Abstract:
:Cerebrovascular disease resulting in stroke is a serious and preventable complication of sickle cell anaemia (SCA). Children at high risk of preventable stroke can be identified by transcranial Doppler ultrasound (TCD). Current guidelines in the UK recommend annual TCD screening from 3 years, although studies suggest an earlier peak incidence, between 2 and 5 years. A single centre retrospective review was undertaken to identify the prevalence of stroke and success of TCD screening in young children. We report five episodes of stroke in under 3s and outcome of TCD screening in children under 3, compared to over 3. TCD analysis was as successful in the 2-3-year age group as in the 3-4-year group. We therefore propose that all children with SCA should be offered TCD screening from the age of 2 years. Furthermore, infants with high risk features of SCA should undergo a first attempt at TCD screening even earlier.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Roberts L,O'Driscoll S,Dick MC,Height SE,Deane C,Goss DE,Pohl K,Rees DCdoi
10.1007/s00277-009-0757-zsubject
Has Abstractpub_date
2009-10-01 00:00:00pages
943-6issue
10eissn
0939-5555issn
1432-0584journal_volume
88pub_type
杂志文章abstract::To gain insight into the natural history of cytomegalovirus (CMV) infection following unrelated cord blood transplantation (UCBT) in seropositive patients, we analyzed the data of 349 seropositive patients who received UCBT in Korea between 2000 and 2011. CMV reactivation occurred in 49 % (171/349) of the CMV-seroposi...
journal_title:Annals of hematology
pub_type: 杂志文章
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-014-2006-3
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abstract::Ninety patients with Philadelphia chromosome-positive chronic myelogenous leukemia in blast crisis were reviewed to identify significant prognostic associations. At diagnosis of blast crisis the main clinical, laboratory, and cytogenetic data were recorded and evaluated for prognostic significance. At the time of the ...
journal_title:Annals of hematology
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journal_title:Annals of hematology
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更新日期:2000-08-01 00:00:00
abstract::Cells of the macrophage lineage are a major source of various cytokines and hematopoietic growth factors. With regard to the growth factors acting on cells of their own lineage, macrophage colony-stimulating factor (M-CSF) has been proven to be secreted by monocytes (MO) and macrophages (MAC), whereas the production o...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/BF01696222
更新日期:1992-04-01 00:00:00
abstract::Chronic idiopathic neutropenia (CIN) has been well recognized as a granulocytic disorder not associated with increased risk to malignant transformation. Four cases, however, of acute myeloid leukemia have been recently reported in patients with CIN. In the current paper, we report on a CIN patient who developed acute ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-004-0862-y
更新日期:2004-06-01 00:00:00
abstract::A female patient presenting with B-CLL and coincident eosinophilia-myalgia syndrome (EMS) after ingestion of L-tryptophan is described. The manifestations of EMS disappeared completely during treatment with cyclophosphamide/prednisone. and there was an intermittent clinical remission of CLL with absence of the monoclo...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770050449
更新日期:1998-11-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-003-0645-x
更新日期:2003-08-01 00:00:00
abstract::Bernard-Soulier syndrome (BSS) is a rare autosomal recessive genetic disorder characterized by thrombocytopenia, circulating giant platelets, and prolonged bleeding time. BSS is explained by a defect in primary hemostasis owing to quantitative or qualitative defect in the GPIb-IX-V complex, composed of four subunits: ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-008-0611-8
更新日期:2009-05-01 00:00:00
abstract::The prognosis of patients with stage III/IV NK/T-cell lymphoma (NTCL) is extremely poor. Although L-asparaginase (L-asp) is effective for NTCL, its significance has not been clearly demonstrated. In addition, there are few studies comparing treatment outcomes in stage III/IV NTCL. This study evaluated the efficacy of ...
journal_title:Annals of hematology
pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00
abstract::Early cytomegalovirus (CMV) replication (eCMV) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been suggested as an independent factor that reduces leukemia relapse risk. We retrospectively analyzed 74 patients with acute myeloid leukemia (AML) who underwent allo-HSCT between August 2006 and S...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-014-2190-1
更新日期:2015-02-01 00:00:00
abstract::The evidence that leukocytes may contribute to the pathogenesis of thrombosis in Chronic Myeloproliferative Neoplasms is increasing but not definitive. To further enforces whether an increased leukocyte count is associated with thrombosis and whether this effect can be modulated by cytoreductive therapy, we analyzed t...
journal_title:Annals of hematology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00277-009-0706-x
更新日期:2009-10-01 00:00:00
abstract::Extreme thrombocytosis (ExT) has been associated with an increased bleeding risk in myeloproliferative neoplasm (MPN) patients and is included in the high risk category in treatment guidelines. Treatment of patients with ExT has not been studied in prospective trials. To study physicians' approaches to ExT, we distrib...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-016-2826-4
更新日期:2017-01-01 00:00:00
abstract::Primary non-Hodgkin's lymphoma (NHL) of the genital tract is a rare entity. Etiology and pathogenesis of these NHLs are unknown, although there might be a possible association between chronic inflammation and lymphomas. The most common histological subtype is the diffuse large B-cell lymphoma. We report two cases of u...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-009-0741-7
更新日期:2009-12-01 00:00:00
abstract::The prognostic impact of extramedullary plasmacytomas (EMPs) on newly diagnosed symptomatic multiple myeloma (MM) was evaluated in the context of treatment approach including autologous stem cell transplantation (ASCT) and chemotherapy alone. A total of 275 consecutive patients with newly diagnosed MM were included, a...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-014-2216-8
更新日期:2015-03-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770050582
更新日期:2000-04-01 00:00:00
abstract::As ethnic variations are known to exist in inherited genetic defects, the clinico-haematological profile of Indian children with thrombophilia may be different from that of Caucasians. The aim of the study was to analyse the phenotypic and genotypic causes of thrombophilia in Indian children. Forty patients with arter...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-004-0952-x
更新日期:2005-02-01 00:00:00
abstract::In contrast to adult medicine, specific scoring systems predicting the treatment response for an individual pediatric patient (pt) with chronic myeloid leukemia (CML) have not yet been defined. We evaluated to what extend prognostic scores as described for adults (e.g., Sokal, Hasford, EUTOS score) resulted in compara...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-015-2367-2
更新日期:2015-08-01 00:00:00
abstract::This retrospective single-center study compared thromboembolic and hemorrhagic complications, survival and causes of death in a cohort of 102 consecutive patients with myeloproliferative disorders (MPD). We included 17 patients with essential thrombocythemia (ET), 59 with polycythemia vera (PV), and 26 with osteomyelo...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002779900136
更新日期:2000-06-01 00:00:00
abstract::Bone marrow transplantation (BMT) and immunosuppression (IS) have improved the prognosis of aplastic anemia; both treatments have specific advantages and drawbacks but similar survival rates. Analysis of additional endpoints may help in treatment decisions. In a single-center study, patients with aplastic anemia treat...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-004-0930-3
更新日期:2005-01-01 00:00:00
abstract::Allogeneic hematopoietic stem cell transplantation (allo-SCT) is a therapeutic option for relapsed, advanced, and otherwise incurable non-Hodgkin's lymphomas (NHL) suggested by the existence of a graft-versus-lymphoma effect. The main complications are graft-versus-host disease and infections. We performed a retrospec...
journal_title:Annals of hematology
pub_type: 杂志文章
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更新日期:2017-05-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章,meta分析
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更新日期:2020-06-01 00:00:00
abstract::Philadelphia-negative myeloproliferative neoplasms (Ph-negative MPN) comprise a heterogeneous group of chronic hematologic malignancies. The quality of life, morbidity, and mortality of patients with MPN are primarily affected by disease-related symptoms, thromboembolic and hemorrhagic complications, and progression t...
journal_title:Annals of hematology
pub_type: 共识发展会议,杂志文章,实务指引,评审
doi:10.1007/s00277-016-2621-2
更新日期:2016-04-01 00:00:00
abstract::Cryoglobulinemia is uncommon in Southern Chinese in Hong Kong, with tropical climates and low incidence of hepatitis C virus (HCV) infection. Eight positive cases were detected among 481 patients screened for cryoglobulins over a 10-year period. Three HCV carriers (38%) ran benign courses. The others included two carr...
journal_title:Annals of hematology
pub_type: 杂志文章
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更新日期:2005-02-01 00:00:00
abstract::It is often difficult for standard blood banks in Korea to supply adequate amounts of blood for patients with rare phenotype. Moreover, the definition of a blood in need is ambiguous, and much remains to be learned. In this study, we determined the prevalence of various red blood cell (RBC) antigens from a donor viewp...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-016-2645-7
更新日期:2016-05-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
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更新日期:2007-11-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-008-0581-x
更新日期:2009-03-01 00:00:00
abstract::A case of an 82-year-old man who suffered an acute ST-elevation myocardial infarction while receiving treatment with intravenous immunoglobulin (IVIg) for thrombocytopenia is discussed. A total of 29 other cases of thromboembolism related to IVIg therapy have been reported, and the incidence seems to be especially hig...
journal_title:Annals of hematology
pub_type: 杂志文章,评审
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更新日期:2004-10-01 00:00:00
abstract::We investigated the efficacy and toxicity of the combination of busulfan, cyclophosphamide, and etoposide (Bu/Cy/VP-16) as a preparative regimen prior to autologous hematopoietic stem cell transplantation (ASCT) in patients with Hodgkin's disease (HD) or non-Hodgkin's lymphoma (NHL). Fifty-three patients with recurren...
journal_title:Annals of hematology
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更新日期:2002-02-01 00:00:00