当前位置： SCI文献检索 > ANNALS OF HEMATOLOGY期刊下所有文献 > JAK2V617F and calreticulin mutations in recurrent venous thromboembolism: results from the EDITH prospective cohort.

JAK2V617F and calreticulin mutations in recurrent venous thromboembolism: results from the EDITH prospective cohort.

Abstract：

:Cancer incidence in patients with recurrent unprovoked venous thromboembolism (VTE) is much higher than after a first event, but the incidence of myeloproliferative neoplasms (MPN) in this situation is still unknown. We tested for JAK2V617F and calreticulin mutants, 372 DNA samples of patients treated for (VTR). Among these patients, 10 (2.7%) were carrying JAK2V617F mutation and none of them any of the calreticulin (CALR) mutations. Among the 19 patients who had VTE recurrence under vitamin K antagonists, 4 patients (21.0%) were positive for JAK2V617F. Despite the identification of JAK2V617F mutation, only three patients were diagnosed for MPN despite a median follow-up of 4 years. We showed that the screening for JAK2V617F not CALR mutations should be helpful in this indication especially if recurrence happened under VKA therapy.

journal_name

Ann Hematol

journal_title

Annals of hematology

authors

Ianotto JC,Chauveau A,Mottier D,Ugo V,Berthou C,Lippert E,Delluc A

doi

10.1007/s00277-016-2853-1

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

383-386

issue

3

eissn

0939-5555

issn

1432-0584

pii

10.1007/s00277-016-2853-1

journal_volume

96

pub_type

杂志文章

相关文献

ANNALS OF HEMATOLOGY文献大全
  • Oral high-dose sucrosomial iron vs intravenous iron in sideropenic anemia patients intolerant/refractory to iron sulfate: a multicentric randomized study.

    abstract：:Iron deficiency anemia is among the most frequent causes of disability. Intravenous iron is the quickest way to correct iron deficiency, bypassing the bottleneck of iron intestinal absorption, the only true mechanism of iron balance regulation in human body. Intravenous iron administration is suggested in patients who...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-020-04361-3

    authors： Giordano G,Napolitano M,Di Battista V,Lucchesi A

    更新日期：2020-12-02 00:00:00

  • Decreased expression of indoleamine 2,3-dioxygenase 1 in dendritic cells contributes to impaired regulatory T cell development in immune thrombocytopenia.

    abstract：:Along with their immunogenic role, dendritic cells (DCs) are also critical in maintaining tolerance to self-antigens by inducing regulatory T cells (Tregs) via the expression of the immunomodulatory enzyme indoleamine 2,3-dioxygenase 1 (IDO1). In turn, Tregs modulate the maturation and/or function of DCs. In immune th...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-012-1556-5

    authors： Catani L,Sollazzo D,Trabanelli S,Curti A,Evangelisti C,Polverelli N,Palandri F,Baccarani M,Vianelli N,Lemoli RM

    更新日期：2013-01-01 00:00:00

  • Progression of disease within 2 years (POD24) is a clinically relevant endpoint to identify high-risk follicular lymphoma patients in real life.

    abstract：:Follicular lymphoma (FL) is an indolent non-Hodgkin's lymphoma with heterogeneous outcomes. Progression or relapse of FL within 2 years (so-called POD24) after diagnosis is associated with a poor outcome for patients treated with R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, prednisone) in clinica...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-020-04025-2

    authors： Sortais C,Lok A,Tessoulin B,Gastinne T,Mahé B,Dubruille V,Blin N,Touzeau C,Moreau A,Bossard C,Peterlin P,Garnier A,Guillaume T,Le Bourgeois A,Chevallier P,Moreau P,Leux C,Le Gouill S

    更新日期：2020-07-01 00:00:00

  • Early post-transplantation positron emission tomography in patients with Hodgkin lymphoma is an independent prognostic factor with an impact on overall survival.

    abstract：:The aim of the present study was to investigate the prognostic role of pre- and/or early post-autologous stem cell transplantation (ASCT) (18)F-flourodeoxyglucose (FDG) positron emission tomography (PET) in patients with relapsed/refractory Hodgkin lymphoma. Forty-three consecutive patients were enrolled in this study...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-011-1209-0

    authors： Sucak GT,Özkurt ZN,Suyani E,Yaşar DG,Akdemir ÖÜ,Aki Z,Yeğin ZA,Yağci M,Kapucu ÖL

    更新日期：2011-11-01 00:00:00

  • A novel NAP1L4/NUTM1 fusion arising from translocation t(11;15)(p15;q12) in a myeloid neoplasm with eosinophilia and rearrangement of PDGFRA highlights an unusual clinical feature and therapeutic reaction.

    abstract：:NUT midline carcinoma (NMC) is an aggressive neoplasm and mainly involved in the head and neck area. The defining genetic hallmark on these tumors is that testis-specific nuclear gene (NUTM1) fuses to bromodomain protein family member 4 gene (BRD4), resulting in the formation of BRD4-NUTM1 transcript. Here, we report ...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-020-04000-x

    authors： Cheng Z,Luo Y,Zhang Y,Wang Y,Chen Y,Xu Y,Peng H,Zhang G

    更新日期：2020-07-01 00:00:00

  • Rare primary extranodal lymphomas: diffuse large B-cell lymphomas of the genital tract.

    abstract：:Primary non-Hodgkin's lymphoma (NHL) of the genital tract is a rare entity. Etiology and pathogenesis of these NHLs are unknown, although there might be a possible association between chronic inflammation and lymphomas. The most common histological subtype is the diffuse large B-cell lymphoma. We report two cases of u...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-009-0741-7

    authors： Rajnics P,Demeter J,Csomor J,Krenács L,Pajor L,Kollár B,Kertész Z,Egyed M

    更新日期：2009-12-01 00:00:00

  • Lymphoma-associated hemophagocytic lymphohistiocytosis: experience in adults from a single institution.

    abstract：:Lymphoma-associated hemophagocytic lymphohistiocytosis (HLH) is a rare but fatal disease. Differences between B cell and T cell lymphoma-associated HLH remain unclear, specifically clinical characteristics and survival. We retrospectively analyzed 30 lymphoma-associated HLH patients from July 2004 to October 2012. Pat...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-013-1784-3

    authors： Yu JT,Wang CY,Yang Y,Wang RC,Chang KH,Hwang WL,Teng CL

    更新日期：2013-11-01 00:00:00

  • B cell-activating factor: its clinical significance in multiple myeloma patients.

    abstract：:B cell-activating factor (BAFF) is a cytokine that plays a major role in the maintenance of normal B-cell development and homeostasis. It has been suggested that in multiple myeloma (MM) it might have regulatory effects on the proliferation and viability of malignant plasma cells. The aim of this study was to evaluate...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-012-1470-x

    authors： Fragioudaki M,Boula A,Tsirakis G,Psarakis F,Spanoudakis M,Papadakis IS,Pappa CA,Alexandrakis MG

    更新日期：2012-09-01 00:00:00

  • Cationic lipid mediated transfer of c-abl and bcr antisense oligonucleotides to immature normal myeloid cells: uptake, biological effects and modulation of gene expression.

    abstract：:Uptake and biochemical and biological effects of antisense oligodeoxynucleotides (ODN) specific for c-abl and bcr genes were studied in normal immature myeloid cells. CD34-positive cells were purified by positive and negative selection and cultured in liquid culture for 7 days. These cells were then incubated with ODN...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/BF00641311

    authors： Albrecht T,Schwab R,Peschel C,Engels HJ,Fischer T,Huber C,Aulitzky WE

    更新日期：1996-02-01 00:00:00

  • Diffuse thyroid 18F-FDG uptake after R-CHOP therapy predicts favorable outcome in patients with DLBCL.

    abstract：:Therapy-induced autoimmunity may mediate the destruction of cancer cells. Previous studies have demonstrated that presence of autoimmune thyroid disorder is associated with favorable outcome in patients with solid cancer. Patients with diffuse large B cell lymphoma (DLBCL) who achieved complete response on positron em...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-015-2311-5

    authors： Song MK,Chung JS,Kim SJ,Kim SS,Shin HJ

    更新日期：2015-06-01 00:00:00

  • Second- versus first-generation azoles for antifungal prophylaxis in hematology patients: a systematic review and meta-analysis.

    abstract：:Second-generation azoles may be more effective than first-generation azoles in the prevention of fungal infections in hematology patients. We performed a systematic review with meta-analysis of randomized controlled trials comparing second- with first-generation azoles in hematology patients with respect to proven or ...

    journal_title：Annals of hematology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1007/s00277-013-1693-5

    authors： Ping B,Zhu Y,Gao Y,Yue C,Wu B

    更新日期：2013-06-01 00:00:00

  • Patients with primary diffuse large B-cell lymphoma of female genital tract have high risk of central nervous system relapse.

    abstract：:The objective of this study was to evaluate retrospectively the clinical characteristics, treatments, and outcomes of patients with primary diffuse large B-cell lymphoma (DLBCL) of the female genital tract. The basic characteristics, treatments, and outcomes of six patients diagnosed with primary DLBCL of the female g...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-013-2003-y

    authors： Cao XX,Li J,Zhang W,Duan MH,Shen T,Zhou DB

    更新日期：2014-06-01 00:00:00

  • Hemoglobin F in myelodysplastic syndrome.

    abstract：:Reactivation of fetal hemoglobin synthesis in adulthood can be seen in hematological disorders affecting the erythropoietic system. The objective of the present study was to evaluate the incidence and prognostic significance of increased hemoglobin F in patients with myelodysplastic syndrome. Hemoglobin F concentratio...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s002770050377

    authors： Reinhardt D,Haase D,Schoch C,Wollenweber S,Hinkelmann E,v Heyden W,Lentini G,Wörmann B,Schröter W,Pekrun A

    更新日期：1998-03-01 00:00:00

  • Multiple myeloma: effect of daily dichloromethylene bisphosphonate on skeletal complications.

    abstract：:In 1989, a prospective randomized multicenter study was initiated in order to determine the safety and efficacy of oral clodronate in myeloma patients. The primary objective of this long-term trial is to evaluate whether supportive clodronate is able to prevent or retard the progression of bone disease and reduce the ...

    journal_title：Annals of hematology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1007/BF01697625

    authors： Clemens MR,Fessele K,Heim ME

    更新日期：1993-03-01 00:00:00

  • A phase 1 clinical trial of flavopiridol consolidation in chronic lymphocytic leukemia patients following chemoimmunotherapy.

    abstract：:Patients with chronic lymphocytic leukemia (CLL) who receive chemoimmunotherapy and do not achieve complete remission experience significantly shortened progression-free interval (PFS). Additionally, the majority of patients treated for relapsed disease demonstrate evidence of measurable disease. Eradication of minima...

    journal_title：Annals of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00277-016-2683-1

    authors： Awan FT,Jones JA,Maddocks K,Poi M,Grever MR,Johnson A,Byrd JC,Andritsos LA

    更新日期：2016-06-01 00:00:00

  • Quality-adjusted survival analysis shows differences in outcome after immunosuppression or bone marrow transplantation in aplastic anemia.

    abstract：:Bone marrow transplantation (BMT) and immunosuppression (IS) have improved the prognosis of aplastic anemia; both treatments have specific advantages and drawbacks but similar survival rates. Analysis of additional endpoints may help in treatment decisions. In a single-center study, patients with aplastic anemia treat...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-004-0930-3

    authors： Viollier R,Passweg J,Gregor M,Favre G,Kühne T,Nissen C,Gratwohl A,Tichelli A

    更新日期：2005-01-01 00:00:00

  • The effects of air quality on haematological and clinical parameters in children with sickle cell anaemia.

    abstract：:Sickle cell anaemia (SCA; HbSS) is characterised by its clinical variability, which is only partly explained by known genetic factors. Environmental factors are known to contribute to acute problems but their importance in chronic complications has not been analysed. We have studied 93 children with SCA in a single in...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-008-0598-1

    authors： Mittal H,Roberts L,Fuller GW,O'Driscoll S,Dick MC,Height SE,Thein SL,Rees DC

    更新日期：2009-06-01 00:00:00

  • Human peripheral blood mononuclear cells require factor X and platelets for expression of prothrombinase activity in response to bacterial lipopolysaccharide.

    abstract：:We investigated whether human peripheral blood mononuclear cells (PBMC) express prothrombinase following stimulation with bacterial lipopolysaccharide (LPS). LPS-stimulated PBMC devoid of contaminating platelets failed to activate prothrombin directly. Addition of platelets did not result in expression of prothrombina...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s002770100288

    authors： Pejler G,Geczy CL

    更新日期：2001-05-01 00:00:00

  • Myelodysplastic syndrome presenting as third malignancy after non-Hodgkin's lymphoma and osteosarcoma.

    abstract：:The patient was initially diagnosed as having non-Hodgkin's lymphoma and was cured following treatment with prednisolone, vincristine, daunorubicin, 1-asparaginase, and cyclophosphamide. Seven years and two months later, he developed osteosarcoma in his right femur. He received chemotherapy consisting of methotrexate,...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s002770050264

    authors： Kubota M,Sawada M,Watanabe K,Koishi S,Kataoka A,Usami I,Lin YW,Okuda A,Akiyama Y,Furusho K

    更新日期：1997-02-01 00:00:00

  • Correction to: Clinical outcomes in patients with diffuse large B cell lymphoma with a partial response to first-line R-CHOP chemotherapy: prognostic value of secondary International Prognostic Index scores and Deauville scores.

    abstract：:An additional affiliation for the first author was not indicated. Hyewon Lee is also affiliated with: Department of Internal Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, South Korea. ...

    journal_title：Annals of hematology

    pub_type： 杂志文章,已发布勘误

    doi：10.1007/s00277-019-03868-8

    authors： Lee H,Kim YR,Kim SJ,Park Y,Eom HS,Oh SY,Kim HJ,Kang HJ,Lee WS,Moon JH,Won YW,Kim TS,Kim JS

    更新日期：2020-01-01 00:00:00

  • Non-invasive urinary biomarkers of renal function in sickle cell disease: an overview.

    abstract：:Sickle cell disease (SCD) is a hereditary condition characterized by homozygosis of the hemoglobin S (HbS) gene. Marked morbimortality is observed due to chronic hemolysis, endothelial injury, and episodes of vaso-occlusion, which leads to multi-organ damage. Renal impairment is common and may have different presentat...

    journal_title：Annals of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s00277-019-03813-9

    authors： Laurentino MR,Parente Filho SLA,Parente LLC,da Silva Júnior GB,Daher EF,Lemes RPG

    更新日期：2019-12-01 00:00:00

  • Acute megakaryoblastic leukaemia with extreme thrombocytosis and p190(bcr/abl)rearrangement.

    abstract：:Acute megakaryoblastic leukaemia (AML-M7) is an uncommon disease, composing 0.5-1.2% of newly diagnosed adult acute myeloid leukaemias (AML). It is characterised by higher incidence and complexity of cytogenetic abnormalities. We report a rare case of Philadelphia (Ph) chromosome-positive AML-M7, presenting with extre...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-003-0783-1

    authors： Balatzenko G,Guenova M,Zechev J,Toshkov S

    更新日期：2004-06-01 00:00:00

  • Individual outcome prediction for myelodysplastic syndrome (MDS) and secondary acute myeloid leukemia from MDS after allogeneic hematopoietic cell transplantation.

    abstract：:We integrated molecular data with available prognostic factors in patients undergoing allogeneic hematopoietic cell transplantation (alloHCT) for myelodysplastic syndrome (MDS) or secondary acute myeloid leukemia (sAML) from MDS to evaluate their impact on prognosis. Three hundred four patients were sequenced for muta...

    journal_title：Annals of hematology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00277-017-3027-5

    authors： Heuser M,Gabdoulline R,Löffeld P,Dobbernack V,Kreimeyer H,Pankratz M,Flintrop M,Liebich A,Klesse S,Panagiota V,Stadler M,Wichmann M,Shahswar R,Platzbecker U,Thiede C,Schroeder T,Kobbe G,Geffers R,Schlegelberger B,Gö

    更新日期：2017-08-01 00:00:00

  • Standard induction chemotherapy followed by attenuated consolidation in elderly patients with acute myeloid leukemia.

    abstract：:The benefits of intensive post-remission chemotherapy have not been verified in elderly patients with acute myeloid leukemia (AML). To reduce fatal complications caused by intensive post-remission therapy, we performed a prospective phase II multicenter trial of standard induction chemotherapy ('7+3' of cytarabine plu...

    journal_title：Annals of hematology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00277-006-0110-8

    authors： Lee JH,Choi SJ,Lee JH,Park JH,Kim H,Joo YD,Lee WS,Zang DY,Kim HJ,Lee KH,Cooperative Study Group A for Hematology.

    更新日期：2006-06-01 00:00:00

  • Erythropoietin production: evidence for multiple oxygen sensing pathways.

    abstract：:The production of erythropoietin (Epo), the glycoprotein hormone which controls red blood cell formation, is regulated by feedback mechanisms sensing tissue oxygenation. The mechanism of the putative oxygen sensor has yet to be elucidated. There is evidence that at least two pathways participate in hypoxia signal tran...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s002770050514

    authors： Daghman NA,Elder GE,Savage GA,Winter PC,Maxwell AP,Lappin TR

    更新日期：1999-06-01 00:00:00

  • Prediction of thrombosis risk in patients with paroxysmal nocturnal hemoglobinuria.

    abstract：:Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic disease with thrombosis as a major complication. The mechanism of thrombosis and related risk factors in PNH patients are still not well characterized. We retrospectively enrolled 99 patients with newly diagnosed PNH at our institute from 2011 to 2016....

    journal_title：Annals of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00277-019-03770-3

    authors： Huang Y,Liu X,Chen F,Zhou W,Li H,Long Z,Yang C,Chen M,Han B

    更新日期：2019-10-01 00:00:00

  • The clinical characteristics and prognostic significance of MN1 gene and MN1-associated microRNA expression in adult patients with de novo acute myeloid leukemia.

    abstract：:This study aimed to determine the clinical characteristics and prognostic significance of the meningioma 1 (MN1) gene and MN1-associated microRNA expression in Chinese adult de novo acute myeloid leukemia (AML) patients. The expression level of MN1, microRNA-20 (miR-20a), and microRNA-181b (miR-181b) in bone marrow mo...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-013-1729-x

    authors： Xiang L,Li M,Liu Y,Cen J,Chen Z,Zhen X,Xie X,Cao X,Gu W

    更新日期：2013-08-01 00:00:00

  • Myeloproliferative disorders: complications, survival and causes of death.

    abstract：:This retrospective single-center study compared thromboembolic and hemorrhagic complications, survival and causes of death in a cohort of 102 consecutive patients with myeloproliferative disorders (MPD). We included 17 patients with essential thrombocythemia (ET), 59 with polycythemia vera (PV), and 26 with osteomyelo...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s002779900136

    authors： Brodmann S,Passweg JR,Gratwohl A,Tichelli A,Skoda RC

    更新日期：2000-06-01 00:00:00

  • Clinical usefulness of free light chain concentration as a tumor marker in multiple myeloma.

    abstract：:Monoclonal immunoglobulin, as a marker for monoclonal gammopathy, is evaluated by protein electrophoresis (PEP) and immunofixation electrophoresis (IFE). However, PEP and IFE are not satisfactory in sensitivity, objectivity, and facility. Recently, a highly sensitive, automated immunoassay for measurement of free ligh...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-005-1047-z

    authors： Kang SY,Suh JT,Lee HJ,Yoon HJ,Lee WI

    更新日期：2005-09-01 00:00:00

  • CTLA-4 polymorphisms are associated with treatment outcomes of patients with multiple myeloma receiving bortezomib-based regimens.

    abstract：:Single-nucleotide polymorphisms (SNPs) of cytotoxic T lymphocyte antigen-4 (CTLA-4) are important risk factors associated with autoimmune diseases and malignancies. This study explored the association of CTLA-4SNPs with the development of myeloma and evaluated the outcome of patients receiving bortezomib-based regimen...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-017-3203-7

    authors： Qin XY,Lu J,Li GX,Wen L,Liu Y,Xu LP,Chang YJ,Liu KY,Jiang ZF,Huang XJ

    更新日期：2018-03-01 00:00:00