The Role of IL-17 in the Pathogenesis of Psoriasis and Update on IL-17 Inhibitors for the Treatment of Plaque Psoriasis.

Abstract:

BACKGROUND:Major advances have been made in the understanding of the pathophysiology of psoriasis. OBJECTIVES:The authors review the role of interleukin (IL) 17 in the pathogenesis of psoriasis and provide updates on approved and investigational therapies targeting IL-17 and the IL-17 receptor. METHODS:A PubMed search was performed for relevant literature. CONCLUSION:The IL-23/Th17 signaling pathway (including IL-17) plays a central role in the pathogenesis of psoriasis. Biologic agents that block IL-17 (secukinumab and ixekizumab) or its receptor (brodalumab) are effective and safe for the treatment of psoriasis.

journal_name

J Cutan Med Surg

authors

AbuHilal M,Walsh S,Shear N

doi

10.1177/1203475416651605

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

509-516

issue

6

eissn

1203-4754

issn

1615-7109

pii

1203475416651605

journal_volume

20

pub_type

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