Exacerbation of psoriasis under efalizumab therapy.

Abstract:

BACKGROUND:Efalizumab is a recombinant humanized IgG1-kappa isotype monoclonal antibody that binds to CD11a, inhibiting T-cell activation. It has been approved for the treatment of moderate to severe plaque psoriasis. Efalizumab has been associated with the development of skin eruptions during the administration period, and this probably represents the potential psoriasis events observed during its administration. OBJECTIVE:We report a case of exacerbation of psoriasis under efalizumab administration. A reversible increase in lymphocyte count with normal total white blood cell count was also noticed. CONCLUSION:Larger series are probably needed to establish clinical and histopathologic criteria and to determine the terminology used regarding the psoriasis adverse events seen with efalizumab treatment.

journal_name

J Cutan Med Surg

authors

Rallis E,Verros C,Karanikola E,Valaskatzi A,Papaconstantis M

doi

10.2310/7750.2008.07087

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

106-9

issue

2

eissn

1203-4754

issn

1615-7109

journal_volume

13

pub_type

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