Abstract：
:Extreme thrombocytosis (ExT) has been associated with an increased bleeding risk in myeloproliferative neoplasm (MPN) patients and is included in the high risk category in treatment guidelines. Treatment of patients with ExT has not been studied in prospective trials. To study physicians' approaches to ExT, we distributed a web based questionnaire with clinical case scenarios to 202 members of MPN working groups. Cases included low thrombotic risk essential thrombocythemia (ET) with either JAK2V617F or CALR mutation, polycythemia vera with ExT either with or without leukocytosis, an ET patient needing urgent orthopedic surgery, and a poorly controlled ET patient with acute cerebral venous sinus thrombosis. Responses were received from 90 physicians (45 %) and were variable in most case scenarios. Country of practice had the most significant influence on physician response. The USA and Israel physicians responded similarly in most cases and differently to the Europe physicians. Treatment of asymptomatic JAK2V617F positive ET and target platelet count on cytoreduction were significantly influenced by physician years of experience. Responses were not influenced by the volume of MPN practice or by whether MPN was considered a major interest by the physician. Our results show a lack of consensus on how to manage MPN patients with ExT. Randomized controlled trials properly designed to address these questions are needed.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Koren-Michowitz M,Lavi N,Ellis MH,Vannucchi AM,Mesa R,Harrison CNdoi
10.1007/s00277-016-2826-4subject
Has Abstractpub_date
2017-01-01 00:00:00pages
87-92issue
1eissn
0939-5555issn
1432-0584pii
10.1007/s00277-016-2826-4journal_volume
96pub_type
杂志文章abstract：:This paper describes six Indian families in which silent-gene beta-thalassemia was encountered by us in the past 2 years. This stresses the importance of globin-chain synthesis in the diagnosis of beta-thalassemia. Of these six cases, five were diagnosed retrospectively when they had a homozygous beta-thalassemia offs...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01715386
更新日期：1995-01-01 00:00:00
abstract：:Secondary hemophagocytic lymphohistiocytosis (HLH) is a rare but fatal condition with various underlying disorders in adult patients and is diagnosed based on the HLH-2004 criteria, which were established based on experience in pediatric patients. However, few studies have prospectively evaluated the treatment outcome...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-020-04083-6
更新日期：2020-09-01 00:00:00
abstract：:HbE/Beta thalassemia (HbE/β-thalassemia) is one of the common genetic disorders in South East Asia. It is heterogeneous in its clinical presentation and molecular defects. There are genetic modifiers which have been reported to influence the disease severity of this disorder. The aim of this study was to determine the...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-020-03927-5
更新日期：2020-04-01 00:00:00
abstract：:MicroRNAs are short noncoding RNAs, known regulators of several signaling pathways cell differentiation and proliferation, development, and apoptosis, which are deregulated in acute leukemia. Mixed lineage leukemia (MLL) gene encodes a protein with histone methyltransferase activity, which is essential for the fine tu...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s00277-013-1803-4
更新日期：2013-11-01 00:00:00
abstract：:High-dose immunosuppressive therapy (HDIT) with autologous hematopoietic stem cell transplantation (AHSCT) is a promising approach to treatment of multiple sclerosis (MS) patients. In this paper, we present the long-term outcomes of a prospective single-center study with the analysis of the safety and efficacy of HDIT...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-015-2337-8
更新日期：2015-07-01 00:00:00
abstract：:Venous thromboembolism (VTE), including deep venous thrombosis (DVT) and pulmonary embolism (PE), occurs secondary to a number of hereditary and acquired disorders of hemostasis. A recently recognized polymorphism in Factor V (FV) gene H1299R (also named HR2) has been reported to be a possible risk factor for the deve...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-008-0543-3
更新日期：2008-12-01 00:00:00
abstract：:The aim of the present study was to investigate the prevalence of chronic idiopathic neutropenia of adults (CINA) among an apparently healthy population born and living on the island of Crete. The study was carried out with 778 subjects, 392 men aged 16-78 years (median 43 years) and 386 women aged 15-79 years (median...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050518
更新日期：1999-07-01 00:00:00
abstract：:Raised percentage hypochromic red cells (%HRC) were detected at diagnosis in 10 of 34 consecutive patients with low-risk myelodysplastic syndrome (MDS) [refractory anemia (RA) (4/26) and RA with ring sideroblasts (6/8)], all of whom had normal or increased serum ferritin and bone marrow iron stores. Elevated %HRC has ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-006-0107-3
更新日期：2006-07-01 00:00:00
abstract：:The presenting features of 356 previously untreated multiple myeloma (MM) patients grouped according to age were analyzed in order (a) to elucidate the possible differences in initial clinical and laboratory features between patients younger than 50 years and the older ones and (b) to statistically assess the prognost...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050365
更新日期：1998-02-01 00:00:00
abstract：:Eculizumab is indicated for the therapy of patients with symptomatic paroxysmal nocturnal hemoglobinuria (PNH). Due to inhibition of terminal complement cascade, patients on eculizumab are susceptible to Neisseria meningitidis infections. The two mainstays to reduce the risk of infection are vaccination and antibiotic...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-017-2924-y
更新日期：2017-04-01 00:00:00
abstract：:Hodgkin lymphoma (HL) can be aggressive and intractable in some cases. Patients who relapse after autologous HCT (auto-HCT) have limited treatment options. City of Hope reports our experience in the use of reduced intensity allogeneic hematopoietic cell transplantation (allo-HCT) in 24 heavily pretreated patients with...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-010-1146-3
更新日期：2011-07-01 00:00:00
abstract：:Single-nucleotide polymorphisms (SNPs) of cytotoxic T lymphocyte antigen-4 (CTLA-4) are important risk factors associated with autoimmune diseases and malignancies. This study explored the association of CTLA-4SNPs with the development of myeloma and evaluated the outcome of patients receiving bortezomib-based regimen...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-017-3203-7
更新日期：2018-03-01 00:00:00
abstract：:Children with sickle cell disease (SCD) benefit from newborn screening, because life-threatening complications can be prevented by pre-symptomatic diagnosis. In Germany, the immigration of people from endemic countries is steadily growing. Comprehensive data about the epidemiology and prevalence of SCD in Germany are ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-015-2573-y
更新日期：2016-02-01 00:00:00
abstract：:The cytogenetic and molecular data is recognized as the most valuable prognostic factor in acute myeloid leukemia (AML). Our aim was to systemically analyze the cytogenetics of Korean AML patients and to compare the cytogenetic profiles of various races to identify possible geographic heterogeneity. We retrospectively...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-016-2691-1
更新日期：2016-08-01 00:00:00
abstract：:Spontaneous splenic rupture is a rare, though life-threatening complication of some hematological malignancies and is even more infrequent as the initial symptom of acute lymphoblastic leukemia. We describe the fourth case, to our knowledge, of acute lymphoblastic leukemia presenting as splenic rupture, and for the fi...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01727419
更新日期：1994-03-01 00:00:00
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journal_title：Annals of hematology
pub_type： 杂志文章,meta分析
doi：10.1007/s00277-020-04016-3
更新日期：2020-06-01 00:00:00
abstract：:Bortezomib is one of the most widely used novel drugs for the treatment of multiple myeloma (MM). However, twice-weekly intravenous administration is associated with innegligible adverse events and treatment discontinuation. We therefore evaluated the long-term efficacy and feasibility of reduced frequency treatment w...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-016-2661-7
更新日期：2016-05-01 00:00:00
abstract：:Previous studies have suggested that adherence to imatinib therapy can be an obstacle among patients with chronic myeloid leukemia (CML). We studied adherence to imatinib therapy among CML patients treated at the Sahlgrenska University Hospital. We identified all CML patients that were alive at the 1st of January 2010...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-011-1359-0
更新日期：2012-05-01 00:00:00
abstract：:Several revisions of International Prognostic Index (IPI) have been proposed for patients with diffuse large B-cell lymphoma (DLBCL) after the introduction of rituximab. Expanding evidence suggests that baseline absolute lymphocyte count (ALC) is also an independent factor for outcome prediction. We investigated the o...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-013-1807-0
更新日期：2013-11-01 00:00:00
abstract：:The purine analogs (PAs) cladribine and pentostatin have transformed the prognosis of hairy cell leukemia (HCL). However, some patients still relapse after PAs, or fail to reach an optimal response, and new agents are needed to further improve treatment outcome. We retrospectively studied 41 HCL patients from 10 cente...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-014-2175-0
更新日期：2015-01-01 00:00:00
abstract：:Alterations in hemoglobin oxygen affinity can be detected by exposing blood to different PO2 and recording oxygen saturation, a method termed tonometry. It is the gold standard to measure the PO2 associated with 50 % oxygen saturation, the index used to quantify oxygen affinity (P50Tono). P50Tono is used in the evalua...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-012-1667-z
更新日期：2013-04-01 00:00:00
abstract：:Interferon alpha (IFN) inhibits the growth of the abnormal clone in patients with myeloproliferative disorders, leading to a reduction of the clinical and laboratory signs of the pathologic myeloproliferation. The therapeutic efficacy of IFN in polycythemia vera (PV) is demonstrated by the summarized treatment results...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s002770050563
更新日期：2000-03-01 00:00:00
abstract：:Anthracyclines are a major component in the therapy of non-Hodgkin's lymphoma. However, due to their cardiac toxicity potential, curative and palliative treatment is often limited in patients with preexisting cardiac dysfunction. Liposomal doxorubicin formulations have been described to be less cardiotoxic than conven...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-011-1308-y
更新日期：2012-03-01 00:00:00
abstract：:The appropriate management of patients with moderate aplastic anemia (mAA) remains to be unclear and controversial. A cohort of 118 patients with mAA received a novel immunosuppressive strategy of cyclosporine alternately combined with levamisole (CSA and LMS regimen), which included 42 newly diagnosed and 76 chronic ...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-013-1764-7
更新日期：2013-09-01 00:00:00
abstract：:A case of disseminated infection with Fusarium oxysporum following chemotherapy of acute myelogenous leukemia is reported. Antifungal treatment was successful with a 13-day course of oral terbinafine 250 mg t.i.d. in combination with amphotericin B deoxycholate 1.0-1.5 mg/kg qd and subsequently intravenous liposomal a...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-003-0795-x
更新日期：2004-06-01 00:00:00
abstract：:This study aimed to determine whether dose-dense therapy improves 3-year survival over the standard therapy for untreated aggressive lymphoma. One hundred and fifteen patients with untreated aggressive lymphoma were stratified by center, age, and international prognostic index and randomized to one of two treatment ar...
journal_title：Annals of hematology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00277-009-0811-x
更新日期：2010-03-01 00:00:00
abstract：:Preliminary data suggest a faster immune recovery following non-myeloablative stem cell transplantation because of the persistence of recipient T cells, but the real impact on post-transplant infectious complications remains unknown. We retrospectively analysed the incidence of cytomegalovirus (CMV) infection in twent...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-003-0706-1
更新日期：2003-10-01 00:00:00
abstract：PURPOSE AND METHODS:Nowadays more people are becoming older. The median age of a patient with non-Hodgkin's lymphoma (NHL) at diagnosis is over 60 years. The incidence of NHL in elderly has increased in the last decades. Therefore, in the future, NHL will be diagnosed more often in the elderly. Data of all patients in ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770000255
更新日期：2001-03-01 00:00:00
abstract：:Cerebrovascular disease resulting in stroke is a serious and preventable complication of sickle cell anaemia (SCA). Children at high risk of preventable stroke can be identified by transcranial Doppler ultrasound (TCD). Current guidelines in the UK recommend annual TCD screening from 3 years, although studies suggest ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-009-0757-z
更新日期：2009-10-01 00:00:00
abstract：:To explore the clinicopathological characteristics and outcomes of light chain deposition disease (LCDD) in a Chinese population, we retrospectively studied the clinicopathological data, treatment, and outcomes of 48 patients with biopsy-proven LCDD from a single center. Among the patients, there were 29 males and 19 ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-016-2659-1
更新日期：2016-05-01 00:00:00
