Abstract:
:Sickle cell disease (SCD) is a hereditary condition characterized by homozygosis of the hemoglobin S (HbS) gene. Marked morbimortality is observed due to chronic hemolysis, endothelial injury, and episodes of vaso-occlusion, which leads to multi-organ damage. Renal impairment is common and may have different presentations, such as deficiency in urinary acidification or concentration, glomerulopathies, proteinuria, and hematuria, frequently resulting in end-stage renal disease (ESRD). Novel biomarkers of renal function, such as kidney injury molecule 1 (KIM-1), and neutrophil gelatinase-associated lipocalin (NGAL) and monocyte chemoattractant protein 1 (MCP-1) are being studied in order to enable early diagnosis of kidney damage in SCD.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Laurentino MR,Parente Filho SLA,Parente LLC,da Silva Júnior GB,Daher EF,Lemes RPGdoi
10.1007/s00277-019-03813-9subject
Has Abstractpub_date
2019-12-01 00:00:00pages
2653-2660issue
12eissn
0939-5555issn
1432-0584pii
10.1007/s00277-019-03813-9journal_volume
98pub_type
杂志文章,评审abstract::Follicular lymphoma (FL) is an indolent non-Hodgkin's lymphoma with heterogeneous outcomes. Progression or relapse of FL within 2 years (so-called POD24) after diagnosis is associated with a poor outcome for patients treated with R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, prednisone) in clinica...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-020-04025-2
更新日期:2020-07-01 00:00:00
abstract::Anthracyclines are a major component in the therapy of non-Hodgkin's lymphoma. However, due to their cardiac toxicity potential, curative and palliative treatment is often limited in patients with preexisting cardiac dysfunction. Liposomal doxorubicin formulations have been described to be less cardiotoxic than conven...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-011-1308-y
更新日期:2012-03-01 00:00:00
abstract::We retrospectively analyzed very early chimerism before and ongoing neutrophil engraftment (days 7, 14, 21, 28) and investigated the influence of conditioning regimens and stem cell sources on donor-type chimerism in 59 Japanese patients who had received allogeneic hematopoietic stem cell transplantation. The percenta...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-008-0542-4
更新日期:2008-12-01 00:00:00
abstract::Follicular lymphoma (FL) is generally considered an indolent disorder. With modern day treatments, long remissions are often achieved both in the front-line and relapsed setting. However, a subset of patients has a more aggressive course and a worse outcome. Their identification is the main purpose of modern day progn...
journal_title:Annals of hematology
pub_type: 杂志文章,评审
doi:10.1007/s00277-017-3154-z
更新日期:2018-02-01 00:00:00
abstract::A prospective randomized phase III study was performed to evaluate whether intensified cytarabine would induce a higher response rate and longer event-free interval as compared to low-dose cytarabine in chronic myeloid leukemia (CML). One hundred and eighteen patients with CML in early chronic phase entered the study....
journal_title:Annals of hematology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00277-006-0186-1
更新日期:2007-02-01 00:00:00
abstract::We integrated molecular data with available prognostic factors in patients undergoing allogeneic hematopoietic cell transplantation (alloHCT) for myelodysplastic syndrome (MDS) or secondary acute myeloid leukemia (sAML) from MDS to evaluate their impact on prognosis. Three hundred four patients were sequenced for muta...
journal_title:Annals of hematology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00277-017-3027-5
更新日期:2017-08-01 00:00:00
abstract::Thrombotic thrombocytopenia purpura (TTP) and atypical hemolytic uremic syndromes (aHUS) are distinct clinical disorders characterized by hemolytic anemia, thrombocytopenia, microthrombi, and end organ damage. TTP is characterized by a low ADAMTS13 activity level at diagnosis of <10 % ADAMTS13 activity, while aHUS is ...
journal_title:Annals of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s00277-015-2411-2
更新日期:2015-09-01 00:00:00
abstract::Antithymocyte globulin (ATG) is the drug of choice for immunosuppressive therapy (IST) in patients with severe aplastic anemia (SAA) ineligible for allogeneic stem cell transplantation. Recently, rabbit ATG with cyclosporine A has been used as a first-line IST regimen in patients with SAA because of unavailability of ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-013-1674-8
更新日期:2013-06-01 00:00:00
abstract::The cytogenetic and molecular data is recognized as the most valuable prognostic factor in acute myeloid leukemia (AML). Our aim was to systemically analyze the cytogenetics of Korean AML patients and to compare the cytogenetic profiles of various races to identify possible geographic heterogeneity. We retrospectively...
journal_title:Annals of hematology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00277-016-2691-1
更新日期:2016-08-01 00:00:00
abstract::A case of an 82-year-old man who suffered an acute ST-elevation myocardial infarction while receiving treatment with intravenous immunoglobulin (IVIg) for thrombocytopenia is discussed. A total of 29 other cases of thromboembolism related to IVIg therapy have been reported, and the incidence seems to be especially hig...
journal_title:Annals of hematology
pub_type: 杂志文章,评审
doi:10.1007/s00277-004-0895-2
更新日期:2004-10-01 00:00:00
abstract::Hydroxyurea is increasingly being used to control myeloproliferative disorders, in part because of its relative lack of side effects. We present a case of life-threatening alveolitis in a patient treated with hydroxyurea for myeloproliferative syndrome. Absence of exposure to other drugs and the clinical course sugges...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/BF01701737
更新日期:1993-09-01 00:00:00
abstract::Genes involved in the hemostatic mechanism are logical candidate genes for association studies in prothrombotic conditions such as stroke. Since the underlying etiology in pediatric strokes is different than adults, looking for genetic causes would be the logical thing to do in the pediatric stroke population. Fifty-e...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-008-0613-6
更新日期:2009-05-01 00:00:00
abstract::Two male patients with severe and recurrent bleeding episodes under phenprocoumon therapy are reported. Both patients exhibited a strong decrease of their factor IX activities below 1% of normal, whereas the activities of the vitamin K-dependent factors prothrombin, VII, and X were found to be within or above the expe...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770050297
更新日期:1997-06-01 00:00:00
abstract::Symptomatic multiple myeloma (MM) is a plasma cell neoplasm that represents the final stage of a continuum of clinical conditions that start from monoclonal gammopathy of unknown significance (MGUS), then transits in the more advance, but still asymptomatic, smoldering MM (SMM), with a final evolution in symptomatic M...
journal_title:Annals of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s00277-019-03648-4
更新日期:2019-07-01 00:00:00
abstract::Autoantibody against erythrocytes has occasionally been observed in patients with de novo acute myelocytic leukemia (AML). However, it is not clear whether this autoantibody in AML patients induces frank hemolysis (autoimmune hemolytic anemia, AIHA), as seen in lymphoid neoplasms. We present two de novo AML patients w...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/BF00663016
更新日期:1996-01-01 00:00:00
abstract::We describe a unique case of IgG lambda myeloma in which a plasma cell leukemia developed and the paraprotein changed from IgG lambda to lambda chain, the latter inducing fatal renal failure. In addition, J-chain was detected in the cytoplasm of the plasma cell leukemia cells. ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/BF01703239
更新日期:1993-04-01 00:00:00
abstract::B cell-activating factor (BAFF) is a cytokine that plays a major role in the maintenance of normal B-cell development and homeostasis. It has been suggested that in multiple myeloma (MM) it might have regulatory effects on the proliferation and viability of malignant plasma cells. The aim of this study was to evaluate...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-012-1470-x
更新日期:2012-09-01 00:00:00
abstract::The appropriate management of patients with moderate aplastic anemia (mAA) remains to be unclear and controversial. A cohort of 118 patients with mAA received a novel immunosuppressive strategy of cyclosporine alternately combined with levamisole (CSA and LMS regimen), which included 42 newly diagnosed and 76 chronic ...
journal_title:Annals of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s00277-013-1764-7
更新日期:2013-09-01 00:00:00
abstract::In hematopoietic system development, PU.1 and GATA-1 as lineage-specific transcription factors (TF) are expressed in common myeloid progenitors. The cross antagonism between them ascertains gene expression programs of monocytic and erythroid cells, respectively. This concept in transdifferentiation approaches has not ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-015-2583-9
更新日期:2016-03-01 00:00:00
abstract::We describe three cases of acute promyelocytic leukemia (APL) with long-term disease-free survival who developed congestive heart failure (CHF) requiring cardiac transplantation. All three patients presented late-onset cardiotoxicity. Cardiac failure occurred progressively after 31-month, 32-month, and 14-month interv...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-002-0534-8
更新日期:2002-09-01 00:00:00
abstract::von Willebrand disease (VWD) is the commonest inherited bleeding disorder, yet it has not been well recognized in Southeast Asia. The aim of this prospective study was to report our experience of VWD diagnosis and to establish the clinical presentations of VWD in Taiwan. From October 2003 to April 2010, 863 patients w...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-011-1266-4
更新日期:2011-10-01 00:00:00
abstract::Marked polyclonal immunoglobulin (Ig)G4 hypergammaglobulinemia has exceptionally been reported. Here we report on two Algerian patients who presented a syndrome characterized by anemia, plasmacytic lymphadenopathy, renal manifestations, and a marked polyclonal IgG4 hypergammaglobulinemia leading to a hyperviscosity sy...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-006-0158-5
更新日期:2006-12-01 00:00:00
abstract::Recently, the combination of rituximab and bendamustine (R-Benda) has been defined as highly active in patients with follicular lymphomas, but little is known about the efficacy of R-Benda in mucosa-associated lymphoid tissue (MALT) lymphoma. In a retrospective analysis, we have defined 14 patients with MALT lymphoma ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-013-1865-3
更新日期:2014-02-01 00:00:00
abstract::The prognostic significance of molecular mutations (FLT3-ITD, NPM1, and CEBPA mutations) was examined in patients with normal-karyotype acute myeloid leukaemia (NK-AML) after allogeneic haematopoietic cell transplantation (HCT). In total, 115 patients received allogeneic HCT for NK-AML and were evaluated for FLT3-ITD,...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-015-2580-z
更新日期:2016-03-01 00:00:00
abstract::Myelodysplastic syndromes (MDS) are hematopoietic stem cell malignancies associated with an erythroid maturation defect, resulting in anemia. Treatments for MDS include erythropoiesis-stimulating agents (ESAs). The identification of prognostic markers is important to help predict response and improve outcomes. Various...
journal_title:Annals of hematology
pub_type: 杂志文章,评审
doi:10.1007/s00277-019-03799-4
更新日期:2020-01-01 00:00:00
abstract::We present a patient with chronic myelomonocytic leukemia who showed disseminated papules and nodules. Arguments in favor of leukemia cutis are the clinical appearance, the cyclic pattern with which the lesions appeared and disappeared, and the histologic features. The lesions reproducibly responded to treatment with ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770000156
更新日期:2000-07-01 00:00:00
abstract::The aim of this study was to analyze the ability of an alloantibody from a patient with severe von Willebrand disease (vWD) to interfere with the vWF domain for FVIII, to inhibit factor VIII (FVIII), and to compare it with a rabbit polyclonal antibody. The vWF domain for binding to FVIII was assayed by a method previo...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770050323
更新日期:1997-09-01 00:00:00
abstract::Pulmonary infections are a major cause of morbidity and mortality in patients with hematologic malignancy. Bronchoscopy is at present still the traditional first investigation in immunosuppressed patients that have developed pulmonary infiltrates. There is limited data available on the validity of fiberoptic bronchosc...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-014-2172-3
更新日期:2015-01-01 00:00:00
abstract::Idarubicin belongs to a group of anthracyclines in which the methoxyl group in position 4 of the D ring in the aglycone moiety is replaced by a hydrogen atom. Lipophilicity is increased compared with other anthracyclines; as a result, idarubicin is the first anthracycline that can be administered orally while at the s...
journal_title:Annals of hematology
pub_type: 杂志文章,评审
doi:10.1007/BF01737687
更新日期:1993-01-01 00:00:00
abstract::Philadelphia-negative myeloproliferative neoplasms (Ph-negative MPN) comprise a heterogeneous group of chronic hematologic malignancies. The quality of life, morbidity, and mortality of patients with MPN are primarily affected by disease-related symptoms, thromboembolic and hemorrhagic complications, and progression t...
journal_title:Annals of hematology
pub_type: 共识发展会议,杂志文章,实务指引,评审
doi:10.1007/s00277-016-2621-2
更新日期:2016-04-01 00:00:00