Epidemiology of chronic myeloid leukaemia: an update.

abstract：:High-dose immunosuppressive therapy (HDIT) with autologous hematopoietic stem cell transplantation (AHSCT) is a promising approach to treatment of multiple sclerosis (MS) patients. In this paper, we present the long-term outcomes of a prospective single-center study with the analysis of the safety and efficacy of HDIT...

journal_title：Annals of hematology

authors： Shevchenko JL,Kuznetsov AN,Ionova TI,Melnichenko VY,Fedorenko DA,Kurbatova KA,Gorodokin GI,Novik AA

更新日期：2015-07-01 00:00:00

abstract：:The purpose of this cross-sectional prospective study was to determine the prevalence of anemia among elderly hospitalized patients in Germany and to investigate its association with multidimensional loss of function (MLF). One hundred participants aged 70 years or older from two distinct wards (50 each from an emerge...

journal_title：Annals of hematology

authors： Zilinski J,Zillmann R,Becker I,Benzing T,Schulz RJ,Roehrig G

更新日期：2014-10-01 00:00:00

abstract：:The introduction of rituximab into the primary treatment of malignant lymphomas of the B cell lineage has had a major impact on the management of these diseases. In addition, prolonged exposure to rituximab as maintenance therapy has been beneficial in patients with follicular lymphoma and mantle cell lymphoma. For th...

journal_title：Annals of hematology

authors： Witzens-Harig M,Reiz M,Heiss C,Benner A,Hensel M,Neben K,Dreger P,Kraemer A,Ho AD

更新日期：2009-01-01 00:00:00

abstract：:Patients with chronic lymphocytic leukemia (CLL) who receive chemoimmunotherapy and do not achieve complete remission experience significantly shortened progression-free interval (PFS). Additionally, the majority of patients treated for relapsed disease demonstrate evidence of measurable disease. Eradication of minima...

journal_title：Annals of hematology

authors： Awan FT,Jones JA,Maddocks K,Poi M,Grever MR,Johnson A,Byrd JC,Andritsos LA

更新日期：2016-06-01 00:00:00

abstract：:The patient was initially diagnosed as having non-Hodgkin's lymphoma and was cured following treatment with prednisolone, vincristine, daunorubicin, 1-asparaginase, and cyclophosphamide. Seven years and two months later, he developed osteosarcoma in his right femur. He received chemotherapy consisting of methotrexate,...

journal_title：Annals of hematology

authors： Kubota M,Sawada M,Watanabe K,Koishi S,Kataoka A,Usami I,Lin YW,Okuda A,Akiyama Y,Furusho K

更新日期：1997-02-01 00:00:00

abstract：:Hematopoietic recovery after high-dose chemotherapy (HDC) in the treatment of hematological diseases may be slow and/or incomplete. This is generally attributed to progressive hematopoietic stem cell failure, although defective hematopoiesis may be in part due to poor stromal function. Chemotherapy is known to damage ...

journal_title：Annals of hematology

authors： Kemp K,Morse R,Wexler S,Cox C,Mallam E,Hows J,Donaldson C

更新日期：2010-07-01 00:00:00

abstract：:Thirty-four patients with acute myeloid leukemia (AML) in complete remission (CR), 30 of them aged over 60, received maintenance therapy scheduling four courses of low-dose cytarabine (LDA) 20 mg/m2/day in two subcutaneous injections for 3 weeks every 6 weeks. Each course was stopped when hematologic toxicity occurred...

journal_title：Annals of hematology

authors： Archimbaud E,Anglaret B,Thomas X,Jaubert J,Sebban C,Guyotat D,Fiere D

更新日期：1992-08-01 00:00:00

abstract：:The prognostic significance of molecular mutations (FLT3-ITD, NPM1, and CEBPA mutations) was examined in patients with normal-karyotype acute myeloid leukaemia (NK-AML) after allogeneic haematopoietic cell transplantation (HCT). In total, 115 patients received allogeneic HCT for NK-AML and were evaluated for FLT3-ITD,...

journal_title：Annals of hematology

authors： Ahn JS,Kim HJ,Kim YK,Jung SH,Yang DH,Lee JJ,Kim NY,Choi SH,Jung CW,Jang JH,Kim HJ,Moon JH,Sohn SK,Won JH,Kim SH,Kim DD

更新日期：2016-03-01 00:00:00

abstract：:Parainfluenza virus (PIV) infection is a significant cause of morbidity and mortality, especially in hematologic malignancy patients including hematopoietic stem cell transplantation (HCT) recipients. However, limited information is available for risk stratification in PIV-infected patients with hematologic malignancy...

journal_title：Annals of hematology

authors： Lee J,Jung J,Kim MJ,Chong YP,Lee SO,Choi SH,Kim YS,Woo JH,Choi EJ,Park HS,Lee JH,Lee JH,Lee KH,Kim SH

更新日期：2020-06-01 00:00:00

abstract：:The aim of this epidemiologic population survey was to assess the penetrance of the most frequent hemochromatosis (HFE) gene variants in ethnic Danish men. A cohort of 6,020 men aged 30-53 years was screened for HFE C282Y, H63D, and S65C variants by restriction fragment length polymorphism analysis. Subsequently, iron...

journal_title：Annals of hematology

authors： Pedersen P,Milman N

更新日期：2009-08-01 00:00:00

abstract：:The prognostic value of peripheral blasts (PB) is not well-studied in patients with myelodysplastic syndromes (MDS). We evaluated the impact of PB on overall survival (OS) and transformation to acute myeloid leukemia (AML) in a large cohort. The MDS database at the Moffitt Cancer Center was retrospectively reviewed to...

journal_title：Annals of hematology

authors： Duong VH,Padron E,Al Ali NH,Lancet JE,Hall J,Kwok B,Zhang L,Epling-Burnette PK,List AF,Komrokji RS

更新日期：2018-02-01 00:00:00

abstract：:We conducted an investigation to clarify whether or not the levels of total, free, and functional protein S and C4-binding protein (C4bp) in plasma are decreased in systemic lupus erythematosus (SLE) patients, especially those with antiphospholipid antibody (aPL), which is known to be a causative factor of such compli...

journal_title：Annals of hematology

authors： Matsuda J,Gohchi K,Gotoh M,Tsukamoto M,Saitoh N

更新日期：1994-12-01 00:00:00

abstract：:Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) is an atypical lympho-proliferative disorder with borderline features that often constitute a diagnostic challenge for the hematopathologist and a therapeutic dilemma for the treating clinician. Morphologically, the involved lymph nodes in this disorder are...

journal_title：Annals of hematology

authors： Sallah AS,Bernard S

更新日期：1996-12-01 00:00:00

abstract：:Autologous stem cell transplant (ASCT) is standard consolidation therapy in management of multiple myeloma (MM) patients. We reviewed records of all consecutive MM patients who underwent ASCT with high-dose melphalan at our center from year 2002 to 2016. A total of 141 ASCT were conducted (90 males and 51 females) wit...

journal_title：Annals of hematology

authors： Aggarwal M,Agrawal N,Yadav N,Verma P,Ahmed R,Mehta P,Kapoor J,Bhurani D

更新日期：2018-10-01 00:00:00

abstract：:Polycythemia vera (PV) is a myeloproliferative neoplasm characterized by overproduction of red blood cells. We have performed a comprehensive characterization of blood immune cells for expression of naïve and memory receptors as well as β2m-associated and β2m-free MHC class I heavy chains, also known as closed and ope...

journal_title：Annals of hematology

authors： Cardoso EM,Esgalhado AJ,Patrão L,Santos M,Neves VP,Martinez J,Patto MAV,Silva H,Arosa FA

更新日期：2018-09-01 00:00:00

abstract：:Although eosinophilia has been reported as a side effect of purine analogues, there is no report on fludarabine-induced eosinophilia in chronic lymphocytic leukemia (CLL). During chemotherapy with fludarabine and cyclophosphamide, we observed two cases of significant eosinophilia. A 67-year-old patient with CLL develo...

journal_title：Annals of hematology

authors： Sezer O,Schmid P,Hallek M,Schweigert M,Beinert T,Langelotz C,Mergenthaler HG,Possinger K

更新日期：1999-10-01 00:00:00

abstract：:Ruxolitinib, a JAK1 and JAK2 inhibitor, has been tested and approved for the treatment of primary and secondary myelofibrosis (MF). Aim of our study is to report safety and efficacy of ruxolitinib in 98 patients affected by MF treated outside clinical trials and collected and treated consecutively by the Lazio Coopera...

journal_title：Annals of hematology

authors： Breccia M,Andriani A,Montanaro M,Abruzzese E,Buccisano F,Cedrone M,Centra A,Villivà N,Celesti F,Trawinska MM,Massaro F,Di Veroli A,Anaclerico B,Colafigli G,Molica M,Spadea A,Petriccione L,Cimino G,Latagliata R

更新日期：2017-03-01 00:00:00

abstract：:During the last few years, new insights into the biology of mantle cell lymphoma have been obtained. However, with a median survival of only 3 years, mantle cell lymphoma remains the lymphoma subtype with the poorest prognosis. At initial diagnosis most patients present with advanced Ann Arbor stage III or IV and conv...

journal_title：Annals of hematology

authors： Lenz G,Dreyling M,Hiddemann W

更新日期：2004-02-01 00:00:00

abstract：:A prospective randomized phase III study was performed to evaluate whether intensified cytarabine would induce a higher response rate and longer event-free interval as compared to low-dose cytarabine in chronic myeloid leukemia (CML). One hundred and eighteen patients with CML in early chronic phase entered the study....

journal_title：Annals of hematology

authors： Deenik W,van der Holt B,Verhoef GE,Schattenberg AV,Verdonck LF,Daenen SM,Zachée P,Westveer PH,Smit WM,Wittebol S,Schouten HC,Löwenberg B,Ossenkoppele GJ,Cornelissen JJ

更新日期：2007-02-01 00:00:00

abstract：:Hematopoietic recovery in 115 patients with metastatic breast cancer or metastatic melanoma, enrolled in phase-I studies of recombinant growth factors while undergoing treatment with high-dose chemotherapy with autologous bone marrow support, was examined with assays of bone marrow progenitor cells and peripheral bloo...

journal_title：Annals of hematology

authors： Laughlin MJ,Kirkpatrick G,Sabiston N,Peters W,Kurtzberg J

更新日期：1993-12-01 00:00:00

abstract：:Delayed platelet engraftment (DPE) is a common complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT). This phenomenon is also a predictor of increased treatment-related mortality and poor survival. Therefore, therapies that promote platelet engraftment to prevent DPE are needed. This pr...

journal_title：Annals of hematology

authors： Han TT,Xu LP,Liu DH,Liu KY,Wang FR,Wang Y,Yan CH,Chen YH,Sun YQ,Ji Y,Wang JZ,Zhang XH,Huang XJ

更新日期：2015-01-01 00:00:00

abstract：:Recent developments in the field of targeted therapy have led to the discovery of a new drug, plerixafor, that is a specific inhibitor of the CXCR4 receptor. Plerixafor acts in concert with granulocyte colony-stimulating factor (G-CSF) to increase the number of stem cells circulating in the peripheral blood (PB). Ther...

journal_title：Annals of hematology

authors： Basak GW,Knopinska-Posluszny W,Matuszak M,Kisiel E,Hawrylecka D,Szmigielska-Kaplon A,Urbaniak-Kujda D,Dybko J,Zielinska P,Dabrowska-Iwanicka A,Werkun J,Rzepecki P,Wroblewska W,Wiktor-Jedrzejczak W

更新日期：2011-05-01 00:00:00

abstract：:Early cytomegalovirus (CMV) replication (eCMV) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been suggested as an independent factor that reduces leukemia relapse risk. We retrospectively analyzed 74 patients with acute myeloid leukemia (AML) who underwent allo-HSCT between August 2006 and S...

journal_title：Annals of hematology

authors： Jang JE,Kim SJ,Cheong JW,Hyun SY,Kim YD,Kim YR,Kim JS,Min YH

更新日期：2015-02-01 00:00:00

abstract：:Primary mediastinal large B cell lymphomas (MLCL) differ from other diffuse large cell lymphomas, leading to a description as a separate entity in the current World Health Organization classification. Dose intensification improves long-term results, but no standard therapy has been established so far. We investigated ...

journal_title：Annals of hematology

authors： Fietz T,Knauf WU,Hänel M,Franke A,Freund M,Thiel E,East German Study Group on Hematology and Oncology-OSHO.

更新日期：2009-05-01 00:00:00

abstract：:Venous thromboembolism (VTE) is a well-recognized complication in pediatric oncology patients. Studies in adult oncology patients have suggested a potential negative association between VTE and survival, but this association has not been examined in pediatric patients yet. The aim of this study was to assess the assoc...

journal_title：Annals of hematology

authors： Forbrigger Z,Kuhle S,Brown MM,Moorehead PC,Digout C,Kulkarni K

更新日期：2018-10-01 00:00:00

abstract：:The clinical impact of KIT mutations in core binding factor acute myeloid leukemia (CBF-AML) is still unclear. In the present study, we analyzed the prognostic significance of each KIT mutation (D816, N822K, and other mutations) in Japanese patients with CBF-AML. We retrospectively analyzed 136 cases of CBF-AML that h...

journal_title：Annals of hematology

authors： Yui S,Kurosawa S,Yamaguchi H,Kanamori H,Ueki T,Uoshima N,Mizuno I,Shono K,Usuki K,Chiba S,Nakamura Y,Yanada M,Kanda J,Tajika K,Gomi S,Fukunaga K,Wakita S,Ryotokuji T,Fukuda T,Inokuchi K

更新日期：2017-10-01 00:00:00

abstract：:Recent studies in iron-depleted women have challenged the current approach of treating iron-deficiency anemia (IDA) with oral iron in divided daily doses. Alternate day dosing leads to more fractional absorption of iron. In this randomized controlled trial, we looked at the efficacy and safety of alternate-day (AD) ve...

journal_title：Annals of hematology

authors： Kaundal R,Bhatia P,Jain A,Jain A,Nampoothiri RV,Mishra K,Jandial A,Goni D,Sandal R,Jindal N,Meshram A,Sharma R,Khaire N,Singh C,Khadwal A,Prakash G,Das R,Varma N,Varma S,Malhotra P,Lad DP

更新日期：2020-01-01 00:00:00

abstract：:Children with sickle cell disease (SCD) benefit from newborn screening, because life-threatening complications can be prevented by pre-symptomatic diagnosis. In Germany, the immigration of people from endemic countries is steadily growing. Comprehensive data about the epidemiology and prevalence of SCD in Germany are ...

journal_title：Annals of hematology

authors： Kunz JB,Awad S,Happich M,Muckenthaler L,Lindner M,Gramer G,Okun JG,Hoffmann GF,Bruckner T,Muckenthaler MU,Kulozik AE

更新日期：2016-02-01 00:00:00

abstract：:Neutrophil-lymphocyte ratio (NLR), an indicator of inflammation, has been lately demonstrated as a prognostic factor and an indicator of disease activity in various diseases. However, the effects of NLR have not been investigated in mycosis fungoides (MF) patients yet. The aim of this study is to investigate the relat...

journal_title：Annals of hematology

authors： Eren R,Nizam N,Doğu MH,Mercan S,Erdemir AV,Suyanı E

更新日期：2016-10-01 00:00:00

abstract：:Thrombotic thrombocytopenia purpura (TTP) and atypical hemolytic uremic syndromes (aHUS) are distinct clinical disorders characterized by hemolytic anemia, thrombocytopenia, microthrombi, and end organ damage. TTP is characterized by a low ADAMTS13 activity level at diagnosis of <10 % ADAMTS13 activity, while aHUS is ...

journal_title：Annals of hematology

authors： Saultz JN,Wu HM,Cataland S

更新日期：2015-09-01 00:00:00