Abstract:
:Patients with non-Hodgkin's lymphoma (NHL) receiving rituximab-containing chemotherapy are at risk of developing respiratory complications, but comprehensive information on these complications and their impact on survival is lacking. We performed a retrospective cohort analysis on 123 NHL patients who received rituximab-containing chemotherapy between 2009 and 2016 in order to describe the incidence, etiologies and effect on survival of respiratory complications defined by new or worsening respiratory symptoms requiring diagnostic work-up or hospitalization. Thirty patients (24%) developed respiratory complications during a follow-up time of 825 (555-1338) days after chemotherapy. They had a higher prevalence of congestive heart failure and lung or pleural involvement at diagnosis as compared to patients who did not develop complications. Overall, 58 episodes of pulmonary complications were observed after median (interquartile) times from the first and last rituximab doses of 205 (75-580) days and 27 (14-163) days respectively. Infectious etiologies accounted for 75% of the respiratory complications, followed by heart failure exacerbation, lymphomatous involvement, and ARDS. Two Pneumocystis jirovecii pneumonias were observed, and no complication was ascribed to rituximab toxicity. Respiratory complications required ICU admission in 19 cases (33%) and invasive mechanical ventilation in 14 cases (24%). Using a time-dependent Cox regression analysis, we observed that the occurrence of respiratory complications was associated with a 170% increase in death hazard (hazard ratio 2.65, 95% CI 1.60-4.40, p = 0.001). In conclusion, respiratory complications in NHL patients receiving chemotherapy are relatively frequent, severe, and mostly infectious and are associated with increased mortality.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Keefer K,Bender R,Liao J,Sivik J,Van de Louw Adoi
10.1007/s00277-018-3448-9subject
Has Abstractpub_date
2018-12-01 00:00:00pages
2373-2380issue
12eissn
0939-5555issn
1432-0584pii
10.1007/s00277-018-3448-9journal_volume
97pub_type
临床试验,杂志文章abstract::Isocitrate dehydrogenase IDH 1 and IDH 2 mutations were reported in several cancer forms, especially in hematological malignancies, but were never been investigated in familial aggregation. The aim of this study is to determine whether germline isocitrate dehydrogenase genes mutations are involved.We targeted IDH1 and...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-016-2813-9
更新日期:2016-12-01 00:00:00
abstract::Chronic idiopathic neutropenia (CIN) has been well recognized as a granulocytic disorder not associated with increased risk to malignant transformation. Four cases, however, of acute myeloid leukemia have been recently reported in patients with CIN. In the current paper, we report on a CIN patient who developed acute ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-004-0862-y
更新日期:2004-06-01 00:00:00
abstract::The requirement of antifungal prophylaxis has not been established in the chemotherapies for malignant lymphoma. This study was conducted to explore the incidence of invasive fungal diseases (IFD) and their risk factors in patients receiving salvage therapies for malignant lymphoma. We retrospectively analyzed 177 con...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-014-2093-1
更新日期:2014-10-01 00:00:00
abstract::Although lenalidomide plus dexamethasone (RD) is a therapeutic option for relapsed/refractory multiple myeloma (RRMM), limited real-world clinical data exist. The purpose of this study was to estimate efficacy and safety of RD in RRMM patients of the clinical practice. Data from patients at 25 university hospitals in ...
journal_title:Annals of hematology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s00277-019-03904-7
更新日期:2020-02-01 00:00:00
abstract::The aim of this study was to analyze the ability of an alloantibody from a patient with severe von Willebrand disease (vWD) to interfere with the vWF domain for FVIII, to inhibit factor VIII (FVIII), and to compare it with a rabbit polyclonal antibody. The vWF domain for binding to FVIII was assayed by a method previo...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770050323
更新日期:1997-09-01 00:00:00
abstract::A retrospective study of 120 patients with the clinically and histologically established diagnosis of idiopathic (primary) myelofibrosis (IMF) was performed to determine prognostic factors of predictive value, including parameters characterizing the dynamics of hematopoietic cell kinetics. In contrast to previous stud...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770050474
更新日期:1999-02-01 00:00:00
abstract::The patient was initially diagnosed as having non-Hodgkin's lymphoma and was cured following treatment with prednisolone, vincristine, daunorubicin, 1-asparaginase, and cyclophosphamide. Seven years and two months later, he developed osteosarcoma in his right femur. He received chemotherapy consisting of methotrexate,...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770050264
更新日期:1997-02-01 00:00:00
abstract::Although eosinophilia has been reported as a side effect of purine analogues, there is no report on fludarabine-induced eosinophilia in chronic lymphocytic leukemia (CLL). During chemotherapy with fludarabine and cyclophosphamide, we observed two cases of significant eosinophilia. A 67-year-old patient with CLL develo...
journal_title:Annals of hematology
pub_type: 杂志文章,评审
doi:10.1007/s002770050602
更新日期:1999-10-01 00:00:00
abstract::Although retreatment with alemtuzumab in relapsing B-cell chronic lymphocytic leukemia (CLL) may be beneficial, there has thus far been no thorough analysis available on this topic. Data were collected from 30 chemotherapy-pretreated patients with progressive CLL who had received alemtuzumab twice in consecutive, dist...
journal_title:Annals of hematology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00277-011-1192-5
更新日期:2011-09-01 00:00:00
abstract::The aim of this review is to summarize the current knowledge on the clinical results of biotherapy of chronic myelogenous leukemia (CML) and potential mechanisms of the antitumor action of interferon alpha. IFN alpha treatment induces hematologic and cytogenetic remissions in patients with chronic phase CML. In additi...
journal_title:Annals of hematology
pub_type: 杂志文章,评审
doi:10.1007/BF01682030
更新日期:1995-03-01 00:00:00
abstract::The incidence of multiple myeloma (MM) has increased in the last 20 years, particularly in middle and low-middle income countries. Access to diagnostic and prognostic tests and the availability of effective care is highly variable globally. Latin America represents 10% of the world population, distributed in countries...
journal_title:Annals of hematology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s00277-020-03983-x
更新日期:2020-05-01 00:00:00
abstract::We discuss possible justifications to split study populations from a biometrical point of view. The existence of prognostic differences between subgroups are neither a sufficient nor a necessary reason to justify a splitting decision. There are essentially two separate types of relevant arguments to justify a split of...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/pl00022792
更新日期:2001-01-01 00:00:00
abstract::Chronic graft-versus-host disease (cGVHD) is an important complication after allogeneic hematopoietic stem cell transplantation (HSCT). To define the roles of T-cells and B-cells in cGVHD, a murine minor histocompatibility complex-mismatched HSCT model was used. Depletion of donor splenocyte CD4(+) T-cells and B220(+)...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-015-2394-z
更新日期:2015-09-01 00:00:00
abstract::Gastrointestinal graft-versus-host disease (GVHD) is one of the main causes of therapy-related death after allogeneic hemopoietic stem cell transplantation. Early diagnosis and immediate treatment are probably essential for improving clinical outcome. High-resolution sonography allows the evaluation of single bowel wa...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-004-0893-4
更新日期:2005-01-01 00:00:00
abstract::The relationship between Epstein-Barr virus (EBV) and the host is profoundly disturbed by allogeneic bone marrow transplantation (BMT) because EBV resides in the recipient's hematopoietic system, which has to be destroyed in the majority of cases, and in the donor's hematopoietic system, i.e., the marrow graft. We hav...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/BF01715373
更新日期:1992-06-01 00:00:00
abstract::A 40-year-old patient with low-grade B-NHL developed a generalized macular-papular rash following the first cycle of fludarabine treatment which progressed to a complete epidermal necrolysis following the second cycle. Clinical symptoms and the results of the direct and indirect immunofluorescence were consistent with...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770050347
更新日期:1997-11-01 00:00:00
abstract::In the context of discussions on the reproducibility of clinical studies, we reanalyzed a prospective randomized study on the role of splenic irradiation as adjunct to the conditioning for hematopoietic stem cell transplantation (HSCT) for chronic myeloid leukemia (CML). Between 1986 and 1989, a total of 229 patients ...
journal_title:Annals of hematology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00277-016-2638-6
更新日期:2016-05-01 00:00:00
abstract::Pulmonary infections are a major cause of morbidity and mortality in patients with hematologic malignancy. Bronchoscopy is at present still the traditional first investigation in immunosuppressed patients that have developed pulmonary infiltrates. There is limited data available on the validity of fiberoptic bronchosc...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-014-2172-3
更新日期:2015-01-01 00:00:00
abstract::This retrospective study evaluated the benefit of alemtuzumab monotherapy in unselected patients with advanced B-cell chronic lymphocytic leukemia (CLL) and prolymphocytic leukemia (B-PLL) to definitely describe the impact of this antibody in clinical routine use. Data were collected from 208 consecutive, mainly pretr...
journal_title:Annals of hematology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s00277-013-1966-z
更新日期:2014-02-01 00:00:00
abstract::Asplenic and hyposplenic patients have an increased risk for overwhelming pneumococcal infections, even several decades after splenectomy. Pneumococcal vaccination and daily oral administration of penicillin V are recommended to prevent such infections, 2-5 years after splenectomy, and for at least 5 years in children...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-003-0779-x
更新日期:2004-01-01 00:00:00
abstract::During the last few years, new insights into the biology of mantle cell lymphoma have been obtained. However, with a median survival of only 3 years, mantle cell lymphoma remains the lymphoma subtype with the poorest prognosis. At initial diagnosis most patients present with advanced Ann Arbor stage III or IV and conv...
journal_title:Annals of hematology
pub_type: 杂志文章,评审
doi:10.1007/s00277-003-0774-2
更新日期:2004-02-01 00:00:00
abstract::We have established reference values of peripheral blood lymphocyte subsets in healthy female Wistar rats under highly standardized conditions. Using monoclonal antibodies and flow cytometry, T lymphocytes (OX19+), B lymphocytes (OX6+ and anti-Ig+), T-helper/inducer (W3/25+), and T-suppressor/cytotoxic subsets (OX8+) ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/BF01701732
更新日期:1993-09-01 00:00:00
abstract::Polycythemias or erythrocytoses in childhood and adolescence are very rare. Systematic data on the clinical presentation and laboratory evaluations as well as on treatment regimens are sparse. The diagnostic program in absolute erythrocytosis includes extensive clinical, hematological, biochemical, and molecular biolo...
journal_title:Annals of hematology
pub_type: 杂志文章,评审
doi:10.1007/s00277-004-0985-1
更新日期:2005-03-01 00:00:00
abstract::Rituximab was recently described also as first-line therapy of chronic graft-versus-host disease (cGvHD). We retrospectively analyzed the efficacy and safety of all patients receiving rituximab for treatment of cGvHD between 2005 and 2016 at the Regensburg University transplant center with a median follow-up after rit...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-019-03768-x
更新日期:2019-10-01 00:00:00
abstract::We describe the beneficial effect of recombinant alpha 2b interferon in a woman with an idiopathic and refractory IgM-mediated autoimmune hemolytic anemia due to low-titer, high-thermal-amplitude cold agglutinins. The response was partial but sustained, 2 months after interruption of interferon, with hemoglobin concen...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/BF01695696
更新日期:1994-09-01 00:00:00
abstract::We report about a 28-year-old woman with relapsed mantle cell lymphoma (MCL, centrocytic lymphoma according to the Kiel classification) refractory to salvage chemotherapy. The patient underwent allogeneic bone marrow transplantation from a HLA-identical brother after myeloablative chemotherapy consisting of busulfan, ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770000196
更新日期:2000-10-01 00:00:00
abstract::Allogeneic hematopoietic stem cell transplantation (allo-SCT) is a therapeutic option for relapsed, advanced, and otherwise incurable non-Hodgkin's lymphomas (NHL) suggested by the existence of a graft-versus-lymphoma effect. The main complications are graft-versus-host disease and infections. We performed a retrospec...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-017-2934-9
更新日期:2017-05-01 00:00:00
abstract::This retrospective single-center analysis studied the impact of the conditioning and the graft-versus-host disease (GVHD) prophylaxis on outcome in unselected patients allografted for chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML) secondary to documented prior CMML. A total of 44 patients (med...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-020-03952-4
更新日期:2020-04-01 00:00:00
abstract::There is little information about cardiovascular adverse event (CV-AE) incidence in chronic myeloid leukemia (CML) patients treated with bosutinib in the real-life practice. We identified 54 consecutive CML patients treated with bosutinib, stratified according to the Systematic Coronary Risk Evaluation (SCORE) assessm...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-019-03705-y
更新日期:2019-08-01 00:00:00
abstract::Paul Kaznelson is credited with describing the first case of pure red cell aplasia. He was also known for his contribution to the discovery of the therapeutic role of splenectomy in idiopathic thrombocytopenic purpura. Most of his academic works appeared in 1910s and 1920s, when he used to work in Karl-Ferdinand Unive...
journal_title:Annals of hematology
pub_type: 传,历史文章,杂志文章
doi:10.1007/s00277-008-0553-1
更新日期:2008-11-01 00:00:00