Antepartum intravenous immunoglobulin therapy in refractory pemphigoid gestationis: case report and literature review.

Abstract:

BACKGROUND:pemphigoid gestationis is an autoimmune blistering disease affecting pregnant women. Treatment often consists of topical corticosteroids, oral antihistamines, and oral prednisone followed by immunosuppressants. Refractory cases in antepartum patients present a particular therapeutic challenge as the majority of second-line agents are contraindicated until the patient has delivered. OBJECTIVE:the following report describes the case of a 34-year-old woman pregnant for the third time at 16 weeks' gestation. Her previous two pregnancies were complicated by pemphigoid gestationis but were successfully managed with oral prednisone and topical agents. During her third pregnancy, the initial lesions were controlled with oral prednisone, but attempts to decrease her dose resulted in disease flare. CONCLUSION:monthly infusions of intravenous immunoglobulin (40 g intravenously for 3 consecutive days for 120 g total) proved to be successful in reducing the dose of oral prednisone required to maintain disease remission. A healthy baby was delivered at 37.5 weeks.

journal_name

J Cutan Med Surg

authors

Doiron P,Pratt M

doi

10.2310/7750.2009.09001

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

189-92

issue

4

eissn

1203-4754

issn

1615-7109

journal_volume

14

pub_type

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