Abstract:
:We describe the beneficial effect of recombinant alpha 2b interferon in a woman with an idiopathic and refractory IgM-mediated autoimmune hemolytic anemia due to low-titer, high-thermal-amplitude cold agglutinins. The response was partial but sustained, 2 months after interruption of interferon, with hemoglobin concentrations ranging between 8.5 and 10 g/dl. In the literature, such rarely encountered hemolyzing warm-reacting agglutinins are described as causing severe hemolysis with a frequently fatal clinical outcome.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Fest T,de Wazières B,Lamy B,Maskani M,Vuitton D,Dupond JLdoi
10.1007/BF01695696subject
Has Abstractpub_date
1994-09-01 00:00:00pages
147-9issue
3eissn
0939-5555issn
1432-0584journal_volume
69pub_type
杂志文章abstract::Recently we described a cutaneous T-cell lymphoma expressing the gamma/delta T-cell receptor [5]. The patient suffering from this lymphoma showed low numbers of myeloid and T cells in peripheral blood, while B and NK cells were relatively increased. In vitro culture of the patient's bone marrow (BM) cells revealed a s...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/BF01695808
更新日期:1992-09-01 00:00:00
abstract::Multiresistant bacterial infections are a potentially life-threatening condition in acute leukaemia (AL) patients. We aimed to better define the very recent epidemiology and outcome of bloodstream infections (BSIs) in a real-life setting. We prospectively collected all consecutive febrile/infectious episodes occurring...
journal_title:Annals of hematology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00277-016-2815-7
更新日期:2016-12-01 00:00:00
abstract::Immune thrombocytopenia (ITP) is characterised by a transient or persistent decrease in platelets accompanied by an increased risk of bleeding, which can have a significant negative impact on patients' health-related quality of life. The condition has long been associated with an increased rate of immune-mediated plat...
journal_title:Annals of hematology
pub_type: 杂志文章,评审
doi:10.1007/s00277-010-0953-x
更新日期:2010-07-01 00:00:00
abstract::Although retreatment with alemtuzumab in relapsing B-cell chronic lymphocytic leukemia (CLL) may be beneficial, there has thus far been no thorough analysis available on this topic. Data were collected from 30 chemotherapy-pretreated patients with progressive CLL who had received alemtuzumab twice in consecutive, dist...
journal_title:Annals of hematology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00277-011-1192-5
更新日期:2011-09-01 00:00:00
abstract::Hematopoietic recovery after high-dose chemotherapy (HDC) in the treatment of hematological diseases may be slow and/or incomplete. This is generally attributed to progressive hematopoietic stem cell failure, although defective hematopoiesis may be in part due to poor stromal function. Chemotherapy is known to damage ...
journal_title:Annals of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s00277-009-0896-2
更新日期:2010-07-01 00:00:00
abstract::We tested two Fc gamma receptor I (Fc gamma RI); six Fc gamma RII; and six Fc gamma RIII-specific monoclonal antibodies (mAb) for their capacity to inhibit monocyte and polymorphonuclear granulocyte (PMN) immune phagocytosis which is mediated by Fc gamma R. We used human red blood cells (rbc) coated with hIgG1 or mIgG...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770050249
更新日期:1997-01-01 00:00:00
abstract::We retrospectively evaluated the role of rituximab (R) in maintenance treatment after autologous stem cell transplantation performed in patients with relapsed follicular lymphoma. We compared the outcome of 67 follicular lymphoma (FL) patients according to the use of rituximab maintenance (RM) or not. All patients rec...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-016-2705-z
更新日期:2016-08-01 00:00:00
abstract::The practical usefulness of Helicobacter pylori eradication for immune thrombocytopenia (ITP) patients is still controversial. However, some ITP patients respond to H. pylori eradication. We conducted a multi-center, open label, prospective phase II study to define the efficacy and toxicities of H. pylori eradication ...
journal_title:Annals of hematology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00277-014-2268-9
更新日期:2015-05-01 00:00:00
abstract::Extranodal natural killer/T cell lymphoma, nasal type (ENKTL) is an aggressive disease with a poor prognosis, requiring risk stratification in affected patients. We designed a new prognostic model specifically for ENKTL to identify high-risk patients who need more aggressive therapy. We retrospectively reviewed 158 pa...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-014-2089-x
更新日期:2014-09-01 00:00:00
abstract::The cytogenetic and molecular data is recognized as the most valuable prognostic factor in acute myeloid leukemia (AML). Our aim was to systemically analyze the cytogenetics of Korean AML patients and to compare the cytogenetic profiles of various races to identify possible geographic heterogeneity. We retrospectively...
journal_title:Annals of hematology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00277-016-2691-1
更新日期:2016-08-01 00:00:00
abstract::The aim of this epidemiologic population survey was to assess the penetrance of the most frequent hemochromatosis (HFE) gene variants in ethnic Danish men. A cohort of 6,020 men aged 30-53 years was screened for HFE C282Y, H63D, and S65C variants by restriction fragment length polymorphism analysis. Subsequently, iron...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-008-0679-1
更新日期:2009-08-01 00:00:00
abstract::Treatment of relapse and primary progression in aggressive lymphoma remains unsatisfactory; outcome is still poor. Better treatment strategies are much needed for this patient population. The R1 study is a prospective multi-center phase I/II study evaluating a dose finding approach with a triple transplant regimen in ...
journal_title:Annals of hematology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00277-016-2671-5
更新日期:2016-06-01 00:00:00
abstract::It is often difficult for standard blood banks in Korea to supply adequate amounts of blood for patients with rare phenotype. Moreover, the definition of a blood in need is ambiguous, and much remains to be learned. In this study, we determined the prevalence of various red blood cell (RBC) antigens from a donor viewp...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-016-2645-7
更新日期:2016-05-01 00:00:00
abstract::We encountered two patients who presented with hypochromic-microcytic anemia and were refractory to iron therapy. The symptoms were suggestive of anemia of chronic disease (ACD); however, there was no evidence of any such disease, either inflammatory or malignant. These patients were reminiscent of patients originally...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770000180
更新日期:2000-08-01 00:00:00
abstract::The prognostic impact of extramedullary plasmacytomas (EMPs) on newly diagnosed symptomatic multiple myeloma (MM) was evaluated in the context of treatment approach including autologous stem cell transplantation (ASCT) and chemotherapy alone. A total of 275 consecutive patients with newly diagnosed MM were included, a...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-014-2216-8
更新日期:2015-03-01 00:00:00
abstract::The effects of romiplostim on bone marrow morphology were evaluated in adults with immune thrombocytopenia (ITP). Patients with platelet counts <50 × 10(9)/L, ≥1 prior ITP therapies, and no collagen at baseline received weekly subcutaneous romiplostim starting at 1 μg/kg, adjusted to maintain platelet counts between 5...
journal_title:Annals of hematology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00277-016-2682-2
更新日期:2016-06-01 00:00:00
abstract::The hemoglobinopathies are a group of disorders passed down through families (inherited) in which there is abnormal production or structure of the hemoglobin molecule. They are among the most common inherited diseases around the world. Those that produce abnormal hemoglobin are called structural hemoglobinopathies whi...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-019-03696-w
更新日期:2019-07-01 00:00:00
abstract::Gastrointestinal graft-versus-host disease (GVHD) is one of the main causes of therapy-related death after allogeneic hemopoietic stem cell transplantation. Early diagnosis and immediate treatment are probably essential for improving clinical outcome. High-resolution sonography allows the evaluation of single bowel wa...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-004-0893-4
更新日期:2005-01-01 00:00:00
abstract::Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in European adults. We aimed to evaluate time trends in CLL incidence and medical resource utilisation of CLL patients in the UK. We conducted a retrospective, observational cohort analysis using the UK Clinical Practice Research Datalink (CPRD) comprisi...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-014-2217-7
更新日期:2015-03-01 00:00:00
abstract::t(8;16)(p11.2;p13.3)/KAT6A-CREBBP is a rare recurrent cytogenetic abnormality associated with acute myeloid leukemia (AML). We report 15 cases with t(8;16)(p11.2;p13.3). All patients were adult and had AML: 13 women and 2 men, with a median age of 50 years. Ten patients had a history of malignancy and received cytotox...
journal_title:Annals of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s00277-019-03637-7
更新日期:2019-05-01 00:00:00
abstract::An acute leukemia with an unusual immunophenotype developed in a 17-year-old girl. At the initial presentation, extramedullary involvement was not evident, but with advancing disease, massive splenomegaly and an osteolytic rib tumor developed. The disease was aggressive and refractory to intensive chemotherapeutic reg...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770050472
更新日期:1999-01-01 00:00:00
abstract::Repeated courses of HD IVIg are reported to induce stable remission in a significant proportion of adults with chronic refractory ITP. We have treated 14 such patients obtaining a remission rate quite comparable to the 5-10% of spontaneous remission. ...
journal_title:Annals of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/BF01834386
更新日期:1995-02-01 00:00:00
abstract::Evaluation of bone marrow involvement (BMI) by conventional bone marrow biopsy (BMB) can generate false-negative results if marrow disease is focal. The sensitivity of 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) in assessing BMI in extranodal NK/T cell lymphoma (ENKL) h...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-014-2289-4
更新日期:2015-06-01 00:00:00
abstract::Patients with chronic lymphocytic leukemia (CLL) who receive chemoimmunotherapy and do not achieve complete remission experience significantly shortened progression-free interval (PFS). Additionally, the majority of patients treated for relapsed disease demonstrate evidence of measurable disease. Eradication of minima...
journal_title:Annals of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s00277-016-2683-1
更新日期:2016-06-01 00:00:00
abstract::Cancer incidence in patients with recurrent unprovoked venous thromboembolism (VTE) is much higher than after a first event, but the incidence of myeloproliferative neoplasms (MPN) in this situation is still unknown. We tested for JAK2V617F and calreticulin mutants, 372 DNA samples of patients treated for (VTR). Among...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-016-2853-1
更新日期:2017-03-01 00:00:00
abstract::Rituximab was recently described also as first-line therapy of chronic graft-versus-host disease (cGvHD). We retrospectively analyzed the efficacy and safety of all patients receiving rituximab for treatment of cGvHD between 2005 and 2016 at the Regensburg University transplant center with a median follow-up after rit...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-019-03768-x
更新日期:2019-10-01 00:00:00
abstract::We investigated the efficacy of an antithymocyte globulin/cyclophosphamide preparative regimen prior to allogeneic stem cell transplantation from HLA-identical siblings in patients with severe aplastic anemia. Since 1990, 21 patients, 6 males and 15 females, with a median age of 25 years (range: 7-43) have been enroll...
journal_title:Annals of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s00277-002-0566-0
更新日期:2002-11-01 00:00:00
abstract::Information regarding prognostic determinants of outcome after splenectomy for adult immune thrombocytopenic purpura (ITP) and the management of postsplenectomy relapse is limited. Among 140 adult patients with ITP who had therapeutic splenectomy at our institution, 88% achieved either a complete (platelets > 150 x 10...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-002-0461-8
更新日期:2002-06-01 00:00:00
abstract::The benefits of intensive post-remission chemotherapy have not been verified in elderly patients with acute myeloid leukemia (AML). To reduce fatal complications caused by intensive post-remission therapy, we performed a prospective phase II multicenter trial of standard induction chemotherapy ('7+3' of cytarabine plu...
journal_title:Annals of hematology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00277-006-0110-8
更新日期:2006-06-01 00:00:00
abstract::Several revisions of International Prognostic Index (IPI) have been proposed for patients with diffuse large B-cell lymphoma (DLBCL) after the introduction of rituximab. Expanding evidence suggests that baseline absolute lymphocyte count (ALC) is also an independent factor for outcome prediction. We investigated the o...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-013-1807-0
更新日期:2013-11-01 00:00:00