Abstract:
BACKGROUND:Stress is thought to exacerbate a number of diseases, some of which are skin disorders. Epidermal Langerhans' cells play a major role in cutaneous immune reactions. OBJECTIVE:The effects of two types of stress on the cutaneous immune system were to be assessed in mice. METHODS:Mice received stress by immobilization or housing at various population densities. Epidermal sheets were stained for I-A molecules (a member of class II major histocompatibility complex) and analyzed with a confocal-laser- scanning microscope. Contact hypersensitivity reaction to 2,4,6-trinitrochlorobenzene was elicited in mouse ears. RESULTS:The cell density, intensity of I-A expression, and number of dendrites were decreased as the population density increased. Elicitation of contact hypersensitivity was suppressed in mice that received either population or immobilization stress. Increased I-A expression and number of dendrites were observed in adrenalectomized compared to sham-operated mice. The population-dependent suppression of contact hypersensitivity reaction was not observed in adrenalectomized mice. After incubation with serum from mice that received either immobilization stress or population stress, the expression of I-A molecules on a XS52 Langerhans' cell-like cell line was reduced. CONCLUSION:Stress affected the cutaneous immune system. There were indications that adrenergic hormones played a role in the regulation of the system.
journal_name
J Cutan Med Surgjournal_title
Journal of cutaneous medicine and surgeryauthors
Hosoi J,Tsuchiya T,Denda M,Ashida Y,Takashima A,Granstein RD,Koyama Jdoi
10.1177/120347549800300205subject
Has Abstractpub_date
1998-10-01 00:00:00pages
79-84issue
2eissn
1203-4754issn
1615-7109journal_volume
3pub_type
杂志文章abstract:BACKGROUND:Schnitzler syndrome (SS) is a rare autoinflammatory disorder characterized by a recurrent urticarial rash and a monoclonal immunoglobulin M gammopathy, as well as 2 of the following minor criteria: recurrent fever (>38°C), objective signs of abnormal bone remodeling, elevated C-reactive protein level or leuk...
journal_title:Journal of cutaneous medicine and surgery
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journal_title:Journal of cutaneous medicine and surgery
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journal_title:Journal of cutaneous medicine and surgery
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更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Sarcoidosis is a systemic granulomatous disease of unknown etiology that affects multiple organ systems, including the pulmonary, lymphatic, skeletal, and integumentary systems. Improved understanding of the intrinsic immunology and molecular biology in sarcoidosis can be applied to the treatment of this dis...
journal_title:Journal of cutaneous medicine and surgery
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journal_title:Journal of cutaneous medicine and surgery
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journal_title:Journal of cutaneous medicine and surgery
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journal_title:Journal of cutaneous medicine and surgery
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journal_title:Journal of cutaneous medicine and surgery
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更新日期:2009-11-01 00:00:00
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journal_title:Journal of cutaneous medicine and surgery
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更新日期:2015-05-01 00:00:00
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journal_title:Journal of cutaneous medicine and surgery
pub_type: 传,历史文章,杂志文章
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journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章,评审
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更新日期:2010-03-01 00:00:00
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journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
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更新日期:2012-07-01 00:00:00
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journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
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更新日期:2001-05-01 00:00:00
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journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
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更新日期:2016-05-01 00:00:00
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journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.2310/7750.2008.07094
更新日期:2009-05-01 00:00:00
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journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
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更新日期:2017-05-01 00:00:00
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journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章,评审
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更新日期:2010-07-01 00:00:00
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journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
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更新日期:2003-03-01 00:00:00