Unusual case of proximal calciphylaxis without renal failure.

Abstract:

BACKGROUND:Calciphylaxis is a rare syndrome of vascular calcification with subsequent cutaneous and tissue necrosis. It usually manifests as a complication of end-stage renal failure, affecting 1 to 4% of long-term dialysis patients. Very exceptionally, it can occur without chronic renal failure. OBJECTIVE:The goal of this study was to discuss an exceptional case of extensive calciphylaxis in the absence of chronic renal failure and its successful management. METHODS:We present a case of a 31-year-old woman with extensive proximal, ulcerated calciphylaxis without associated chronic renal failure. Our patient had quite a few risk factors associated with the pathogenesis of calciphylaxis, such as obesity, malnutrition, and a transient episode of acute renal failure. RESULTS:She was successfully treated with sodium thiosulfate, extensive wound débridement (more than 30% total body surface), and subsequent skin grafts. The patient has miraculously survived this often fatal condition. CONCLUSION:Calciphylaxis can occur even in the absence of chronic renal failure. This often fatal condition can be managed successfully with a combination of aggressive wound control and the fairly newly described sodium thiosulfate therapy.

journal_name

J Cutan Med Surg

authors

Stanciu M,Gagné-Henley A,Thérien G

doi

10.2310/7750.2011.10046

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

290-2

issue

5

eissn

1203-4754

issn

1615-7109

journal_volume

15

pub_type

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