Non-melanoma Skin Cancer in Canada Chapter 5: Management of Squamous Cell Carcinoma.

abstract：BACKGROUND:Efalizumab is a recombinant humanized IgG1-kappa isotype monoclonal antibody that binds to CD11a, inhibiting T-cell activation. It has been approved for the treatment of moderate to severe plaque psoriasis. Efalizumab has been associated with the development of skin eruptions during the administration period...

journal_title：Journal of cutaneous medicine and surgery

authors： Rallis E,Verros C,Karanikola E,Valaskatzi A,Papaconstantis M

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Cryptococcosis is an opportunistic infection caused by the encapsulated yeast Cryptococcus neoformans. This ubiquitous organism has emerged as a frequent finding in immunosuppressed patients, especially those with underlying malignancies, organ transplants, and the acquired immune deficiency syndrome (AIDS)....

journal_title：Journal of cutaneous medicine and surgery

authors： Ingleton R,Koestenblatt E,Don P,Levy H,Szaniawski W,Weinberg JM

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Plantar warts are typically resistant to treatment. In recent years, treatments have included administration of intralesional tuberculin; measles, mumps, rubella vaccine; and Candida albicans antigen immunotherapy. To the best of our knowledge, there are no reports of intralesional vitamin D administration f...

journal_title：Journal of cutaneous medicine and surgery

authors： Aktaş H,Ergin C,Demir B,Ekiz Ö

更新日期：2016-03-01 00:00:00

abstract：:Juvenile xanthogranuloma (JXG) is a member of the non-Langerhans cell group of proliferative disorders of mononuclear phagocytes. JXG is a benign tumour of histiocytic cells. Classic JXG is divided into 2 main clinical subtypes: dome-shaped papules (<0.5 cm) and single/multiple nodules (<2.0 cm). A rare variant is ref...

journal_title：Journal of cutaneous medicine and surgery

authors： Ladha MA,Haber RM

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Major advances have been made in the understanding of the pathophysiology of psoriasis. OBJECTIVES:The authors review the role of interleukin (IL) 17 in the pathogenesis of psoriasis and provide updates on approved and investigational therapies targeting IL-17 and the IL-17 receptor. METHODS:A PubMed searc...

journal_title：Journal of cutaneous medicine and surgery

authors： AbuHilal M,Walsh S,Shear N

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Lymphangiosarcoma is a rare, aggressive malignancy that originates from the endothelial cells lining lymphatic vessels and carries an extremely poor prognosis. Its clinical and histologic features are often indistinguishable from angiosarcoma. OBJECTIVE:We sought to better characterize the clinical and hist...

journal_title：Journal of cutaneous medicine and surgery

authors： Mamelak AJ,Collie MR,Kroll R,Hanson ML,Harris HM

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Skin cancer is extremely common. Epidemiological studies indicated that ultraviolet radiation (UV) is the primary cause for skin cancers, and that retinoic acid (RA) is able to inhibit this UV-induced skin carcinogenesis; however, the molecular mechanism of the anti-UV action of RA is unclear. OBJECTIVE:The...

journal_title：Journal of cutaneous medicine and surgery

authors： Li G,Bush JA,Ho VC

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Merkel cell carcinoma is a rare, aggressive, malignant cutaneous tumor of the elderly or immunosuppressed individuals that usually appears on sun-exposed areas of the body. Its pathogenesis is still debated, and, currently, no standardized treatment exists. OBJECTIVE:To provide a current updated review of t...

journal_title：Journal of cutaneous medicine and surgery

authors： Zampetti A,Feliciani C,Massi G,Tulli A

更新日期：2010-03-01 00:00:00

abstract：:The Maintenance of Certification (MOC) Program administered by the Royal College of Physicians and Surgeons applies to all Fellows of the Royal College including dermatologists. It is mandatory for those who wish to maintain their fellowship in the Royal College and can be critical for maintaining licensure requiremen...

journal_title：Journal of cutaneous medicine and surgery

authors： Rich P

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Vitiligo can negatively affect patients' quality of life (QoL). Assessment of QoL provides relevant information about treatment benefits. OBJECTIVES:To examine the effects of excimer laser treatment on vitiligo patients' QoL and to identify overall patient satisfaction. The literature review failed to show ...

journal_title：Journal of cutaneous medicine and surgery

authors： Al-Shobaili HA

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Psoriasis in clinical trials is often measured by the Psoriasis Area and Severity Index (PASI). This measurement is well understood by clinical trialists and many dermatologists but rarely by patients and some clinicians. Patients may not understand their chance of improvement based on a PASI-50 or PASI-75 v...

journal_title：Journal of cutaneous medicine and surgery

authors： English PL,Vender R

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Mast cells stimulate inflammation and itch sensation in the skin by releasing various mediators when they are activated. Stress exacerbates some skin diseases. We have reported that inhalation of certain odorants modulates immune reactions in the skin. OBJECTIVE:The possible usage of odorants in the regulat...

journal_title：Journal of cutaneous medicine and surgery

authors： Hosoi J,Tanida M,Tsuchiya T

更新日期：2003-07-01 00:00:00

abstract：:We report a case of an 17-year-old male with a drug reaction in the spectrum of Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), triggered by carbamazepine, who was succesfully treated with the combination of dexamethasone, cyclosporine, and etanercept. This triple therapy halted and prevented skin epi...

journal_title：Journal of cutaneous medicine and surgery

authors： Coulombe J,Belzile E,Duhamel A,Rault P,Buteau C,DeBruycker JJ,Bussières JF

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:In 1995, a Rosacea Awareness Program (RAP) was initiated in Canada to make available educational resources for physicians and rosacea patients. Material is in French or English, and is accessible though physician offices and by toll-free telephone. Information was communicated to the public via noncommercial...

journal_title：Journal of cutaneous medicine and surgery

authors： Shear NH,Levine C

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:Darier's disease is an autosomal dominant genodermatosis typified by hyperkeratotic papules and plaques in a predominately seborrheic distribution. The vesiculo-bullous variant of Darier's disease is rare. Several previously reported cases have demonstrated clinical and microscopic features resembling famili...

journal_title：Journal of cutaneous medicine and surgery

authors： Klimas N,West C,Tarbox M

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Stress is thought to exacerbate a number of diseases, some of which are skin disorders. Epidermal Langerhans' cells play a major role in cutaneous immune reactions. OBJECTIVE:The effects of two types of stress on the cutaneous immune system were to be assessed in mice. METHODS:Mice received stress by immob...

journal_title：Journal of cutaneous medicine and surgery

authors： Hosoi J,Tsuchiya T,Denda M,Ashida Y,Takashima A,Granstein RD,Koyama J

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:Local skin reactions are common during imiquimod treatment of actinic keratosis (AK). Cyclical application of imiquimod may improve tolerability while maintaining efficacy. OBJECTIVE:To assess the tolerability of imiquimod and clearance rate of AK lesions after imiquimod application. METHODS:Imiquimod 5% c...

journal_title：Journal of cutaneous medicine and surgery

authors： Rivers JK,Rosoph L,Provost N,Bissonnette R

更新日期：2008-05-01 00:00:00

abstract：:Atopic dermatitis is one of the most common skin disorders in the developed world, affecting up to 20% of children and 1% to 3% of adults. This review concisely explains the pathophysiology and epidemiology of atopic dermatitis, as well as potential challenges facing its successful treatment. Furthermore, mainstay top...

journal_title：Journal of cutaneous medicine and surgery

authors： Mayba JN,Gooderham MJ

更新日期：2017-05-01 00:00:00

abstract：:Larva currens is the cutaneous manifestation of human infection with the geotropic helminth Strongyloides stercoralis. Strongyloidiasis is a lifelong infection unless treated. A high index of suspicion is needed to prevent chronic symptoms of strongyloidiasis (eg, larva currens, eosinophilia, abdominal discomfort) and...

journal_title：Journal of cutaneous medicine and surgery

authors： Bailey KE,Danylo A,Boggild AK

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Any scientific discipline needs a sharply defined set of words for exact and reproducible communication. Surprisingly this has never been a strong point in dermatological science, especially as regards the living gross pathology of skin disease. OBJECTIVE:This article briefly reviews the four editions of a ...

journal_title：Journal of cutaneous medicine and surgery

authors： Jackson R

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:Nail changes are common in psoriatic arthritis (PsA), with varying relationships existing between skin, nail, and joint disease. OBJECTIVE:To further characterize relationships between nail changes, psoriasis, and joint involvement in PsA patients. METHODS:One hundred eighty-eight PsA patients had skin, fi...

journal_title：Journal of cutaneous medicine and surgery

authors： Sandre MK,Rohekar S,Guenther L

更新日期：2015-07-01 00:00:00

abstract：:Lichen planus (LP) is a chronic inflammatory disorder that most commonly affects middle-aged individuals. LP involves the skin and/or mucous membranes, including oral, vulvovaginal, esophageal, laryngeal, and conjunctival mucosa. Linear LP, a rare distinct variant of LP, is characterised by pruritic eruption of lichen...

journal_title：Journal of cutaneous medicine and surgery

authors： Thomas MG,Betsy A

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Oral psychostimulant (PS) drugs, the pharmacologic treatment of choice for attention-deficit/hyperactivity disorder (ADHD), have been associated with diseases of abnormal sensitivity to cold (DASC) such as Raynaud phenomenon and acrocyanosis. OBJECTIVES:In a cohort of pediatric patients with DASC, we sought...

journal_title：Journal of cutaneous medicine and surgery

authors： Coulombe J,Powell J,Hatami A,McCuaig C,Renet S,Marcoux D

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Moderate to severe chronic hand dermatitis (CHD) is not well controlled by current medical strategies; however, recent studies have shown significant improvement in patients treated with up to 6 months of oral alitretinoin (9-cis-retinoic acid). The results of longer-term continuous treatment are lacking. O...

journal_title：Journal of cutaneous medicine and surgery

authors： Gulliver WP,Baker KA

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Dabrafenib, a novel selective small-molecule inhibitor of BRAF, has been shown to increase overall survival in patients with unresectable metastatic melanoma harboring the BRAF V600E mutation. The development of resistance has led to combination therapy with selective MEK inhibitor trametinib. Compared with ...

journal_title：Journal of cutaneous medicine and surgery

authors： Lacroix JP,Wang B

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Hypohidrotic ectodermal dysplasia (HED) is a rare multisystem disorder that typically affects hair, teeth, nails, and sweat glands in combination with abnormalities of ectodermal originated tissues. OBJECTIVE:To raise the issue of whether heightened awareness is required in the follow-up of pigmented lesion...

journal_title：Journal of cutaneous medicine and surgery

authors： Gregoriou S,Rigopoulos D,Vergou T,Korfitis C,Menegakis G,Kontochristopoulos G

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Laser epilation is now used widely as a clinical alternative to electrolysis for the removal of unwanted hair. All of the laser systems presently being used produce a reliable temporary hair loss by inducing telogen. Most of the published studies use follow-up periods of 6 months or less after the last treat...

journal_title：Journal of cutaneous medicine and surgery

authors： Laughlin SA,Dudley DK

更新日期：2000-04-01 00:00:00

abstract：:As clinical dermatologists, we are all striving to achieve the highest possible accuracy in our clinical acumen and diagnostic skills. Over the past decade, one relatively simple advance, epiluminescence microscopy with the use of the dermatoscope, has significantly contributed to our diagnostic skills in the detectio...

journal_title：Journal of cutaneous medicine and surgery

authors： Sauder DN

更新日期：1998-04-01 00:00:00

abstract：:Actinic keratosis (AK), located on sun-exposed areas of the skin, is an increasing global health burden. Multiple ablative and topical treatment options are available to manage this disease; however, topical treatment options are receiving significant interest because AK is commonly associated with areas of substantia...

journal_title：Journal of cutaneous medicine and surgery

authors： Jorizzo JL

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:The development of knowledge concerning the role of sun exposure in causing skin cancer has been a gradual one. OBJECTIVE:This article reviews the article by Urbach who used manikin coated with an ultraviolet dosimeter to see exactly where on the head and neck the exposure was greatest. CONCLUSION:Urbach s...

journal_title：Journal of cutaneous medicine and surgery

authors： Jackson R

更新日期：1999-01-01 00:00:00