Successful alemtuzumab retreatment in progressive B-cell chronic lymphocytic leukemia: a multicenter survey in 30 patients.


:Although retreatment with alemtuzumab in relapsing B-cell chronic lymphocytic leukemia (CLL) may be beneficial, there has thus far been no thorough analysis available on this topic. Data were collected from 30 chemotherapy-pretreated patients with progressive CLL who had received alemtuzumab twice in consecutive, distinct therapy lines. The median dose of alemtuzumab retreatment was 402 mg (range, 43-1,090 mg). Retreatment with alemtuzumab induced an overall response rate of 47%. From the start of alemtuzumab retreatment, median progression-free survival (PFS) and overall survival (OS) were 6.3 and 20.0 months, respectively. Response rates, PFS and OS upon alemtuzumab retreatment were correlated with response to initial alemtuzumab treatment, the time interval between the initial course of alemtuzumab and start of retreatment, and the hemoglobin concentration prior to retreatment. Reported toxicities from 24 cases included infections (50%), febrile reactions upon alemtuzumab administration (38%), exanthema (21%), and grade 4 neutropenia (13%) and thrombocytopenia (17%). We conclude that alemtuzumab retreatment represents an effective and tolerable therapeutic option for selected patients with CLL.


Ann Hematol


Annals of hematology


Fiegl M,Falkner F,Steurer M,Zojer N,Hopfinger G,Haslbauer F,Winder G,Voskova D,Andel J,Lang A,Brychtova Y,Mayer J,Greil R,Gastl G,Austrian Collaborative Study Group on Alemtuzumab in Chronic Lymphocytic Leukemia.,Czech Leuk




Has Abstract


2011-09-01 00:00:00












  • Phase II study of safety and efficacy of BEB (bendamustine, etoposide, and busulfan) conditioning regimen for autologous stem cell transplantation in non-Hodgkin lymphoma.

    abstract::Autologous stem cell transplant (ASCT) is an effective treatment for non-Hodgkin lymphoma (NHL). However, recent supply issues and toxicity of carmustine have necessitated a new conditioning regimen. We conducted a multicenter, phase II study of BEB (busulfan, etoposide, and bendamustine) conditioning regimen for ASCT...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究


    authors: Kim DY,Chung JS,Jo JC,Cho SH,Shin HJ

    更新日期:2020-04-01 00:00:00

  • Clinical significance of metabolic tumor volume by PET/CT in stages II and III of diffuse large B cell lymphoma without extranodal site involvement.

    abstract::The objective of this study was to investigate whether metabolic tumor volume (MTV) by positron emission tomography (PET) can be a potential prognostic tool when compared with Ann Arbor stage, in stages II and III nodal diffuse large B cell lymphoma (DLBCL). We evaluated 169 patients with nodal stages II and III DLBCL...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Song MK,Chung JS,Shin HJ,Lee SM,Lee SE,Lee HS,Lee GW,Kim SJ,Lee SM,Chung DS

    更新日期:2012-05-01 00:00:00

  • Treatment of primary mediastinal large B cell lymphoma with an alternating chemotherapy regimen based on high-dose methotrexate.

    abstract::Primary mediastinal large B cell lymphomas (MLCL) differ from other diffuse large cell lymphomas, leading to a description as a separate entity in the current World Health Organization classification. Dose intensification improves long-term results, but no standard therapy has been established so far. We investigated ...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Fietz T,Knauf WU,Hänel M,Franke A,Freund M,Thiel E,East German Study Group on Hematology and Oncology-OSHO.

    更新日期:2009-05-01 00:00:00

  • A novel scoring system to predict the incidence of invasive fungal disease in salvage chemotherapies for malignant lymphoma.

    abstract::The requirement of antifungal prophylaxis has not been established in the chemotherapies for malignant lymphoma. This study was conducted to explore the incidence of invasive fungal diseases (IFD) and their risk factors in patients receiving salvage therapies for malignant lymphoma. We retrospectively analyzed 177 con...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Takaoka K,Nannya Y,Shinohara A,Arai S,Nakamura F,Kurokawa M

    更新日期:2014-10-01 00:00:00

  • Two novel factor X gene mutations in a Chinese family with factor X deficiency.

    abstract::We report a factor X (FX)-deficient Chinese family with two novel FX gene (F10) mutations. Two sibling probands had a bleeding tendency since childhood. Both had very low FX:C (<0.01 IU/ml) and FX:Ag (5-6%) levels and were heterozygous for two novel F10 mutations, a 2-bp GC deletion involving nucleotides 33 and 34, le...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Au WY,Lam CC,Cheung WC,Kwong YL

    更新日期:2004-05-01 00:00:00

  • Decreased expression of indoleamine 2,3-dioxygenase 1 in dendritic cells contributes to impaired regulatory T cell development in immune thrombocytopenia.

    abstract::Along with their immunogenic role, dendritic cells (DCs) are also critical in maintaining tolerance to self-antigens by inducing regulatory T cells (Tregs) via the expression of the immunomodulatory enzyme indoleamine 2,3-dioxygenase 1 (IDO1). In turn, Tregs modulate the maturation and/or function of DCs. In immune th...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Catani L,Sollazzo D,Trabanelli S,Curti A,Evangelisti C,Polverelli N,Palandri F,Baccarani M,Vianelli N,Lemoli RM

    更新日期:2013-01-01 00:00:00

  • The 6-min walk test: an independent correlate of elevated tricuspid regurgitant jet velocity in children and young adult sickle cell patients.

    abstract::Elevation of echocardiography-determined tricuspid regurgitant jet velocity (TRV) predicts high systolic pulmonary artery pressure. The present study tested the hypotheses that elevated tricuspid regurgitant jet velocity is associated with both hemolysis and hypoxia and abnormal 6-min walk test (6MWT) results. This st...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Agha H,El Tagui M,El Ghamrawy M,Abdel Hady M

    更新日期:2014-07-01 00:00:00

  • Clinical heterogeneity of silent-gene b-thalassemia among Indians.

    abstract::This paper describes six Indian families in which silent-gene beta-thalassemia was encountered by us in the past 2 years. This stresses the importance of globin-chain synthesis in the diagnosis of beta-thalassemia. Of these six cases, five were diagnosed retrospectively when they had a homozygous beta-thalassemia offs...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Nadkarni A,Pawar A,Mudera VC,Mohanty D,Colah R

    更新日期:1995-01-01 00:00:00

  • Aerosol amphotericin B inhalations for prevention of invasive pulmonary aspergillosis in neutropenic cancer patients.

    abstract::To determine the value of aerosol amphotericin B inhalations for prevention of invasive pulmonary aspergillosis (IPA), we initiated a prospective randomized multicenter trial. The scheduled intent-to-treat interim analysis included 115 patients (30%) with prolonged neutropenia after chemotherapy for acute myeloid leuk...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Behre GF,Schwartz S,Lenz K,Ludwig WD,Wandt H,Schilling E,Heinemann V,Link H,Trittin A,Boenisch O

    更新日期:1995-12-01 00:00:00

  • Reduced intensity allogeneic hematopoietic cell transplantation can induce durable remission in heavily pretreated relapsed Hodgkin lymphoma.

    abstract::Hodgkin lymphoma (HL) can be aggressive and intractable in some cases. Patients who relapse after autologous HCT (auto-HCT) have limited treatment options. City of Hope reports our experience in the use of reduced intensity allogeneic hematopoietic cell transplantation (allo-HCT) in 24 heavily pretreated patients with...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Chen R,Palmer JM,Popplewell L,Shen J,Smith E,Delioukina M,Kogut N,Rosenthal J,Forman S,Nademanee A

    更新日期:2011-07-01 00:00:00

  • Primary acquired sideroblastic anemia, thrombocytosis, and trisomy 8.

    abstract::Myelodysplastic syndromes are usually associated with pancytopenia. Disorders involving deletion of the long arm of chromosome 5 (5q-syndrome) and, rarely, patients with karyotypic abnormalities involving chromosome 3 associated with abnormal thrombopoiesis may have a normal or even raised platelet count. Other cytoge...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Patel K,Kelsey P

    更新日期:1997-04-01 00:00:00

  • Second German consensus on immunogenetic donor search for allotransplantation of hematopoietic stem cells.

    abstract::The present paper summarizes the results of the second German consensus meeting on immunogenetic donor search for allotransplantation of hematopoietic stem cells held in Essen in November 1999 under the auspices of the German Society for Immunogenetics (DGI) and the German Working Party for Blood and Marrow Transplant...

    journal_title:Annals of hematology

    pub_type: 共识发展会议,杂志文章,评审


    authors: Ottinger HD,Müller CR,Goldmann SF,Albert E,Arnold R,Beelen DW,Blasczyk R,Bunjes D,Casper J,Ebell W,Ehninger G,Eiermann T,Einsele H,Fauser A,Ferencik S,Finke J,Hertenstein B,Heyll A,Klingebiel T,Knipper A,Kremens B

    更新日期:2001-12-01 00:00:00

  • Improved clinical outcomes for multiple myeloma patients treated at a single specialty clinic.

    abstract::Despite recent advances made in its treatment, multiple myeloma (MM) remains an incurable B cell malignancy. Thus, the objective for treating these patients is to prolong overall survival (OS) and preserve patients' quality of life. We have analyzed data from 264 consecutive MM patients who had their initial visit bet...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Berenson A,Vardanyan S,David M,Wang J,Harutyunyan NM,Gottlieb J,Halleluyan R,Spektor TM,Udd KA,Eshaghian S,Nassir Y,Eades B,Swift R,Berenson JR

    更新日期:2017-03-01 00:00:00

  • Alemtuzumab in chronic lymphocytic leukemia: final results of a large observational multicenter study in mostly pretreated patients.

    abstract::This retrospective study evaluated the benefit of alemtuzumab monotherapy in unselected patients with advanced B-cell chronic lymphocytic leukemia (CLL) and prolymphocytic leukemia (B-PLL) to definitely describe the impact of this antibody in clinical routine use. Data were collected from 208 consecutive, mainly pretr...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Fiegl M,Stauder R,Steurer M,Mian M,Hopfinger G,Brychtova Y,Skrabs C,Zabernigg A,Schmid F,Haslbaur F,Winder G,Walder A,Lang A,Voskova D,Greil R,Mayer J,Gastl G,Austrian Collaborative Study Group on Alemtuzumab in Chronic

    更新日期:2014-02-01 00:00:00

  • IDEC-C2B8 (Rituximab) anti-CD20 antibody treatment in relapsed advanced-stage follicular lymphomas: results of a phase-II study of the German Low-Grade Lymphoma Study Group.

    abstract:PURPOSE:The current study was initiated to assess the clinical efficacy and side effects of rituximab in patients with relapsed advanced stage follicular lymphoma. PATIENTS AND METHODS:The study was performed as an open-label non-randomized multicenter phase-II trial and included patients older than 18 years of age wi...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章


    authors: Feuring-Buske M,Kneba M,Unterhalt M,Engert A,Gramatzki M,Hiller E,Trümper L,Brugger W,Ostermann H,Atzpodien J,Hallek M,Aulitzky E,Hiddemann W

    更新日期:2000-09-01 00:00:00

  • Autoimmune hemolytic anemia in patients with de novo acute myelocytic leukemia.

    abstract::Autoantibody against erythrocytes has occasionally been observed in patients with de novo acute myelocytic leukemia (AML). However, it is not clear whether this autoantibody in AML patients induces frank hemolysis (autoimmune hemolytic anemia, AIHA), as seen in lymphoid neoplasms. We present two de novo AML patients w...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Tamura H,Ogata K,Yokose N,An E,Kamikubo K,Dan K,Kajii E,Nomura T

    更新日期:1996-01-01 00:00:00

  • Incidence, clinical characteristics, and outcome of interstitial pneumonia in patients with lymphoma.

    abstract::Interstitial pneumonia (IP) is a lethal complication in lymphoma patients undergoing chemotherapy. A total of 2212 consecutive patients diagnosed with lymphoma between 2009 and 2014 were enrolled in the present study. IP was defined as diffuse pulmonary interstitial infiltrate found on computed tomography scans. IP wa...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Liu WP,Wang XP,Zheng W,Xie Y,Tu MF,Lin NJ,Ping LY,Ying ZT,Zhang C,Deng LJ,Ding N,Wang XG,Song YQ,Zhu J

    更新日期:2018-01-01 00:00:00

  • Eltrombopag: an update on the novel, non-peptide thrombopoietin receptor agonist for the treatment of immune thrombocytopenia.

    abstract::Immune thrombocytopenia (ITP) is characterised by a transient or persistent decrease in platelets accompanied by an increased risk of bleeding, which can have a significant negative impact on patients' health-related quality of life. The condition has long been associated with an increased rate of immune-mediated plat...

    journal_title:Annals of hematology

    pub_type: 杂志文章,评审


    authors: Kühne T,Imbach P

    更新日期:2010-07-01 00:00:00

  • IDH1 and IDH2 mutation analysis in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome.

    abstract::The somatic mutations of isocitrate dehydrogenase genes (IDH1 and IDH2) have been identified in a proportion of hematologic malignancies. We examined IDH1 R132 and IDH2 R140/R172 mutations by high resolution melting analysis and direct sequencing in Chinese patients with different myeloid malignancies including 198 ac...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Lin J,Yao DM,Qian J,Chen Q,Qian W,Li Y,Yang J,Wang CZ,Chai HY,Qian Z,Xiao GF,Xu WR

    更新日期:2012-04-01 00:00:00

  • Radiotherapy and PGEMOX/GELOX regimen improved prognosis in elderly patients with early-stage extranodal NK/T-cell lymphoma.

    abstract::The optimal treatment strategy for elderly patients with natural killer/T-cell lymphoma (NKTCL) remains to be established. A total of 63 elderly patients with newly diagnosed NKTCL were retrospectively reviewed. Among the patients with stage I-II disease, 58.3 % received radiotherapy (RT) ± chemotherapy, and 41.7 % re...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章


    authors: Bi XW,Xia Y,Zhang WW,Sun P,Liu PP,Wang Y,Huang JJ,Jiang WQ,Li ZM

    更新日期:2015-09-01 00:00:00

  • Establishment of serum-free pre-colony forming unit assays for differentiation of primitive hematopoietic progenitors: serum induces early macrophage differentiation and inhibits early erythroid differentiation of CD34++CD38- cells.

    abstract::In this report we show that serum has differentiation-inducing effects on primitive hematopoietic progenitor cells with the CD34++CD38- immunophenotype. Using the pre-colony forming unit (pre-CFU) assay as a model for early myelopoiesis, we compared the effects of serum-containing and serum-free media and evaluated di...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Willems R,Henckaerts E,Lenjou M,Nijs G,Rodrigus I,Moulijn AC,Slegers H,Berneman ZN,Van Bockstaele DR

    更新日期:2001-01-01 00:00:00

  • Distinct clinical and biological characteristics of acute myeloid leukemia with higher expression of long noncoding RNA KIAA0125.

    abstract::Expression of long non-coding RNA KIAA0125 has been incorporated in various gene expression signatures for prognostic prediction in acute myeloid leukemia (AML) patients, yet its functions and clinical significance remain unclear. This study aimed to investigate the clinical and biological characteristics of AML beari...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章


    authors: Wang YH,Lin CC,Hsu CL,Hung SY,Yao CY,Lee SH,Tsai CH,Hou HA,Chou WC,Tien HF

    更新日期:2021-02-01 00:00:00

  • Biological activity of lenalidomide in myelodysplastic syndromes with del5q: results of gene expression profiling from a multicenter phase II study.

    abstract::In vitro studies suggest that haploinsufficiency is involved in the pathogenesis of myelodysplastic syndromes (MDS). In patients with del5q cytogenetic abnormality, RPS-14 and microRNAs (miRNAs) play a major role. In a multicenter phase II single-arm trial with lenalidomide in anemic primary del5q MDS patients with lo...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Oliva EN,Cuzzola M,Aloe Spiriti MA,Poloni A,Laganà C,Rigolino C,Morabito F,Galimberti S,Ghio R,Cortelezzi A,Palumbo GA,Sanpaolo G,Finelli C,Ricco A,Volpe A,Rodà F,Breccia M,Alimena G,Nobile F,Latagliata R

    更新日期:2013-01-01 00:00:00

  • Correlation study between osteoporosis and hematopoiesis in the context of adjuvant chemotherapy for breast cancer.

    abstract::This retrospective study attempts to establish if a correlation exists between osteoporosis and hematopoiesis before and after adjuvant chemotherapy in the context of non-metastatic breast cancer. Osteoporosis is interpreted both as a direct marker of osteoblastic decline and as an indirect marker of increased bone ma...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Schyrr F,Wolfer A,Pasquier J,Nicoulaz AL,Lamy O,Naveiras O

    更新日期:2018-02-01 00:00:00

  • Second- versus first-generation azoles for antifungal prophylaxis in hematology patients: a systematic review and meta-analysis.

    abstract::Second-generation azoles may be more effective than first-generation azoles in the prevention of fungal infections in hematology patients. We performed a systematic review with meta-analysis of randomized controlled trials comparing second- with first-generation azoles in hematology patients with respect to proven or ...

    journal_title:Annals of hematology

    pub_type: 杂志文章,meta分析,评审


    authors: Ping B,Zhu Y,Gao Y,Yue C,Wu B

    更新日期:2013-06-01 00:00:00

  • Phase-II trial of idarubicin, fludarabine, cytosine arabinoside, and filgrastim (Ida-FLAG) for treatment of refractory, relapsed, and secondary AML.

    abstract::The current phase-II trial was initiated to assess the efficacy and toxicity of the Ida-FLAG regimen in patients with poor-risk acute myeloid leukemia (AML). Three subgroups of patients with AML were eligible for the study: (a) refractory, (b) first relapse, or (c) secondary AML (i.e., signs of trilineage myelodysplas...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Steinmetz HT,Schulz A,Staib P,Scheid C,Glasmacher A,Neufang A,Franklin J,Tesch H,Diehl V,Dias Wickramanayake P

    更新日期:1999-09-01 00:00:00

  • Anaphylactoid reaction with bronchospasm following intravenous cyclophosphamide administration.

    abstract::Anaphylactoid reaction to cyclophosphamide administration in a 85-year old woman is described. Symptomatology was restricted to bronchospasm, which regressed within one hour. This incomplete and rapidly regressive symptomatology might be explained by previous administration of methylprednisolone. No anaphylactoid symp...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Salles G,Vial T,Archimbaud E

    更新日期:1991-02-01 00:00:00

  • Quality of life during maintenance therapy with the anti-CD20 antibody rituximab in patients with B cell non-Hodgkin's lymphoma: results of a prospective randomized controlled trial.

    abstract::The introduction of rituximab into the primary treatment of malignant lymphomas of the B cell lineage has had a major impact on the management of these diseases. In addition, prolonged exposure to rituximab as maintenance therapy has been beneficial in patients with follicular lymphoma and mantle cell lymphoma. For th...

    journal_title:Annals of hematology

    pub_type: 杂志文章,随机对照试验


    authors: Witzens-Harig M,Reiz M,Heiss C,Benner A,Hensel M,Neben K,Dreger P,Kraemer A,Ho AD

    更新日期:2009-01-01 00:00:00

  • Eosinophilia during fludarabine treatment of chronic lymphocytic leukemia.

    abstract::Although eosinophilia has been reported as a side effect of purine analogues, there is no report on fludarabine-induced eosinophilia in chronic lymphocytic leukemia (CLL). During chemotherapy with fludarabine and cyclophosphamide, we observed two cases of significant eosinophilia. A 67-year-old patient with CLL develo...

    journal_title:Annals of hematology

    pub_type: 杂志文章,评审


    authors: Sezer O,Schmid P,Hallek M,Schweigert M,Beinert T,Langelotz C,Mergenthaler HG,Possinger K

    更新日期:1999-10-01 00:00:00

  • Clinicopathological characteristics and outcomes of light chain deposition disease: an analysis of 48 patients in a single Chinese center.

    abstract::To explore the clinicopathological characteristics and outcomes of light chain deposition disease (LCDD) in a Chinese population, we retrospectively studied the clinicopathological data, treatment, and outcomes of 48 patients with biopsy-proven LCDD from a single center. Among the patients, there were 29 males and 19 ...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Li XM,Rui HC,Liang DD,Xu F,Liang SS,Zhu XD,Huang XH,Liu ZH,Zeng CH

    更新日期:2016-05-01 00:00:00