Betamethasone valerate foam for treatment of nonscalp psoriasis.

Abstract:

BACKGROUND:Although betamethasone valerate (BMV) foam, 0.12% (Luxiq, Connectics Corporation, Palo Alto, CA) is approved by the Food and Drug Administration for the treatment of corticosteroid-responsive scalp dermatoses, no data are available for its use on nonscalp psoriasis. OBJECTIVE:We evaluated the safety and efficacy of BMV foam in treating psoriatic lesions at nonscalp sites. METHODS:We conducted a randomized, double-blind, placebo-controlled, paired-comparison, split-body study of 40 patients with mild to moderate plaque-type psoriasis. Patients applied BMV foam and placebo foam twice daily for 12 weeks. RESULTS:At the end of the treatment period, 70% of patients had greater than 50% improvement of lesions on their active foam-treated side compared with 24% of patients with similar improvement on their placebo foam-treated side. Adverse effects were limited to temporary stinging, burning, or itching in several patients. Three patients (7.5%) withdrew because of stinging or itching. CONCLUSIONS:The results indicate that BMV foam is effective against nonscalp psoriasis. Twice-daily applications are well tolerated, compliance exceeds 90%, cosmetic characteristics are acceptable, and the medication may reduce the need for multiple prescriptions.

journal_name

J Cutan Med Surg

authors

Stein LF,Sherr A,Solodkina G,Gottlieb AB,Chaudhari U

doi

10.1007/s10227-001-0006-0

subject

Has Abstract

pub_date

2001-07-01 00:00:00

pages

303-7

issue

4

eissn

1203-4754

issn

1615-7109

journal_volume

5

pub_type

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