Abstract：
:Rituximab was recently described also as first-line therapy of chronic graft-versus-host disease (cGvHD). We retrospectively analyzed the efficacy and safety of all patients receiving rituximab for treatment of cGvHD between 2005 and 2016 at the Regensburg University transplant center with a median follow-up after rituximab therapy of 2.8 years. Responses of 29 allogeneic stem cell-transplanted patients (median age 49) with previous failure of response to steroids including one patient after donor lymphocyte infusion were assessed. Three months after rituximab application, the overall response rate was 31% (7% complete (n = 2) and 24% partial remission (n = 7)). At 12 months, overall survival was 72% (n = 21) and failure-free survival was 24% (n = 7). We further analyzed associations of rituximab response with clinical characteristics showing a higher response rate in steroid-dependent cGvHD patients (89% of 9 responding compared to steroid refractory patients (11% responding)). However, this difference was not statistically significant. Seven patients (24%) (including four lethal infectious complications) developed serious infections requiring hospitalization within 1-9 months after rituximab therapy exclusively in patients failing to respond to rituximab. In conclusion, rituximab appears to be an effective treatment of cGvHD especially in steroid dependent patients, but identification of biomarker predicting response will be crucial to avoid long-term infectious morbidity and mortality in non-responders.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Klobuch S,Weber D,Holler B,Edinger M,Herr W,Holler E,Wolff Ddoi
10.1007/s00277-019-03768-xsubject
Has Abstractpub_date
2019-10-01 00:00:00pages
2399-2405issue
10eissn
0939-5555issn
1432-0584pii
10.1007/s00277-019-03768-xjournal_volume
98pub_type
杂志文章abstract：:B cell-activating factor (BAFF) is a cytokine that plays a major role in the maintenance of normal B-cell development and homeostasis. It has been suggested that in multiple myeloma (MM) it might have regulatory effects on the proliferation and viability of malignant plasma cells. The aim of this study was to evaluate...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-012-1470-x
更新日期：2012-09-01 00:00:00
abstract：:Methods to estimate bone marrow plasma cells (BMPC) basically include histopathology, cytomorphology, and flow cytometry. The present study compares the outcomes of these methods with special focus on the impact of BMPC-specific characteristics on their recovery by either method. Laboratory reports of diagnostic sampl...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-020-04249-2
更新日期：2020-11-01 00:00:00
abstract：:We report the case of a 23-year-old female with severe neurologic dysfunction without a clear cause at the time of initial presentation. The search for an underlying malignancy revealed a slightly enlarged cervical lymph node with Hodgkin's disease (HD). There was no evidence of a brain tumor despite nonspecific brigh...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-002-0445-8
更新日期：2002-05-01 00:00:00
abstract：:Although lenalidomide plus dexamethasone (RD) is a therapeutic option for relapsed/refractory multiple myeloma (RRMM), limited real-world clinical data exist. The purpose of this study was to estimate efficacy and safety of RD in RRMM patients of the clinical practice. Data from patients at 25 university hospitals in ...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s00277-019-03904-7
更新日期：2020-02-01 00:00:00
abstract：:A 24-year-old woman with a large cell anaplastic CD 30-positive T-cell non-Hodgkin's lymphoma (NHL) developed downbeat nystagmus, anisocoria, and oscillopsia. Prior to overt cerebral invasion by NHL, she had a thiamine deficiency with very low thiamine concentrations in the CSF, probably caused by protracted vomiting ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050484
更新日期：1999-02-01 00:00:00
abstract：:The purpose of this report is to provide long-term follow-up of 38 patients diagnosed of post-transplant lymphoproliferative disease (PTLD) included in a phase 2 clinical trial of first line therapy with rituximab and to evaluate the same therapy in a real world cohort of 21 consecutive patients treated once the trial...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-020-04056-9
更新日期：2020-05-04 00:00:00
abstract：:Erythropoietin, alone or in combination with colony-stimulating factors, is a promising agent in the treatment of patients with cancer-related 'anemia of chronic disorders', chemo/radiotherapy-induced anemia, or anemia due to myelodysplastic or myeloproliferative syndromes. In the first two groups, at least half of th...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/BF01700275
更新日期：1994-11-01 00:00:00
abstract：:Uptake and biochemical and biological effects of antisense oligodeoxynucleotides (ODN) specific for c-abl and bcr genes were studied in normal immature myeloid cells. CD34-positive cells were purified by positive and negative selection and cultured in liquid culture for 7 days. These cells were then incubated with ODN...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF00641311
更新日期：1996-02-01 00:00:00
abstract：:The benefits of intensive post-remission chemotherapy have not been verified in elderly patients with acute myeloid leukemia (AML). To reduce fatal complications caused by intensive post-remission therapy, we performed a prospective phase II multicenter trial of standard induction chemotherapy ('7+3' of cytarabine plu...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-006-0110-8
更新日期：2006-06-01 00:00:00
abstract：:Patients with chronic lymphocytic leukemia (CLL) who receive chemoimmunotherapy and do not achieve complete remission experience significantly shortened progression-free interval (PFS). Additionally, the majority of patients treated for relapsed disease demonstrate evidence of measurable disease. Eradication of minima...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-016-2683-1
更新日期：2016-06-01 00:00:00
abstract：:A female patient presenting with B-CLL and coincident eosinophilia-myalgia syndrome (EMS) after ingestion of L-tryptophan is described. The manifestations of EMS disappeared completely during treatment with cyclophosphamide/prednisone. and there was an intermittent clinical remission of CLL with absence of the monoclo...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050449
更新日期：1998-11-01 00:00:00
abstract：:Primary mediastinal large B cell lymphomas (MLCL) differ from other diffuse large cell lymphomas, leading to a description as a separate entity in the current World Health Organization classification. Dose intensification improves long-term results, but no standard therapy has been established so far. We investigated ...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s00277-008-0625-2
更新日期：2009-05-01 00:00:00
abstract：:Secondary hemophagocytic lymphohistiocytosis (HLH) is a rare but fatal condition with various underlying disorders in adult patients and is diagnosed based on the HLH-2004 criteria, which were established based on experience in pediatric patients. However, few studies have prospectively evaluated the treatment outcome...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-020-04083-6
更新日期：2020-09-01 00:00:00
abstract：:High-dose chemotherapy (HDT) and stem cell transplantation is a newer treatment option widely applied in poor-risk germ cell tumor patients. Due to the increasing practical clinical experience and the availability of hematopoietic growth factors, this treatment approach has become a relatively safe procedure. Dependin...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s002770050386
更新日期：1998-05-01 00:00:00
abstract：:Mixed phenotype acute leukemia (MPAL) is a rare type of leukemia with a limited number of studies conducted to characterize its clinical spectrum and most importantly the best treatment modality. MPAL blasts show more than one phenotype either myeloid/monocytic with T- or B-lymphoid or extremely rare triple lineage as...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-020-04354-2
更新日期：2020-11-23 00:00:00
abstract：:Cerebrovascular disease resulting in stroke is a serious and preventable complication of sickle cell anaemia (SCA). Children at high risk of preventable stroke can be identified by transcranial Doppler ultrasound (TCD). Current guidelines in the UK recommend annual TCD screening from 3 years, although studies suggest ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-009-0757-z
更新日期：2009-10-01 00:00:00
abstract：:Reactive oxygen intermediates (ROI) generated in the respiratory burst reaction are crucial for the killing of bacteria and fungi in phagocytes. The key enzyme for the respiratory burst reaction is the NADPH oxidase. Reactive oxygen intermediates have additionally been proposed to be of general importance for the expr...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-003-0837-4
更新日期：2004-04-01 00:00:00
abstract：:The aim of this phase IV study was to (1) to define efficacy of escalating dose imatinib in chronic myeloid leukemia (CML) patients showing suboptimal response to standard dose imatinib and (2) to find markers that predict the response to escalating doses of imatinib. CML patients in chronic phase (CP) who failed to a...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-010-0910-8
更新日期：2010-07-01 00:00:00
abstract：:In view of obscure clinical and biological significance of leukemic cells heterogeneity, we studied the efficacy of apoptosis, proliferation, and expression levels of the Bcl-2, MDR1, LRP, and BCRP genes in sorted CD34+ and CD34- subpopulations of childhood AML leukemic samples. In five out of nine cases, CD34+ cells ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-008-0439-2
更新日期：2008-05-01 00:00:00
abstract：:Acute megakaryoblastic leukaemia (AML-M7) is an uncommon disease, composing 0.5-1.2% of newly diagnosed adult acute myeloid leukaemias (AML). It is characterised by higher incidence and complexity of cytogenetic abnormalities. We report a rare case of Philadelphia (Ph) chromosome-positive AML-M7, presenting with extre...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-003-0783-1
更新日期：2004-06-01 00:00:00
abstract：:An improvement in quality of life and survival occurred among thalassemia major (TM) patients: pregnancy in such patients has become a reality. Safe pregnancy and delivery require efforts to ensure the best outcomes. Between 2007 and 2016, 30 TM patients had 37 pregnancies. We analyzed the hematological parameters bef...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-017-2979-9
更新日期：2017-06-01 00:00:00
abstract：:Although retreatment with alemtuzumab in relapsing B-cell chronic lymphocytic leukemia (CLL) may be beneficial, there has thus far been no thorough analysis available on this topic. Data were collected from 30 chemotherapy-pretreated patients with progressive CLL who had received alemtuzumab twice in consecutive, dist...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-011-1192-5
更新日期：2011-09-01 00:00:00
abstract：:Allogeneic hematopoietic cell transplantation (allo-HCT) remains the only curative treatment option for myelofibrosis (MF) despite the emergence of novel targeted therapies. To reduce graft rejection and graft-versus-host disease (GvHD), current allo-HCT protocols often include in vivo T lymphocyte depletion using pol...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-016-2758-z
更新日期：2016-10-01 00:00:00
abstract：:Polycythemias or erythrocytoses in childhood and adolescence are very rare. Systematic data on the clinical presentation and laboratory evaluations as well as on treatment regimens are sparse. The diagnostic program in absolute erythrocytosis includes extensive clinical, hematological, biochemical, and molecular biolo...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s00277-004-0985-1
更新日期：2005-03-01 00:00:00
abstract：:In 1989, a prospective randomized multicenter study was initiated in order to determine the safety and efficacy of oral clodronate in myeloma patients. The primary objective of this long-term trial is to evaluate whether supportive clodronate is able to prevent or retard the progression of bone disease and reduce the ...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/BF01697625
更新日期：1993-03-01 00:00:00
abstract：:The aim of the present study was to investigate the prevalence of chronic idiopathic neutropenia of adults (CINA) among an apparently healthy population born and living on the island of Crete. The study was carried out with 778 subjects, 392 men aged 16-78 years (median 43 years) and 386 women aged 15-79 years (median...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050518
更新日期：1999-07-01 00:00:00
abstract：:We tested two Fc gamma receptor I (Fc gamma RI); six Fc gamma RII; and six Fc gamma RIII-specific monoclonal antibodies (mAb) for their capacity to inhibit monocyte and polymorphonuclear granulocyte (PMN) immune phagocytosis which is mediated by Fc gamma R. We used human red blood cells (rbc) coated with hIgG1 or mIgG...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050249
更新日期：1997-01-01 00:00:00
abstract：:The possibility that human mesenchymal stromal cells (hMSC) may derive from the malignant clone in hematological malignancies (HM) is a controversial issue. In order to clarify hMSC origin and disclose possible cytogenetic heterogeneity in hMSC belonging to different patients, bone marrow (BM)-derived hMSC samples fro...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-012-1500-8
更新日期：2012-10-01 00:00:00
abstract：:An investigation into the effects of irradiation and of the storage time on aging and quality are a relevant issue to ensure the safety and the efficiency of irradiation in the prevention of transfusion-associated graft-versus-host disease (TA-GVHD). In this work, the biochemical properties and alterations presented b...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-013-1944-5
更新日期：2014-05-01 00:00:00
abstract：:To evaluate the outcomes of refractory/relapsed cHL patients after high-dose chemotherapy (HDCT) and autologous stem cell transplantation (ASCT) in Beijing Cancer hospital and to identify the prognostic risk factors. We retrospectively analyzed 115 relapsed/refractory cHL patients who accepted HDCT and ASCT in our can...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-019-03812-w
更新日期：2020-03-01 00:00:00
