Abstract：
BACKGROUND:Laser epilation is now used widely as a clinical alternative to electrolysis for the removal of unwanted hair. All of the laser systems presently being used produce a reliable temporary hair loss by inducing telogen. Most of the published studies use follow-up periods of 6 months or less after the last treatment and cannot address the issue of permanency. Since many patients desire permanent hair loss, there is a need for specific information on the exact benefits and limitations of each particular system. OBJECTIVE:The purpose of this study was to assess the degree of hair loss attained by a single treatment with a 3-msec alexandrite laser. A designated period for follow-up was used to address the issue of long-term benefits. METHODS:A single treatment was carried out on 25 study sites with a 3-msec alexandrite laser at 755 nm using fluences of 30 to 50 joules/cm(2). Hair counts were obtained manually by two independent observers marking terminal hairs under magnification. The counts were repeated using photographic images and the average of the four readings taken. The degree of hair loss was calculated at a time after treatment equal to one complete growth cycle for the particular anatomic site. A second measurement was obtained at a time equal to one growth cycle plus 6 months to determine whether any hair loss had remained stable. RESULTS:The average hair loss at the first follow-up time was 43%, with 60% of sites showing a hair loss of >30%. The hair loss remained stable and the reduction in hair density at both designated times was statistically significant (p <.05). CONCLUSION:A normal-mode alexandrite laser achieves a long-term alopecia and may result in a permanent loss of terminal hair after one treatment at fluences of 30 to 50 joules/cm(2).
journal_name
J Cutan Med Surgjournal_title
Journal of cutaneous medicine and surgeryauthors
Laughlin SA,Dudley DKdoi
10.1177/120347540000400208subject
Has Abstractpub_date
2000-04-01 00:00:00pages
83-8issue
2eissn
1203-4754issn
1615-7109journal_volume
4pub_type
杂志文章abstract：BACKGROUND:Lichen amyloidosis, a type of primary localized cutaneous amyloidosis, is characterized by pruritic brown or grayish pigmented papules. OBJECTIVE:We report a case of lichen amyloidosis in which the skin lesion consisted of asymptomatic salmon-pink-colored papules on the back of the neck to the upper back. T...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1007/s10227-001-0052-7
更新日期：2002-07-01 00:00:00
abstract：BACKGROUND:To date, there is no standard treatment of folliculitis decalvans (FD), a rare type of cicatricial alopecia. OBJECTIVE AND METHODS:The records of 23 patients with FD (1998-2012) were retrospectively analyzed, with added data review on the course and treatment of long-standing cases. RESULTS:Initial managem...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：
更新日期：2014-10-01 00:00:00
abstract：:The duration of response to treatment with alefacept has been assessed in patients with moderate to severe chronic plaque psoriasis who responded to alefacept therapy in phase 2 and phase 3 clinical studies. In a phase 2 trial, duration of response was based on time to retreatment with alefacept. In two phase 3 studie...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1007/s10227-004-9503-2
更新日期：2004-12-01 00:00:00
abstract：BACKGROUND:It has been demonstrated that hypertrophic scar fibroblasts (HSFs) overexpress collagen messenger ribonucleic acid (mRNA) and protein, especially alpha1 collagen. Antisense nucleic acids are effective in inhibiting harmful or uncontrolled gene expression, suggesting that antisense ribonucleic acid (RNA) can ...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.2310/7750.2008.07094
更新日期：2009-05-01 00:00:00
abstract：BACKGROUND:Local skin reactions are common during imiquimod treatment of actinic keratosis (AK). Cyclical application of imiquimod may improve tolerability while maintaining efficacy. OBJECTIVE:To assess the tolerability of imiquimod and clearance rate of AK lesions after imiquimod application. METHODS:Imiquimod 5% c...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.2310/7750.2008.07045
更新日期：2008-05-01 00:00:00
abstract：:Psoriasis is a T-cell mediated skin disease that affects approximately 2% of the population worldwide. Despite the prevalence of the disease and long-standing efforts to develop strategies to treat it, there is a need for safe and effective therapies to treat psoriasis, particularly the more severe forms. Biological a...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1007/s10227-006-0103-1
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:Darier's disease is an autosomal dominant genodermatosis typified by hyperkeratotic papules and plaques in a predominately seborrheic distribution. The vesiculo-bullous variant of Darier's disease is rare. Several previously reported cases have demonstrated clinical and microscopic features resembling famili...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/1203475416660295
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:Nail changes are common in psoriatic arthritis (PsA), with varying relationships existing between skin, nail, and joint disease. OBJECTIVE:To further characterize relationships between nail changes, psoriasis, and joint involvement in PsA patients. METHODS:One hundred eighty-eight PsA patients had skin, fi...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/1203475415573663
更新日期：2015-07-01 00:00:00
abstract：:Psoriasis is a common inflammatory disease with significant comorbidities, whose management can be challenging given the variety of treatment options. It is critical for nurse practitioners, physician assistants, general practitioners, and dermatology trainees to have useful information about the treatment and monitor...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1177/1203475415623508
更新日期：2016-05-01 00:00:00
abstract：BACKGROUND:Giant basal cell carcinomas (GBCC) can demonstrate very malignant behavior and pose a surgical challenge. OBJECTIVE:To present a surgical technique utilizing Mohs and the resection of narrow bands of tissue to excise a GBCC that created a large facial defect of 5 cm × 2 cm. METHODS:A unique combination of ...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/120347541201600623
更新日期：2012-11-01 00:00:00
abstract：BACKGROUND:Major advances have been made in the understanding of the pathophysiology of psoriasis. OBJECTIVES:The authors review the role of interleukin (IL) 17 in the pathogenesis of psoriasis and provide updates on approved and investigational therapies targeting IL-17 and the IL-17 receptor. METHODS:A PubMed searc...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1177/1203475416651605
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:In 1997, it was reported that a PTEN gene deletion, a common genetic mutation in Cowden's disease (CD), was identified in a patient with Bannayan-Riley-Ruvacalba (BRR), suggesting that the two diseases were allelic. However, the clinical overlap between the two diseases has largely remained unclear. OBJECTI...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/120347540100500307
更新日期：2001-05-01 00:00:00
abstract：BACKGROUND:We present a case of strongyloidiasis presenting as larva currens 38 years after potential exposure in a country with what is typically thought of as low epidemiologic risk. CONCLUSION:This case highlights several important features of strongyloidiasis, including its varied epidemiology, long incubation per...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/120347541201600613
更新日期：2012-11-01 00:00:00
abstract：BACKGROUND:Mast cells stimulate inflammation and itch sensation in the skin by releasing various mediators when they are activated. Stress exacerbates some skin diseases. We have reported that inhalation of certain odorants modulates immune reactions in the skin. OBJECTIVE:The possible usage of odorants in the regulat...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1007/s10227-002-0129-y
更新日期：2003-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:We report on a 42-year-old man with Stage IIA non-Hodgkin's lymphoma who developed a severe mucocutaneous blistering eruption. His diagnosis, paraneoplastic pemphigus, was based on clinical, histological, and immunofluorescence findings and confirmed by immunoprecipitation. Despite maximal ther...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1007/s10227-001-0130-x
更新日期：2002-09-01 00:00:00
abstract：:Actinic keratosis (AK), located on sun-exposed areas of the skin, is an increasing global health burden. Multiple ablative and topical treatment options are available to manage this disease; however, topical treatment options are receiving significant interest because AK is commonly associated with areas of substantia...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1007/s10227-004-0804-2
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND:Emotional stress has been associated with the development of alopecia areata (AA) and androgenetic alopecia (AGA). Emotional intelligence (EI), a component of general intelligence, is thought to govern the recognition, expression, and control of stress and other emotions. People with low EI are unable to ade...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.2310/7750.2012.12003
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Liquid nitrogen cryotherapy is a commonly used technique to treat a wide variety of dermatologic conditions including actinic keratoses, non-melanoma skin cancers, verrucae, and seborrheic keratoses. The risks associated with liquid nitrogen cryotherapy are important to know and discuss with patients prior t...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/1203475417702152
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:Pemphigus vegetans is a rare variant of pemphigus vulgaris, comprising 1 to 2% of all pemphigus cases. Exposures to oral agents such as captopril and penicillamine and, less commonly, physical or chemical factors have been implicated in the development of pemphigus. METHODS:We report a 42-year-old white mal...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/120347541201600512
更新日期：2012-09-01 00:00:00
abstract：BACKGROUND:Selective cyclooxygenase (COX) 2 nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with a general lower incidence of side effects compared with nonselective NSAIDs. Postmarketing information has highlighted the need to reassess the risk evaluation for specific organs, including the skin. OB...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1007/7140.2006.00012
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:The onychodystrophies associated with Sézary syndrome (SzS) have rarely been described in the literature. We performed a retrospective analysis of SzS patients at a single institution and compared our data with previous publications. OBJECTIVES:The objectives of this study were to identify and describe the ...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1177/1203475419839937
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:A patient with concurrent Raynaud disease presented for hyperhidrosis of the axillae and palms. After a positive response to botulinum toxin type A (BoNTA) for axillary hyperhidrosis, she returned requesting palmar treatment. OBJECTIVES:Our goal was to investigate the effect of BoNTA on Raynaud disease in c...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.2310/7750.2008.07044
更新日期：2008-07-01 00:00:00
abstract：BACKGROUND:Patient nonattendance is a frequent occurrence in dermatology clinics, and our responsibility regarding the follow-up of these patients remains nebulous. OBJECTIVE:This study sought to evaluate the beliefs and practices of physicians at a university-affiliated medical dermatology clinic regarding patient no...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.2310/7750.2011.11004
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND:Lichen planopilaris (LPP) is believed to be a follicular variant of lichen planus that affects pilosebaceous units, mainly of the scalp. An extremely rare variant of LPP is a linear form, which follows the lines of Blaschko. Of the five previously documented cases of linear LPP, all were limited to the face....
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.2310/7750.2006.00036
更新日期：2006-05-01 00:00:00
abstract：:Acne vulgaris, a condition that can affect people at any age, is the most common cause of referral to a dermatologist. Isotretinoin (ITT) is the most effective treatment available, but serious adverse effects, including a possible association with depression and suicide, limit its use. We review the current literature...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1177/1203475417719052
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:In 1995, a Rosacea Awareness Program (RAP) was initiated in Canada to make available educational resources for physicians and rosacea patients. Material is in French or English, and is accessible though physician offices and by toll-free telephone. Information was communicated to the public via noncommercial...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/120347549900300403
更新日期：1999-04-01 00:00:00
abstract：:We describe a family with supernumerary nipples and kidney and urinary tract malformations. The proband is a 59-year-old man with a supernumerary nipple and recently identified hypoplastic kidney, bladder diverticulum, and hypotonic bladder. His mother also has a supernumerary nipple and a recently identified hypoplas...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1007/s10227-003-0166-1
更新日期：2004-05-01 00:00:00
abstract：:Psoriasis has been associated with a number of behavioral and systemic comorbidities, including psoriatic arthritis, anxiety, depression, obesity, hypertension, diabetes mellitus, hyperlipidemia, metabolic syndrome, smoking, cardiovascular disease, alcoholism, Crohn's disease, lymphoma, and multiple sclerosis. Many of...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.2310/7750.2009.00024
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:Skin cancer is extremely common. Epidemiological studies indicated that ultraviolet radiation (UV) is the primary cause for skin cancers, and that retinoic acid (RA) is able to inhibit this UV-induced skin carcinogenesis; however, the molecular mechanism of the anti-UV action of RA is unclear. OBJECTIVE:The...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/120347540000400102
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Optimal aesthetic results are achieved when nasal defects after Mohs micrographic surgery (MMS) are reconstructed as entire nasal subunits. OBJECTIVE:To illustrate the importance of reconstructing the nose in entire subunits and explore the possibilities of expanding the principles of subunit reconstruction...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/1203475416629594
更新日期：2016-07-01 00:00:00
