC

doi

10.1177/120347540000400102

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

2-7

issue

1

eissn

1203-4754

issn

1615-7109

journal_volume

4

pub_type

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