Paraneoplastic pemphigus: a refractory autoimmune mucocutaneous disease.

Abstract:

BACKGROUND AND OBJECTIVE:We report on a 42-year-old man with Stage IIA non-Hodgkin's lymphoma who developed a severe mucocutaneous blistering eruption. His diagnosis, paraneoplastic pemphigus, was based on clinical, histological, and immunofluorescence findings and confirmed by immunoprecipitation. Despite maximal therapy with plasmapheresis, corticosteroids, and mycophenolate mofetil and the subsequent addition of cyclophosphamide and cyclosporine, the condition was fatal. CONCLUSION:This case illustrates the refractory nature of this disease and the inadequacy of existing therapies.

journal_name

J Cutan Med Surg

authors

Ng PP,Rencic A,Nousari HC

doi

10.1007/s10227-001-0130-x

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

434-7

issue

5

eissn

1203-4754

issn

1615-7109

journal_volume

6

pub_type

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