Abstract:
:Actinic keratosis (AK), located on sun-exposed areas of the skin, is an increasing global health burden. Multiple ablative and topical treatment options are available to manage this disease; however, topical treatment options are receiving significant interest because AK is commonly associated with areas of substantial photodamage, and destructive modalities cannot effectively treat subclinical AK. Several topical therapies, including 0.5% and other 5-fluorouracil concentrations, photodynamic therapy, 3% diclofenac sodium gel, and imiquimod 5% cream, are indicated in the treatment of AK. This article will review key data on the efficacy and safety of several topical therapies in the treatment and management of AK. The review includes discussions of imiquimod 5% cream, approved in 2004 in the treatment of AK of the face or scalp. Whether administered as monotherapy or adjunctive therapy, topical therapies provide the opportunity to effectively manage AK and will likely emerge as an important tool for healthcare providers.
journal_name
J Cutan Med Surgjournal_title
Journal of cutaneous medicine and surgeryauthors
Jorizzo JLdoi
10.1007/s10227-004-0804-2subject
Has Abstractpub_date
2004-01-01 00:00:00pages
13-21eissn
1203-4754issn
1615-7109journal_volume
8 Suppl 3pub_type
杂志文章,评审abstract::Larva currens is the cutaneous manifestation of human infection with the geotropic helminth Strongyloides stercoralis. Strongyloidiasis is a lifelong infection unless treated. A high index of suspicion is needed to prevent chronic symptoms of strongyloidiasis (eg, larva currens, eosinophilia, abdominal discomfort) and...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1177/1203475415575247
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Oral isotretinoin treatment can cause ocular side effects. OBJECTIVE:This study was performed to detect possible toxic effects of oral isotretinoin treatment on the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL). METHODS:The study population consisted of 54 eyes of 27 patients with nodulocy...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 临床试验,杂志文章
doi:10.2310/7750.2013.13168
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:A new treatment for actinic keratoses, ingenol mebutate, was recently approved by the US Food and Drug Administration. OBJECTIVE:To review the mechanisms of action, efficacy and safety data, and practical recommendations for ingenol mebutate. METHODS:The PubMed and clinicaltrials.gov databases were searche...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.2310/7750.2012.12050
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Skin cancer is extremely common. Epidemiological studies indicated that ultraviolet radiation (UV) is the primary cause for skin cancers, and that retinoic acid (RA) is able to inhibit this UV-induced skin carcinogenesis; however, the molecular mechanism of the anti-UV action of RA is unclear. OBJECTIVE:The...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1177/120347540000400102
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Dermatofibrosarcoma protuberans with fibrosarcomatous differentiation (DFSP-FS) is a rare variant of DFSP with a more aggressive clinical course, characterized by higher rates of local recurrence, metastasis, and death. METHODS:We conducted a clinicopathologic review of all DFSP-FS cases that occurred in Al...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.2310/7750.2014.13192
更新日期:2015-01-01 00:00:00
abstract::The Maintenance of Certification (MOC) Program administered by the Royal College of Physicians and Surgeons applies to all Fellows of the Royal College including dermatologists. It is mandatory for those who wish to maintain their fellowship in the Royal College and can be critical for maintaining licensure requiremen...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1177/1203475417709194
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Bullous pemphigoid (BP) is an autoimmune polymorphic skin disease characterized by erythematous papules and plaques and tense bullae. A skin biopsy for direct immunofluorescence (DIF) is used to detect autoantibodies and complement proteins. OBJECTIVE:We sought to determine which location would provide the ...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.2310/7750.2014.14004
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Forty-nine years ago the first complete and authoritative English text on the physiology and biochemistry of the skin was published by Stephen Rothman, an early basic researcher in dermatology. OBJECTIVE:The purpose of the article is to learn more about Stephen Rothman and his 1954 text, to learn more about...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 传,历史文章,杂志文章
doi:10.1007/s10227-005-0040-4
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:Elastosis perforans serpiginosa (EPS) is a rare skin disease in which abnormal elastic tissue fibers, other connective tissue elements, and cellular debris are expelled from the papillary dermis via transepithelial elimination. It is characterized by an eruption of small grouped hyperkeratotic papules in a s...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.2310/7750.2009.08064
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Onychomycosis is a persistent fungal nail infection that is notoriously hard to treat. Approximately 20% to 25% of patients with onychomycosis do not respond to treatment, and 10% to 53% of patients relapse. As such, successful treatment is imperative for long-term disease management. OBJECTIVE:To identify ...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1177/1203475416653734
更新日期:2016-11-01 00:00:00
abstract::We report a case of an 17-year-old male with a drug reaction in the spectrum of Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), triggered by carbamazepine, who was succesfully treated with the combination of dexamethasone, cyclosporine, and etanercept. This triple therapy halted and prevented skin epi...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1177/1203475419861078
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Several clinical trials have established the benefit of using a topical corticosteroid in conjunction with tazarotene gel in the treatment of plaque psoriasis. However, there is little information comparing the relative benefits of different corticosteroids, or different formulations of corticosteroids, when...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/s10227-001-0031-z
更新日期:2002-03-01 00:00:00
abstract::A renaissance is taking place in the field of wound healing. Interest in wounds has probably never been so great, and a number of key therapeutic advances in the last 2 or 3 years are only an indication of more progress to come. In large part, we are benefitting from decades of basic research that has provided the kno...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND:Apligraf is a bioengineered skin product composed of neonatal fibroblasts and keratinocytes. The FDA has approved Apligraf for the treatment of chronic venous ulcers and diabetic ulcers. OBJECTIVE:We review the development of bioengineered skin, examine the cellular activities of various growth factors that...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1007/s10227-002-0106-5
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:Aquagenic pruritus is an intense prickling sensation that develops in affected individuals immediately after contact with water at any temperature. It is most commonly associated with polycythemia rubra vera. Common but often ineffective treatments include anticholinergics and antihistamines. Other moderatel...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1007/s10227-005-0144-x
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:Moderate to severe chronic hand dermatitis (CHD) is not well controlled by current medical strategies; however, recent studies have shown significant improvement in patients treated with up to 6 months of oral alitretinoin (9-cis-retinoic acid). The results of longer-term continuous treatment are lacking. O...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1177/120347541201600409
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:pemphigoid gestationis is an autoimmune blistering disease affecting pregnant women. Treatment often consists of topical corticosteroids, oral antihistamines, and oral prednisone followed by immunosuppressants. Refractory cases in antepartum patients present a particular therapeutic challenge as the majority...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.2310/7750.2009.09001
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:Extramedullary plasmacytoma of the skin, a rare type of cutaneous B-cell lymphoma, is characterized by clonal proliferation of plasma cells primarily in the skin without evidence of multiple myeloma. Only about 30 cases with extramedullary plasmacytoma of the skin are reported in the literature. CASE REPORT...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.2310/7750.2013.13103
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:This is a somewhat rare case of a 19-year-old African American female with multiple cutaneous granular cell tumors. Granular cell tumors are of neural origin, except in rare cases, and are considered benign, with a low incidence of malignancy. The clinical presentation varies greatly, but these...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.2310/7750.2011.10088
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:Direct-acting antivirals (DAAs) are known to present with additional dermatological events over pegylated-interferon/ribavirin (Peg-IFN/RBV). OBJECTIVE:A systematic review and meta-analysis was conducted to assess the incidence/risk of cutaneous adverse events (AEs) for simeprevir, sofosbuvir, ABT450/r-ombi...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章,meta分析,评审
doi:10.1177/1203475415595775
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:A patient with concurrent Raynaud disease presented for hyperhidrosis of the axillae and palms. After a positive response to botulinum toxin type A (BoNTA) for axillary hyperhidrosis, she returned requesting palmar treatment. OBJECTIVES:Our goal was to investigate the effect of BoNTA on Raynaud disease in c...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.2310/7750.2008.07044
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:Laser epilation is now used widely as a clinical alternative to electrolysis for the removal of unwanted hair. All of the laser systems presently being used produce a reliable temporary hair loss by inducing telogen. Most of the published studies use follow-up periods of 6 months or less after the last treat...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1177/120347540000400208
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:Biologics have transformed the management of moderate to severe psoriasis. The persistency of biologics lacks real-world data. OBJECTIVES:To quantify drug survival of infliximab (IFX), adalimumab (ADA), etanercept (ETA), and ustekinumab (UST) and to identify potential factors affecting drug survival. METHO...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1177/1203475417733957
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Oral psychostimulant (PS) drugs, the pharmacologic treatment of choice for attention-deficit/hyperactivity disorder (ADHD), have been associated with diseases of abnormal sensitivity to cold (DASC) such as Raynaud phenomenon and acrocyanosis. OBJECTIVES:In a cohort of pediatric patients with DASC, we sought...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.2310/7750.2014.14052
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Tumour size is a crucial factor used to plan Mohs procedures. Larger tumours require more time and stages of excision, and they need to be triaged as a higher priority. Therefore, the accuracy in measurement of tumour size is critical. OBJECTIVE:To investigate if there is a significant difference in accurac...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1177/1203475416683391
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:Perforating dermatoses are a rare group of dermatologic conditions characterized by transepidermal elimination of dermal material that can be primary or acquired secondary to systemic disease. OBJECTIVE:We present an atypical case of perforating dermatosis resembling elastosis perforans serpiginosa (EPS) pr...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1177/1203475417702145
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:PASI is an inadequate outcome measure for the assessment of psoriasis treatments. No currently used endpoints provide a benefit: risk assessment of treatment taking into consideration all available efficacy and safety data. OBJECTIVE:To propose a new outcome measure called "safe psoriasis control" (SPC), wh...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1007/s10227-005-0121-4
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Hybrid skin adnexal tumors are common, and spiradenocylindroma is well described. OBJECTIVE:However, malignant transformation in this setting is infrequent, especially resemblance to lymphoepithelioma-like carcinoma of skin, which is not associated with Epstein-Barr virus. METHODS:A 65-year-old female pres...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.2310/7750.2008.08059
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:Granular parakeratosis is a hyperkeratotic eruption of unknown etiology that occurs in the axilla and other intertriginous areas. The histologic features are unique for the retention of keratohyalin granules in the stratum corneum. OBJECTIVE:The aim of the article is to review the clinical manifestations an...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1007/s10227-002-0131-4
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:Vitiligo can negatively affect patients' quality of life (QoL). Assessment of QoL provides relevant information about treatment benefits. OBJECTIVES:To examine the effects of excimer laser treatment on vitiligo patients' QoL and to identify overall patient satisfaction. The literature review failed to show ...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:
更新日期:2014-10-01 00:00:00