Persistency of Biologic Therapies for Plaque Psoriasis in 2 Large Community Practices.

Abstract:

BACKGROUND:Biologics have transformed the management of moderate to severe psoriasis. The persistency of biologics lacks real-world data. OBJECTIVES:To quantify drug survival of infliximab (IFX), adalimumab (ADA), etanercept (ETA), and ustekinumab (UST) and to identify potential factors affecting drug survival. METHODS:An observational, retrospective 2-centre study consisting of 906 patients from private practices in Ontario between July 2003 and June 13, 2016, was conducted, including patients with plaque psoriasis receiving commercial treatment with ADA, ETA, IFX, and UST. Paper and electronic records of each patient were reviewed. RESULTS:Median survival times for UST, IFX, ADA, and ETA were respectively, in months, 68, 23, 33, and 28. Female sex was determined to be a statistically significant positive predictor of drug survival. Our study was consistent with the literature in that UST had the highest survival rate compared to the other biologics, and the shape of our drug survival curve suggested that loss of drug efficacy is a stochastic occurrence. Compared to other studies, our data exhibited lower survival rates at various time points for all the biologics studied, and female sex did not predict drug survival in other studies. We also investigated potential reasons for differences in biologic survival times between different practices; the main differentiator was drug dosage, as higher dosages were associated with greater survival. CONCLUSION:UST has a higher drug survival rate than ADA, ETA, and IFX, as observed in other studies. When practice patterns are compared, dosage difference is the main factor that may cause differing survival rates.

journal_name

J Cutan Med Surg

authors

Verma L,Mayba JN,Gooderham MJ,Verma A,Papp KA

doi

10.1177/1203475417733957

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

38-43

issue

1

eissn

1203-4754

issn

1615-7109

journal_volume

22

pub_type

杂志文章
  • Contemporary Role of Topical Calcineurin Inhibitors: A Pediatric Dermatology Perspective.

    abstract::Atopic dermatitis (AD) is the most common pediatric chronic inflammatory skin disease in North America, often involving complex treatment regimens and impairing the quality of life of affected children and their families. Two topical calcineurin inhibitors (TCIs) have been available for the treatment of AD in pediatri...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1177/1203475419857975

    authors: Fiorillo L,Marcoux D,Ramien M

    更新日期:2019-09-01 00:00:00

  • Adverse cutaneous reactions to selective cyclooxygenase 2 inhibitors: experience of an Italian drug-surveillance center.

    abstract:BACKGROUND:Selective cyclooxygenase (COX) 2 nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with a general lower incidence of side effects compared with nonselective NSAIDs. Postmarketing information has highlighted the need to reassess the risk evaluation for specific organs, including the skin. OB...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1007/7140.2006.00012

    authors: Atzori L,Pinna AL,Pau M,Aste N,Zucca M,Ferreli C

    更新日期:2006-01-01 00:00:00

  • Rationale and Argument for Subunit Mohs Excision in Nasal Reconstruction.

    abstract:BACKGROUND:Optimal aesthetic results are achieved when nasal defects after Mohs micrographic surgery (MMS) are reconstructed as entire nasal subunits. OBJECTIVE:To illustrate the importance of reconstructing the nose in entire subunits and explore the possibilities of expanding the principles of subunit reconstruction...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/1203475416629594

    authors: Jergensen ZR,Pezeshk RA,Thornton JF

    更新日期:2016-07-01 00:00:00

  • Modification of LC phenotype and suppression of contact hypersensitivity response by stress.

    abstract:BACKGROUND:Stress is thought to exacerbate a number of diseases, some of which are skin disorders. Epidermal Langerhans' cells play a major role in cutaneous immune reactions. OBJECTIVE:The effects of two types of stress on the cutaneous immune system were to be assessed in mice. METHODS:Mice received stress by immob...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/120347549800300205

    authors: Hosoi J,Tsuchiya T,Denda M,Ashida Y,Takashima A,Granstein RD,Koyama J

    更新日期:1998-10-01 00:00:00

  • Unusual case of proximal calciphylaxis without renal failure.

    abstract:BACKGROUND:Calciphylaxis is a rare syndrome of vascular calcification with subsequent cutaneous and tissue necrosis. It usually manifests as a complication of end-stage renal failure, affecting 1 to 4% of long-term dialysis patients. Very exceptionally, it can occur without chronic renal failure. OBJECTIVE:The goal of...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.2310/7750.2011.10046

    authors: Stanciu M,Gagné-Henley A,Thérien G

    更新日期:2011-09-01 00:00:00

  • Spectrum of dermoscopic patterns in lichen planus: a case series from China.

    abstract:BACKGROUND:Dermoscopy has been shown to be a promising method to facilitate the diagnosis of lichen planus (LP) outside of China. OBJECTIVE:To investigate the spectrum of dermoscopic patterns in Chinese LP patients. METHODS:The clinical data and dermoscopic patterns of nine LP cases with a total of 43 lesions were ev...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.2310/7750.2013.13049

    authors: Tan C,Min ZS,Xue Y,Zhu WY

    更新日期:2014-01-01 00:00:00

  • Pseudoxanthoma Elasticum-Like Papillary Dermal Elastolysis: A Single Case Report.

    abstract:BACKGROUND:Pseudoxanthoma elasticum-like papillary dermal elastolysis (PXE-PDE), a rare acquired elastolytic disorder, occurs in postmenopausal, elderly women and is characterized by soft, white-yellow papules that localize on the neck and supraclavicular regions and often coalesce into cobblestone plaques. It has no s...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/1203475417699407

    authors: Valbuena V,Assaad D,Yeung J

    更新日期:2017-07-01 00:00:00

  • Multiple cutaneous granular cell tumors: case report of a 19-year-old African American female.

    abstract:BACKGROUND AND OBJECTIVE:This is a somewhat rare case of a 19-year-old African American female with multiple cutaneous granular cell tumors. Granular cell tumors are of neural origin, except in rare cases, and are considered benign, with a low incidence of malignancy. The clinical presentation varies greatly, but these...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.2310/7750.2011.10088

    authors: Henry M,Perry A

    更新日期:2011-11-01 00:00:00

  • Keratoelastoidosis marginalis.

    abstract:BACKGROUND:Keratoelastoidosis marginalis is a rare disease that is a variant of solar elastosis. Long-term ultraviolet radiation exposure and chronic trauma secondary to manual labor are considered to be inciting factors. OBJECTIVE:To outline the clinical and histological features of this disorder. METHODS:We report ...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1007/s10227-001-0025-x

    authors: Mengesha YM,Kayal JD,Swerlick RA

    更新日期:2002-01-01 00:00:00

  • Vulvar Basal Cell Carcinoma: Four Case Reports With Immunohistochemical Study.

    abstract::Basal cell carcinomas (BCC) are the most frequent tumours in humans and normally appear in photoexposed areas of the skin. It is widely accepted that BCCs originate at follicular stem cells and consequently are very rare in nonhairy areas. Here, we report 4 cases of vulvar BCC, 3 of which were located in a vulvar semi...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/1203475417712498

    authors: García-de-la-Fuente MR,Santacana M,Vilardell F,Pujol RM,Gari E,Casanova JM

    更新日期:2017-09-01 00:00:00

  • Skin manifestations of outpatient adverse drug events in the United States: a national analysis.

    abstract:BACKGROUND:Cutaneous reactions to drugs are among the most common clinical manifestations of adverse drug events (ADEs); however, data on outpatient cutaneous adverse drug events (CADEs) are limited. PURPOSE:To provide national estimates of outpatient CADEs and determine their most frequent causes. METHODS:Outpatient...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.2310/7750.2013.12096

    authors: Koelblinger P,Dabade TS,Gustafson CJ,Davis SA,Yentzer BA,Kiracofe EA,Feldman SR

    更新日期:2013-07-01 00:00:00

  • Nodular amyloidosis: case report and literature review.

    abstract:BACKGROUND:Amyloidosis refers to a group of depositional diseases that are classified into two main types: systemic and localized. Large nodules of localized cutaneous amyloidosis of the nasal ala and surrounding skin are rare and the treatment is often unsatisfactory. OBJECTIVE:We report a case of rapidly enlarging, ...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1007/BF02737862

    authors: Kakani RS,Goldstein AE,Meisher I,Hoffman C

    更新日期:2001-03-01 00:00:00

  • Effect of retinoic acid on apoptosis and DNA repair in human keratinocytes after UVB irradiation.

    abstract:BACKGROUND:Skin cancer is extremely common. Epidemiological studies indicated that ultraviolet radiation (UV) is the primary cause for skin cancers, and that retinoic acid (RA) is able to inhibit this UV-induced skin carcinogenesis; however, the molecular mechanism of the anti-UV action of RA is unclear. OBJECTIVE:The...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/120347540000400102

    authors: Li G,Bush JA,Ho VC

    更新日期:2000-01-01 00:00:00

  • Multiple primary cutaneous plasmacytomas: an unusual presentation.

    abstract:BACKGROUND:Extramedullary plasmacytoma of the skin, a rare type of cutaneous B-cell lymphoma, is characterized by clonal proliferation of plasma cells primarily in the skin without evidence of multiple myeloma. Only about 30 cases with extramedullary plasmacytoma of the skin are reported in the literature. CASE REPORT...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.2310/7750.2013.13103

    authors: Uçmak D,Meltem Akkurt Z,Türkçü G,Harman M,Sinan Dal M,Uçmak F

    更新日期:2014-10-01 00:00:00

  • Multiple large-surface photodynamic therapy sessions with topical or systemic aminolevulinic acid and blue light in UV-exposed hairless mice.

    abstract:BACKGROUND:The use of photodynamic therapy (PDT) with topical aminolevulinic acid (ALA) on large skin surfaces has recently been reported for patients with multiple actinic keratoses. OBJECTIVE:The current study compared the ability of topical and systemic ALA-PDT as well as topical ALA-PDT with blue light to delay th...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1007/s10227-004-0117-5

    authors: Liu Y,Viau G,Bissonnette R

    更新日期:2004-03-01 00:00:00

  • Canadian hand dermatitis management guidelines.

    abstract:BACKGROUND:Hand dermatitis (HD) is one of the most common skin conditions; however, it is not a homogeneous disease entity. The severity of HD may range from very mild cases to severe chronic forms, which may result in prolonged disability and, occasionally, refractory HD. Chronic hand dermatitis (CHD) is associated wi...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.2310/7750.2010.09094

    authors: Lynde C,Guenther L,Diepgen TL,Sasseville D,Poulin Y,Gulliver W,Agner T,Barber K,Bissonnette R,Ho V,Shear NH,Toole J

    更新日期:2010-11-01 00:00:00

  • Recommendations for incorporating biologicals into management of moderate to severe plaque psoriasis: individualized patient approaches.

    abstract::Psoriasis is a T-cell mediated skin disease that affects approximately 2% of the population worldwide. Despite the prevalence of the disease and long-standing efforts to develop strategies to treat it, there is a need for safe and effective therapies to treat psoriasis, particularly the more severe forms. Biological a...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1007/s10227-006-0103-1

    authors: Langley RG,Ho V,Lynde C,Papp KA,Poulin Y,Shear N,Toole J,Zip C

    更新日期:2006-01-01 00:00:00

  • Purse-string suture for round and oval defects: a useful technique in dermatologic surgery.

    abstract:BACKGROUND:Round and oval skin wounds, like facial pigmented nevi after excision, are traditionally sutured linearly for closure, leaving significant scars, which greatly influences their appearance. OBJECTIVE:This article provides an overview of our experience using intradermal purse-string suture for round and oval ...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/120347541201600104

    authors: Zhu JW,Wu XJ,Lu ZF,Cai SQ,Zheng M

    更新日期:2012-01-01 00:00:00

  • An Approach to Minimising Risk of Adrenal Insufficiency When Discontinuing Oral Glucocorticoids.

    abstract::Oral glucocorticoids are commonly used across every field of medicine; however, discontinuing them in patients can be challenging. The risk of acute adrenal crises secondary to glucocorticoid withdrawal can be fatal and arises from chronic suppression of the adrenal glands. Identifying risk factors for adrenal suppres...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1177/1203475417736278

    authors: Nicholas MN,Li SK,Dytoc M

    更新日期:2018-03-01 00:00:00

  • Psoriatic Nail Changes Are Associated With Clinical Outcomes in Psoriatic Arthritis.

    abstract:BACKGROUND:Nail changes are common in psoriatic arthritis (PsA), with varying relationships existing between skin, nail, and joint disease. OBJECTIVE:To further characterize relationships between nail changes, psoriasis, and joint involvement in PsA patients. METHODS:One hundred eighty-eight PsA patients had skin, fi...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/1203475415573663

    authors: Sandre MK,Rohekar S,Guenther L

    更新日期:2015-07-01 00:00:00

  • Improvement in both Raynaud disease and hyperhidrosis in response to botulinum toxin type A treatment.

    abstract:BACKGROUND:A patient with concurrent Raynaud disease presented for hyperhidrosis of the axillae and palms. After a positive response to botulinum toxin type A (BoNTA) for axillary hyperhidrosis, she returned requesting palmar treatment. OBJECTIVES:Our goal was to investigate the effect of BoNTA on Raynaud disease in c...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.2310/7750.2008.07044

    authors: Kossintseva I,Barankin B

    更新日期:2008-07-01 00:00:00

  • Naftifine: a review.

    abstract:BACKGROUND:Naftifine is a topical allylamine that is effective and safe in the management of superficial dermatomycoses. Naftifine is fungicidal in vitro against a broad spectrum of dermatophyte fungi and provides good activity against Candida and Aspergillus species. It is also effective against gram-negative and gram...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.2310/7750.2008.06009

    authors: Gupta AK,Ryder JE,Cooper EA

    更新日期:2008-03-01 00:00:00

  • Pyoblepharitis Vegetans in Association With Pyodermatitis-Pyostomatitis Vegetans: Expanding the Spectrum of a Rare, Multisystem Disorder.

    abstract:BACKGROUND:Pyodermatitis-pyostomatitis vegetans (PDPSV) is a rare inflammatory disorder of the skin and oral mucosa that is commonly associated with inflammatory bowel disease (IBD). Ocular involvement is uncommon. OBJECTIVE:Given the association with IBD, it is important for dermatologists to be aware of the varying ...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/1203475415615324

    authors: Dupuis EC,Haber RM,Robertson LH

    更新日期:2016-03-01 00:00:00

  • Non-melanoma Skin Cancer in Canada Chapter 5: Management of Squamous Cell Carcinoma.

    abstract:BACKGROUND:Squamous cell carcinoma (SCC) is the second-most common form of non-melanoma skin cancer (NMSC). OBJECTIVE:To provide guidance to Canadian health care practitioners regarding management of SCCs. METHODS:Literature searches and development of graded recommendations were carried out as discussed in the accom...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,实务指引

    doi:10.1177/1203475415582318

    authors: Sapijaszko M,Zloty D,Bourcier M,Poulin Y,Janiszewski P,Ashkenas J,Canadian Non-melanoma Skin Cancer Guidelines Committee.

    更新日期:2015-05-01 00:00:00

  • Current and novel treatment options for actinic keratosis.

    abstract::Actinic keratosis (AK), located on sun-exposed areas of the skin, is an increasing global health burden. Multiple ablative and topical treatment options are available to manage this disease; however, topical treatment options are receiving significant interest because AK is commonly associated with areas of substantia...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1007/s10227-004-0804-2

    authors: Jorizzo JL

    更新日期:2004-01-01 00:00:00

  • Approach to the Assessment and Management of Adult Patients With Atopic Dermatitis: A Consensus Document. Section V: Consensus Statements on the Assessment and Management of Adult Patients With Moderate-to-Severe Atopic Dermatitis.

    abstract::This document is a concise, current, and practical guide for dermatologists and other health care providers managing adult patients with moderate-to-severe atopic dermatitis (AD). The recommendations made here are based on a consensus of specialists with extensive experience managing patients with AD. Topics reviewed ...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/1203475418803625

    authors: Hong CH,Gooderham MJ,Albrecht L,Bissonnette R,Dhadwal G,Gniadecki R,Grewal P,Kirchhof MG,Landells I,Lansang P,Lynde CW,Papp KA,Poulin Y,Sussman G,Turchin I,Wiseman M,Yeung J

    更新日期:2018-11-01 00:00:00

  • Editorial

    abstract::As clinical dermatologists, we are all striving to achieve the highest possible accuracy in our clinical acumen and diagnostic skills. Over the past decade, one relatively simple advance, epiluminescence microscopy with the use of the dermatoscope, has significantly contributed to our diagnostic skills in the detectio...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/120347549800200401

    authors: Sauder DN

    更新日期:1998-04-01 00:00:00

  • Dermatologic manifestations of Sjögren syndrome.

    abstract:BACKGROUND:Sjögren syndrome (SS) is a chronic autoimmune inflammatory disease that involves primarily the exocrine glands, resulting in their functional impairment. SS typically presents as dry eyes (xerophthalmia) and dry mouth (xerostomia). This process can manifest either as the independent phenomenon of primary SS ...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.2310/7750.2010.09033

    authors: Kittridge A,Routhouska SB,Korman NJ

    更新日期:2011-01-01 00:00:00

  • Treatment of Linear Scleroderma (en Coup de Sabre) With Dermal Fat Grafting.

    abstract:BACKGROUND:Linear scleroderma, also known as "en coup de sabre," is a subtype of localized scleroderma that warrants aesthetic correction because it appears on the forehead region in children. OBJECTIVE:To report dermal fat grafting as a novel and effective surgical treatment option in linear scleroderma. METHODS:Und...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/1203475415624912

    authors: Barin EZ,Cinal H,Cakmak MA,Tan O

    更新日期:2016-05-01 00:00:00

  • Treatment of molluscum contagiosum in adult, pediatric, and immunodeficient populations.

    abstract:BACKGROUND:Molluscum contagiosum is a viral infection of the skin that is widely considered to be a self-resolving disease that can be treated with benign neglect. However, the clinical reality is that the disease can vary widely by anatomic site and by recalcitrance to treatment and remains a significant cause of morb...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.2310/7750.2013.13133

    authors: Nguyen HP,Franz E,Stiegel KR,Hsu S,Tyring SK

    更新日期:2014-10-01 00:00:00