Biopsy location for direct immunofluorescence in patients with suspected bullous pemphigoid impacts probability of a positive test result.

abstract：:We report a case of an 17-year-old male with a drug reaction in the spectrum of Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), triggered by carbamazepine, who was succesfully treated with the combination of dexamethasone, cyclosporine, and etanercept. This triple therapy halted and prevented skin epi...

journal_title：Journal of cutaneous medicine and surgery

authors： Coulombe J,Belzile E,Duhamel A,Rault P,Buteau C,DeBruycker JJ,Bussières JF

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Major advances have been made in the understanding of the pathophysiology of psoriasis. OBJECTIVES:The authors review the role of interleukin (IL) 17 in the pathogenesis of psoriasis and provide updates on approved and investigational therapies targeting IL-17 and the IL-17 receptor. METHODS:A PubMed searc...

journal_title：Journal of cutaneous medicine and surgery

authors： AbuHilal M,Walsh S,Shear N

更新日期：2016-11-01 00:00:00

abstract：:This document is a concise, current, and practical guide for dermatologists and other health care providers managing adult patients with moderate-to-severe atopic dermatitis (AD). The recommendations made here are based on a consensus of specialists with extensive experience managing patients with AD. Topics reviewed ...

journal_title：Journal of cutaneous medicine and surgery

authors： Hong CH,Gooderham MJ,Albrecht L,Bissonnette R,Dhadwal G,Gniadecki R,Grewal P,Kirchhof MG,Landells I,Lansang P,Lynde CW,Papp KA,Poulin Y,Sussman G,Turchin I,Wiseman M,Yeung J

更新日期：2018-11-01 00:00:00

abstract：:Psoriasis is a T-cell mediated skin disease that affects approximately 2% of the population worldwide. Despite the prevalence of the disease and long-standing efforts to develop strategies to treat it, there is a need for safe and effective therapies to treat psoriasis, particularly the more severe forms. Biological a...

journal_title：Journal of cutaneous medicine and surgery

authors： Langley RG,Ho V,Lynde C,Papp KA,Poulin Y,Shear N,Toole J,Zip C

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Vitiligo can negatively affect patients' quality of life (QoL). Assessment of QoL provides relevant information about treatment benefits. OBJECTIVES:To examine the effects of excimer laser treatment on vitiligo patients' QoL and to identify overall patient satisfaction. The literature review failed to show ...

journal_title：Journal of cutaneous medicine and surgery

authors： Al-Shobaili HA

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Plaque psoriasis (PsO) is a chronic inflammatory disease that often presents at peak reproductive age in women of child-bearing potential (WOCBP). With the emergence of biologic therapies to treat PsO, guidance on disease management in WOCBP is needed to inform treatment decisions before, during, and after p...

journal_title：Journal of cutaneous medicine and surgery

authors： Yeung J,Gooderham MJ,Grewal P,Hong CH,Lansang P,Papp KA,Poulin Y,Turchin I,Vender R

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Epidermolysis bullosa acquisita (EBA) is a chronic subepidermal blistering disease that is frequently resistant to therapy. OBJECTIVE:A 58-year-old man who had a one-year history of a bullous eruption involving the hands, forearms, trunk, scalp, and oral mucosa. Histopathology revealed a subepidermal bulla,...

journal_title：Journal of cutaneous medicine and surgery

authors： Hughes AP,Callen JP

更新日期：2001-09-01 00:00:00

abstract：:Leprosy reactions are acute inflammatory episodes that occur in the setting of Mycobacterium leprae infection. Precipitants of reactions can be pharmacologic and nonpharmacologic. Both type 1 and type 2 reactions typically occur before and during leprosy treatment but may also occur after treatment has been completed....

journal_title：Journal of cutaneous medicine and surgery

authors： Wu J,Boggild AK

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:The development of knowledge concerning the role of sun exposure in causing skin cancer has been a gradual one. OBJECTIVE:This article reviews the article by Urbach who used manikin coated with an ultraviolet dosimeter to see exactly where on the head and neck the exposure was greatest. CONCLUSION:Urbach s...

journal_title：Journal of cutaneous medicine and surgery

authors： Jackson R

更新日期：1999-01-01 00:00:00

abstract：:Sarcoidosis is a multisystem inflammatory condition of unknown etiology. Variability in the cutaneous features of sarcoidosis is profound, and its protean manifestations affirm the condition's designation as one of dermatology's "great mimics." Cutaneous phenotypes of sarcoidosis include but are by no means limited to...

journal_title：Journal of cutaneous medicine and surgery

authors： Hudson AD,Klimas NK,Stetson CL

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Squamous cell carcinoma (SCC) is the second-most common form of non-melanoma skin cancer (NMSC). OBJECTIVE:To provide guidance to Canadian health care practitioners regarding management of SCCs. METHODS:Literature searches and development of graded recommendations were carried out as discussed in the accom...

journal_title：Journal of cutaneous medicine and surgery

authors： Sapijaszko M,Zloty D,Bourcier M,Poulin Y,Janiszewski P,Ashkenas J,Canadian Non-melanoma Skin Cancer Guidelines Committee.

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Psoriasis in clinical trials is often measured by the Psoriasis Area and Severity Index (PASI). This measurement is well understood by clinical trialists and many dermatologists but rarely by patients and some clinicians. Patients may not understand their chance of improvement based on a PASI-50 or PASI-75 v...

journal_title：Journal of cutaneous medicine and surgery

authors： English PL,Vender R

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Multiple symmetric lipomatosis (MSL) is a relatively uncommon entity of unknown etiology characterized by symmetrically subcutaneous accumulation of nonencapsulated adipose tissue. Approximately 200 to 300 cases have been published. OBJECTIVES:The aims of this article are to report the case of a 58-year-old...

journal_title：Journal of cutaneous medicine and surgery

authors： Gomes da Silva R,Detoffol Bragança R,Ribeiro Costa C,Torres de Melo L,Weiss Telles R,Costa Silva L

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Stress is thought to exacerbate a number of diseases, some of which are skin disorders. Epidermal Langerhans' cells play a major role in cutaneous immune reactions. OBJECTIVE:The effects of two types of stress on the cutaneous immune system were to be assessed in mice. METHODS:Mice received stress by immob...

journal_title：Journal of cutaneous medicine and surgery

authors： Hosoi J,Tsuchiya T,Denda M,Ashida Y,Takashima A,Granstein RD,Koyama J

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:Naftifine is a topical allylamine that is effective and safe in the management of superficial dermatomycoses. Naftifine is fungicidal in vitro against a broad spectrum of dermatophyte fungi and provides good activity against Candida and Aspergillus species. It is also effective against gram-negative and gram...

journal_title：Journal of cutaneous medicine and surgery

authors： Gupta AK,Ryder JE,Cooper EA

更新日期：2008-03-01 00:00:00

abstract：:Acne is a disease of the pilosebaceous units and these are mainly under hormonal control. In female patients, hormonal therapy is a unique opportunity for the treatment of acne. Several combined oral contraceptives (COCs), cyproterone acetate, spironolactone, flutamide, and others, have been tried for the control of a...

journal_title：Journal of cutaneous medicine and surgery

authors： Poulin Y

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Several clinical trials have established the benefit of using a topical corticosteroid in conjunction with tazarotene gel in the treatment of plaque psoriasis. However, there is little information comparing the relative benefits of different corticosteroids, or different formulations of corticosteroids, when...

journal_title：Journal of cutaneous medicine and surgery

authors： Green L,Sadoff W

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Cellular angiofibroma is a benign and rare tumor. It usually arises in middle-aged women and involves the vulva. Complete local excision of the tumor is the best cure, and, usually, there is no recurrence after surgery. CASE REPORT:We describe a 20-year-old woman with a painless, growing vulvar mass who pre...

journal_title：Journal of cutaneous medicine and surgery

authors： Ahmadnia H,Kamalati A,Dolati M,Akhavan Rezayat A,Katebi M

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Informed shared decision making is a mutual process engaging both doctor and patient and informed by best medical evidence and patient values and preferences. OBJECTIVE:Our aim was to identify the needs of psoriasis patients in decisions on selecting treatment. METHODS:Psoriasis subjects participated in an...

journal_title：Journal of cutaneous medicine and surgery

authors： Tan J,Stacey D,Fung K,Barankin B,Bissonnette R,Gulliver W,Lui H,Shear N,Jackson C,Zhang X

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Biologics have transformed the management of moderate to severe psoriasis. The persistency of biologics lacks real-world data. OBJECTIVES:To quantify drug survival of infliximab (IFX), adalimumab (ADA), etanercept (ETA), and ustekinumab (UST) and to identify potential factors affecting drug survival. METHO...

journal_title：Journal of cutaneous medicine and surgery

authors： Verma L,Mayba JN,Gooderham MJ,Verma A,Papp KA

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Whereas several literature reviews have discussed the role of excipients in drug-related reactions, no article has focused specifically on those found in oral dermatologic medications. METHODS:The Compendium of Pharmaceuticals and Specialties (CPS) was used to reference the inert ingredients found in oral d...

journal_title：Journal of cutaneous medicine and surgery

authors： Noiles K,Vender R

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:It has been postulated that periodic acid-Schiff staining of basement membrane can predict direct immunofluorescence patterns seen in epidermolysis bullosa acquisita and bullous pemphigoid. It has also been suggested that the type of inflammatory infiltrate or presence of fraying of basal keratinocytes may d...

journal_title：Journal of cutaneous medicine and surgery

authors： Gardner KM,Crawford RI

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Molluscum contagiosum is a viral infection of the skin that is widely considered to be a self-resolving disease that can be treated with benign neglect. However, the clinical reality is that the disease can vary widely by anatomic site and by recalcitrance to treatment and remains a significant cause of morb...

journal_title：Journal of cutaneous medicine and surgery

authors： Nguyen HP,Franz E,Stiegel KR,Hsu S,Tyring SK

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:The classification of many pigmented lesions is not well defined, and an association with melanoma has not been established. OBJECTIVE:To better define the spectrum of pigmented lesions (excluding common and dysplastic nevi) and explore links to melanoma. METHODS:Retrospective review of patients with total...

journal_title：Journal of cutaneous medicine and surgery

authors： Menon K,Dusza SW,Marghoob AA,Halpern AC,Nehal KS

更新日期：2006-03-01 00:00:00

abstract：:Lichen planus (LP) is a chronic inflammatory disorder that most commonly affects middle-aged individuals. LP involves the skin and/or mucous membranes, including oral, vulvovaginal, esophageal, laryngeal, and conjunctival mucosa. Linear LP, a rare distinct variant of LP, is characterised by pruritic eruption of lichen...

journal_title：Journal of cutaneous medicine and surgery

authors： Thomas MG,Betsy A

更新日期：2018-03-01 00:00:00

abstract：:We present the extraordinary case of a 72-year-old man with a history of primary cutaneous peripheral T-cell lymphoma not otherwise specified (pcPTCL-NOS) previously controlled with topical agents who developed tumours in a sporotrichoid pattern. Culture of the tumours was negative, and histopathology showed findings ...

journal_title：Journal of cutaneous medicine and surgery

authors： Lewis DJ,Vin H,Hinojosa T,Tetzlaff MT,Dabaja BS,Duvic M

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:The number of dermatology residency positions in Canada has not reflected the growing workforce shortage. Until 2005, all dermatology residents at the University of Ottawa were committed to return to their funding area at the completion of their training. This has left Eastern Ontario with a critical shortag...

journal_title：Journal of cutaneous medicine and surgery

authors： Heughan C,Kanigsberg N,Amdemichael E,Fergusson D,Ammerman D

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Forty-nine years ago the first complete and authoritative English text on the physiology and biochemistry of the skin was published by Stephen Rothman, an early basic researcher in dermatology. OBJECTIVE:The purpose of the article is to learn more about Stephen Rothman and his 1954 text, to learn more about...

journal_title：Journal of cutaneous medicine and surgery

authors： Jackson R

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Sjögren syndrome (SS) is a chronic autoimmune inflammatory disease that involves primarily the exocrine glands, resulting in their functional impairment. SS typically presents as dry eyes (xerophthalmia) and dry mouth (xerostomia). This process can manifest either as the independent phenomenon of primary SS ...

journal_title：Journal of cutaneous medicine and surgery

authors： Kittridge A,Routhouska SB,Korman NJ

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Dermatofibrosarcoma protuberans with fibrosarcomatous differentiation (DFSP-FS) is a rare variant of DFSP with a more aggressive clinical course, characterized by higher rates of local recurrence, metastasis, and death. METHODS:We conducted a clinicopathologic review of all DFSP-FS cases that occurred in Al...

journal_title：Journal of cutaneous medicine and surgery

authors： Kuzel P,Mahmood MN,Metelitsa AI,Salopek TG

更新日期：2015-01-01 00:00:00