Innovative therapies in wound healing.

Abstract:

BACKGROUND:Apligraf is a bioengineered skin product composed of neonatal fibroblasts and keratinocytes. The FDA has approved Apligraf for the treatment of chronic venous ulcers and diabetic ulcers. OBJECTIVE:We review the development of bioengineered skin, examine the cellular activities of various growth factors that may facilitate wound healing, and discuss the results of clinical trials with a particular construct, Apligraf, as proof of principle. CONCLUSION:Bioengineered skin acts as a "smart" delivery system for growth factors and other stimulatory substances. Not only does it present a novel treatment for chronic and diabetic ulcers, but it could also be considered for application to other types of acute wounds.

journal_name

J Cutan Med Surg

authors

Shen JT,Falanga V

doi

10.1007/s10227-002-0106-5

subject

Has Abstract

pub_date

2003-05-01 00:00:00

pages

217-24

issue

3

eissn

1203-4754

issn

1615-7109

journal_volume

7

pub_type

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