Abstract：
:Neutropenic enterocolitis (NE) is a severe gastrointestinal complication in patients who undergo aggressive chemotherapy. It is a necrotizing inflammation of the cecum, colon, and the terminal part of the ileum. The serious clinical state of NE patients requires very frequent surgical consultations; however, in a few particular cases of NE, e.g., perforation of the bowels, a surgical intervention is necessary. Here, we report on six cases of NE in patients with acute leukemias. The patients were all women aged 21-55 years. Two of them had acute myeloid leukemia and four had lymphoblastic leukemia. NE occurred 7-10 days after the completion of chemotherapy, during the neutropenic phase. They represented a typical picture of NE: two of them died because of septic shock; five patients had subileus with irritation of the peritoneum; and one had hepatosplenic abscesses confirmed 6 months later by post-mortem examination. In each case, a surgical opinion was required. None of these patients were operated on. We present a report summarizing our experience and problems with six patients who had a clinical picture of NE and offer a short review of the current literature on the subject.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Wach M,Dmoszynska A,Wasik-Szczepanek E,Pozarowski A,Drop A,Szczepanek Ddoi
10.1007/s00277-003-0815-xsubject
Has Abstractpub_date
2004-08-01 00:00:00pages
522-6issue
8eissn
0939-5555issn
1432-0584journal_volume
83pub_type
杂志文章,评审abstract：:In the present study, we questioned whether the cholesterol synthesis inhibitor lovastatin potentiates the cytotoxicity of chemotherapeutic agents in the primitive CD34(+) subpopulation of acute myeloid leukemia (AML) cells. AML mononuclear cells (n = 17) were sorted in CD34(+) and CD34(-) fractions and compared to no...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-008-0633-2
更新日期：2009-06-01 00:00:00
abstract：:Extreme thrombocytosis (ExT) has been associated with an increased bleeding risk in myeloproliferative neoplasm (MPN) patients and is included in the high risk category in treatment guidelines. Treatment of patients with ExT has not been studied in prospective trials. To study physicians' approaches to ExT, we distrib...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-016-2826-4
更新日期：2017-01-01 00:00:00
abstract：:We monitored platelet activation by means of P-selectin and platelet monocyte aggregates (PMA) and platelet function by whole blood multiple electrode aggregometry and platelet adhesion under high shear in chronic immune thrombocytopenia patients to define changes in platelet activation during treatment with eltrombop...
journal_title：Annals of hematology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00277-011-1249-5
更新日期：2012-01-01 00:00:00
abstract：:Only about one third of all patients with acute myeloid leukemia (AML) will be cured by common chemotherapy regimens. Susceptibility towards chemotherapy either of the leukemic bulk or the leukemic stem cell is considered the major determining parameter for long-term outcome. The purpose of the present study was to in...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-007-0361-z
更新日期：2008-01-01 00:00:00
abstract：:Primary non-Hodgkin's lymphoma of bone (PLB) is a rare entity. We present three new cases and a review of the literature. If PLB is suspected radiologically, the diagnosis must be confirmed by open biopsy. Histopathologically, PLB usually represents diffuse large B-cell lymphoma or lymphoma of the follicular center ty...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s00277-003-0674-5
更新日期：2003-07-01 00:00:00
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journal_title：Annals of hematology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01703445
更新日期：1991-10-01 00:00:00
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journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01698483
更新日期：1994-08-01 00:00:00
abstract：:Ixazomib, the first oral proteasome inhibitor (PI), has been approved for the treatment of relapsed refractory multiple myeloma (RRMM) in combination with lenalidomide and dexamethasone, based on the TOURMALINE-MM1 phase 3 trial, which demonstrated the efficacy and safety of this all-oral triplet, compared with lenali...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-020-03985-9
更新日期：2020-06-01 00:00:00
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journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-016-2683-1
更新日期：2016-06-01 00:00:00
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journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050233
更新日期：1996-11-01 00:00:00
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journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01834365
更新日期：1994-04-01 00:00:00
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journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-008-0574-9
更新日期：2009-03-01 00:00:00
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journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-013-1865-3
更新日期：2014-02-01 00:00:00
abstract：:Interferon-α (IFNα) was the first effective drug therapy for hairy cell leukemia (HCL). Nowadays, it is used as an alternative treatment in selected patients. Due to unlimited treatment time, monitoring and early prediction of response are important. Moreover, IFNα is used in the therapy of chronic hepatitis C, where ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-017-2943-8
更新日期：2017-05-01 00:00:00
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journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s00277-020-04221-0
更新日期：2020-10-01 00:00:00
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journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s00277-009-0829-0
更新日期：2009-12-01 00:00:00
abstract：:Since December 2019, a novel coronavirus has spread throughout China and across the world, causing a continuous increase in confirmed cases within a short period of time. Some studies reported cases of thrombocytopenia, but hardly any studies mentioned how the virus causes thrombocytopenia. We propose several mechanis...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s00277-020-04019-0
更新日期：2020-06-01 00:00:00
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journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-007-0275-9
更新日期：2007-06-01 00:00:00
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journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-019-03696-w
更新日期：2019-07-01 00:00:00
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journal_title：Annals of hematology
pub_type： 杂志文章
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journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-019-03746-3
更新日期：2019-09-01 00:00:00
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journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-013-1785-2
更新日期：2013-11-01 00:00:00
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journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s00277-019-03813-9
更新日期：2019-12-01 00:00:00
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journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050347
更新日期：1997-11-01 00:00:00
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journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770000156
更新日期：2000-07-01 00:00:00
abstract：:It has been suggested that Asian and Western myelodysplastic syndrome (MDS) patients have different cytogenetic and prognostic features. In this study, we retrospectively analyzed clinical and cytogenetic data from 435 Chinese adult primary MDS patients. In addition, we evaluated the prognostic value of the World Heal...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-009-0861-0
更新日期：2010-06-01 00:00:00
abstract：:The current phase-II trial was initiated to assess the efficacy and toxicity of the Ida-FLAG regimen in patients with poor-risk acute myeloid leukemia (AML). Three subgroups of patients with AML were eligible for the study: (a) refractory, (b) first relapse, or (c) secondary AML (i.e., signs of trilineage myelodysplas...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s002770050541
更新日期：1999-09-01 00:00:00
abstract：:MicroRNAs are a class of small non-coding RNAs that are 19-22 nucleotides in length and regulate a variety of biological processes at the post-transcriptional level. MicroRNA dysregulation disrupts normal biological processes, resulting in tumorigenesis. Acute myeloid leukemia is an invasive hematological malignancy c...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s00277-019-03887-5
更新日期：2020-03-01 00:00:00
abstract：:An additional affiliation for the first author was not indicated. Hyewon Lee is also affiliated with: Department of Internal Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, South Korea. ...
journal_title：Annals of hematology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00277-019-03868-8
更新日期：2020-01-01 00:00:00
abstract：:Blastic transformation of essential thrombocythemia (ET) preceded by chemotherapy is occasionally described in the literature. In ET as well as in other myeloproliferative disorders the leukemogenic effect of alkylating agents and (32)P is well established, and recent reports also indicate a certain leukemogenic effec...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050007
更新日期：2000-01-01 00:00:00
