Open-label study to assess the safety and efficacy of imiquimod 5% cream applied once daily three times per week in cycles for treatment of actinic keratoses on the head.

abstract：BACKGROUND:Any scientific discipline needs a sharply defined set of words for exact and reproducible communication. Surprisingly this has never been a strong point in dermatological science, especially as regards the living gross pathology of skin disease. OBJECTIVE:This article briefly reviews the four editions of a ...

journal_title：Journal of cutaneous medicine and surgery

authors： Jackson R

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:A number of inflammatory and immune diseases are associated with vascular changes. Psoriasis, as an example, is a common inflammatory skin disease with dilation of capillaries as an early histological change. In more developed psoriatic lesions there is proliferation of blood vessels and neovascularization. ...

journal_title：Journal of cutaneous medicine and surgery

authors： Dupont E,Savard PE,Jourdain C,Juneau C,Thibodeau A,Ross N,Marenus K,Maes DH,Pelletier G,Sauder DN

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:The self-inflicted dermatoses such as acne excorieé and neurotic excoriations are often chronic, recurring, and resistant to standard dermatologic therapies. OBJECTIVE:We present a 28-year-old woman with longstanding acne excorieé, whose acne started at age 14 years and was followed by acne excorieé at age ...

journal_title：Journal of cutaneous medicine and surgery

authors： Gupta MA,Gupta AK

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by massive infection with human papillomaviruses (HPVs) and development of skin cancer. Myelodysplastic syndromes (MDSs) are a group of chronic conditions that involve dysplastic hematopoiesis, peripheral blood cytopenias, and a high...

journal_title：Journal of cutaneous medicine and surgery

authors： Oliveira WR,Ferreira GN,Rady PL,Festa C,Tyring SK

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Darier's disease is an autosomal dominant genodermatosis typified by hyperkeratotic papules and plaques in a predominately seborrheic distribution. The vesiculo-bullous variant of Darier's disease is rare. Several previously reported cases have demonstrated clinical and microscopic features resembling famili...

journal_title：Journal of cutaneous medicine and surgery

authors： Klimas N,West C,Tarbox M

更新日期：2016-11-01 00:00:00

abstract：:As clinical dermatologists, we are all striving to achieve the highest possible accuracy in our clinical acumen and diagnostic skills. Over the past decade, one relatively simple advance, epiluminescence microscopy with the use of the dermatoscope, has significantly contributed to our diagnostic skills in the detectio...

journal_title：Journal of cutaneous medicine and surgery

authors： Sauder DN

更新日期：1998-04-01 00:00:00

abstract：:We describe a family with supernumerary nipples and kidney and urinary tract malformations. The proband is a 59-year-old man with a supernumerary nipple and recently identified hypoplastic kidney, bladder diverticulum, and hypotonic bladder. His mother also has a supernumerary nipple and a recently identified hypoplas...

journal_title：Journal of cutaneous medicine and surgery

authors： Brown J,Schwartz RA

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Although betamethasone valerate (BMV) foam, 0.12% (Luxiq, Connectics Corporation, Palo Alto, CA) is approved by the Food and Drug Administration for the treatment of corticosteroid-responsive scalp dermatoses, no data are available for its use on nonscalp psoriasis. OBJECTIVE:We evaluated the safety and eff...

journal_title：Journal of cutaneous medicine and surgery

authors： Stein LF,Sherr A,Solodkina G,Gottlieb AB,Chaudhari U

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:Plantar warts are typically resistant to treatment. In recent years, treatments have included administration of intralesional tuberculin; measles, mumps, rubella vaccine; and Candida albicans antigen immunotherapy. To the best of our knowledge, there are no reports of intralesional vitamin D administration f...

journal_title：Journal of cutaneous medicine and surgery

authors： Aktaş H,Ergin C,Demir B,Ekiz Ö

更新日期：2016-03-01 00:00:00

abstract：:Genital ulcer disease can be caused by a wide variety of sources. Most commonly, genital ulcer disease is grouped into infectious and noninfectious causes. HSV, syphilis, lymphogranuloma venereum, and chancroid represent some common infectious ulcers. Noninfectious causes on the other hand can be inflammatory, noninfl...

journal_title：Journal of cutaneous medicine and surgery

authors： Maliyar K,Mufti A,Syed M,Selk A,Dutil M,Bunce PE,Alavi A

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Although methotrexate is a highly effective treatment for psoriasis, nausea and vomiting may be dose-limiting side effects. Various approaches have been used to improve the tolerability of methotrexate therapy, including changing the dose or form of administration of the methotrexate or concomitant administr...

journal_title：Journal of cutaneous medicine and surgery

authors： Wilson JK,Phelps KC,Feldman SR

更新日期：2002-11-01 00:00:00

abstract：:The primary goal of treatment for external genital warts (EGWs) is to eradicate visible lesions and address symptoms that may accompany them, but it does not address the underlying virus. Left untreated, warts may grow, remain the same, or spontaneously regress as a result of being cleared by the immune system. Howeve...

journal_title：Journal of cutaneous medicine and surgery

authors： Vender R,Bourcier M,Bhatia N,Lynde C

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:A patient with concurrent Raynaud disease presented for hyperhidrosis of the axillae and palms. After a positive response to botulinum toxin type A (BoNTA) for axillary hyperhidrosis, she returned requesting palmar treatment. OBJECTIVES:Our goal was to investigate the effect of BoNTA on Raynaud disease in c...

journal_title：Journal of cutaneous medicine and surgery

authors： Kossintseva I,Barankin B

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Dermoscopy has been shown to be a promising method to facilitate the diagnosis of lichen planus (LP) outside of China. OBJECTIVE:To investigate the spectrum of dermoscopic patterns in Chinese LP patients. METHODS:The clinical data and dermoscopic patterns of nine LP cases with a total of 43 lesions were ev...

journal_title：Journal of cutaneous medicine and surgery

authors： Tan C,Min ZS,Xue Y,Zhu WY

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Squamous cell carcinoma (SCC) is the second-most common form of non-melanoma skin cancer (NMSC). OBJECTIVE:To provide guidance to Canadian health care practitioners regarding management of SCCs. METHODS:Literature searches and development of graded recommendations were carried out as discussed in the accom...

journal_title：Journal of cutaneous medicine and surgery

authors： Sapijaszko M,Zloty D,Bourcier M,Poulin Y,Janiszewski P,Ashkenas J,Canadian Non-melanoma Skin Cancer Guidelines Committee.

更新日期：2015-05-01 00:00:00

abstract：:Actinic keratosis (AK), located on sun-exposed areas of the skin, is an increasing global health burden. Multiple ablative and topical treatment options are available to manage this disease; however, topical treatment options are receiving significant interest because AK is commonly associated with areas of substantia...

journal_title：Journal of cutaneous medicine and surgery

authors： Jorizzo JL

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Diphenylcyclopropenone (DPCP) immunotherapy for viral warts has been used for many years, but no studies have analyzed the treatment effects of DPCP alone, without the use of conventional therapy before immunotherapy. OBJECTIVES:We evaluated clinical efficacy of DPCP monotherapy compared to cryotherapy and ...

journal_title：Journal of cutaneous medicine and surgery

authors： Park JY,Park BW,Cho EB,Park EJ,Kim KH,Kim KJ

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Aquagenic pruritus is an intense prickling sensation that develops in affected individuals immediately after contact with water at any temperature. It is most commonly associated with polycythemia rubra vera. Common but often ineffective treatments include anticholinergics and antihistamines. Other moderatel...

journal_title：Journal of cutaneous medicine and surgery

authors： Ingber S,Cohen PD

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Skin cancer is extremely common. Epidemiological studies indicated that ultraviolet radiation (UV) is the primary cause for skin cancers, and that retinoic acid (RA) is able to inhibit this UV-induced skin carcinogenesis; however, the molecular mechanism of the anti-UV action of RA is unclear. OBJECTIVE:The...

journal_title：Journal of cutaneous medicine and surgery

authors： Li G,Bush JA,Ho VC

更新日期：2000-01-01 00:00:00

abstract：:Atopic dermatitis is one of the most common skin disorders in the developed world, affecting up to 20% of children and 1% to 3% of adults. This review concisely explains the pathophysiology and epidemiology of atopic dermatitis, as well as potential challenges facing its successful treatment. Furthermore, mainstay top...

journal_title：Journal of cutaneous medicine and surgery

authors： Mayba JN,Gooderham MJ

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Sun-induced malignancies (basal cell and squamous cell carcinomas) are common in oculocutaneous albinism, however, the incidence of malignant melanoma is a topic of controversy. OBJECTIVE:We have reviewed the literature and report a case of a woman with oculocutaneous albinism with an amelanotic melanoma of...

journal_title：Journal of cutaneous medicine and surgery

authors： Streutker CJ,McCready D,Jimbow K,From L

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Emotional stress has been associated with the development of alopecia areata (AA) and androgenetic alopecia (AGA). Emotional intelligence (EI), a component of general intelligence, is thought to govern the recognition, expression, and control of stress and other emotions. People with low EI are unable to ade...

journal_title：Journal of cutaneous medicine and surgery

authors： Monselise A,Bar-On R,Chan L,Leibushor N,McElwee K,Shapiro J

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Alefacept (Amevive) is a fully human LFA-3/IgG1 fusion protein with a dual mechanism of action inhibiting T-cell activation and selectively reducing memory T cells. Alefacept is currently approved as a 12-week course of weekly 15 mg intramuscular (IM) injections for the treatment of adults with moderate to s...

journal_title：Journal of cutaneous medicine and surgery

authors： Moul DK,Routhouska SB,Korman NJ

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Plaque psoriasis (PsO) is a chronic inflammatory disease that often presents at peak reproductive age in women of child-bearing potential (WOCBP). With the emergence of biologic therapies to treat PsO, guidance on disease management in WOCBP is needed to inform treatment decisions before, during, and after p...

journal_title：Journal of cutaneous medicine and surgery

authors： Yeung J,Gooderham MJ,Grewal P,Hong CH,Lansang P,Papp KA,Poulin Y,Turchin I,Vender R

更新日期：2020-07-01 00:00:00

abstract：:The intention of the Summary Notes section is to provide the practitioner and trainee with a current, concise reference source to dermatologic diseases and to serve as a form of Continuing Medical Education. Each installment will deal with a specific disease. When included, the pretest questions indicate some of the a...

journal_title：Journal of cutaneous medicine and surgery

authors： Katz AM

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Efalizumab is a recombinant humanized IgG1-kappa isotype monoclonal antibody that binds to CD11a, inhibiting T-cell activation. It has been approved for the treatment of moderate to severe plaque psoriasis. Efalizumab has been associated with the development of skin eruptions during the administration period...

journal_title：Journal of cutaneous medicine and surgery

authors： Rallis E,Verros C,Karanikola E,Valaskatzi A,Papaconstantis M

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Whereas several literature reviews have discussed the role of excipients in drug-related reactions, no article has focused specifically on those found in oral dermatologic medications. METHODS:The Compendium of Pharmaceuticals and Specialties (CPS) was used to reference the inert ingredients found in oral d...

journal_title：Journal of cutaneous medicine and surgery

authors： Noiles K,Vender R

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Naftifine is a topical allylamine that is effective and safe in the management of superficial dermatomycoses. Naftifine is fungicidal in vitro against a broad spectrum of dermatophyte fungi and provides good activity against Candida and Aspergillus species. It is also effective against gram-negative and gram...

journal_title：Journal of cutaneous medicine and surgery

authors： Gupta AK,Ryder JE,Cooper EA

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Cryptococcosis is an opportunistic infection caused by the encapsulated yeast Cryptococcus neoformans. This ubiquitous organism has emerged as a frequent finding in immunosuppressed patients, especially those with underlying malignancies, organ transplants, and the acquired immune deficiency syndrome (AIDS)....

journal_title：Journal of cutaneous medicine and surgery

authors： Ingleton R,Koestenblatt E,Don P,Levy H,Szaniawski W,Weinberg JM

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Systemic therapy for atopic dermatitis (AD) has been challenging with limited safe and efficacious long-term treatment options. In 2017, dupilumab was approved in the United States, Europe, and Canada as the first targeted therapy for patients with moderate-to-severe AD. Despite promising efficacy and safety...

journal_title：Journal of cutaneous medicine and surgery

authors： Jo CE,Georgakopoulos JR,Ladda M,Ighani A,Mufti A,Drucker AM,Piguet V,Yeung J

更新日期：2020-09-01 00:00:00