Abstract:
BACKGROUND:Schnitzler syndrome (SS) is a rare autoinflammatory disorder characterized by a recurrent urticarial rash and a monoclonal immunoglobulin M gammopathy, as well as 2 of the following minor criteria: recurrent fever (>38°C), objective signs of abnormal bone remodeling, elevated C-reactive protein level or leukocytosis, and a neutrophilic infiltrate on skin biopsy. Alternatively, a monoclonal immunoglobulin G gammopathy may be present along with 3 minor criteria for diagnosis. OBJECTIVE:To report a rare case of SS without monoclonal gammopathy and inform physicians of this possible clinical presentation so that treatment is not delayed. METHODS:We report a case of a 62-year-old white man with a clinical diagnosis of SS without monoclonal gammopathy. He presented with chronic urticaria unresponsive to conventional therapy. RESULTS AND CONCLUSIONS:To our knowledge, there have only been 3 case reports of SS in the absence of monoclonal gammopathy documented in the literature. SS should be considered based on clinical presentation, even in the absence of monoclonal gammopathy, to facilitate appropriate management.
journal_name
J Cutan Med Surgjournal_title
Journal of cutaneous medicine and surgeryauthors
Urbanski M,Holfeld K,Milne A,Abbas Mdoi
10.1177/1203475416657999subject
Has Abstractpub_date
2016-11-01 00:00:00pages
575-578issue
6eissn
1203-4754issn
1615-7109pii
1203475416657999journal_volume
20pub_type
杂志文章abstract:BACKGROUND:Molluscum contagiosum is a viral infection of the skin that is widely considered to be a self-resolving disease that can be treated with benign neglect. However, the clinical reality is that the disease can vary widely by anatomic site and by recalcitrance to treatment and remains a significant cause of morb...
journal_title:Journal of cutaneous medicine and surgery
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journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
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journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章,评审
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journal_title:Journal of cutaneous medicine and surgery
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journal_title:Journal of cutaneous medicine and surgery
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journal_title:Journal of cutaneous medicine and surgery
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journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章,评审
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journal_title:Journal of cutaneous medicine and surgery
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
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journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
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abstract::Psoriasis has been associated with a number of behavioral and systemic comorbidities, including psoriatic arthritis, anxiety, depression, obesity, hypertension, diabetes mellitus, hyperlipidemia, metabolic syndrome, smoking, cardiovascular disease, alcoholism, Crohn's disease, lymphoma, and multiple sclerosis. Many of...
journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章,评审
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journal_title:Journal of cutaneous medicine and surgery
pub_type: 传,历史文章,杂志文章
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journal_title:Journal of cutaneous medicine and surgery
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title:Journal of cutaneous medicine and surgery
pub_type: 杂志文章
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journal_title:Journal of cutaneous medicine and surgery
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