Successful response to alpha-interferon 2b in a refractory IgM autoagglutinin-mediated hemolytic anemia.

Abstract:

:We describe the beneficial effect of recombinant alpha 2b interferon in a woman with an idiopathic and refractory IgM-mediated autoimmune hemolytic anemia due to low-titer, high-thermal-amplitude cold agglutinins. The response was partial but sustained, 2 months after interruption of interferon, with hemoglobin concentrations ranging between 8.5 and 10 g/dl. In the literature, such rarely encountered hemolyzing warm-reacting agglutinins are described as causing severe hemolysis with a frequently fatal clinical outcome.

journal_name

Ann Hematol

journal_title

Annals of hematology

authors

Fest T,de Wazières B,Lamy B,Maskani M,Vuitton D,Dupond JL

doi

10.1007/BF01695696

subject

Has Abstract

pub_date

1994-09-01 00:00:00

pages

147-9

issue

3

eissn

0939-5555

issn

1432-0584

journal_volume

69

pub_type

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