Effective treatment of chronic hand dermatitis with 36 continuous months of alitretinoin administration: report of three cases.

Abstract:

BACKGROUND:Moderate to severe chronic hand dermatitis (CHD) is not well controlled by current medical strategies; however, recent studies have shown significant improvement in patients treated with up to 6 months of oral alitretinoin (9-cis-retinoic acid). The results of longer-term continuous treatment are lacking. OBJECTIVE:To evaluate the long-term safety and efficacy of alitretinoin for the treatment of CHD. METHODS:The Physician's Global Assessment (PGA) and Modified Total Lesion Symptom Score (MTLSS) were used to assess CHD improvement in three patients treated with alitretinoin (10-30 mg/d). Patients had routine bloodwork and were monitored for adverse events. RESULTS:Significant improvement in MTLSS scores (≈ 76%) was seen at 2 months (p < .002) and maintained for the 3-year treatment period with occasional dosage adjustments. No significant adverse events developed that necessitated treatment withdrawal. CONCLUSION:Alitretinoin was well tolerated in the treatment of these three CHD patients who were carefully monitored over this prolonged treatment period.

journal_name

J Cutan Med Surg

authors

Gulliver WP,Baker KA

doi

10.1177/120347541201600409

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

267-71

issue

4

eissn

1203-4754

issn

1615-7109

journal_volume

16

pub_type

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