Stephen Rothman's text on physiology and biochemistry of the skin.

abstract：:Lichen planus (LP) is a chronic inflammatory disorder that most commonly affects middle-aged individuals. LP involves the skin and/or mucous membranes, including oral, vulvovaginal, esophageal, laryngeal, and conjunctival mucosa. Linear LP, a rare distinct variant of LP, is characterised by pruritic eruption of lichen...

journal_title：Journal of cutaneous medicine and surgery

authors： Thomas MG,Betsy A

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Cutaneous reactions to drugs are among the most common clinical manifestations of adverse drug events (ADEs); however, data on outpatient cutaneous adverse drug events (CADEs) are limited. PURPOSE:To provide national estimates of outpatient CADEs and determine their most frequent causes. METHODS:Outpatient...

journal_title：Journal of cutaneous medicine and surgery

authors： Koelblinger P,Dabade TS,Gustafson CJ,Davis SA,Yentzer BA,Kiracofe EA,Feldman SR

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Molluscum contagiosum is a viral infection of the skin that is widely considered to be a self-resolving disease that can be treated with benign neglect. However, the clinical reality is that the disease can vary widely by anatomic site and by recalcitrance to treatment and remains a significant cause of morb...

journal_title：Journal of cutaneous medicine and surgery

authors： Nguyen HP,Franz E,Stiegel KR,Hsu S,Tyring SK

更新日期：2014-10-01 00:00:00

abstract：:Sarcoidosis is a multisystem inflammatory condition of unknown etiology. Variability in the cutaneous features of sarcoidosis is profound, and its protean manifestations affirm the condition's designation as one of dermatology's "great mimics." Cutaneous phenotypes of sarcoidosis include but are by no means limited to...

journal_title：Journal of cutaneous medicine and surgery

authors： Hudson AD,Klimas NK,Stetson CL

更新日期：2018-07-01 00:00:00

abstract：:Coronavirus disease (COVID-19), a respiratory disease caused by a novel coronavirus designated severe acute respiratory syndrome coronavirus 2, has rapidly spread worldwide and has been recognized as a pandemic by the World Health Organization. Patients with altered immunologic function are at higher risk of acquiring...

journal_title：Journal of cutaneous medicine and surgery

authors： Ladda M,Lynde C,Fleming P

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Granular parakeratosis is a hyperkeratotic eruption of unknown etiology that occurs in the axilla and other intertriginous areas. The histologic features are unique for the retention of keratohyalin granules in the stratum corneum. OBJECTIVE:The aim of the article is to review the clinical manifestations an...

journal_title：Journal of cutaneous medicine and surgery

authors： English JC 3rd,Derdeyn AS,Wilson WM,Patterson JW

更新日期：2003-07-01 00:00:00

abstract：:Actinic keratosis (AK), located on sun-exposed areas of the skin, is an increasing global health burden. Multiple ablative and topical treatment options are available to manage this disease; however, topical treatment options are receiving significant interest because AK is commonly associated with areas of substantia...

journal_title：Journal of cutaneous medicine and surgery

authors： Jorizzo JL

更新日期：2004-01-01 00:00:00

abstract：:Acne is a disease of the pilosebaceous units and these are mainly under hormonal control. In female patients, hormonal therapy is a unique opportunity for the treatment of acne. Several combined oral contraceptives (COCs), cyproterone acetate, spironolactone, flutamide, and others, have been tried for the control of a...

journal_title：Journal of cutaneous medicine and surgery

authors： Poulin Y

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Apligraf is a bioengineered skin product composed of neonatal fibroblasts and keratinocytes. The FDA has approved Apligraf for the treatment of chronic venous ulcers and diabetic ulcers. OBJECTIVE:We review the development of bioengineered skin, examine the cellular activities of various growth factors that...

journal_title：Journal of cutaneous medicine and surgery

authors： Shen JT,Falanga V

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Bullous pemphigoid (BP) is an autoimmune polymorphic skin disease characterized by erythematous papules and plaques and tense bullae. A skin biopsy for direct immunofluorescence (DIF) is used to detect autoantibodies and complement proteins. OBJECTIVE:We sought to determine which location would provide the ...

journal_title：Journal of cutaneous medicine and surgery

authors： Sladden C,Kirchhof MG,Crawford RI

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Local skin reactions are common during imiquimod treatment of actinic keratosis (AK). Cyclical application of imiquimod may improve tolerability while maintaining efficacy. OBJECTIVE:To assess the tolerability of imiquimod and clearance rate of AK lesions after imiquimod application. METHODS:Imiquimod 5% c...

journal_title：Journal of cutaneous medicine and surgery

authors： Rivers JK,Rosoph L,Provost N,Bissonnette R

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:In 1995, a Rosacea Awareness Program (RAP) was initiated in Canada to make available educational resources for physicians and rosacea patients. Material is in French or English, and is accessible though physician offices and by toll-free telephone. Information was communicated to the public via noncommercial...

journal_title：Journal of cutaneous medicine and surgery

authors： Shear NH,Levine C

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:Systemic therapy for atopic dermatitis (AD) has been challenging with limited safe and efficacious long-term treatment options. In 2017, dupilumab was approved in the United States, Europe, and Canada as the first targeted therapy for patients with moderate-to-severe AD. Despite promising efficacy and safety...

journal_title：Journal of cutaneous medicine and surgery

authors： Jo CE,Georgakopoulos JR,Ladda M,Ighani A,Mufti A,Drucker AM,Piguet V,Yeung J

更新日期：2020-09-01 00:00:00

abstract：:Genital ulcer disease can be caused by a wide variety of sources. Most commonly, genital ulcer disease is grouped into infectious and noninfectious causes. HSV, syphilis, lymphogranuloma venereum, and chancroid represent some common infectious ulcers. Noninfectious causes on the other hand can be inflammatory, noninfl...

journal_title：Journal of cutaneous medicine and surgery

authors： Maliyar K,Mufti A,Syed M,Selk A,Dutil M,Bunce PE,Alavi A

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Multiple symmetric lipomatosis (MSL) is a relatively uncommon entity of unknown etiology characterized by symmetrically subcutaneous accumulation of nonencapsulated adipose tissue. Approximately 200 to 300 cases have been published. OBJECTIVES:The aims of this article are to report the case of a 58-year-old...

journal_title：Journal of cutaneous medicine and surgery

authors： Gomes da Silva R,Detoffol Bragança R,Ribeiro Costa C,Torres de Melo L,Weiss Telles R,Costa Silva L

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by massive infection with human papillomaviruses (HPVs) and development of skin cancer. Myelodysplastic syndromes (MDSs) are a group of chronic conditions that involve dysplastic hematopoiesis, peripheral blood cytopenias, and a high...

journal_title：Journal of cutaneous medicine and surgery

authors： Oliveira WR,Ferreira GN,Rady PL,Festa C,Tyring SK

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Hand dermatitis (HD) is one of the most common skin conditions; however, it is not a homogeneous disease entity. The severity of HD may range from very mild cases to severe chronic forms, which may result in prolonged disability and, occasionally, refractory HD. Chronic hand dermatitis (CHD) is associated wi...

journal_title：Journal of cutaneous medicine and surgery

authors： Lynde C,Guenther L,Diepgen TL,Sasseville D,Poulin Y,Gulliver W,Agner T,Barber K,Bissonnette R,Ho V,Shear NH,Toole J

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Moderate to severe chronic hand dermatitis (CHD) is not well controlled by current medical strategies; however, recent studies have shown significant improvement in patients treated with up to 6 months of oral alitretinoin (9-cis-retinoic acid). The results of longer-term continuous treatment are lacking. O...

journal_title：Journal of cutaneous medicine and surgery

authors： Gulliver WP,Baker KA

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Topical minoxidil solution (TMS) is widely used for androgenetic alopecia (AGA), and this is the first report of a large safety trial. OBJECTIVES:The aim of the study was to evaluate the safety profile of TMS by comparing hospitalization and death rates among subjects using TMS with controls. Cardiovascular...

journal_title：Journal of cutaneous medicine and surgery

authors： Shapiro J

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:Encephalocraniocutaneous lipomatosis (ECCL) is a relatively new, nonhereditary, but congenital, neurocutaneous syndrome with unilateral cutaneous tumors and ipsilateral ophthalmologic and neurologic malformations. The syndrome is rare, with only 25 cases reported since first communication in 1970. The primar...

journal_title：Journal of cutaneous medicine and surgery

authors： Gawel J,Schwartz RA,Józwiak S

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Elephantiasis is a well-known condition in dermatology usually affecting the legs and external genitalia. It is characterized by chronic inflammation and obstruction of the lymphatic channels and by hypertrophy of the skin and subcutaneous tissues. The etiology is either idiopathic or caused by a variety of ...

journal_title：Journal of cutaneous medicine and surgery

authors： Hanna D,Cloutier R,Lapointe R,Desgagné A

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Efalizumab is a recombinant humanized IgG1-kappa isotype monoclonal antibody that binds to CD11a, inhibiting T-cell activation. It has been approved for the treatment of moderate to severe plaque psoriasis. Efalizumab has been associated with the development of skin eruptions during the administration period...

journal_title：Journal of cutaneous medicine and surgery

authors： Rallis E,Verros C,Karanikola E,Valaskatzi A,Papaconstantis M

更新日期：2009-03-01 00:00:00

abstract：:The intention of the Summary Notes section is to provide the practitioner and trainee with a current, concise reference source to dermatologic diseases and to serve as a form of Continuing Medical Education. Each installment will deal with a specific disease. When included, the pretest questions indicate some of the a...

journal_title：Journal of cutaneous medicine and surgery

authors： Katz AM

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Erosive lichen planus is a painful and disabling disease that is frequently resistant to topical and systemic therapies. Current therapies are considered palliative rather than curative as many patients relapse after discontinuing treatment. An association has been reported between some cases of oral lichen ...

journal_title：Journal of cutaneous medicine and surgery

authors： Donovan JC,Hayes RC,Burgess K,Leong IT,Rosen CF

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Patient nonattendance is a frequent occurrence in dermatology clinics, and our responsibility regarding the follow-up of these patients remains nebulous. OBJECTIVE:This study sought to evaluate the beliefs and practices of physicians at a university-affiliated medical dermatology clinic regarding patient no...

journal_title：Journal of cutaneous medicine and surgery

authors： Nasseri E,Bertrand J,Brassard D,Fortier-Riberdy G,Marcil I

更新日期：2012-03-01 00:00:00

abstract：:Oral glucocorticoids are commonly used across every field of medicine; however, discontinuing them in patients can be challenging. The risk of acute adrenal crises secondary to glucocorticoid withdrawal can be fatal and arises from chronic suppression of the adrenal glands. Identifying risk factors for adrenal suppres...

journal_title：Journal of cutaneous medicine and surgery

authors： Nicholas MN,Li SK,Dytoc M

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Keratoelastoidosis marginalis is a rare disease that is a variant of solar elastosis. Long-term ultraviolet radiation exposure and chronic trauma secondary to manual labor are considered to be inciting factors. OBJECTIVE:To outline the clinical and histological features of this disorder. METHODS:We report ...

journal_title：Journal of cutaneous medicine and surgery

authors： Mengesha YM,Kayal JD,Swerlick RA

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:To better understand cutaneous photosensitivity reactions, a review of its etiologic factors, clinical characteristics, pathogenesis, and treatment modalities was undertaken. METHODS:Articles discussing the above aspects of phototoxic and photoallergic reactions were used to demonstrate what is currently kno...

journal_title：Journal of cutaneous medicine and surgery

authors： Lankerani L,Baron ED

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Giant basal cell carcinomas (GBCC) can demonstrate very malignant behavior and pose a surgical challenge. OBJECTIVE:To present a surgical technique utilizing Mohs and the resection of narrow bands of tissue to excise a GBCC that created a large facial defect of 5 cm × 2 cm. METHODS:A unique combination of ...

journal_title：Journal of cutaneous medicine and surgery

authors： Nolan K,Henry M,Shohet M,Elahi E,Marmur E

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Acne affects a large proportion of the Canadian population and has psychosocial and financial consequences. OBJECTIVE:We provide cost information for treatments recommended by the Canadian acne guidelines. METHODS:Highest level recommendations were selected for 3-month usage cost. RESULTS:Three-month esti...

journal_title：Journal of cutaneous medicine and surgery

authors： Czilli T,Tan J,Knezevic S,Peters C

更新日期：2016-11-01 00:00:00