Diagnostic and therapeutic quandaries in primary manifestation of Hodgkin's disease in the central nervous system.

abstract：:Neutrophil-lymphocyte ratio (NLR), an indicator of inflammation, has been lately demonstrated as a prognostic factor and an indicator of disease activity in various diseases. However, the effects of NLR have not been investigated in mycosis fungoides (MF) patients yet. The aim of this study is to investigate the relat...

journal_title：Annals of hematology

authors： Eren R,Nizam N,Doğu MH,Mercan S,Erdemir AV,Suyanı E

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Low folate intake and changes in folate metabolism due to polymorphisms in the methylentetrahydrofolate reductase (MTHFR) gene have been associated with myelomagenesis. However, controversial data have been published regarding a protective role of variant alleles of MTHFR on MM. PATIENTS AND METHODS:To inve...

journal_title：Annals of hematology

authors： Chiusolo P,Farina G,Putzulu R,Reddiconto G,Fiorini A,De Stefano V,Rossi E,Palladino M,Leone G,Sica S

更新日期：2006-07-01 00:00:00

abstract：:Eighteen patients with myeloproliferative syndrome (14 with chronic myeloid leukemia, four with essential thrombocytosis) were investigated for modulation of HLA antigens on peripheral blood lymphocytes, monocytes, and hematopoietic precursors during IFN alpha therapy as a sign of potentially increased immune recognit...

journal_title：Annals of hematology

authors： Müller CA,Walz J,Zinser R,Bühring HJ,Steinke B,Schmidt H

更新日期：1991-11-01 00:00:00

abstract：:This retrospective study evaluated the benefit of alemtuzumab monotherapy in unselected patients with advanced B-cell chronic lymphocytic leukemia (CLL) and prolymphocytic leukemia (B-PLL) to definitely describe the impact of this antibody in clinical routine use. Data were collected from 208 consecutive, mainly pretr...

journal_title：Annals of hematology

authors： Fiegl M,Stauder R,Steurer M,Mian M,Hopfinger G,Brychtova Y,Skrabs C,Zabernigg A,Schmid F,Haslbaur F,Winder G,Walder A,Lang A,Voskova D,Greil R,Mayer J,Gastl G,Austrian Collaborative Study Group on Alemtuzumab in Chronic

更新日期：2014-02-01 00:00:00

abstract：:Single-nucleotide polymorphisms (SNPs) of cytotoxic T lymphocyte antigen-4 (CTLA-4) are important risk factors associated with autoimmune diseases and malignancies. This study explored the association of CTLA-4SNPs with the development of myeloma and evaluated the outcome of patients receiving bortezomib-based regimen...

journal_title：Annals of hematology

authors： Qin XY,Lu J,Li GX,Wen L,Liu Y,Xu LP,Chang YJ,Liu KY,Jiang ZF,Huang XJ

更新日期：2018-03-01 00:00:00

abstract：:Nondeletional hereditary persistence of fetal hemoglobin (nd-HPFH), a rare hereditary condition resulting in elevated levels of fetal hemoglobin (Hb F) in adults, is associated with promoter mutations in the human fetal globin (HBG1 and HBG2) genes. In this paper, we report a novel type of nd-HPFH due to a HBG2 gene p...

journal_title：Annals of hematology

authors： Chassanidis C,Kalamaras A,Phylactides M,Pourfarzad F,Likousi S,Maroulis V,Papadakis MN,Vamvakopoulos NK,Aleporou-Marinou V,Patrinos GP,Kollia P

更新日期：2009-06-01 00:00:00

abstract：:To evaluate the outcomes of refractory/relapsed cHL patients after high-dose chemotherapy (HDCT) and autologous stem cell transplantation (ASCT) in Beijing Cancer hospital and to identify the prognostic risk factors. We retrospectively analyzed 115 relapsed/refractory cHL patients who accepted HDCT and ASCT in our can...

journal_title：Annals of hematology

authors： Xie Y,Wang X,Leng X,Zheng W,Ping L,Zhang C,Liu W,Deng L,Wu M,Song Y,Zhu J

更新日期：2020-03-01 00:00:00

abstract：:Indolent primary cutaneous B cell lymphomas (PCBCL) generally have a good prognosis, but they often relapse leading in some cases to extracutaneous disease and therefore, to poor survival. We developed a prognostic model to improve the therapeutic approach to these lymphomas. Two hundred and seventeen patients with di...

journal_title：Annals of hematology

authors： Mian M,Marcheselli L,Luminari S,Federico M,Cantonetti M,Sarris AH,Rossi A,Rambaldi A,Frontani M,Devizzi L,Gianni AM,Busetto M,Berti E,Martinelli G,Tsang RW,Ferreri AJ,Pinotti G,Pogliani E,Zucca E,Cortelazzo S

更新日期：2011-04-01 00:00:00

abstract：:Raised percentage hypochromic red cells (%HRC) were detected at diagnosis in 10 of 34 consecutive patients with low-risk myelodysplastic syndrome (MDS) [refractory anemia (RA) (4/26) and RA with ring sideroblasts (6/8)], all of whom had normal or increased serum ferritin and bone marrow iron stores. Elevated %HRC has ...

journal_title：Annals of hematology

authors： Murphy PT,Quinn JP,O'Donghaile D,Swords R,O'Donnell JR

更新日期：2006-07-01 00:00:00

abstract：:Follicular lymphoma (FL) is an indolent non-Hodgkin's lymphoma with heterogeneous outcomes. Progression or relapse of FL within 2 years (so-called POD24) after diagnosis is associated with a poor outcome for patients treated with R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, prednisone) in clinica...

journal_title：Annals of hematology

authors： Sortais C,Lok A,Tessoulin B,Gastinne T,Mahé B,Dubruille V,Blin N,Touzeau C,Moreau A,Bossard C,Peterlin P,Garnier A,Guillaume T,Le Bourgeois A,Chevallier P,Moreau P,Leux C,Le Gouill S

更新日期：2020-07-01 00:00:00

abstract：:Ruxolitinib, a JAK1 and JAK2 inhibitor, has been tested and approved for the treatment of primary and secondary myelofibrosis (MF). Aim of our study is to report safety and efficacy of ruxolitinib in 98 patients affected by MF treated outside clinical trials and collected and treated consecutively by the Lazio Coopera...

journal_title：Annals of hematology

authors： Breccia M,Andriani A,Montanaro M,Abruzzese E,Buccisano F,Cedrone M,Centra A,Villivà N,Celesti F,Trawinska MM,Massaro F,Di Veroli A,Anaclerico B,Colafigli G,Molica M,Spadea A,Petriccione L,Cimino G,Latagliata R

更新日期：2017-03-01 00:00:00

abstract：:Spontaneous splenic rupture is a rare, though life-threatening complication of some hematological malignancies and is even more infrequent as the initial symptom of acute lymphoblastic leukemia. We describe the fourth case, to our knowledge, of acute lymphoblastic leukemia presenting as splenic rupture, and for the fi...

journal_title：Annals of hematology

authors： Altès A,Brunet S,Martinez C,Soler J,Ayats R,Sureda A,López R,Domingo A

更新日期：1994-03-01 00:00:00

abstract：:Lymphoma-associated hemophagocytic lymphohistiocytosis (HLH) is a rare but fatal disease. Differences between B cell and T cell lymphoma-associated HLH remain unclear, specifically clinical characteristics and survival. We retrospectively analyzed 30 lymphoma-associated HLH patients from July 2004 to October 2012. Pat...

journal_title：Annals of hematology

authors： Yu JT,Wang CY,Yang Y,Wang RC,Chang KH,Hwang WL,Teng CL

更新日期：2013-11-01 00:00:00

abstract：:Infections and especially blood stream infections (BSI) with gram-negative bacteria (GNB) represent a major threat for patients with hematological diseases undergoing chemotherapy and mainly contribute to morbidity and mortality. In this retrospective single-center study, we analyzed the impact of BSI with different g...

journal_title：Annals of hematology

authors： Scheich S,Weber S,Reinheimer C,Wichelhaus TA,Hogardt M,Kempf VAJ,Kessel J,Serve H,Steffen B

更新日期：2018-11-01 00:00:00

abstract：:Transplantation of peripheral blood stem cells (PBSC), positively and/or negatively selected immediately after harvest, has become a widely applied therapeutic option in hematological or oncological patients. The following case of peripheral blood stem cell transplantation represents the first case of successful trans...

journal_title：Annals of hematology

authors： Humpe A,Riggert J,Wolf C,Binder C,Köhler M

更新日期：2001-02-01 00:00:00

abstract：:Although B chronic lymphocytic leukemia (B-CLL) cells express the alpha chain of the interleukin-2 (IL-2) receptor CD25, little is known about the effect of IL-2 on apoptosis in B-CLL cells. We have shown previously that stimulation of B-CLL cells with a CpG-oligonucleotide induces IL-2 high affinity receptors. In our...

journal_title：Annals of hematology

authors： Decker T,Bogner C,Oelsner M,Peschel C,Ringshausen I

更新日期：2010-11-01 00:00:00

abstract：:Treatment of acute lymphoblastic leukemia (ALL) requires the combination of multiple drugs to integrate a complete remission. The different prognostic factors (age, leukocytes, risk, cytogenetic alterations) allow identifying those patients with a high risk of relapse, but there are few described factors that impact t...

journal_title：Annals of hematology

authors： Ramos-Peñafiel C,Olarte-Carrillo I,Maldonado RC,de la Cruz Rosas A,Collazo-Jaloma J,Martínez-Tovar A

更新日期：2020-11-01 00:00:00

abstract：:Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic disease with thrombosis as a major complication. The mechanism of thrombosis and related risk factors in PNH patients are still not well characterized. We retrospectively enrolled 99 patients with newly diagnosed PNH at our institute from 2011 to 2016....

journal_title：Annals of hematology

authors： Huang Y,Liu X,Chen F,Zhou W,Li H,Long Z,Yang C,Chen M,Han B

更新日期：2019-10-01 00:00:00

abstract：:Patients with non-Hodgkin's lymphoma (NHL) receiving rituximab-containing chemotherapy are at risk of developing respiratory complications, but comprehensive information on these complications and their impact on survival is lacking. We performed a retrospective cohort analysis on 123 NHL patients who received rituxim...

journal_title：Annals of hematology

authors： Keefer K,Bender R,Liao J,Sivik J,Van de Louw A

更新日期：2018-12-01 00:00:00

abstract：:Hodgkin lymphoma (HL) in resource-poor population shows an early childhood peak with predominance of mixed cellularity (MCHL) and high Epstein-Barr virus (EBV) association, whereas HL in resource-rich population has a peak in ages 15-29 years with the predominance of nodular sclerosis (NSHL) and low EBV association. W...

journal_title：Annals of hematology

authors： Koh YW,Kang HJ,Yoon DH,Suh C,Kim JE,Kim CW,Huh J

更新日期：2013-12-01 00:00:00

abstract：:Thirty-four patients with acute myeloid leukemia (AML) in complete remission (CR), 30 of them aged over 60, received maintenance therapy scheduling four courses of low-dose cytarabine (LDA) 20 mg/m2/day in two subcutaneous injections for 3 weeks every 6 weeks. Each course was stopped when hematologic toxicity occurred...

journal_title：Annals of hematology

authors： Archimbaud E,Anglaret B,Thomas X,Jaubert J,Sebban C,Guyotat D,Fiere D

更新日期：1992-08-01 00:00:00

abstract：:The prognostic value of cytogenetics in adult acute lymphoblastic leukemia (ALL) is not as established as in childhood ALL. We have analyzed the outcome and prognostic value of karyotype in 84 adults diagnosed with Philadelphia-negative ALL from a single institution that received induction chemotherapy and had success...

journal_title：Annals of hematology

authors： Gómez-Seguí I,Cervera J,Such E,Martínez-Cuadrón D,Luna I,Ibáñez M,López-Pavía M,Gascón A,Roig M,Martínez J,Sanz J,Montesinos P,Martín-Aragonés G,Lorenzo I,Senent L,Barragán E,Cordón L,Sempere A,Sanz GF,Sanz MA

更新日期：2012-01-01 00:00:00

abstract：:Asplenic and hyposplenic patients have an increased risk for overwhelming pneumococcal infections, even several decades after splenectomy. Pneumococcal vaccination and daily oral administration of penicillin V are recommended to prevent such infections, 2-5 years after splenectomy, and for at least 5 years in children...

journal_title：Annals of hematology

authors： de Montalembert M,Lenoir G

更新日期：2004-01-01 00:00:00

abstract：:We screened for increased osmotic fragility of erythrocytes in 1464 healthy German blood donors. The osmotic fragility was determined by an acidified glycerol lysis test (AGLT) using glycerol-sodium phosphate-buffered NaCl solution. Since the original test described by Zanella et al. [23] showed only low specificity f...

journal_title：Annals of hematology

authors： Eber SW,Pekrun A,Neufeldt A,Schröter W

更新日期：1992-02-01 00:00:00

abstract：:It is often difficult for standard blood banks in Korea to supply adequate amounts of blood for patients with rare phenotype. Moreover, the definition of a blood in need is ambiguous, and much remains to be learned. In this study, we determined the prevalence of various red blood cell (RBC) antigens from a donor viewp...

journal_title：Annals of hematology

authors： Hong YJ,Chung Y,Hwang SM,Park JS,Kwon JR,Choi YS,Kim JN,Lee DH,Kwon SY,Cho NS,Song EY,Park KU,Song J,Han KS

更新日期：2016-05-01 00:00:00

abstract：:Rituximab induces B-cell depletion; therefore, it has been used in the treatment of immune thrombocytopenic purpura (ITP). The aim of this retrospective study was to evaluate the effectiveness of rituximab in the treatment of 89 patients with chronic ITP refractory to several treatments. All the patients had platelet ...

journal_title：Annals of hematology

authors： Peñalver FJ,Jiménez-Yuste V,Almagro M,Alvarez-Larrán A,Rodríguez L,Casado M,Gallur L,Giraldo P,Hernández R,Menor D,Rodríguez MJ,Caballero D,González R,Mayans J,Millán I,Cabrera JR,Multi-institutional Retrospective Spanish

更新日期：2006-06-01 00:00:00

abstract：:Chronic idiopathic neutropenia of adults (CINA) is a granulocytic disorder characterised by the "unexplained" decrease in the number of circulating neutrophils. Serum inflammatory cytokines and chemokines are increased in CINA. In addition, cytokines gene polymorphisms are associated with increased levels of respectiv...

journal_title：Annals of hematology

authors： Addas-Carvalho M,de Paula EV,Lima CS,Saad ST

更新日期：2005-10-01 00:00:00

abstract：:Somatic mutations in the SF3B1 gene, a gene encoding the splicing factor 3B subunit 1, were recently reported in myelodysplastic syndromes (MDS), particularly in the presence of ring sideroblasts (RS). The authors investigated the prevalence and clinical significance of SF3B1 mutations in Korean patients with myeloid ...

journal_title：Annals of hematology

authors： Seo JY,Lee KO,Kim SH,Kim K,Jung CW,Jang JH,Kim HJ

更新日期：2014-04-01 00:00:00

abstract：:Due to their homing properties, extranodal marginal zone B-cell lymphoma (MZBL) of mucosa-associated lymphoid tissue (MALT) type remain localized for long periods of time, and therefore have an excellent prognosis. However, if generalization and/or transformation into a diffuse large-cell lymphoma occurs, the prognosi...

journal_title：Annals of hematology

authors： Neumeister P,Hoefler G,Beham-Schmid C,Sill H,Linkesch W

更新日期：2000-12-01 00:00:00

abstract：:The laboratory diagnosis of hereditary spherocytosis (HS) is based on several screening and confirmatory tests; our algorithm includes clinical features, red blood cell morphology analysis and cryohaemolysis test, and, in case of positive screening, sodium dodecyl sulphate polyacrylamide gel electrophoresis as a diagn...

journal_title：Annals of hematology

authors： Lazarova E,Pradier O,Cotton F,Gulbis B

更新日期：2014-11-01 00:00:00