Increased cell apoptosis in bone marrow trephine biopsies and immunomagnetically isolated myeloid progenitor cells in patients with chronic idiopathic neutropenia.

abstract：:Gastrointestinal graft-versus-host disease (GVHD) is one of the main causes of therapy-related death after allogeneic hemopoietic stem cell transplantation. Early diagnosis and immediate treatment are probably essential for improving clinical outcome. High-resolution sonography allows the evaluation of single bowel wa...

journal_title：Annals of hematology

authors： Görg C,Wollenberg B,Beyer J,Stolte MS,Neubauer A

更新日期：2005-01-01 00:00:00

abstract：:The objective of this study was to evaluate the efficacy and safety of rituximab in the treatment of patients with idiopathic thrombocytopenic purpura (ITP). A prospective study was performed at Mubarak Al-Kabeer University Hospital involving the use of rituximab in 14 patients who had previously been treated with ste...

journal_title：Annals of hematology

authors： Alasfoor K,Alrasheed M,Alsayegh F,Mousa SA

更新日期：2009-03-01 00:00:00

abstract：:Second-generation azoles may be more effective than first-generation azoles in the prevention of fungal infections in hematology patients. We performed a systematic review with meta-analysis of randomized controlled trials comparing second- with first-generation azoles in hematology patients with respect to proven or ...

journal_title：Annals of hematology

authors： Ping B,Zhu Y,Gao Y,Yue C,Wu B

更新日期：2013-06-01 00:00:00

abstract：:Isocitrate dehydrogenase IDH 1 and IDH 2 mutations were reported in several cancer forms, especially in hematological malignancies, but were never been investigated in familial aggregation. The aim of this study is to determine whether germline isocitrate dehydrogenase genes mutations are involved.We targeted IDH1 and...

journal_title：Annals of hematology

authors： Hamadou WS,Bourdon V,Létard S,Brenet F,Laarif S,Besbes S,Paci A,David M,Penard-Lacronique V,Youssef YB,Laatiri MA,Eisinger F,Mari V,Gesta P,Dreyfus H,Bonadona V,Dugast C,Zattara H,Faivre L,Noguchi T,Khélif A,Sal

更新日期：2016-12-01 00:00:00

abstract：:We have studied the effects of recombinant human thrombopoietin (TPO, mpl ligand) on the megakaryocyte colony formation from control human bone marrow cells, human leukemia cells at diagnosis, and human bone marrow cells after induction chemotherapy for acute leukemias. In the control human bone marrow cells from four...

journal_title：Annals of hematology

authors： Liang DC,Shih LY,Kuo MC,Chen SH,Liu HC,Shimosaka A

更新日期：1998-07-01 00:00:00

abstract：:Blastic transformation of essential thrombocythemia (ET) preceded by chemotherapy is occasionally described in the literature. In ET as well as in other myeloproliferative disorders the leukemogenic effect of alkylating agents and (32)P is well established, and recent reports also indicate a certain leukemogenic effec...

journal_title：Annals of hematology

authors： Andersson PO,Ridell B,Wadenvik H,Kutti J

更新日期：2000-01-01 00:00:00

abstract：:This retrospective single-center study compared thromboembolic and hemorrhagic complications, survival and causes of death in a cohort of 102 consecutive patients with myeloproliferative disorders (MPD). We included 17 patients with essential thrombocythemia (ET), 59 with polycythemia vera (PV), and 26 with osteomyelo...

journal_title：Annals of hematology

authors： Brodmann S,Passweg JR,Gratwohl A,Tichelli A,Skoda RC

更新日期：2000-06-01 00:00:00

abstract：:Cells of the macrophage lineage are a major source of various cytokines and hematopoietic growth factors. With regard to the growth factors acting on cells of their own lineage, macrophage colony-stimulating factor (M-CSF) has been proven to be secreted by monocytes (MO) and macrophages (MAC), whereas the production o...

journal_title：Annals of hematology

authors： Krause SW,Kreutz M,Zenke G,Andreesen R

更新日期：1992-04-01 00:00:00

abstract：:Immune thrombocytopenia (ITP) is characterised by a transient or persistent decrease in platelets accompanied by an increased risk of bleeding, which can have a significant negative impact on patients' health-related quality of life. The condition has long been associated with an increased rate of immune-mediated plat...

journal_title：Annals of hematology

authors： Kühne T,Imbach P

更新日期：2010-07-01 00:00:00

abstract：:To evaluate the outcomes of refractory/relapsed cHL patients after high-dose chemotherapy (HDCT) and autologous stem cell transplantation (ASCT) in Beijing Cancer hospital and to identify the prognostic risk factors. We retrospectively analyzed 115 relapsed/refractory cHL patients who accepted HDCT and ASCT in our can...

journal_title：Annals of hematology

authors： Xie Y,Wang X,Leng X,Zheng W,Ping L,Zhang C,Liu W,Deng L,Wu M,Song Y,Zhu J

更新日期：2020-03-01 00:00:00

abstract：:A 4-day colorimetric tetrazolium dye (MTT) assay was used to assess the cytotoxicity of adriamycin (ADM), vincristine (VCR), and idarubicin (IDA) in blasts isolated from 37 patients with newly diagnosed and pretreated acute myeloid leukemia (AML). The effect of verapamil (VRP) as a chemosensitizer was studied in relat...

journal_title：Annals of hematology

authors： Müller MR,Lennartz K,Boogen C,Nowrousian MR,Rajewsky MF,Seeber S

更新日期：1992-11-01 00:00:00

abstract：:Defects in central and peripheral tolerance are thought to contribute to life-threatening graft-versus-host disease (GvHD), a severe complication following allogeneic stem cell transplantation (SCT). Recent investigations have demonstrated regulatory T cells (Tregs) to suppress allogeneic immune reactions. Therefore, ...

journal_title：Annals of hematology

authors： Ukena SN,Grosse J,Mischak-Weissinger E,Buchholz S,Stadler M,Ganser A,Franzke A

更新日期：2011-02-01 00:00:00

abstract：:Acute leukemia (AL) patients may experience more than one episode of bloodstream infection (BSI) caused by the same pathogen during the entire chemotherapy program. In order to identify factors influencing BSI recurrence (R-BSI) during subsequent phases of treatment, we analyzed all BSIs occurring to consecutively tre...

journal_title：Annals of hematology

authors： Cattaneo C,Antoniazzi F,Tumbarello M,Skert C,Borlenghi E,Schieppati F,Cerqui E,Pagani C,Petullà M,Re A,Rossi G

更新日期：2014-05-01 00:00:00

abstract：:Bortezomib is one of the most widely used novel drugs for the treatment of multiple myeloma (MM). However, twice-weekly intravenous administration is associated with innegligible adverse events and treatment discontinuation. We therefore evaluated the long-term efficacy and feasibility of reduced frequency treatment w...

journal_title：Annals of hematology

authors： Ozaki S,Hata H,Abe M,Saitoh T,Hanamura I,Yano H,Sunami K,Kosugi H,Sawamura M,Nakazato T,Masunari T,Mori M,Takagi T,Murakami H,Shimizu K

更新日期：2016-05-01 00:00:00

abstract：:Sickle cell disease (SCD) is a hereditary condition characterized by homozygosis of the hemoglobin S (HbS) gene. Marked morbimortality is observed due to chronic hemolysis, endothelial injury, and episodes of vaso-occlusion, which leads to multi-organ damage. Renal impairment is common and may have different presentat...

journal_title：Annals of hematology

authors： Laurentino MR,Parente Filho SLA,Parente LLC,da Silva Júnior GB,Daher EF,Lemes RPG

更新日期：2019-12-01 00:00:00

abstract：:An acute leukemia with an unusual immunophenotype developed in a 17-year-old girl. At the initial presentation, extramedullary involvement was not evident, but with advancing disease, massive splenomegaly and an osteolytic rib tumor developed. The disease was aggressive and refractory to intensive chemotherapeutic reg...

journal_title：Annals of hematology

authors： Ino T,Tsuzuki M,Okamoto M,Shamoto M,Hirano M

更新日期：1999-01-01 00:00:00

abstract：:B cell-activating factor (BAFF) is a cytokine that plays a major role in the maintenance of normal B-cell development and homeostasis. It has been suggested that in multiple myeloma (MM) it might have regulatory effects on the proliferation and viability of malignant plasma cells. The aim of this study was to evaluate...

journal_title：Annals of hematology

authors： Fragioudaki M,Boula A,Tsirakis G,Psarakis F,Spanoudakis M,Papadakis IS,Pappa CA,Alexandrakis MG

更新日期：2012-09-01 00:00:00

abstract：:Post-transplantation cyclophosphamide (PTCy) demonstrated effectiveness to prevent GVHD after haploidentical hematopoietic cell transplantation (HCT). Reducing toxicities with a maximized efficacy is still challenging in HCT. In this retrospective study, we analyzed the safety and efficacy of transplantation from a 1-...

journal_title：Annals of hematology

authors： Soltermann Y,Heim D,Medinger M,Baldomero H,Halter JP,Gerull S,Arranto C,Passweg JR,Kleber M

更新日期：2019-06-01 00:00:00

abstract：:The use of prophylactic antimicrobials during autologous peripheral blood stem cell transplantation (APBSCT) remains controversial. A prospective study was therefore conducted to examine whether the use of prophylactic antimicrobials is necessary. In this study, all the antimicrobials were given therapeutically rather...

journal_title：Annals of hematology

authors： Yeh SP,Chiu CF,Lo WJ,Lin CL,Hsueh CT,Liao YM,Shen YC

更新日期：2003-01-01 00:00:00

abstract：:National and regional population-based registries are, provided diagnostic accuracy and full coverage of the target population, indispensible tools for epidemiological research. Chronic myeloid leukaemia (CML) registries with more comprehensive reporting may also provide complementary data on treatment outcome to thos...

journal_title：Annals of hematology

authors： Höglund M,Sandin F,Simonsson B

更新日期：2015-04-01 00:00:00

abstract：:Extreme thrombocytosis (ExT) has been associated with an increased bleeding risk in myeloproliferative neoplasm (MPN) patients and is included in the high risk category in treatment guidelines. Treatment of patients with ExT has not been studied in prospective trials. To study physicians' approaches to ExT, we distrib...

journal_title：Annals of hematology

authors： Koren-Michowitz M,Lavi N,Ellis MH,Vannucchi AM,Mesa R,Harrison CN

更新日期：2017-01-01 00:00:00

abstract：:In vivo, growth factors are currently investigated for their capacity to trigger leukemic stem cells into cycle and thus overcome kinetic drug resistance. In this study, the susceptibility of leukemic clonogenic cells to individual growth factors was related to cytosine-arabinoside (Ara-C) sensitivity. The effects of ...

journal_title：Annals of hematology

authors： Van der Lely N,De Witte T,Wessels J,Raymakers R,Muus P,Preijers F

更新日期：1994-05-01 00:00:00

abstract：:To determine the value of aerosol amphotericin B inhalations for prevention of invasive pulmonary aspergillosis (IPA), we initiated a prospective randomized multicenter trial. The scheduled intent-to-treat interim analysis included 115 patients (30%) with prolonged neutropenia after chemotherapy for acute myeloid leuk...

journal_title：Annals of hematology

authors： Behre GF,Schwartz S,Lenz K,Ludwig WD,Wandt H,Schilling E,Heinemann V,Link H,Trittin A,Boenisch O

更新日期：1995-12-01 00:00:00

abstract：:Monoclonal immunoglobulin, as a marker for monoclonal gammopathy, is evaluated by protein electrophoresis (PEP) and immunofixation electrophoresis (IFE). However, PEP and IFE are not satisfactory in sensitivity, objectivity, and facility. Recently, a highly sensitive, automated immunoassay for measurement of free ligh...

journal_title：Annals of hematology

authors： Kang SY,Suh JT,Lee HJ,Yoon HJ,Lee WI

更新日期：2005-09-01 00:00:00

abstract：:Cryoglobulinemia is uncommon in Southern Chinese in Hong Kong, with tropical climates and low incidence of hepatitis C virus (HCV) infection. Eight positive cases were detected among 481 patients screened for cryoglobulins over a 10-year period. Three HCV carriers (38%) ran benign courses. The others included two carr...

journal_title：Annals of hematology

authors： Au WY,Kwok JS,Chu KM,Ma ES

更新日期：2005-02-01 00:00:00

abstract：:Multiresistant bacterial infections are a potentially life-threatening condition in acute leukaemia (AL) patients. We aimed to better define the very recent epidemiology and outcome of bloodstream infections (BSIs) in a real-life setting. We prospectively collected all consecutive febrile/infectious episodes occurring...

journal_title：Annals of hematology

authors： Cattaneo C,Zappasodi P,Mancini V,Annaloro C,Pavesi F,Skert C,Ferrario A,Todisco E,Saccà V,Verga L,Passi A,Da Vià M,Ferrari S,Mometto G,Petullà M,Nosari A,Rossi G

更新日期：2016-12-01 00:00:00

abstract：:The microRNA/miR deregulation in BCR-ABL-negative myelodysplastic-myeloproliferative neoplasms (MDS/MPN) is not known. Myelopoiesis-associated miR-10a, miR-17-5p, miR-155, miR-223 and miR-424 were analysed by real-time polymerase chain reaction (PCR) in bone marrow cells of atypical chronic myeloid leukaemia (aCML, n ...

journal_title：Annals of hematology

authors： Hussein K,Büsche G,Muth M,Göhring G,Kreipe H,Bock O

更新日期：2011-03-01 00:00:00

abstract：:The BCR/ABL1 fusion gene is mainly caused by the t(9; 22)(q34; q11.2) translocation, which results in the Philadelphia (Ph) chromosome. The Ph chromosome is the typical hallmark in chronic myeloid leukemia (CML), but can also be present in acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). The BCR/AB...

journal_title：Annals of hematology

authors： Pelz AF,Kröning H,Franke A,Wieacker P,Stumm M

更新日期：2002-03-01 00:00:00

abstract：:Patients with chronic lymphocytic leukemia (CLL) who receive chemoimmunotherapy and do not achieve complete remission experience significantly shortened progression-free interval (PFS). Additionally, the majority of patients treated for relapsed disease demonstrate evidence of measurable disease. Eradication of minima...

journal_title：Annals of hematology

authors： Awan FT,Jones JA,Maddocks K,Poi M,Grever MR,Johnson A,Byrd JC,Andritsos LA

更新日期：2016-06-01 00:00:00

abstract：:We tested two Fc gamma receptor I (Fc gamma RI); six Fc gamma RII; and six Fc gamma RIII-specific monoclonal antibodies (mAb) for their capacity to inhibit monocyte and polymorphonuclear granulocyte (PMN) immune phagocytosis which is mediated by Fc gamma R. We used human red blood cells (rbc) coated with hIgG1 or mIgG...

journal_title：Annals of hematology

authors： Flesch BK,Achtert G,Neppert J

更新日期：1997-01-01 00:00:00