Malignant melanoma in a patient with oculocutaneous albinism.

Abstract:

BACKGROUND:Sun-induced malignancies (basal cell and squamous cell carcinomas) are common in oculocutaneous albinism, however, the incidence of malignant melanoma is a topic of controversy. OBJECTIVE:We have reviewed the literature and report a case of a woman with oculocutaneous albinism with an amelanotic melanoma of the anterior chest wall. RESULTS:There are only 26 previously reported cases (both case reports and African albino population studies) in 25 patients in the literature. A 27th case with immunohistochemical and ultrastructural evaluation is presented. CONCLUSIONS:It appears that melanoma, a malignancy for which sun exposure and light colouration are felt to be major risk factors, has a low incidence among a population that is both hypopigmented and often exposed to high levels of ultraviolet light. This low incidence is poorly understood and frequently disputed.

journal_name

J Cutan Med Surg

authors

Streutker CJ,McCready D,Jimbow K,From L

doi

10.1177/120347540000400307

subject

Has Abstract

pub_date

2000-07-01 00:00:00

pages

149-52

issue

3

eissn

1203-4754

issn

1615-7109

journal_volume

4

pub_type

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