Stroke prevention in the young child with sickle cell anaemia.

Abstract:

:Cerebrovascular disease resulting in stroke is a serious and preventable complication of sickle cell anaemia (SCA). Children at high risk of preventable stroke can be identified by transcranial Doppler ultrasound (TCD). Current guidelines in the UK recommend annual TCD screening from 3 years, although studies suggest an earlier peak incidence, between 2 and 5 years. A single centre retrospective review was undertaken to identify the prevalence of stroke and success of TCD screening in young children. We report five episodes of stroke in under 3s and outcome of TCD screening in children under 3, compared to over 3. TCD analysis was as successful in the 2-3-year age group as in the 3-4-year group. We therefore propose that all children with SCA should be offered TCD screening from the age of 2 years. Furthermore, infants with high risk features of SCA should undergo a first attempt at TCD screening even earlier.

journal_name

Ann Hematol

journal_title

Annals of hematology

authors

Roberts L,O'Driscoll S,Dick MC,Height SE,Deane C,Goss DE,Pohl K,Rees DC

doi

10.1007/s00277-009-0757-z

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

943-6

issue

10

eissn

0939-5555

issn

1432-0584

journal_volume

88

pub_type

杂志文章
  • Cytomegalovirus infection in seropositive unrelated cord blood recipients: a study of 349 Korean patients.

    abstract::To gain insight into the natural history of cytomegalovirus (CMV) infection following unrelated cord blood transplantation (UCBT) in seropositive patients, we analyzed the data of 349 seropositive patients who received UCBT in Korea between 2000 and 2011. CMV reactivation occurred in 49 % (171/349) of the CMV-seroposi...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-014-2222-x

    authors: Park M,Lee YH,Lee SH,Yoo KH,Sung KW,Koo HH,Lee JW,Kang HJ,Park KD,Shin HY,Ahn HS,Lee JW,Chung NG,Cho B,Kim HK,Koh KN,Im HJ,Seo JJ,Baek HJ,Kook H,Hwang TJ,Lee JM,Hah JO,Lim YJ,Park JE,Lyu CJ,Lim YT,Ch

    更新日期:2015-03-01 00:00:00

  • Hereditary gene mutations in Korean patients with isolated erythrocytosis.

    abstract::Most cases of erythrocytosis occur secondary to chronic tissue hypoxia or as a clonal disease such as polycythemia vera with somatic mutations in the Janus kinase 2 (JAK2) gene. Rarely, erythrocytosis is caused by hereditary gene mutations. This study investigated hereditary gene mutations in 38 unrelated Korean patie...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-014-2006-3

    authors: Jang JH,Seo JY,Jang J,Jung CW,Lee KO,Kim SH,Kim HJ

    更新日期:2014-06-01 00:00:00

  • Chronic myelogenous leukemia in blast crisis: retrospective analysis of prognostic factors in 90 patients.

    abstract::Ninety patients with Philadelphia chromosome-positive chronic myelogenous leukemia in blast crisis were reviewed to identify significant prognostic associations. At diagnosis of blast crisis the main clinical, laboratory, and cytogenetic data were recorded and evaluated for prognostic significance. At the time of the ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s002770050233

    authors: Griesshammer M,Heinze B,Hellmann A,Popp C,Anger B,Heil G,Bangerter M,Heimpel H

    更新日期:1996-11-01 00:00:00

  • Treatment of primary defective iron-reutilization syndrome: revisited.

    abstract::We encountered two patients who presented with hypochromic-microcytic anemia and were refractory to iron therapy. The symptoms were suggestive of anemia of chronic disease (ACD); however, there was no evidence of any such disease, either inflammatory or malignant. These patients were reminiscent of patients originally...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s002770000180

    authors: Besa EC,Kim PW,Haurani FI

    更新日期:2000-08-01 00:00:00

  • Developmental regulation of granulocyte-macrophage colony-stimulating factor production during human monocyte-to-macrophage maturation.

    abstract::Cells of the macrophage lineage are a major source of various cytokines and hematopoietic growth factors. With regard to the growth factors acting on cells of their own lineage, macrophage colony-stimulating factor (M-CSF) has been proven to be secreted by monocytes (MO) and macrophages (MAC), whereas the production o...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/BF01696222

    authors: Krause SW,Kreutz M,Zenke G,Andreesen R

    更新日期:1992-04-01 00:00:00

  • Acute myeloid/NK precursor cell leukemia with trisomy 4 and a novel point mutation in the extracellular domain of the G-CSF receptor in a patient with chronic idiopathic neutropenia.

    abstract::Chronic idiopathic neutropenia (CIN) has been well recognized as a granulocytic disorder not associated with increased risk to malignant transformation. Four cases, however, of acute myeloid leukemia have been recently reported in patients with CIN. In the current paper, we report on a CIN patient who developed acute ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-004-0862-y

    authors: Papadaki HA,Kosteas T,Gemetzi C,Damianaki A,Anagnou NP,Eliopoulos GD

    更新日期:2004-06-01 00:00:00

  • L-tryptophan-related eosinophilia-myalgia syndrome possibly associated with a chronic B-lymphocytic leukemia.

    abstract::A female patient presenting with B-CLL and coincident eosinophilia-myalgia syndrome (EMS) after ingestion of L-tryptophan is described. The manifestations of EMS disappeared completely during treatment with cyclophosphamide/prednisone. and there was an intermittent clinical remission of CLL with absence of the monoclo...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s002770050449

    authors: Böhme A,Wolter M,Hoelzer D

    更新日期:1998-11-01 00:00:00

  • Involvement of Fas and TNF pathways in the induction of apoptosis of T cells by antithymocyte globulin.

    abstract::Antithymocyte globulin (ATG) is the treatment of choice for those aplastic anemia patients who are not suitable for bone marrow transplantation (BMT). ATG is also used for the treatment of rejections in organ transplantation and as a conditioning regimen in BMT. Despite the proven efficacy of ATG in these areas, its m...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-003-0645-x

    authors: Dubey S,Nityanand S

    更新日期:2003-08-01 00:00:00

  • Bernard-Soulier syndrome: novel nonsense mutation in GPIbbeta gene affecting GPIb-IX complex expression.

    abstract::Bernard-Soulier syndrome (BSS) is a rare autosomal recessive genetic disorder characterized by thrombocytopenia, circulating giant platelets, and prolonged bleeding time. BSS is explained by a defect in primary hemostasis owing to quantitative or qualitative defect in the GPIb-IX-V complex, composed of four subunits: ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-008-0611-8

    authors: Hadjkacem B,Elleuch H,Gargouri J,Gargouri A

    更新日期:2009-05-01 00:00:00

  • Ifosfamide, methotrexate, etoposide, and prednisolone (IMEP) plus L-asparaginase as a first-line therapy improves outcomes in stage III/IV NK/T cell-lymphoma, nasal type (NTCL).

    abstract::The prognosis of patients with stage III/IV NK/T-cell lymphoma (NTCL) is extremely poor. Although L-asparaginase (L-asp) is effective for NTCL, its significance has not been clearly demonstrated. In addition, there are few studies comparing treatment outcomes in stage III/IV NTCL. This study evaluated the efficacy of ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-014-2228-4

    authors: Kim M,Kim TM,Kim KH,Keam B,Lee SH,Kim DW,Lee JS,Jeon YK,Kim CW,Heo DS

    更新日期:2015-03-01 00:00:00

  • Early CMV replication and subsequent chronic GVHD have a significant anti-leukemic effect after allogeneic HSCT in acute myeloid leukemia.

    abstract::Early cytomegalovirus (CMV) replication (eCMV) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been suggested as an independent factor that reduces leukemia relapse risk. We retrospectively analyzed 74 patients with acute myeloid leukemia (AML) who underwent allo-HSCT between August 2006 and S...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-014-2190-1

    authors: Jang JE,Kim SJ,Cheong JW,Hyun SY,Kim YD,Kim YR,Kim JS,Min YH

    更新日期:2015-02-01 00:00:00

  • Correlation between leukocytosis and thrombosis in Philadelphia-negative chronic myeloproliferative neoplasms.

    abstract::The evidence that leukocytes may contribute to the pathogenesis of thrombosis in Chronic Myeloproliferative Neoplasms is increasing but not definitive. To further enforces whether an increased leukocyte count is associated with thrombosis and whether this effect can be modulated by cytoreductive therapy, we analyzed t...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00277-009-0706-x

    authors: Caramazza D,Caracciolo C,Barone R,Malato A,Saccullo G,Cigna V,Berretta S,Schinocca L,Quintini G,Abbadessa V,Di Raimondo F,Siragusa S

    更新日期:2009-10-01 00:00:00

  • Management of extreme thrombocytosis in myeloproliferative neoplasms: an international physician survey.

    abstract::Extreme thrombocytosis (ExT) has been associated with an increased bleeding risk in myeloproliferative neoplasm (MPN) patients and is included in the high risk category in treatment guidelines. Treatment of patients with ExT has not been studied in prospective trials. To study physicians' approaches to ExT, we distrib...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-016-2826-4

    authors: Koren-Michowitz M,Lavi N,Ellis MH,Vannucchi AM,Mesa R,Harrison CN

    更新日期:2017-01-01 00:00:00

  • Rare primary extranodal lymphomas: diffuse large B-cell lymphomas of the genital tract.

    abstract::Primary non-Hodgkin's lymphoma (NHL) of the genital tract is a rare entity. Etiology and pathogenesis of these NHLs are unknown, although there might be a possible association between chronic inflammation and lymphomas. The most common histological subtype is the diffuse large B-cell lymphoma. We report two cases of u...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-009-0741-7

    authors: Rajnics P,Demeter J,Csomor J,Krenács L,Pajor L,Kollár B,Kertész Z,Egyed M

    更新日期:2009-12-01 00:00:00

  • Impact of extramedullary plasmacytomas on outcomes according to treatment approach in newly diagnosed symptomatic multiple myeloma.

    abstract::The prognostic impact of extramedullary plasmacytomas (EMPs) on newly diagnosed symptomatic multiple myeloma (MM) was evaluated in the context of treatment approach including autologous stem cell transplantation (ASCT) and chemotherapy alone. A total of 275 consecutive patients with newly diagnosed MM were included, a...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-014-2216-8

    authors: Lee SE,Kim JH,Jeon YW,Yoon JH,Shin SH,Eom KS,Kim YJ,Kim HJ,Lee S,Cho SG,Lee JW,Min WS,Park CW,Min CK

    更新日期:2015-03-01 00:00:00

  • An unusual case of leukemic non-Hodgkin's lymphoma with blastic transformation.

    abstract::We report on a patient who was diagnosed as having B-cell chronic lymphocytic leukemia (CLL) with atypical morphology. Flow cytometry disclosed CD5, CD19, and CD23 positivity, an immunophenotype seen mostly in B-CLL. Histology of the spleen and bone marrow suggested a diagnosis of small lymphocytic lymphoma. Upon blas...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s002770050582

    authors: Späth-Schwalbe E,Flath B,Kaufmann O,Thiel G,Brinckmann R,Dietel M,Possinger K

    更新日期:2000-04-01 00:00:00

  • Protein C system defects in Indian children with thrombosis.

    abstract::As ethnic variations are known to exist in inherited genetic defects, the clinico-haematological profile of Indian children with thrombophilia may be different from that of Caucasians. The aim of the study was to analyse the phenotypic and genotypic causes of thrombophilia in Indian children. Forty patients with arter...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-004-0952-x

    authors: Gupta PK,Ahmed RP,Bhattacharyya M,Kannan M,Biswas A,Kalra V,Saxena R

    更新日期:2005-02-01 00:00:00

  • Can prognostic scoring systems for chronic myeloid leukemia as established in adults be applied to pediatric patients?

    abstract::In contrast to adult medicine, specific scoring systems predicting the treatment response for an individual pediatric patient (pt) with chronic myeloid leukemia (CML) have not yet been defined. We evaluated to what extend prognostic scores as described for adults (e.g., Sokal, Hasford, EUTOS score) resulted in compara...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-015-2367-2

    authors: Gurrea Salas D,Glauche I,Tauer JT,Thiede C,Suttorp M

    更新日期:2015-08-01 00:00:00

  • Myeloproliferative disorders: complications, survival and causes of death.

    abstract::This retrospective single-center study compared thromboembolic and hemorrhagic complications, survival and causes of death in a cohort of 102 consecutive patients with myeloproliferative disorders (MPD). We included 17 patients with essential thrombocythemia (ET), 59 with polycythemia vera (PV), and 26 with osteomyelo...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s002779900136

    authors: Brodmann S,Passweg JR,Gratwohl A,Tichelli A,Skoda RC

    更新日期:2000-06-01 00:00:00

  • Quality-adjusted survival analysis shows differences in outcome after immunosuppression or bone marrow transplantation in aplastic anemia.

    abstract::Bone marrow transplantation (BMT) and immunosuppression (IS) have improved the prognosis of aplastic anemia; both treatments have specific advantages and drawbacks but similar survival rates. Analysis of additional endpoints may help in treatment decisions. In a single-center study, patients with aplastic anemia treat...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-004-0930-3

    authors: Viollier R,Passweg J,Gregor M,Favre G,Kühne T,Nissen C,Gratwohl A,Tichelli A

    更新日期:2005-01-01 00:00:00

  • Allogeneic hematopoietic stem cell transplantation for non-Hodgkin's lymphomas: a retrospective analysis of 77 cases.

    abstract::Allogeneic hematopoietic stem cell transplantation (allo-SCT) is a therapeutic option for relapsed, advanced, and otherwise incurable non-Hodgkin's lymphomas (NHL) suggested by the existence of a graft-versus-lymphoma effect. The main complications are graft-versus-host disease and infections. We performed a retrospec...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-017-2934-9

    authors: Picleanu AM,Novelli S,Monter A,Garcia-Cadenas I,Caballero AC,Martino R,Esquirol A,Briones J,Sierra J

    更新日期:2017-05-01 00:00:00

  • Immune thrombocytopenia: epidemiological and clinical features of 216 patients in northwestern Turkey.

    abstract::We evaluated the clinical features, treatment modalities, treatment responses, and prognosis of our patients with immune thrombocytopenia (ITP). Furthermore, we estimated the frequency of ITP in the Thrace region of Turkey. Two hundred sixteen patients diagnosed with ITP between 2000 and 2012 at our center were retros...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-014-2220-z

    authors: Koylu A,Pamuk GE,Uyanik MS,Demir M,Pamuk ON

    更新日期:2015-03-01 00:00:00

  • Upfront autologous stem cell transplantation for untreated diffuse large B cell lymphoma patients in rituximab era: a systematic review and meta-analysis.

    abstract::To assess the survival outcomes and adverse events (AEs) of high-intermediate- or high-risk patients with diffuse large B cell lymphoma (DLBCL) who underwent conventional chemotherapy plus rituximab with or without first-line autologous stem cell transplantation (ASCT). Related studies published on Medline, Embase, Co...

    journal_title:Annals of hematology

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00277-020-04016-3

    authors: Ma SY,Tian XP,Cai J,Zhong GZ,Chen X,Huang HQ,Lin TY,Li ZM,Cai QQ

    更新日期:2020-06-01 00:00:00

  • Diagnosis, prevention, and management of bleeding episodes in Philadelphia-negative myeloproliferative neoplasms: recommendations by the Hemostasis Working Party of the German Society of Hematology and Medical Oncology (DGHO) and the Society of Thrombosis

    abstract::Philadelphia-negative myeloproliferative neoplasms (Ph-negative MPN) comprise a heterogeneous group of chronic hematologic malignancies. The quality of life, morbidity, and mortality of patients with MPN are primarily affected by disease-related symptoms, thromboembolic and hemorrhagic complications, and progression t...

    journal_title:Annals of hematology

    pub_type: 共识发展会议,杂志文章,实务指引,评审

    doi:10.1007/s00277-016-2621-2

    authors: Appelmann I,Kreher S,Parmentier S,Wolf HH,Bisping G,Kirschner M,Bergmann F,Schilling K,Brümmendorf TH,Petrides PE,Tiede A,Matzdorff A,Griesshammer M,Riess H,Koschmieder S

    更新日期:2016-04-01 00:00:00

  • Life-threatening cryoglobulinemia in HCV-negative Southern Chinese and a novel association with structural aortic abnormalities.

    abstract::Cryoglobulinemia is uncommon in Southern Chinese in Hong Kong, with tropical climates and low incidence of hepatitis C virus (HCV) infection. Eight positive cases were detected among 481 patients screened for cryoglobulins over a 10-year period. Three HCV carriers (38%) ran benign courses. The others included two carr...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-004-0955-7

    authors: Au WY,Kwok JS,Chu KM,Ma ES

    更新日期:2005-02-01 00:00:00

  • Genotyping of 22 blood group antigen polymorphisms and establishing a national recipient registry in the Korean population.

    abstract::It is often difficult for standard blood banks in Korea to supply adequate amounts of blood for patients with rare phenotype. Moreover, the definition of a blood in need is ambiguous, and much remains to be learned. In this study, we determined the prevalence of various red blood cell (RBC) antigens from a donor viewp...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-016-2645-7

    authors: Hong YJ,Chung Y,Hwang SM,Park JS,Kwon JR,Choi YS,Kim JN,Lee DH,Kwon SY,Cho NS,Song EY,Park KU,Song J,Han KS

    更新日期:2016-05-01 00:00:00

  • A human Burkitt's lymphoma cell line carrying t(8;22) and t(14;18) translocations.

    abstract::A combination of chromosomal translocations associated with bcl-2 re-arrangement (t(14;18)) and c-myc re-arrangement (t(8;14), t(8;22), or t(2;8)) is a rare event. We describe the first cell line exhibiting t(14;18) and t(8;22), which will enable us to study the interactions of bcl-2 and c-myc systematically. Cell cul...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-007-0313-7

    authors: Kiefer T,Schüler F,Knopp A,Wimmer M,Hirt C,Schaefer HE,Dölken G

    更新日期:2007-11-01 00:00:00

  • Haemoglobinopathies with high oxygen affinity. Experience of Erythropathology Cooperative Spanish Group.

    abstract::Haemoglobinopathies are the world's most frequently found monogenic disorders. In the cases with high oxygen affinity, the decrease in the liberation of the oxygen determines a secondary erythrocytosis. In this work, we present 17 unrelated families of Caucasian race and of Spanish origin, with ten variants of haemogl...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-008-0581-x

    authors: González Fernández FA,Villegas A,Ropero P,Carreño MD,Anguita E,Polo M,Pascual A,Henández A

    更新日期:2009-03-01 00:00:00

  • Thromboembolic events as an emerging adverse effect during high-dose intravenous immunoglobulin therapy in elderly patients: a case report and discussion of the relevant literature.

    abstract::A case of an 82-year-old man who suffered an acute ST-elevation myocardial infarction while receiving treatment with intravenous immunoglobulin (IVIg) for thrombocytopenia is discussed. A total of 29 other cases of thromboembolism related to IVIg therapy have been reported, and the incidence seems to be especially hig...

    journal_title:Annals of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s00277-004-0895-2

    authors: Hefer D,Jaloudi M

    更新日期:2004-10-01 00:00:00

  • Busulfan, cyclophosphamide, and etoposide as high-dose conditioning regimen in patients with malignant lymphoma.

    abstract::We investigated the efficacy and toxicity of the combination of busulfan, cyclophosphamide, and etoposide (Bu/Cy/VP-16) as a preparative regimen prior to autologous hematopoietic stem cell transplantation (ASCT) in patients with Hodgkin's disease (HD) or non-Hodgkin's lymphoma (NHL). Fifty-three patients with recurren...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-001-0413-8

    authors: Hänel M,Kröger N,Sonnenberg S,Bornhäuser M,Krüger W,Kroschinsky F,Hänel A,Metzner B,Birkmann J,Schmid B,Hoffknecht MM,Fiedler F,Ehninger G,Zander AR

    更新日期:2002-02-01 00:00:00