Abstract：
:The current phase-II trial was initiated to assess the efficacy and toxicity of the Ida-FLAG regimen in patients with poor-risk acute myeloid leukemia (AML). Three subgroups of patients with AML were eligible for the study: (a) refractory, (b) first relapse, or (c) secondary AML (i.e., signs of trilineage myelodysplasia at diagnosis or the history of a myelodysplasia or myeloproliferative disorder). Fifty-seven fully evaluable patients were included in the study. Twenty patients received a second course of Ida-FLAG. Complete remission was achieved by 1/14 patients with refractory AML, 12/15 patients with relapsed AML, and 17/28 patients with secondary AML. The median duration of ANC <1000/microl was 17 days (10-36); of platelets <30,000/microl 23 days (9-65); of days with fever >38.0 degrees C 6 days (1-33). Thirteen patients (22.8%) died within 42 days of severe infection or hemorrhage. Overall survival at 20 weeks in the subgroups was 24% for patients with refractory, 78% for patients with relapsed, and 55% for patients with secondary AML. The toxicity of the first cycle of Ida-FLAG is moderate. The feasibility and subjective tolerance of the Ida-FLAG regimen are acceptable. There is no evidence for an increase of atypical infections. The efficacy for patients with secondary AML and especially those with first relapse of AML is good, with a high rate of complete remissions. Remission duration seems to be short. Therefore, an intensified post-remission therapy seems necessary.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Steinmetz HT,Schulz A,Staib P,Scheid C,Glasmacher A,Neufang A,Franklin J,Tesch H,Diehl V,Dias Wickramanayake Pdoi
10.1007/s002770050541subject
Has Abstractpub_date
1999-09-01 00:00:00pages
418-25issue
9eissn
0939-5555issn
1432-0584pii
90780418.277journal_volume
78pub_type
临床试验,杂志文章,多中心研究abstract：:Primary myelofibrosis (PMF)-associated pruritus is often severe and requires treatment. Fifty-one patients with bone marrow-proven PMF with associated pruritus were identified from a primary cohort of patients with PMF (n = 566) seen at our institution. We conducted a retrospective review of the clinical characteristi...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-016-2674-2
更新日期：2016-06-01 00:00:00
abstract：:Despite recent advances made in its treatment, multiple myeloma (MM) remains an incurable B cell malignancy. Thus, the objective for treating these patients is to prolong overall survival (OS) and preserve patients' quality of life. We have analyzed data from 264 consecutive MM patients who had their initial visit bet...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-016-2888-3
更新日期：2017-03-01 00:00:00
abstract：:Autologous stem cell transplant (ASCT) is an effective treatment for non-Hodgkin lymphoma (NHL). However, recent supply issues and toxicity of carmustine have necessitated a new conditioning regimen. We conducted a multicenter, phase II study of BEB (busulfan, etoposide, and bendamustine) conditioning regimen for ASCT...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-020-03942-6
更新日期：2020-04-01 00:00:00
abstract：:African Americans have two- to three-fold higher incidence of multiple myeloma and MGUS compared to other ethnic groups in the USA. Some physicians often perform diagnostic evaluations for plasma cell disorders (PCD) in African American patients on the basis of hematological abnormalities (thrombocytopenia, leucopenia...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-013-1990-z
更新日期：2014-06-01 00:00:00
abstract：:The clinical experience of the significant difference in iron metabolism between multiple myeloma and myelodysplasia prompted us to analyse patients according to mutation frequency in the hemochromatosis gene (HFE) known to participate in the regulation of iron metabolism. HFE genotyping results were also evaluated in...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-006-0178-1
更新日期：2006-12-01 00:00:00
abstract：:An improvement in quality of life and survival occurred among thalassemia major (TM) patients: pregnancy in such patients has become a reality. Safe pregnancy and delivery require efforts to ensure the best outcomes. Between 2007 and 2016, 30 TM patients had 37 pregnancies. We analyzed the hematological parameters bef...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-017-2979-9
更新日期：2017-06-01 00:00:00
abstract：:Vitamin K2 induces differentiation of leukemic cell lines and apoptosis of immature blasts in myelodysplastic syndrome (MDS). We recently reported a case of MDS-refractory anemia (MDS-RA) with trilineage hematologic response to oral administration of menatetrenone, a vitamin K2 analog. To determine a possible role of ...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00277-001-0391-x
更新日期：2002-01-01 00:00:00
abstract：:Reactive oxygen intermediates (ROI) generated in the respiratory burst reaction are crucial for the killing of bacteria and fungi in phagocytes. The key enzyme for the respiratory burst reaction is the NADPH oxidase. Reactive oxygen intermediates have additionally been proposed to be of general importance for the expr...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-003-0837-4
更新日期：2004-04-01 00:00:00
abstract：:Gastric mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B cell lymphoma (DLBCL) show a spectrum of disease characterized by varying proportions of low-grade and high-grade components. While the natural history and optimum treatment for low-grade gastric MALT lymphoma and DLBCL is well established, ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-008-0604-7
更新日期：2009-05-01 00:00:00
abstract：:B cell acute lymphoblastic leukemia (B-ALL) is an aggressive hematologic malignancy with limited treatment strategies. Histone deacetylases inhibitors (HDACis) are promising novel tools for cancer therapy, whose anti-tumor effects and the underlying mechanisms on B-ALL remain to be elucidated. Recently, Notch1 signali...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-012-1561-8
更新日期：2013-01-01 00:00:00
abstract：:Neutropenic enterocolitis (NE) is a severe gastrointestinal complication in patients who undergo aggressive chemotherapy. It is a necrotizing inflammation of the cecum, colon, and the terminal part of the ileum. The serious clinical state of NE patients requires very frequent surgical consultations; however, in a few ...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s00277-003-0815-x
更新日期：2004-08-01 00:00:00
abstract：:Autologous stem cell transplant (ASCT) is standard consolidation therapy in management of multiple myeloma (MM) patients. We reviewed records of all consecutive MM patients who underwent ASCT with high-dose melphalan at our center from year 2002 to 2016. A total of 141 ASCT were conducted (90 males and 51 females) wit...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-018-3370-1
更新日期：2018-10-01 00:00:00
abstract：:Cells of the macrophage lineage are a major source of various cytokines and hematopoietic growth factors. With regard to the growth factors acting on cells of their own lineage, macrophage colony-stimulating factor (M-CSF) has been proven to be secreted by monocytes (MO) and macrophages (MAC), whereas the production o...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01696222
更新日期：1992-04-01 00:00:00
abstract：:Rituximab was recently described also as first-line therapy of chronic graft-versus-host disease (cGvHD). We retrospectively analyzed the efficacy and safety of all patients receiving rituximab for treatment of cGvHD between 2005 and 2016 at the Regensburg University transplant center with a median follow-up after rit...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-019-03768-x
更新日期：2019-10-01 00:00:00
abstract：:A 77-year-old man developed pneumonitis while on chlorambucil therapy for chronic lymphocytic leukemia, with a cumulative dose of 2700 mg. The condition improved promptly with the discontinuation of the drug and initiation of steroids. A case report and review of the literature are presented in this paper. ...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s002770050418
更新日期：1998-07-01 00:00:00
abstract：:Patients with primary refractory or relapsed acute myeloid leukemia (AML) who undergo intensive salvage chemotherapy carry a high risk of treatment failure due to infectious complications and early relapses. The study presented here assessed the effect of granulocyte colony-stimulating factor (G-CSF) on the duration o...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s002770050425
更新日期：1998-09-01 00:00:00
abstract：:Autosomal recessive "malignant" osteopetrosis is a rare congenital disorder relating to bone resorption abnormalities. It is believed to arise due to the failure of osteoclasts to resorb immature bone. This leads to abnormal bone marrow cavity formation and, clinically, to the signs and symptoms of bone marrow failure...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s00277-002-0578-9
更新日期：2003-01-01 00:00:00
abstract：:This paper describes six Indian families in which silent-gene beta-thalassemia was encountered by us in the past 2 years. This stresses the importance of globin-chain synthesis in the diagnosis of beta-thalassemia. Of these six cases, five were diagnosed retrospectively when they had a homozygous beta-thalassemia offs...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01715386
更新日期：1995-01-01 00:00:00
abstract：:Therapy-induced autoimmunity may mediate the destruction of cancer cells. Previous studies have demonstrated that presence of autoimmune thyroid disorder is associated with favorable outcome in patients with solid cancer. Patients with diffuse large B cell lymphoma (DLBCL) who achieved complete response on positron em...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-015-2311-5
更新日期：2015-06-01 00:00:00
abstract：:The efficacy of a single dose of MCNU 150 mg was evaluated in nine symptomatic patients with essential thrombocythemia (ET). As the platelet counts increased during the following 4 weeks, an extra dose of 100 mg of MCNU was administered to three patients. All patients had thrombotic or hemorrhagic complications. Seven...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01738474
更新日期：1993-05-01 00:00:00
abstract：:The requirement of antifungal prophylaxis has not been established in the chemotherapies for malignant lymphoma. This study was conducted to explore the incidence of invasive fungal diseases (IFD) and their risk factors in patients receiving salvage therapies for malignant lymphoma. We retrospectively analyzed 177 con...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-014-2093-1
更新日期：2014-10-01 00:00:00
abstract：:Cancer incidence in patients with recurrent unprovoked venous thromboembolism (VTE) is much higher than after a first event, but the incidence of myeloproliferative neoplasms (MPN) in this situation is still unknown. We tested for JAK2V617F and calreticulin mutants, 372 DNA samples of patients treated for (VTR). Among...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-016-2853-1
更新日期：2017-03-01 00:00:00
abstract：:The purpose of this report is to provide long-term follow-up of 38 patients diagnosed of post-transplant lymphoproliferative disease (PTLD) included in a phase 2 clinical trial of first line therapy with rituximab and to evaluate the same therapy in a real world cohort of 21 consecutive patients treated once the trial...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-020-04056-9
更新日期：2020-05-04 00:00:00
abstract：:Immunoglobulin D (IgD) myeloma is a rare subtype that used to lead to a poor outcome. To investigate the current clinical features, cytogenetic changes and survival of patients with IgD myeloma under novel treatments, we analysed 47 patients with IgD myeloma, 31 men and 16 women, with a median age of 54.5 years. We fo...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-018-3582-4
更新日期：2019-04-01 00:00:00
abstract：:In this retrospective study, we evaluated the clinical features and the effects of various treatment modalities on the clinical course in patients diagnosed with idiopathic thrombocytopenic purpura (ITP) at our center between 1984-2000. We retrospectively examined the medical records of 321 (229 females, 92 males) ITP...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-002-0488-x
更新日期：2002-08-01 00:00:00
abstract：:Data are limited in developing countries regarding the clinicopathologic features and response to therapy of chronic myeloid leukemia (CML) in the era of imatinib (IM). The objective of this study is to report on the clinicoepidemiologic features of CML in Tunisia, to evaluate the long-term outcome of patients in chro...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-017-3224-2
更新日期：2018-04-01 00:00:00
abstract：:We encountered two patients who presented with hypochromic-microcytic anemia and were refractory to iron therapy. The symptoms were suggestive of anemia of chronic disease (ACD); however, there was no evidence of any such disease, either inflammatory or malignant. These patients were reminiscent of patients originally...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770000180
更新日期：2000-08-01 00:00:00
abstract：:Primary non-Hodgkin's lymphoma (NHL) of the genital tract is a rare entity. Etiology and pathogenesis of these NHLs are unknown, although there might be a possible association between chronic inflammation and lymphomas. The most common histological subtype is the diffuse large B-cell lymphoma. We report two cases of u...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-009-0741-7
更新日期：2009-12-01 00:00:00
abstract：:We have established reference values of peripheral blood lymphocyte subsets in healthy female Wistar rats under highly standardized conditions. Using monoclonal antibodies and flow cytometry, T lymphocytes (OX19+), B lymphocytes (OX6+ and anti-Ig+), T-helper/inducer (W3/25+), and T-suppressor/cytotoxic subsets (OX8+) ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01701732
更新日期：1993-09-01 00:00:00
abstract：:Ixazomib, the first oral proteasome inhibitor (PI), has been approved for the treatment of relapsed refractory multiple myeloma (RRMM) in combination with lenalidomide and dexamethasone, based on the TOURMALINE-MM1 phase 3 trial, which demonstrated the efficacy and safety of this all-oral triplet, compared with lenali...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-020-03985-9
更新日期：2020-06-01 00:00:00
