当前位置： SCI文献检索 > ANNALS OF HEMATOLOGY期刊下所有文献 > Does venous blood gas analysis provide accurate estimates of hemoglobin oxygen affinity?

Does venous blood gas analysis provide accurate estimates of hemoglobin oxygen affinity?

Abstract：

:Alterations in hemoglobin oxygen affinity can be detected by exposing blood to different PO2 and recording oxygen saturation, a method termed tonometry. It is the gold standard to measure the PO2 associated with 50 % oxygen saturation, the index used to quantify oxygen affinity (P50Tono). P50Tono is used in the evaluation of patients with erythrocytosis suspected to have hemoglobin with abnormal oxygen affinity. Since tonometry is labor intensive and not generally available, we investigated whether accurate estimates of P50 could also be obtained by venous blood gas analysis, co-oximetry, and standard equations (P50Ven). In 50 patients referred for evaluation of erythrocytosis, pH, PO2, and oxygen saturation were measured in venous blood to estimate P50Ven; P50Tono was measured for comparison. Agreement among P50Ven and P50Tono was evaluated (Bland-Altman analysis). Mean P50Tono was 25.8 (range 17.4-34.1) mmHg. The mean difference (bias) of P50Tono-P50Ven was 0.5 mmHg; limits of agreement (95 % confidence limits) were -5.2 to +6.1 mmHg. The sensitivity and specificity of P50Ven to identify the 25 patients with P50Tono outside the normal range of 22.9-26.8 mmHg were 5 and 77 %, respectively. We conclude that estimates of P50 based on venous blood gas analysis and standard equations have a low bias compared to tonometry. However, the precision of P50Ven is not sufficiently high to replace P50Tono in the evaluation of individual patients with suspected disturbances of hemoglobin oxygen affinity.

journal_name

Ann Hematol

journal_title

Annals of hematology

authors

Huber FL,Latshang TD,Goede JS,Bloch KE

doi

10.1007/s00277-012-1667-z

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

517-21

issue

4

eissn

0939-5555

issn

1432-0584

journal_volume

92

pub_type

杂志文章

相关文献

ANNALS OF HEMATOLOGY文献大全
  • Polymorphisms in cytokine genes as prognostic markers in diffuse large B cell lymphoma patients treated with (R)-CHOP.

    abstract：:To investigate whether cytokine genetic polymorphisms influence the outcome of diffuse large B cell lymphoma (DLBCL), we tested 337 consecutive DLBCL treated with CHOP or rituximab-CHOP (R-CHOP) from interleukin 10 (IL10), Bcl-2, and tumor necrosis factor (TNF)-α polymorphisms. Patients who carried the IL10 rs1800871 ...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-016-2857-x

    authors： Liu D,Wang Y,Dong M,Guan S,Wang Y,Sun H,Wu N,Li S,Bai J,Chen F,Sun D,Jin Y

    更新日期：2017-02-01 00:00:00

  • Activation-induced deaminase and its splice variants associate with trisomy 12 in chronic lymphocytic leukemia.

    abstract：:Activation-induced cytidine deaminase (AID) is a mutator enzyme essential for somatic hypermutation (SHM) and class switch recombination (CSR) during effective adaptive immune responses. Its aberrant expression and activity have been detected in lymphomas, leukemias, and solid tumors. In chronic lymphocytic leukemia (...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-018-3520-5

    authors： Zaprazna K,Reblova K,Svobodova V,Radova L,Bystry V,Baloun J,Durechova K,Tom N,Loja T,Buresova M,Stranska K,Oltova A,Doubek M,Atchison ML,Trbusek M,Malcikova J,Pospisilova S

    更新日期：2019-02-01 00:00:00

  • Allogeneic bone marrow transplantation for refractory mantle cell lymphoma.

    abstract：:We report about a 28-year-old woman with relapsed mantle cell lymphoma (MCL, centrocytic lymphoma according to the Kiel classification) refractory to salvage chemotherapy. The patient underwent allogeneic bone marrow transplantation from a HLA-identical brother after myeloablative chemotherapy consisting of busulfan, ...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s002770000196

    authors： Kröger N,Hoffknecht M,Krüger W,Zeller W,Renges H,Stute N,Zschaber R,Zander AR

    更新日期：2000-10-01 00:00:00

  • Effects of thrombopoietin on megakaryocyte colony formation from leukemic cells at diagnosis and from marrow cells after induction chemotherapy for acute leukemias.

    abstract：:We have studied the effects of recombinant human thrombopoietin (TPO, mpl ligand) on the megakaryocyte colony formation from control human bone marrow cells, human leukemia cells at diagnosis, and human bone marrow cells after induction chemotherapy for acute leukemias. In the control human bone marrow cells from four...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s002770050408

    authors： Liang DC,Shih LY,Kuo MC,Chen SH,Liu HC,Shimosaka A

    更新日期：1998-07-01 00:00:00

  • Thromboembolic events as an emerging adverse effect during high-dose intravenous immunoglobulin therapy in elderly patients: a case report and discussion of the relevant literature.

    abstract：:A case of an 82-year-old man who suffered an acute ST-elevation myocardial infarction while receiving treatment with intravenous immunoglobulin (IVIg) for thrombocytopenia is discussed. A total of 29 other cases of thromboembolism related to IVIg therapy have been reported, and the incidence seems to be especially hig...

    journal_title：Annals of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s00277-004-0895-2

    authors： Hefer D,Jaloudi M

    更新日期：2004-10-01 00:00:00

  • Cationic lipid mediated transfer of c-abl and bcr antisense oligonucleotides to immature normal myeloid cells: uptake, biological effects and modulation of gene expression.

    abstract：:Uptake and biochemical and biological effects of antisense oligodeoxynucleotides (ODN) specific for c-abl and bcr genes were studied in normal immature myeloid cells. CD34-positive cells were purified by positive and negative selection and cultured in liquid culture for 7 days. These cells were then incubated with ODN...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/BF00641311

    authors： Albrecht T,Schwab R,Peschel C,Engels HJ,Fischer T,Huber C,Aulitzky WE

    更新日期：1996-02-01 00:00:00

  • Presence of a high-grade component in gastric mucosa-associated lymphoid tissue (MALT) lymphoma is not associated with an adverse prognosis.

    abstract：:Gastric mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B cell lymphoma (DLBCL) show a spectrum of disease characterized by varying proportions of low-grade and high-grade components. While the natural history and optimum treatment for low-grade gastric MALT lymphoma and DLBCL is well established, ...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-008-0604-7

    authors： Ang MK,Hee SW,Quek R,Yap SP,Loong S,Tan L,Tao M,Lim ST

    更新日期：2009-05-01 00:00:00

  • Epidemiology of chronic myeloid leukaemia: an update.

    abstract：:National and regional population-based registries are, provided diagnostic accuracy and full coverage of the target population, indispensible tools for epidemiological research. Chronic myeloid leukaemia (CML) registries with more comprehensive reporting may also provide complementary data on treatment outcome to thos...

    journal_title：Annals of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s00277-015-2314-2

    authors： Höglund M,Sandin F,Simonsson B

    更新日期：2015-04-01 00:00:00

  • Combination therapy of disseminated Fusarium oxysporum infection with terbinafine and amphotericin B.

    abstract：:A case of disseminated infection with Fusarium oxysporum following chemotherapy of acute myelogenous leukemia is reported. Antifungal treatment was successful with a 13-day course of oral terbinafine 250 mg t.i.d. in combination with amphotericin B deoxycholate 1.0-1.5 mg/kg qd and subsequently intravenous liposomal a...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-003-0795-x

    authors： Rothe A,Seibold M,Hoppe T,Seifert H,Engert A,Caspar C,Karthaus M,Fätkenheuer G,Bethe U,Tintelnot K,Cornely OA

    更新日期：2004-06-01 00:00:00

  • Risk for cytomegalovirus infection following reduced intensity allogeneic stem cell transplantation.

    abstract：:Preliminary data suggest a faster immune recovery following non-myeloablative stem cell transplantation because of the persistence of recipient T cells, but the real impact on post-transplant infectious complications remains unknown. We retrospectively analysed the incidence of cytomegalovirus (CMV) infection in twent...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-003-0706-1

    authors： Nachbaur D,Larcher C,Kircher B,Eibl G,Nussbaumer W,Gunsilius E,Haun M,Grünewald K,Gastl G

    更新日期：2003-10-01 00:00:00

  • Alloantibody from a patient with severe von Willebrand disease inhibits von Willebrand factor-FVIII interaction.

    abstract：:The aim of this study was to analyze the ability of an alloantibody from a patient with severe von Willebrand disease (vWD) to interfere with the vWF domain for FVIII, to inhibit factor VIII (FVIII), and to compare it with a rabbit polyclonal antibody. The vWF domain for binding to FVIII was assayed by a method previo...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s002770050323

    authors： Batlle J,Lourés E,Vila P,Hernández MC,Méndez JA,Torea J,Rendal E,Couselo MJ,Filgueira A,López Fernández MF

    更新日期：1997-09-01 00:00:00

  • Acute lymphoblastic leukemia-like treatment regimen provides better response in mixed phenotype acute leukemia: a comparative study between adults and pediatric MPAL patients.

    abstract：:Mixed phenotype acute leukemia (MPAL) is a rare type of leukemia with a limited number of studies conducted to characterize its clinical spectrum and most importantly the best treatment modality. MPAL blasts show more than one phenotype either myeloid/monocytic with T- or B-lymphoid or extremely rare triple lineage as...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-020-04354-2

    authors： Rasekh EO,Osman R,Ibraheem D,Madney Y,Radwan E,Gameel A,Abdelhafiz A,Kamel A,Elfishawi S

    更新日期：2020-11-23 00:00:00

  • Effect of treatment with amifostine used as a single agent in patients with refractory anemia on clinical outcome and serum tumor necrosis factor alpha levels.

    abstract：:Amifostine increases in vitro burst-forming unit-erythroid and colony-forming unit-granulocyte/granulcoyte-macrophage cultured from bone-marrow cells from patients with myelodysplastic syndrome (MDS). Several small clinical studies give divergent informations about the potential of amifostine as single agent to improv...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s002770050589

    authors： Hofmann WK,Seipelt G,Ottmann OG,Kalina U,Koschmieder S,Brücher J,Frickhofen N,Klausmann M,Mitrou PS,Hoelzer D

    更新日期：2000-05-01 00:00:00

  • Randomized controlled trial of twice-daily versus alternate-day oral iron therapy in the treatment of iron-deficiency anemia.

    abstract：:Recent studies in iron-depleted women have challenged the current approach of treating iron-deficiency anemia (IDA) with oral iron in divided daily doses. Alternate day dosing leads to more fractional absorption of iron. In this randomized controlled trial, we looked at the efficacy and safety of alternate-day (AD) ve...

    journal_title：Annals of hematology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00277-019-03871-z

    authors： Kaundal R,Bhatia P,Jain A,Jain A,Nampoothiri RV,Mishra K,Jandial A,Goni D,Sandal R,Jindal N,Meshram A,Sharma R,Khaire N,Singh C,Khadwal A,Prakash G,Das R,Varma N,Varma S,Malhotra P,Lad DP

    更新日期：2020-01-01 00:00:00

  • Interferon alpha in the treatment of polycythemia vera.

    abstract：:Interferon alpha (IFN) inhibits the growth of the abnormal clone in patients with myeloproliferative disorders, leading to a reduction of the clinical and laboratory signs of the pathologic myeloproliferation. The therapeutic efficacy of IFN in polycythemia vera (PV) is demonstrated by the summarized treatment results...

    journal_title：Annals of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s002770050563

    authors： Lengfelder E,Berger U,Hehlmann R

    更新日期：2000-03-01 00:00:00

  • Evaluation of a new protein-C concentrate and comparison of protein-C assays in a child with congenital protein-C deficiency.

    abstract：:We investigated a new protein-C (PC) concentrate in a child with a type-II homozygous deficiency, concerning tolerance and safety. By means of various functional and antigen assays the in vivo recovery and the half-life were determined. In order to compare the results we reduced the measured values to the average half...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/BF01697402

    authors： Auberger K

    更新日期：1992-03-01 00:00:00

  • The 6-min walk test: an independent correlate of elevated tricuspid regurgitant jet velocity in children and young adult sickle cell patients.

    abstract：:Elevation of echocardiography-determined tricuspid regurgitant jet velocity (TRV) predicts high systolic pulmonary artery pressure. The present study tested the hypotheses that elevated tricuspid regurgitant jet velocity is associated with both hemolysis and hypoxia and abnormal 6-min walk test (6MWT) results. This st...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-014-2030-3

    authors： Agha H,El Tagui M,El Ghamrawy M,Abdel Hady M

    更新日期：2014-07-01 00:00:00

  • CD34+ leukemic subpopulation predominantly displays lower spontaneous apoptosis and has higher expression levels of Bcl-2 and MDR1 genes than CD34- cells in childhood AML.

    abstract：:In view of obscure clinical and biological significance of leukemic cells heterogeneity, we studied the efficacy of apoptosis, proliferation, and expression levels of the Bcl-2, MDR1, LRP, and BCRP genes in sorted CD34+ and CD34- subpopulations of childhood AML leukemic samples. In five out of nine cases, CD34+ cells ...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-008-0439-2

    authors： Shman TV,Fedasenka UU,Savitski VP,Aleinikova OV

    更新日期：2008-05-01 00:00:00

  • Long-term follow-up of allogeneic stem cell transplantation in patients with severe aplastic anemia after conditioning with cyclophosphamide plus antithymocyte globulin.

    abstract：:We investigated the efficacy of an antithymocyte globulin/cyclophosphamide preparative regimen prior to allogeneic stem cell transplantation from HLA-identical siblings in patients with severe aplastic anemia. Since 1990, 21 patients, 6 males and 15 females, with a median age of 25 years (range: 7-43) have been enroll...

    journal_title：Annals of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00277-002-0566-0

    authors： Kröger N,Zabelina T,Renges H,Krüger W,Kordes U,Rischewski J,Schrum J,Horstmann M,Ayuk F,Erttmann R,Kabisch H,Zander AR

    更新日期：2002-11-01 00:00:00

  • Thrombocytopenia and the effect of platelet transfusions on the occurrence of intracranial hemorrhage in patients with acute leukemia - a nested case-control study.

    abstract：:We designed a study to describe the incidence of intracranial hemorrhage according to severity and duration of thrombocytopenia and to quantify the associations of platelet transfusions with intracranial hemorrhage in patients with acute leukemia. In this case-control study nested in a cohort of 859 leukemia patients,...

    journal_title：Annals of hematology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00277-020-04298-7

    authors： Cornelissen LL,Kreuger AL,Caram-Deelder C,Middelburg RA,Kerkhoffs JLH,von dem Borne PA,Beckers EAM,de Vooght KMK,Kuball J,Zwaginga JJ,van der Bom JG

    更新日期：2021-01-01 00:00:00

  • Role of radiography, MRI and FDG-PET/CT in diagnosing, staging and therapeutical evaluation of patients with multiple myeloma.

    abstract：:Multiple myeloma is a malignant B-cell neoplasm that involves the skeleton in approximately 80% of the patients. With an average age of 60 years and a 5-years survival of nearly 45% Brenner et al. (Blood 111:2516-2520,35) the onset is to be classified as occurring still early in life while the disease can be very aggr...

    journal_title：Annals of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s00277-009-0829-0

    authors： Lütje S,de Rooy JW,Croockewit S,Koedam E,Oyen WJ,Raymakers RA

    更新日期：2009-12-01 00:00:00

  • Future research in ITP: an ICIS consensus.

    abstract：:While much has been learned about the basic immunology and clinical characteristics of immune thrombocytopenia, many important questions remain with regard to pathogenesis, disease progression, identification of novel therapeutic targets and approaches, and clinical trials that rationalize and optimize use of existing...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-010-0917-1

    authors： Zehnder JL,Semple JW,Imbach P,Neufeld EJ,Buchanan GR,Cines DB,ICIS Study Group on Future Research in ITP.

    更新日期：2010-07-01 00:00:00

  • Haemoglobinopathies with high oxygen affinity. Experience of Erythropathology Cooperative Spanish Group.

    abstract：:Haemoglobinopathies are the world's most frequently found monogenic disorders. In the cases with high oxygen affinity, the decrease in the liberation of the oxygen determines a secondary erythrocytosis. In this work, we present 17 unrelated families of Caucasian race and of Spanish origin, with ten variants of haemogl...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-008-0581-x

    authors： González Fernández FA,Villegas A,Ropero P,Carreño MD,Anguita E,Polo M,Pascual A,Henández A

    更新日期：2009-03-01 00:00:00

  • Cyclosporine-induced graft-versus-host disease after autologous bone marrow transplantation in hematological malignancies.

    abstract：:In the attempt to induce graft-vs-host disease (GVHD) in patients undergoing autologous bone marrow transplantation (ABMT) or blood stem cell transplantation (BSCT), 12 consecutive patients received cyclosporin A (CyA) post transplant. CyA was given at a dose of 1.5 mg/kg/day intravenously for 28 days, starting on the...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/BF01703140

    authors： Carella AM,Gaozza E,Congiu A,Carlier P,Nati S,Truini M,Castellaneta A,Viale M

    更新日期：1991-05-01 00:00:00

  • Transplant outcomes of the triple-negative NPM1/FLT3-ITD/CEBPA mutation subgroup are equivalent to those of the favourable ELN risk group, but significantly better than the intermediate-I risk group after allogeneic transplant in normal-karyotype AML.

    abstract：:The prognostic significance of molecular mutations (FLT3-ITD, NPM1, and CEBPA mutations) was examined in patients with normal-karyotype acute myeloid leukaemia (NK-AML) after allogeneic haematopoietic cell transplantation (HCT). In total, 115 patients received allogeneic HCT for NK-AML and were evaluated for FLT3-ITD,...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-015-2580-z

    authors： Ahn JS,Kim HJ,Kim YK,Jung SH,Yang DH,Lee JJ,Kim NY,Choi SH,Jung CW,Jang JH,Kim HJ,Moon JH,Sohn SK,Won JH,Kim SH,Kim DD

    更新日期：2016-03-01 00:00:00

  • Statin use and the risk of multiple myeloma: a PRISMA-compliant meta-analysis.

    abstract：:Previous studies exploring associations between statin use and risk of multiple myeloma (MM) showed inconsistent results. We searched for articles published in English in databases (PubMed, Web of Science, EMBASE, Medline, and Google Scholar) before October 2019. The multivariate odds ratio (OR)/relative risk (RR) and...

    journal_title：Annals of hematology

    pub_type： 杂志文章,meta分析

    doi：10.1007/s00277-020-04157-5

    authors： Zhang P,Liu B

    更新日期：2020-08-01 00:00:00

  • Intercellular adhesion molecular 1 on monocytes mediates adhesion as well as trans-endothelial migration and can be downregulated using antisense oligonucleotides.

    abstract：:The intercellular adhesion molecule 1 (ICAM-1) on endothelial cells is involved in the recruitment of leukocytes to inflammatory sites. In contrast to ICAM-1 expression on endothelial cells, little is known about its function in leukocytes in inflammation. Using ICAM-1-directed anti-sense oligodeoxyribonucleotides (OD...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s002770000168

    authors： Steidl U,Haas R,Kronenwett R

    更新日期：2000-08-01 00:00:00

  • Failure of repeated courses of high-dose intravenous immunoglobulin to induce stable remission in patients with chronic idiopathic thrombocytopenic purpura.

    abstract：:Repeated courses of HD IVIg are reported to induce stable remission in a significant proportion of adults with chronic refractory ITP. We have treated 14 such patients obtaining a remission rate quite comparable to the 5-10% of spontaneous remission. ...

    journal_title：Annals of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF01834386

    authors： Schiavotto C,Ruggeri M,Rodeghiero F

    更新日期：1995-02-01 00:00:00

  • Chlorambucil-induced pulmonary disease: a case report and review of the literature.

    abstract：:A 77-year-old man developed pneumonitis while on chlorambucil therapy for chronic lymphocytic leukemia, with a cumulative dose of 2700 mg. The condition improved promptly with the discontinuation of the drug and initiation of steroids. A case report and review of the literature are presented in this paper. ...

    journal_title：Annals of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s002770050418

    authors： Khong HT,McCarthy J

    更新日期：1998-07-01 00:00:00

  • Genotyping of 22 blood group antigen polymorphisms and establishing a national recipient registry in the Korean population.

    abstract：:It is often difficult for standard blood banks in Korea to supply adequate amounts of blood for patients with rare phenotype. Moreover, the definition of a blood in need is ambiguous, and much remains to be learned. In this study, we determined the prevalence of various red blood cell (RBC) antigens from a donor viewp...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-016-2645-7

    authors： Hong YJ,Chung Y,Hwang SM,Park JS,Kwon JR,Choi YS,Kim JN,Lee DH,Kwon SY,Cho NS,Song EY,Park KU,Song J,Han KS

    更新日期：2016-05-01 00:00:00