当前位置： SCI文献检索 > ANNALS OF HEMATOLOGY期刊下所有文献 > PD-L1, LAG3, and HLA-DR are increasingly expressed during smoldering myeloma progression.

PD-L1, LAG3, and HLA-DR are increasingly expressed during smoldering myeloma progression.

Abstract：

:Symptomatic multiple myeloma (MM) is a plasma cell neoplasm that represents the final stage of a continuum of clinical conditions that start from monoclonal gammopathy of unknown significance (MGUS), then transits in the more advance, but still asymptomatic, smoldering MM (SMM), with a final evolution in symptomatic MM. To investigate SMM microenvironment modifications, we studied 16 patients diagnosed at our hospital. Eight of them (group A) developed MM within 2 years from diagnosis while the others (group B) had stable SMM. Samples were bone marrow biopsies at diagnosis and after 2 years (± 4 months) and were analyzed by immunohistochemical analysis. Firstly, we found a significant increase in both CD4+ cells (11 vs 17%, p < 0.01) and CD8+ cells (15 vs 18%, p < 0.01) between diagnosis and at follow-up samples (whole cohort). This was associated to an increase in the CD4+/CD8+ ratio (0.74 vs 0.93, p < 0.01). Secondly, we discovered an increased expression of T cell inhibitory molecules during SMM evolution. In fact, plasma cell PD-L1 and microenvironment cell LAG3 expression increased from 1 to 12% (p = 0.03) and 4 to 10% (p = 0.04), respectively, from diagnosis to follow-up. Also, plasma cells and microenvironment cells HLA-DR expression augmented during SMM evolution from 7 to 10% (p = 0.04) and 29 to 39% (p = 0.01), respectively. When comparing group A vs group B, we found an increased CD68-KP1+ cell infiltration in favor of group B at diagnosis (23 vs 28%, p = 0.01) and a greater plasma cell infiltration at follow-up (50 vs 26%, p < 0.01). Our findings suggest how immune escape mechanisms appear earlier during multiple myeloma evolution, and that LAG3 could be a possible immunologic target in this setting.

journal_name

Ann Hematol

journal_title

Annals of hematology

authors

Mussetti A,Pellegrinelli A,Cieri N,Garzone G,Dominoni F,Cabras A,Montefusco V

doi

10.1007/s00277-019-03648-4

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

1713-1720

issue

7

eissn

0939-5555

issn

1432-0584

pii

10.1007/s00277-019-03648-4

journal_volume

98

pub_type

临床试验,杂志文章

相关文献

ANNALS OF HEMATOLOGY文献大全
  • Increased cell apoptosis in bone marrow trephine biopsies and immunomagnetically isolated myeloid progenitor cells in patients with chronic idiopathic neutropenia.

    abstract：:The frequency of apoptotic cells in bone marrow trephine biopsies and cytospins of immunomagnetically isolated myeloid progenitor cells was determined in 39 patients with chronic idiopathic neutropenia (CIN) and 12 hematologically normal individuals using the in situ end-labeling (ISEL) apoptosis detection method. We ...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-003-0709-y

    authors： Koumaki V,Papadaki HA,Stefanaki K,Damianaki A,Gemetzi C,Katonis P,Vrentzos G,Eliopoulos GD

    更新日期：2003-10-01 00:00:00

  • Urinary proteins in multiple myeloma: correlation with clinical parameters and diagnostic implications.

    abstract：:Renal failure is one of the worst complications occurring in multiple myeloma (MM) patients. It does not affect survival if reverted by a prompt chemotherapy before the damage becomes irreversible; therefore, the early diagnosis of renal dysfunction is crucial. High and low molecular weight urinary proteins have prove...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-003-0699-9

    authors： Corso A,Zappasodi P,Pascutto C,Bosoni T,Mangiacavalli S,Lorenzi A,Rusconi C,Lazzarino M

    更新日期：2003-08-01 00:00:00

  • Reduced-intensity haploidentical peripheral blood stem cell transplantation using low-dose thymoglobulin for aggressive adult T cell leukemia/lymphoma patients in non-complete remission.

    abstract：:Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) has been accepted as a treatment option for aggressive (acute or lymphoma type) adult T cell leukemia/lymphoma (ATLL) patients with a poor prognosis, when a suitable HLA-matched donor is not available. However, haplo-HSCT carries a potential risk of t...

    journal_title：Annals of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00277-020-03934-6

    authors： Hirosawa M,Yamaguchi T,Tanaka A,Kominato Y,Higashi T,Morimoto H,Tsukada J

    更新日期：2020-03-01 00:00:00

  • A comprehensive analysis of adult patients with secondary hemophagocytic lymphohistiocytosis: a prospective cohort study.

    abstract：:Secondary hemophagocytic lymphohistiocytosis (HLH) is a rare but fatal condition with various underlying disorders in adult patients and is diagnosed based on the HLH-2004 criteria, which were established based on experience in pediatric patients. However, few studies have prospectively evaluated the treatment outcome...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-020-04083-6

    authors： Yoon SE,Eun Y,Huh K,Chung CR,Yoo IY,Cho J,Cho D,Ko YH,Park S,Kim WS,Kim SJ

    更新日期：2020-09-01 00:00:00

  • Genetic polymorphisms of HbE/beta thalassemia related to clinical presentation: implications for clinical diversity.

    abstract：:HbE/Beta thalassemia (HbE/β-thalassemia) is one of the common genetic disorders in South East Asia. It is heterogeneous in its clinical presentation and molecular defects. There are genetic modifiers which have been reported to influence the disease severity of this disorder. The aim of this study was to determine the...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-020-03927-5

    authors： Azman NF,Abdullah WZ,Hanafi S,Diana R,Bahar R,Johan MF,Zilfalil BA,Hassan R

    更新日期：2020-04-01 00:00:00

  • Transplant outcomes of the triple-negative NPM1/FLT3-ITD/CEBPA mutation subgroup are equivalent to those of the favourable ELN risk group, but significantly better than the intermediate-I risk group after allogeneic transplant in normal-karyotype AML.

    abstract：:The prognostic significance of molecular mutations (FLT3-ITD, NPM1, and CEBPA mutations) was examined in patients with normal-karyotype acute myeloid leukaemia (NK-AML) after allogeneic haematopoietic cell transplantation (HCT). In total, 115 patients received allogeneic HCT for NK-AML and were evaluated for FLT3-ITD,...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-015-2580-z

    authors： Ahn JS,Kim HJ,Kim YK,Jung SH,Yang DH,Lee JJ,Kim NY,Choi SH,Jung CW,Jang JH,Kim HJ,Moon JH,Sohn SK,Won JH,Kim SH,Kim DD

    更新日期：2016-03-01 00:00:00

  • Flow cytometric immunophenotyping is of great value to diagnosis of natural killer cell neoplasms involving bone marrow and peripheral blood.

    abstract：:Natural killer (NK) cell neoplasms are unusual disorders. In this study we compared results of flow cytometric immunophenotype (FCI) with cytomorphology, histopathology and clinical findings in a series of patients with NK cell neoplasms with peripheral blood and/or bone marrow involvement, and the FCI of neoplastic a...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-012-1574-3

    authors： Jiang NG,Jin YM,Niu Q,Zeng TT,Su J,Zhu HL

    更新日期：2013-01-01 00:00:00

  • L-tryptophan-related eosinophilia-myalgia syndrome possibly associated with a chronic B-lymphocytic leukemia.

    abstract：:A female patient presenting with B-CLL and coincident eosinophilia-myalgia syndrome (EMS) after ingestion of L-tryptophan is described. The manifestations of EMS disappeared completely during treatment with cyclophosphamide/prednisone. and there was an intermittent clinical remission of CLL with absence of the monoclo...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s002770050449

    authors： Böhme A,Wolter M,Hoelzer D

    更新日期：1998-11-01 00:00:00

  • The influence of blood donation on iron stores assessed by serum ferritin and hemoglobin in a population survey of 1359 Danish women.

    abstract：:The general impact of blood donation on iron status was studied in a population survey comprising 1359 nonpregnant Danish women in age cohorts of 30, 40, 50, and 60 years; 809 were premenopausal and 550 postmenopausal; 180 (13%) were blood donors. Iron stores were assessed by serum (S)-ferritin and hemoglobin (Hb). Hb...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/BF01714957

    authors： Milman N,Kirchhoff M

    更新日期：1991-07-01 00:00:00

  • Compound heterozygosity for Hb Korle-Bu (beta(73); Asp-Asn) and Hb E (beta(26); Glu-Lys) with a 3.7-kb deletional alpha-thalassemia in Thai patients.

    abstract：:Hemoglobin (Hb) Korle-Bu (beta73; Asp-Asn) is the most frequent of the rare beta-chain variants in the population of West Africa whereas Hb E (beta26; Glu-Lys) is common among the Southeast Asian population. We report a hitherto undescribed condition in which these two beta-chain variants co-segregate. The proband was...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-002-0485-0

    authors： Changtrakun Y,Fucharoen S,Ayukarn K,Siriratmanawong N,Fucharoen G,Sanchaisuriya K

    更新日期：2002-07-01 00:00:00

  • Anti-phospholipid antibodies bind to platelet microparticles in idiopathic (autoimmune) thrombocytopenic purpura.

    abstract：:We recently reported that IgM antibody-related microparticles exist in some patients with idiopathic thrombocytopenic purpura (ITP) [14]. In this study, we investigated the relationship between antiphospholipid (cardiolipin and phosphatidylinositol) antibodies and microparticles in 56 ITP patients. We used an ELISA to...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/BF01715126

    authors： Nomura S,Yanabu M,Fukuroi T,Kido H,Kawakatsu T,Yamaguchi K,Suzuki M,Kokawa T,Yasunaga K

    更新日期：1992-07-01 00:00:00

  • Trends in incidence and medical resource utilisation in patients with chronic lymphocytic leukaemia: insights from the UK Clinical Practice Research Datalink (CPRD).

    abstract：:Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in European adults. We aimed to evaluate time trends in CLL incidence and medical resource utilisation of CLL patients in the UK. We conducted a retrospective, observational cohort analysis using the UK Clinical Practice Research Datalink (CPRD) comprisi...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-014-2217-7

    authors： Pfeil AM,Imfeld P,Pettengell R,Jick SS,Szucs TD,Meier CR,Schwenkglenks M

    更新日期：2015-03-01 00:00:00

  • Spectrum of Von Willebrand disease and inherited platelet function disorders amongst Indian bleeders.

    abstract：:Platelet function disorders (PFD) and Von Willebrand disease (VWD) are among the uncommon causes of bleeding in haematological practice. The inherited variety of PFD includes defects in platelet adhesion, aggregation, secretion and platelet procoagulant activities. VWD is classified into three major categories-type 1 ...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-006-0244-8

    authors： Gupta PK,Charan VD,Saxena R

    更新日期：2007-06-01 00:00:00

  • Individual outcome prediction for myelodysplastic syndrome (MDS) and secondary acute myeloid leukemia from MDS after allogeneic hematopoietic cell transplantation.

    abstract：:We integrated molecular data with available prognostic factors in patients undergoing allogeneic hematopoietic cell transplantation (alloHCT) for myelodysplastic syndrome (MDS) or secondary acute myeloid leukemia (sAML) from MDS to evaluate their impact on prognosis. Three hundred four patients were sequenced for muta...

    journal_title：Annals of hematology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00277-017-3027-5

    authors： Heuser M,Gabdoulline R,Löffeld P,Dobbernack V,Kreimeyer H,Pankratz M,Flintrop M,Liebich A,Klesse S,Panagiota V,Stadler M,Wichmann M,Shahswar R,Platzbecker U,Thiede C,Schroeder T,Kobbe G,Geffers R,Schlegelberger B,Gö

    更新日期：2017-08-01 00:00:00

  • Histone deacetylase inhibitor prevents cell growth in Burkitt's lymphoma by regulating PI3K/Akt pathways and leads to upregulation of miR-143, miR-145, and miR-101.

    abstract：:Burkitt lymphoma (BL) is an aggressive B-cell lymphoma more common in children comprising one third of pediatric non-Hodgkin lymphoma cases. The recent discovery in BL pathogenesis highlighted the activation of PI3K pathway in cooperation with Myc in the development of BL. In this study, we demonstrated that PI3K/Akt ...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-014-2021-4

    authors： Ferreira AC,Robaina MC,Rezende LM,Severino P,Klumb CE

    更新日期：2014-06-01 00:00:00

  • Granulocyte-macrophage colony-stimulating factor and interleukin-3 in combination: a potent and consistent myelodysplastic syndrome bone marrow stimulant in vitro.

    abstract：:In an effort to overcome bone marrow failure in myelodysplastic syndrome (MDS), we have investigated recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3) in phase I-II clinical trials. Although these agents partially increased peripheral blood granulocyte counts, their e...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/BF01709650

    authors： Estrov Z,Kurzrock R,Talpaz M,Blake M,Gutterman JU

    更新日期：1991-12-01 00:00:00

  • CLIPI: a new prognostic index for indolent cutaneous B cell lymphoma proposed by the International Extranodal Lymphoma Study Group (IELSG 11).

    abstract：:Indolent primary cutaneous B cell lymphomas (PCBCL) generally have a good prognosis, but they often relapse leading in some cases to extracutaneous disease and therefore, to poor survival. We developed a prognostic model to improve the therapeutic approach to these lymphomas. Two hundred and seventeen patients with di...

    journal_title：Annals of hematology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00277-010-1083-1

    authors： Mian M,Marcheselli L,Luminari S,Federico M,Cantonetti M,Sarris AH,Rossi A,Rambaldi A,Frontani M,Devizzi L,Gianni AM,Busetto M,Berti E,Martinelli G,Tsang RW,Ferreri AJ,Pinotti G,Pogliani E,Zucca E,Cortelazzo S

    更新日期：2011-04-01 00:00:00

  • Novel treatment strategies in follicular lymphoma.

    abstract：:Malignant lymphomas are a heterogenous group of malignancies, belonging to the 10 most frequent types of cancers worldwide. In indolent lymphoma only patients with limited stage I/II (Ann Arbor) can be potentially cured by local irradiation. However, about 85% of cases present with advanced stage; for these patients n...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-004-0850-2

    authors： Buske C,Dreyling H,Unterhalt M,Hiddemann W

    更新日期：2004-01-01 00:00:00

  • Combination therapy of disseminated Fusarium oxysporum infection with terbinafine and amphotericin B.

    abstract：:A case of disseminated infection with Fusarium oxysporum following chemotherapy of acute myelogenous leukemia is reported. Antifungal treatment was successful with a 13-day course of oral terbinafine 250 mg t.i.d. in combination with amphotericin B deoxycholate 1.0-1.5 mg/kg qd and subsequently intravenous liposomal a...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-003-0795-x

    authors： Rothe A,Seibold M,Hoppe T,Seifert H,Engert A,Caspar C,Karthaus M,Fätkenheuer G,Bethe U,Tintelnot K,Cornely OA

    更新日期：2004-06-01 00:00:00

  • Epstein-Barr virus infection in allogeneic marrow grafting: lessons for transplant physicians and virologists.

    abstract：:The relationship between Epstein-Barr virus (EBV) and the host is profoundly disturbed by allogeneic bone marrow transplantation (BMT) because EBV resides in the recipient's hematopoietic system, which has to be destroyed in the majority of cases, and in the donor's hematopoietic system, i.e., the marrow graft. We hav...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/BF01715373

    authors： Gratama JW,Oosterveer MA,Lepoutre J,Fibbe WE,Ringdén O,Vossen JM,Willemze R,Bolhuis RL,van Rood JJ,Ernberg I

    更新日期：1992-06-01 00:00:00

  • Characteristics of coagulation alteration in patients with COVID-19.

    abstract：:Abnormal blood coagulation often occurs in critically ill patients, which seriously affects their prognosis. This retrospective study investigated the implications of changes in blood coagulation in patients with coronavirus disease 2019 (COVID-19). Records were reviewed for patients admitted with COVID-19 between Feb...

    journal_title：Annals of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00277-020-04305-x

    authors： Luo HC,You CY,Lu SW,Fu YQ

    更新日期：2021-01-01 00:00:00

  • Clinical significance of metabolic tumor volume by PET/CT in stages II and III of diffuse large B cell lymphoma without extranodal site involvement.

    abstract：:The objective of this study was to investigate whether metabolic tumor volume (MTV) by positron emission tomography (PET) can be a potential prognostic tool when compared with Ann Arbor stage, in stages II and III nodal diffuse large B cell lymphoma (DLBCL). We evaluated 169 patients with nodal stages II and III DLBCL...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-011-1357-2

    authors： Song MK,Chung JS,Shin HJ,Lee SM,Lee SE,Lee HS,Lee GW,Kim SJ,Lee SM,Chung DS

    更新日期：2012-05-01 00:00:00

  • Cytotoxicity of adriamycin, idarubicin, and vincristine in acute myeloid leukemia: chemosensitization by verapamil in relation to P-glycoprotein expression.

    abstract：:A 4-day colorimetric tetrazolium dye (MTT) assay was used to assess the cytotoxicity of adriamycin (ADM), vincristine (VCR), and idarubicin (IDA) in blasts isolated from 37 patients with newly diagnosed and pretreated acute myeloid leukemia (AML). The effect of verapamil (VRP) as a chemosensitizer was studied in relat...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/BF01703946

    authors： Müller MR,Lennartz K,Boogen C,Nowrousian MR,Rajewsky MF,Seeber S

    更新日期：1992-11-01 00:00:00

  • IDH1 and IDH2 mutation analysis in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome.

    abstract：:The somatic mutations of isocitrate dehydrogenase genes (IDH1 and IDH2) have been identified in a proportion of hematologic malignancies. We examined IDH1 R132 and IDH2 R140/R172 mutations by high resolution melting analysis and direct sequencing in Chinese patients with different myeloid malignancies including 198 ac...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-011-1352-7

    authors： Lin J,Yao DM,Qian J,Chen Q,Qian W,Li Y,Yang J,Wang CZ,Chai HY,Qian Z,Xiao GF,Xu WR

    更新日期：2012-04-01 00:00:00

  • Childhood polycythemias/erythrocytoses: classification, diagnosis, clinical presentation, and treatment.

    abstract：:Polycythemias or erythrocytoses in childhood and adolescence are very rare. Systematic data on the clinical presentation and laboratory evaluations as well as on treatment regimens are sparse. The diagnostic program in absolute erythrocytosis includes extensive clinical, hematological, biochemical, and molecular biolo...

    journal_title：Annals of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s00277-004-0985-1

    authors： Cario H

    更新日期：2005-03-01 00:00:00

  • Blood leukocyte subsets and cytokine profile after autologous peripheral blood stem cell transplantation.

    abstract：:High-dose chemotherapy with autologous peripheral blood stem cell transplantation (PBSCT) includes the risk of infectious complications due to neutropenia and therapy-induced immune deviation. In order to understand early immune recovery in this situation, we analyzed the distribution of cell subsets by flow cytometry...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-003-0716-z

    authors： Krause SW,Rothe G,Gnad M,Reichle A,Andreesen R

    更新日期：2003-10-01 00:00:00

  • Hepatitis C in patients with β-thalassemia major. A single-centre experience.

    abstract：:Chronic hepatitis C (CHC) and iron overload are the main causes of liver disease in β-thalassemia major (βTM). There is limited data regarding the course of CHC in this population. All patients (n=144) from the thalassemia centre of the University Hospital of Patras were evaluated (January 1981 to June 2012). Patients...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-013-1692-6

    authors： Triantos C,Kourakli A,Kalafateli M,Giannakopoulou D,Koukias N,Thomopoulos K,Lampropoulou P,Bartzavali C,Fragopanagou H,Kagadis GC,Christofidou M,Tsamandas A,Nikolopoulou V,Karakantza M,Labropoulou-Karatza C

    更新日期：2013-06-01 00:00:00

  • Dynamics of circulating t(14;18)-positive cells during first-line and subsequent lines of treatment in follicular lymphoma.

    abstract：:In follicular lymphoma the t(14;18) might be useful as a tumor marker in predicting the quality of the response to treatment. We investigated whether analyzing numbers of t(14;18)-positive cells in peripheral blood correlated with remission status in individual patients receiving a variety of treatments. Numbers of ci...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-003-0762-6

    authors： Mandigers CM,Meijerink JP,van 't Veer MB,Mensink EJ,Raemaekers JM

    更新日期：2003-12-01 00:00:00

  • Treatment of elderly patients with intermediate- and high-grade non-Hodgkin's lymphoma: a retrospective population-based study.

    abstract：PURPOSE AND METHODS:Nowadays more people are becoming older. The median age of a patient with non-Hodgkin's lymphoma (NHL) at diagnosis is over 60 years. The incidence of NHL in elderly has increased in the last decades. Therefore, in the future, NHL will be diagnosed more often in the elderly. Data of all patients in ...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s002770000255

    authors： Peters FP,Lalisang RI,Fickers MM,Erdkamp FL,Wils JA,Houben SG,Wals J,Schouten HC

    更新日期：2001-03-01 00:00:00

  • Characteristics of pulmonary complications in non-Hodgkin's lymphoma patients treated with rituximab-containing chemotherapy and impact on survival.

    abstract：:Patients with non-Hodgkin's lymphoma (NHL) receiving rituximab-containing chemotherapy are at risk of developing respiratory complications, but comprehensive information on these complications and their impact on survival is lacking. We performed a retrospective cohort analysis on 123 NHL patients who received rituxim...

    journal_title：Annals of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00277-018-3448-9

    authors： Keefer K,Bender R,Liao J,Sivik J,Van de Louw A

    更新日期：2018-12-01 00:00:00