Abstract:
:Although B chronic lymphocytic leukemia (B-CLL) cells express the alpha chain of the interleukin-2 (IL-2) receptor CD25, little is known about the effect of IL-2 on apoptosis in B-CLL cells. We have shown previously that stimulation of B-CLL cells with a CpG-oligonucleotide induces IL-2 high affinity receptors. In our current work, we analyzed the effect of IL-2 on apoptosis in resting B-CLL cells and in our model of activated B-CLL cells (CD25 high cells). IL-2 had modest antiapoptotic activity in resting B-CLL cells. In contrast, IL-2 was much more potent to prevent apoptosis in activated cells. Prevention of cell death was also associated with the maintenance of the mitochondrial membrane potential. While only limited regulation of apoptosis controlling proteins was observed in resting B-CLL cells, IL-2 had strong effects on MCL-1, Bcl-xl, and survivin expression and inhibited Bax cleavage in CD25 high cells. Interestingly, expression of Bcl-2 was reduced. Addition of IL-2 to activated B-CLL cells caused rapid phosphorylation of Akt, while IL-2 failed to significantly phosphorylate Akt in resting B-CLL cells. Pharmacological inhibition of Akt by LY294002 restored sensitivity of activated B-CLL cells to fludarabine. IL-2 might be an important survival factor in activated B-CLL cells and might contribute to disease progression by upregulation of several critical antiapoptotic proteins.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Decker T,Bogner C,Oelsner M,Peschel C,Ringshausen Idoi
10.1007/s00277-010-0994-1subject
Has Abstractpub_date
2010-11-01 00:00:00pages
1125-32issue
11eissn
0939-5555issn
1432-0584journal_volume
89pub_type
杂志文章abstract::The prognosis of patients with stage III/IV NK/T-cell lymphoma (NTCL) is extremely poor. Although L-asparaginase (L-asp) is effective for NTCL, its significance has not been clearly demonstrated. In addition, there are few studies comparing treatment outcomes in stage III/IV NTCL. This study evaluated the efficacy of ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-014-2228-4
更新日期:2015-03-01 00:00:00
abstract::We retrospectively evaluated the role of rituximab (R) in maintenance treatment after autologous stem cell transplantation performed in patients with relapsed follicular lymphoma. We compared the outcome of 67 follicular lymphoma (FL) patients according to the use of rituximab maintenance (RM) or not. All patients rec...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-016-2705-z
更新日期:2016-08-01 00:00:00
abstract::Ruxolitinib, a JAK1 and JAK2 inhibitor, has been tested and approved for the treatment of primary and secondary myelofibrosis (MF). Aim of our study is to report safety and efficacy of ruxolitinib in 98 patients affected by MF treated outside clinical trials and collected and treated consecutively by the Lazio Coopera...
journal_title:Annals of hematology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00277-016-2884-7
更新日期:2017-03-01 00:00:00
abstract::Therapy-induced autoimmunity may mediate the destruction of cancer cells. Previous studies have demonstrated that presence of autoimmune thyroid disorder is associated with favorable outcome in patients with solid cancer. Patients with diffuse large B cell lymphoma (DLBCL) who achieved complete response on positron em...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-015-2311-5
更新日期:2015-06-01 00:00:00
abstract::Follicular lymphoma (FL) is a low-grade lymphoma that is usually characterized by generalized lymphadenopathy. Extranodal invasion by FL generally involves the bone marrow, skin, and duodenum; splenic infiltration often occurs in the advanced stages. However, primary splenic FL is very rare. Hence, few studies have be...
journal_title:Annals of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s00277-017-3139-y
更新日期:2017-12-01 00:00:00
abstract::The BCR/ABL1 fusion gene is mainly caused by the t(9; 22)(q34; q11.2) translocation, which results in the Philadelphia (Ph) chromosome. The Ph chromosome is the typical hallmark in chronic myeloid leukemia (CML), but can also be present in acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). The BCR/AB...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-001-0424-5
更新日期:2002-03-01 00:00:00
abstract::Establishing reference ranges by multiparametric immunophenotyping of mature B cells in bone marrow of healthy adults is of interest because the detection of bone marrow infiltration and persistence of light chain restriction, as well as discrimination between reactive and malignant lymphocytes are important applicati...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/BF01702647
更新日期:1995-09-01 00:00:00
abstract::Anthracyclines are a major component in the therapy of non-Hodgkin's lymphoma. However, due to their cardiac toxicity potential, curative and palliative treatment is often limited in patients with preexisting cardiac dysfunction. Liposomal doxorubicin formulations have been described to be less cardiotoxic than conven...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-011-1308-y
更新日期:2012-03-01 00:00:00
abstract::A 4-day colorimetric tetrazolium dye (MTT) assay was used to assess the cytotoxicity of adriamycin (ADM), vincristine (VCR), and idarubicin (IDA) in blasts isolated from 37 patients with newly diagnosed and pretreated acute myeloid leukemia (AML). The effect of verapamil (VRP) as a chemosensitizer was studied in relat...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/BF01703946
更新日期:1992-11-01 00:00:00
abstract::Post-transplantation cyclophosphamide (PTCy) demonstrated effectiveness to prevent GVHD after haploidentical hematopoietic cell transplantation (HCT). Reducing toxicities with a maximized efficacy is still challenging in HCT. In this retrospective study, we analyzed the safety and efficacy of transplantation from a 1-...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-019-03673-3
更新日期:2019-06-01 00:00:00
abstract::Cancer incidence in patients with recurrent unprovoked venous thromboembolism (VTE) is much higher than after a first event, but the incidence of myeloproliferative neoplasms (MPN) in this situation is still unknown. We tested for JAK2V617F and calreticulin mutants, 372 DNA samples of patients treated for (VTR). Among...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-016-2853-1
更新日期:2017-03-01 00:00:00
abstract::This retrospective single-center analysis studied the impact of the conditioning and the graft-versus-host disease (GVHD) prophylaxis on outcome in unselected patients allografted for chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML) secondary to documented prior CMML. A total of 44 patients (med...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-020-03952-4
更新日期:2020-04-01 00:00:00
abstract::Anaphylactoid reaction to cyclophosphamide administration in a 85-year old woman is described. Symptomatology was restricted to bronchospasm, which regressed within one hour. This incomplete and rapidly regressive symptomatology might be explained by previous administration of methylprednisolone. No anaphylactoid symp...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/BF01714904
更新日期:1991-02-01 00:00:00
abstract::Activation-induced cytidine deaminase (AID) is a mutator enzyme essential for somatic hypermutation (SHM) and class switch recombination (CSR) during effective adaptive immune responses. Its aberrant expression and activity have been detected in lymphomas, leukemias, and solid tumors. In chronic lymphocytic leukemia (...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-018-3520-5
更新日期:2019-02-01 00:00:00
abstract::Recommendations for dyslipidemia management aimed at reducing arterial occlusive events (AOEs) have been recently published. So far, no data have been reported on the management of dyslipidemia in chronic myeloid leukemia (CML) patients treated with nilotinib. We investigated 369 CML adult patients, stratified accordi...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-020-04392-w
更新日期:2021-01-03 00:00:00
abstract::Reactivation of fetal hemoglobin synthesis in adulthood can be seen in hematological disorders affecting the erythropoietic system. The objective of the present study was to evaluate the incidence and prognostic significance of increased hemoglobin F in patients with myelodysplastic syndrome. Hemoglobin F concentratio...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770050377
更新日期:1998-03-01 00:00:00
abstract::Abnormal blood coagulation often occurs in critically ill patients, which seriously affects their prognosis. This retrospective study investigated the implications of changes in blood coagulation in patients with coronavirus disease 2019 (COVID-19). Records were reviewed for patients admitted with COVID-19 between Feb...
journal_title:Annals of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s00277-020-04305-x
更新日期:2021-01-01 00:00:00
abstract::High-dose immunosuppressive therapy (HDIT) with autologous hematopoietic stem cell transplantation (AHSCT) is a promising approach to treatment of multiple sclerosis (MS) patients. In this paper, we present the long-term outcomes of a prospective single-center study with the analysis of the safety and efficacy of HDIT...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-015-2337-8
更新日期:2015-07-01 00:00:00
abstract::Overproduction of proinflammatory cytokines is characteristic of hemophagocytic syndrome (HPS), a highly lethal inflammatory disease. Peripheral blood monocytes include two distinct subpopulations according to surface antigen expression: a major type, CD14(+)/CD16(-) (classical monocytes), and a minor type, CD14(+)/CD...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-007-0332-4
更新日期:2007-11-01 00:00:00
abstract::Patients with Philadelphia chromosome-positive (Ph+) and/or BCR-ABL+ acute lymphoblastic leukemia (ALL) have extremely poor prognoses. Most of these patients have additional, heterogenous karyotype abnormalities, the majority of which have uncertain clinical significance. In this study we analyzed the clinical charact...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-006-0099-z
更新日期:2006-06-01 00:00:00
abstract::Pre-eclampsia is a condition observed during pregnancy and threatens the life of both mother and foetus. There are studies, which suggest platelets play a major role in the pathogenesis of pre-eclampsia. The aim of this study is to compare the complete blood count (CBC) parameters, especially platelet count and mean p...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-006-0091-7
更新日期:2006-05-01 00:00:00
abstract::Standard conditioning for allogeneic bone marrow transplantation induces high transplant-related mortality (TRM) in patients with a poor performance status. Less intensive regimens have been tested to reduce the TRM; our purpose was to evaluate the feasibility and tolerability of a new combination: thiotepa and fludar...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770100344
更新日期:2001-09-01 00:00:00
abstract::Cryoglobulinemia is uncommon in Southern Chinese in Hong Kong, with tropical climates and low incidence of hepatitis C virus (HCV) infection. Eight positive cases were detected among 481 patients screened for cryoglobulins over a 10-year period. Three HCV carriers (38%) ran benign courses. The others included two carr...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-004-0955-7
更新日期:2005-02-01 00:00:00
abstract::Marked polyclonal immunoglobulin (Ig)G4 hypergammaglobulinemia has exceptionally been reported. Here we report on two Algerian patients who presented a syndrome characterized by anemia, plasmacytic lymphadenopathy, renal manifestations, and a marked polyclonal IgG4 hypergammaglobulinemia leading to a hyperviscosity sy...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-006-0158-5
更新日期:2006-12-01 00:00:00
abstract::This retrospective study attempts to establish if a correlation exists between osteoporosis and hematopoiesis before and after adjuvant chemotherapy in the context of non-metastatic breast cancer. Osteoporosis is interpreted both as a direct marker of osteoblastic decline and as an indirect marker of increased bone ma...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-017-3184-6
更新日期:2018-02-01 00:00:00
abstract::NUT midline carcinoma (NMC) is an aggressive neoplasm and mainly involved in the head and neck area. The defining genetic hallmark on these tumors is that testis-specific nuclear gene (NUTM1) fuses to bromodomain protein family member 4 gene (BRD4), resulting in the formation of BRD4-NUTM1 transcript. Here, we report ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-020-04000-x
更新日期:2020-07-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) have emerged as a therapeutic approach in a range of medical fields, including regenerative medicine, cancer, autoimmune diseases, and inflammatory diseases, because of their unique properties of tissue repair and major histocompatibility complex-unmatched immunosuppression. Because both ...
journal_title:Annals of hematology
pub_type: 杂志文章,评审
doi:10.1007/s00277-013-1796-z
更新日期:2013-10-01 00:00:00
abstract::The aim of this review is to summarize the current knowledge on the clinical results of biotherapy of chronic myelogenous leukemia (CML) and potential mechanisms of the antitumor action of interferon alpha. IFN alpha treatment induces hematologic and cytogenetic remissions in patients with chronic phase CML. In additi...
journal_title:Annals of hematology
pub_type: 杂志文章,评审
doi:10.1007/BF01682030
更新日期:1995-03-01 00:00:00
abstract::Relapse remains one of the major obstacles in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) even after allogeneic hematopoietic stem cell transplantation. The persistence of leukemia-propagating cells (LPCs) may lead to the recurrence of Ph+ALL. Using a xenograft assay, LPCs enrichment in the ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-018-3253-5
更新日期:2018-05-01 00:00:00
abstract::Myelodysplastic syndromes (MDS) are hematopoietic stem cell malignancies associated with an erythroid maturation defect, resulting in anemia. Treatments for MDS include erythropoiesis-stimulating agents (ESAs). The identification of prognostic markers is important to help predict response and improve outcomes. Various...
journal_title:Annals of hematology
pub_type: 杂志文章,评审
doi:10.1007/s00277-019-03799-4
更新日期:2020-01-01 00:00:00