Abstract:
BACKGROUND:A patient with concurrent Raynaud disease presented for hyperhidrosis of the axillae and palms. After a positive response to botulinum toxin type A (BoNTA) for axillary hyperhidrosis, she returned requesting palmar treatment. OBJECTIVES:Our goal was to investigate the effect of BoNTA on Raynaud disease in concurrent hyperhidrosis with respect to color change, swelling, and digital pain. METHODS:The patient had treatment with 100 units of BoNTA to one hand at first, with the other being a negative control, followed by treatment of the second hand 1 week later. RESULTS:After the injection into the first palm, the patient demonstrated an 85% reduction in palmar hyperhidrosis and a significant improvement in her Raynaud symptoms. Specifically, the BoNTA-treated hand had reduced swelling, color change, and pain, whereas the untreated control hand remained affected. After the second hand was treated, it, too, demonstrated the same positive results. CONCLUSIONS:Our case report of concurrent Raynaud disease and palmar hyperhidrosis shows significant improvement in both conditions to BoNTA administration. The physiology is multifactorial and relates to BoNTA's effect on acetylcholine, noradrenaline, substance P, calcitonin gene-related peptide, and glutamate release from nerve terminals. These results present an encouraging novel treatment option in dermatology for patients with Raynaud disease.
journal_name
J Cutan Med Surgjournal_title
Journal of cutaneous medicine and surgeryauthors
Kossintseva I,Barankin Bdoi
10.2310/7750.2008.07044subject
Has Abstractpub_date
2008-07-01 00:00:00pages
189-93issue
4eissn
1203-4754issn
1615-7109journal_volume
12pub_type
杂志文章abstract:BACKGROUND:PASI is an inadequate outcome measure for the assessment of psoriasis treatments. No currently used endpoints provide a benefit: risk assessment of treatment taking into consideration all available efficacy and safety data. OBJECTIVE:To propose a new outcome measure called "safe psoriasis control" (SPC), wh...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1007/s10227-005-0121-4
更新日期:2005-12-01 00:00:00
abstract::A renaissance is taking place in the field of wound healing. Interest in wounds has probably never been so great, and a number of key therapeutic advances in the last 2 or 3 years are only an indication of more progress to come. In large part, we are benefitting from decades of basic research that has provided the kno...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:
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abstract:BACKGROUND:Forty-nine years ago the first complete and authoritative English text on the physiology and biochemistry of the skin was published by Stephen Rothman, an early basic researcher in dermatology. OBJECTIVE:The purpose of the article is to learn more about Stephen Rothman and his 1954 text, to learn more about...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 传,历史文章,杂志文章
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abstract:BACKGROUND:We present a case of strongyloidiasis presenting as larva currens 38 years after potential exposure in a country with what is typically thought of as low epidemiologic risk. CONCLUSION:This case highlights several important features of strongyloidiasis, including its varied epidemiology, long incubation per...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1177/120347541201600613
更新日期:2012-11-01 00:00:00
abstract::Larva currens is the cutaneous manifestation of human infection with the geotropic helminth Strongyloides stercoralis. Strongyloidiasis is a lifelong infection unless treated. A high index of suspicion is needed to prevent chronic symptoms of strongyloidiasis (eg, larva currens, eosinophilia, abdominal discomfort) and...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1177/1203475415575247
更新日期:2015-07-01 00:00:00
abstract::Atopic dermatitis is one of the most common skin disorders in the developed world, affecting up to 20% of children and 1% to 3% of adults. This review concisely explains the pathophysiology and epidemiology of atopic dermatitis, as well as potential challenges facing its successful treatment. Furthermore, mainstay top...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章,评审
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更新日期:2017-05-01 00:00:00
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journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.2310/7750.2007.00030
更新日期:2007-09-01 00:00:00
abstract::The primary goal of treatment for external genital warts (EGWs) is to eradicate visible lesions and address symptoms that may accompany them, but it does not address the underlying virus. Left untreated, warts may grow, remain the same, or spontaneously regress as a result of being cleared by the immune system. Howeve...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:
更新日期:2013-12-01 00:00:00
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journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1177/120347549800200307
更新日期:1998-01-01 00:00:00
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journal_title:Journal of cutaneous medicine and surgery
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journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
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更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:Intralesional Candida antigen has been used as immunotherapy to treat refractory warts in the immunocompetent pediatric and adult populations but has not been reported in individuals with human immunodeficiency virus (HIV). PURPOSE:To examine if Candida antigen resulted in clearance of medically refractory,...
journal_title:Journal of cutaneous medicine and surgery
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doi:10.2310/7750.2013.12112
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Acne affects a large proportion of the Canadian population and has psychosocial and financial consequences. OBJECTIVE:We provide cost information for treatments recommended by the Canadian acne guidelines. METHODS:Highest level recommendations were selected for 3-month usage cost. RESULTS:Three-month esti...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1177/1203475416653735
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:This is a somewhat rare case of a 19-year-old African American female with multiple cutaneous granular cell tumors. Granular cell tumors are of neural origin, except in rare cases, and are considered benign, with a low incidence of malignancy. The clinical presentation varies greatly, but these...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
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更新日期:2011-11-01 00:00:00
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更新日期:2018-01-01 00:00:00
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更新日期:2016-03-01 00:00:00
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doi:10.1007/s10227-001-0146-2
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:Vitiligo can negatively affect patients' quality of life (QoL). Assessment of QoL provides relevant information about treatment benefits. OBJECTIVES:To examine the effects of excimer laser treatment on vitiligo patients' QoL and to identify overall patient satisfaction. The literature review failed to show ...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:
更新日期:2014-10-01 00:00:00
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journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.2310/7750.2014.14005
更新日期:2015-01-01 00:00:00
abstract::Acne is a disease of the pilosebaceous units and these are mainly under hormonal control. In female patients, hormonal therapy is a unique opportunity for the treatment of acne. Several combined oral contraceptives (COCs), cyproterone acetate, spironolactone, flutamide, and others, have been tried for the control of a...
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journal_title:Journal of cutaneous medicine and surgery
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更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Sarcoidosis is a systemic granulomatous disease of unknown etiology that affects multiple organ systems, including the pulmonary, lymphatic, skeletal, and integumentary systems. Improved understanding of the intrinsic immunology and molecular biology in sarcoidosis can be applied to the treatment of this dis...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.2310/7750.2006.00063
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journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.2310/7750.2008.06009
更新日期:2008-03-01 00:00:00
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journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
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更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Cutaneous reactions to drugs are among the most common clinical manifestations of adverse drug events (ADEs); however, data on outpatient cutaneous adverse drug events (CADEs) are limited. PURPOSE:To provide national estimates of outpatient CADEs and determine their most frequent causes. METHODS:Outpatient...
journal_title:Journal of cutaneous medicine and surgery
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更新日期:2013-07-01 00:00:00
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journal_title:Journal of cutaneous medicine and surgery
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