Non-invasive urinary biomarkers of renal function in sickle cell disease: an overview.

Abstract:

:Sickle cell disease (SCD) is a hereditary condition characterized by homozygosis of the hemoglobin S (HbS) gene. Marked morbimortality is observed due to chronic hemolysis, endothelial injury, and episodes of vaso-occlusion, which leads to multi-organ damage. Renal impairment is common and may have different presentations, such as deficiency in urinary acidification or concentration, glomerulopathies, proteinuria, and hematuria, frequently resulting in end-stage renal disease (ESRD). Novel biomarkers of renal function, such as kidney injury molecule 1 (KIM-1), and neutrophil gelatinase-associated lipocalin (NGAL) and monocyte chemoattractant protein 1 (MCP-1) are being studied in order to enable early diagnosis of kidney damage in SCD.

journal_name

Ann Hematol

journal_title

Annals of hematology

authors

Laurentino MR,Parente Filho SLA,Parente LLC,da Silva Júnior GB,Daher EF,Lemes RPG

doi

10.1007/s00277-019-03813-9

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

2653-2660

issue

12

eissn

0939-5555

issn

1432-0584

pii

10.1007/s00277-019-03813-9

journal_volume

98

pub_type

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