Abstract：
BACKGROUND:Systemic therapy for atopic dermatitis (AD) has been challenging with limited safe and efficacious long-term treatment options. In 2017, dupilumab was approved in the United States, Europe, and Canada as the first targeted therapy for patients with moderate-to-severe AD. Despite promising efficacy and safety results in clinical trials, our understanding of dupilumab in clinical practice remains limited with few studies outside clinical trials in literature. OBJECTIVE:The aim of this study is to evaluate the efficacy and safety of dupilumab in clinical practice and discuss any differences in results between clinical trials and real-world results. METHODS:A retrospective chart review was conducted of consecutive patients receiving dupilumab treatment at two tertiary hospitals in Toronto, Canada, between December 2017 and May 2019. The primary efficacy endpoint was measured by Investigator's Global Assessment (IGA) score of 0/1 at 16 weeks and all adverse events (AEs) experienced by patients were recorded. RESULTS:Of the 93 patients included in the study, 51 (55%) reached IGA 0/1 and 38 (41%) experienced ≥1 AE. There were no severe AEs or discontinuation prior to 16 weeks due to an AE. CONCLUSIONS:These findings suggest a higher IGA-based efficacy profile with no newly identified safety concerns in patients treated with dupilumab at two tertiary hospitals in Toronto, Canada, compared to those in randomized controlled trials.
journal_name
J Cutan Med Surgjournal_title
Journal of cutaneous medicine and surgeryauthors
Jo CE,Georgakopoulos JR,Ladda M,Ighani A,Mufti A,Drucker AM,Piguet V,Yeung Jdoi
10.1177/1203475420928907subject
Has Abstractpub_date
2020-09-01 00:00:00pages
468-473issue
5eissn
1203-4754issn
1615-7109journal_volume
24pub_type
杂志文章abstract：:The primary goal of treatment for external genital warts (EGWs) is to eradicate visible lesions and address symptoms that may accompany them, but it does not address the underlying virus. Left untreated, warts may grow, remain the same, or spontaneously regress as a result of being cleared by the immune system. Howeve...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：
更新日期：2013-12-01 00:00:00
abstract：:Larva currens is the cutaneous manifestation of human infection with the geotropic helminth Strongyloides stercoralis. Strongyloidiasis is a lifelong infection unless treated. A high index of suspicion is needed to prevent chronic symptoms of strongyloidiasis (eg, larva currens, eosinophilia, abdominal discomfort) and...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/1203475415575247
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND:In 1995, a Rosacea Awareness Program (RAP) was initiated in Canada to make available educational resources for physicians and rosacea patients. Material is in French or English, and is accessible though physician offices and by toll-free telephone. Information was communicated to the public via noncommercial...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/120347549900300403
更新日期：1999-04-01 00:00:00
abstract：BACKGROUND:Acne affects a large proportion of the Canadian population and has psychosocial and financial consequences. OBJECTIVE:We provide cost information for treatments recommended by the Canadian acne guidelines. METHODS:Highest level recommendations were selected for 3-month usage cost. RESULTS:Three-month esti...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/1203475416653735
更新日期：2016-11-01 00:00:00
abstract：OBJECTIVE:To better understand cutaneous photosensitivity reactions, a review of its etiologic factors, clinical characteristics, pathogenesis, and treatment modalities was undertaken. METHODS:Articles discussing the above aspects of phototoxic and photoallergic reactions were used to demonstrate what is currently kno...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1007/s10227-005-0017-3
更新日期：2004-11-01 00:00:00
abstract：BACKGROUND:Cryptococcosis is an opportunistic infection caused by the encapsulated yeast Cryptococcus neoformans. This ubiquitous organism has emerged as a frequent finding in immunosuppressed patients, especially those with underlying malignancies, organ transplants, and the acquired immune deficiency syndrome (AIDS)....
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/120347549800300112
更新日期：1998-07-01 00:00:00
abstract：BACKGROUND:Moderate to severe chronic hand dermatitis (CHD) is not well controlled by current medical strategies; however, recent studies have shown significant improvement in patients treated with up to 6 months of oral alitretinoin (9-cis-retinoic acid). The results of longer-term continuous treatment are lacking. O...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/120347541201600409
更新日期：2012-07-01 00:00:00
abstract：BACKGROUND:Mast cells stimulate inflammation and itch sensation in the skin by releasing various mediators when they are activated. Stress exacerbates some skin diseases. We have reported that inhalation of certain odorants modulates immune reactions in the skin. OBJECTIVE:The possible usage of odorants in the regulat...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1007/s10227-002-0129-y
更新日期：2003-07-01 00:00:00
abstract：BACKGROUND:PASI is an inadequate outcome measure for the assessment of psoriasis treatments. No currently used endpoints provide a benefit: risk assessment of treatment taking into consideration all available efficacy and safety data. OBJECTIVE:To propose a new outcome measure called "safe psoriasis control" (SPC), wh...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1007/s10227-005-0121-4
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND:Hypohidrotic ectodermal dysplasia (HED) is a rare multisystem disorder that typically affects hair, teeth, nails, and sweat glands in combination with abnormalities of ectodermal originated tissues. OBJECTIVE:To raise the issue of whether heightened awareness is required in the follow-up of pigmented lesion...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.2310/7750.2007.00030
更新日期：2007-09-01 00:00:00
abstract：BACKGROUND:Any scientific discipline needs a sharply defined set of words for exact and reproducible communication. Surprisingly this has never been a strong point in dermatological science, especially as regards the living gross pathology of skin disease. OBJECTIVE:This article briefly reviews the four editions of a ...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1007/s10227-001-0016-y
更新日期：2001-11-01 00:00:00
abstract：BACKGROUND:Major advances have been made in the understanding of the pathophysiology of psoriasis. OBJECTIVES:The authors review the role of interleukin (IL) 17 in the pathogenesis of psoriasis and provide updates on approved and investigational therapies targeting IL-17 and the IL-17 receptor. METHODS:A PubMed searc...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1177/1203475416651605
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:Genital herpes is a very common sexually transmitted disease. Safe and effective therapies are needed for patients with frequent recurrences. OBJECTIVE:The aim of our study was to determine the efficacy and safety of famciclovir for suppression of herpes simplex virus (HSV) infection in patients with histor...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s10227-002-0141-2
更新日期：2003-11-01 00:00:00
abstract：BACKGROUND:Plantar warts are typically resistant to treatment. In recent years, treatments have included administration of intralesional tuberculin; measles, mumps, rubella vaccine; and Candida albicans antigen immunotherapy. To the best of our knowledge, there are no reports of intralesional vitamin D administration f...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/1203475415602841
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Although betamethasone valerate (BMV) foam, 0.12% (Luxiq, Connectics Corporation, Palo Alto, CA) is approved by the Food and Drug Administration for the treatment of corticosteroid-responsive scalp dermatoses, no data are available for its use on nonscalp psoriasis. OBJECTIVE:We evaluated the safety and eff...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s10227-001-0006-0
更新日期：2001-07-01 00:00:00
abstract：BACKGROUND:Favre-Racouchot syndrome is a cutaneous disease characterized by nodules, cysts, and comedones that typically develops on sun-exposed areas of the face. This syndrome most commonly affects white males between the ages of 40 and 60 years and is frequently associated with chronic sun exposure and, more recentl...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.2310/7750.2013.13011
更新日期：2014-01-01 00:00:00
abstract：:The Maintenance of Certification (MOC) Program administered by the Royal College of Physicians and Surgeons applies to all Fellows of the Royal College including dermatologists. It is mandatory for those who wish to maintain their fellowship in the Royal College and can be critical for maintaining licensure requiremen...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/1203475417709194
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:To date, there is no standard treatment of folliculitis decalvans (FD), a rare type of cicatricial alopecia. OBJECTIVE AND METHODS:The records of 23 patients with FD (1998-2012) were retrospectively analyzed, with added data review on the course and treatment of long-standing cases. RESULTS:Initial managem...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:Intralesional Candida antigen has been used as immunotherapy to treat refractory warts in the immunocompetent pediatric and adult populations but has not been reported in individuals with human immunodeficiency virus (HIV). PURPOSE:To examine if Candida antigen resulted in clearance of medically refractory,...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.2310/7750.2013.12112
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND:Pseudoxanthoma elasticum-like papillary dermal elastolysis (PXE-PDE), a rare acquired elastolytic disorder, occurs in postmenopausal, elderly women and is characterized by soft, white-yellow papules that localize on the neck and supraclavicular regions and often coalesce into cobblestone plaques. It has no s...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/1203475417699407
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:The onychodystrophies associated with Sézary syndrome (SzS) have rarely been described in the literature. We performed a retrospective analysis of SzS patients at a single institution and compared our data with previous publications. OBJECTIVES:The objectives of this study were to identify and describe the ...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1177/1203475419839937
更新日期：2019-07-01 00:00:00
abstract：:Actinic keratosis (AK), located on sun-exposed areas of the skin, is an increasing global health burden. Multiple ablative and topical treatment options are available to manage this disease; however, topical treatment options are receiving significant interest because AK is commonly associated with areas of substantia...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1007/s10227-004-0804-2
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND:Neurofibromatosis type 1 (NF1) is a neurocutaneous disorder caused by loss-of-function mutation in the NF1 gene. Segmental or mosaic NF1 (MNF) is an uncommon presentation of the NF1 result of postzygotic mutations that present with subtle localised clinical findings. OBJECTIVES:Our study's objectives were t...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/1203475417708163
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:Stress is thought to exacerbate a number of diseases, some of which are skin disorders. Epidermal Langerhans' cells play a major role in cutaneous immune reactions. OBJECTIVE:The effects of two types of stress on the cutaneous immune system were to be assessed in mice. METHODS:Mice received stress by immob...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/120347549800300205
更新日期：1998-10-01 00:00:00
abstract：:Basal cell carcinomas (BCC) are the most frequent tumours in humans and normally appear in photoexposed areas of the skin. It is widely accepted that BCCs originate at follicular stem cells and consequently are very rare in nonhairy areas. Here, we report 4 cases of vulvar BCC, 3 of which were located in a vulvar semi...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/1203475417712498
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:Skin cancer is extremely common. Epidemiological studies indicated that ultraviolet radiation (UV) is the primary cause for skin cancers, and that retinoic acid (RA) is able to inhibit this UV-induced skin carcinogenesis; however, the molecular mechanism of the anti-UV action of RA is unclear. OBJECTIVE:The...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/120347540000400102
更新日期：2000-01-01 00:00:00
abstract：:Atopic dermatitis is one of the most common skin disorders in the developed world, affecting up to 20% of children and 1% to 3% of adults. This review concisely explains the pathophysiology and epidemiology of atopic dermatitis, as well as potential challenges facing its successful treatment. Furthermore, mainstay top...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1177/1203475416685077
更新日期：2017-05-01 00:00:00
abstract：:We report a case of an 17-year-old male with a drug reaction in the spectrum of Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), triggered by carbamazepine, who was succesfully treated with the combination of dexamethasone, cyclosporine, and etanercept. This triple therapy halted and prevented skin epi...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/1203475419861078
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND:Dermoscopy has been shown to be a promising method to facilitate the diagnosis of lichen planus (LP) outside of China. OBJECTIVE:To investigate the spectrum of dermoscopic patterns in Chinese LP patients. METHODS:The clinical data and dermoscopic patterns of nine LP cases with a total of 43 lesions were ev...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.2310/7750.2013.13049
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Round and oval skin wounds, like facial pigmented nevi after excision, are traditionally sutured linearly for closure, leaving significant scars, which greatly influences their appearance. OBJECTIVE:This article provides an overview of our experience using intradermal purse-string suture for round and oval ...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/120347541201600104
更新日期：2012-01-01 00:00:00
